Wyniki wyszukiwania dla: OXIRANE RING OPENING
-
Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery
PublikacjaAbstract: Five-membered 1,2,4-oxadiazole heterocyclic ring has received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities. Thus, it is a perfect framework for the novel drug development. After a century since the 1,2,4-oxadiazole have been discovered, the uncommon potential attracted medicinal chemists’ attention, leading to the discovery of a few presently...
-
VUV photofragmentation of the six-membered heterocyclic molecules containing oxygen
PublikacjaCancer is a significant public health concern worldwide, which results in millions of deaths each year. The standard cure routine for cancer is surgery, and nowadays, radiotherapy or a hadrontherapy. Depending on the type of cancer, patients may undergo additional treatment, including targeted therapy. A combination of radio- or hadron-therapy with proper drug treatment can inhibit the proliferation of cancer cells and thus can...
-
Local response surface approximations and variable-fidelity electromagnetic simulations for computationally efficient microwave design optimisation
PublikacjaIn this study, the authors propose a robust and computationally efficient algorithm for simulation-driven design optimisation of microwave structures. Our technique exploits variable-fidelity electromagnetic models of the structure under consideration. The low-fidelity model is optimised using its local response surface approximation surrogates. The high-fidelity model is refined by space mapping with polynomial interpolation of...
-
Analiza odcinków generujących straty czasu w transporcie tramwajowym
PublikacjaW czasie analiz i studiów przedwykonawczych dotyczących budowy nowych i modernizacji istniejących tras tramwajowych, bardzo często zakładane są nierealne czasy przejazdów, które weryfikuje się już po oddaniu linii do eksploatacji i przeprowadzeniu badań obserwacyjnych. Problematyczne wydaje się określenie, przed zakończeniem inwestycji, rzeczywistej prędkości jazdy, jak również strat czasu powstających w miejscach potencjalnych...
-
Chemical and biological stability of polyene macrolides
PublikacjaThe polyene macrolide antibiotics have been used in an-tifungal therapy since first o f them were discovered in 1950's. Up to now, four polyene macrolides are being used in medical practice, namely amphotericin B, nystatin, candi-cidin and pimaricin.The antifungal activity and mode of ac-tion of polyene macrolides is determined by their structure, chemical and physical properties.The main fragment of polyene...
-
Sound intensity distribution around organ pipe
PublikacjaThe aim of the paper was to compare acoustic field around the open and stopped organ pipes. The wooden organ pipe was located in the anechoic chamber and activated with a constant air flow, produced by an external air-compressor. Thus, long-term steady state response was possible to obtain. Multichannel acoustic vector sensor was used to measure the sound intensity distribution of radiated acoustic energy. Measurements have been...
-
Electronic structure of intertwined kagome, honeycomb, and triangular sublattices of the intermetallics MCo2Al9 ( M = Sr, Ba)
PublikacjaIntermetallics are an important playground to stabilize a large variety of physical phenomena, arising from their complex crystal structure. The ease of their chemical tunabilty makes them suitable platforms to realize targeted electronic properties starting from the symmetries hidden in their unit cell. Here, we investigate the family of the recently discovered intermetallics MCo2Al9 (M=Sr, Ba) and we unveil their electronic structure....
-
The Effect of Openings’ Size and Location on Selected Dynamical Properties of Typical Wood Frame Walls
PublikacjaThe wooden frame constructions are now popular in many developed countries of the world. Many of these locations where such buildings are constructed are exposed to seismic and other shocks which are generated by human activities. This paper discusses the effect of the size and location of openings in the wooden frame walls under dynamic loadings. Natural frequencies of such frames with and without openings have been determined....
-
The influence of selected strain-based failure criteria on ship structure damage resulting from a collision with an offshore wind turbine monopile
PublikacjaOffshore wind farms are developing well all over the world, providing green energy from renewable sources. The evaluation of possible consequences of a collision involves Finite Element computer simulations. The goal of this paper was to analyse the influence of selected strain-based failure criteria on ship damage resulting from a collision with an offshore wind turbine monopile. The case of a collision between an offshore supply...
-
Just look at to open it up: A biometric verification facility for password autofill to protect electronic documents
PublikacjaElectronic documents constitute specific units of information, and protecting them against unauthorized access is a challenging task. This is because a password protected document may be stolen from its host computer or intercepted while on transfer and exposed to unlimited offline attacks. The key issue is, therefore, making document passwords hard to crack. We propose to augment a common text password authentication interface...
-
EXPERIMENTAL AND NUMERICAL INVESTIGATION ON SPECIMEN GEOMETRY EFFECT ON THE CTOD VALUE FOR VL-E36 SHIPBUILDING STEEL
PublikacjaThere are special cases in the marine industry, where additional material tests, such as the fracture toughness test, must be performed. Additional fracture toughness tests, such as CTOD (Crack Tip Opening Displacement), are typically performed on three-point bend specimens. The dimension that defines all the specimen dimensions is the thickness of the material to be tested. It is recommended by classification societies (e.g. DNVGL)...
-
Hydrodynamic Model of the New Waterway through the Vistula Spit
PublikacjaThe decision to build a new waterway (strait) in the Polish part of the Vistula Spit was made in 2017. The new connection between the Gulf of Gdańsk and the Vistula Lagoon is planned as an artificial navigable channel with a lock and a small port. During storm surges and wind tides in the gulf or in the lagoon, sluicing will be re-quired for vessels to tackle the Vistula Spit. This procedure does not require significant water flow...
-
Green Approaches in Rubber Recycling Technologies: Present Status and Future Perspective
PublikacjaAs a consequence of massive production and consumption of rubbers, rubber blends, and rubber composites for myriad applications, elastomeric products have enormously accumulated and become an environmental threat. The disposal and burning of rubber wastes have been banned because of environmental and economic reasons. By contrast, a great deal of attention has been directed toward strategies enabling recycling and reuse of rubbers....
-
Open Strategy for Digital Business. Managing in ICT-Driven Environments
PublikacjaThis book offers the reader a novel perspective on how digital contexts and open strategy approaches – the act of opening up strategic initiatives beyond company managers to involve front-line employees, stakeholders, and entrepreneurs – are related. Going beyond the claim that digital media drives open strategy by containing a detailed analyses of the interrelations between the two, the authors examine how ICT have diffused globally...
-
Video DATA - Traffic generation modeling for discount shops - Chrobrego Street
Dane BadawczeThe data includes video traffic data (vehicles, pedestrians, cyclists) registered at 75 Chrobrego street in Gdansk. The data covers the day 01.10.2020 at 6:00-22:00. The video camera was installed at the parking area belonging to the discount store Lidl. The data obtained was used in analysis, providing information about the modal split, the number...
-
Video DATA - Traffic generation modeling for discount shops - Czerska Street
Dane BadawczeThe data includes video traffic data (vehicles, pedestrians, cyclists) registered at 71 Czerska street in Gdansk. The data covers the day 01.10.2020 at 6:00-22:00. The video camera was installed at the parking area belonging to the discount store Lidl. The data obtained was used in analysis, providing information about the modal split, the number of...
-
Video DATA - Traffic generation modeling for discount shops - Gdanska Street
Dane BadawczeThe data includes video traffic data (vehicles, pedestrians, cyclists) registered at 21C Gdanska street in Gdansk. The data covers the day 01.10.2020 at 6:00-22:00. The video camera was installed at the parking area belonging to the discount store Lidl. The data obtained was used in analysis, providing information about the modal split, the number of...
-
Video DATA - Traffic generation modeling for discount shops - Dragana Street
Dane BadawczeThe data includes video traffic data (vehicles, pedestrians, cyclists) registered at 27 Dragana street in Gdansk. The data covers the day 01.10.2020 at 6:00-22:00. The video camera was installed at the parking area belonging to the discount store Lidl. The data obtained was used in analysis, providing information about the modal split, the number of...
-
Bis(ammonium) Zoledronate Dihydrate
PublikacjaNeutralization of 2-(1-imidazole)-1-hydroxyl-1,1`-ethylidenediphosphonic acid (zoledronic acid) by an excess of ammonia yielded bis(ammonium) zoledronate dihydrate, {C5H8N2O7P2 2−, 2(H4N+), 2(H2O)}. The product is readily soluble in water and forms monocrystals for which the X-ray structural analysis was carried out. The zoledronic anion is of double negative charge due to deprotonation of three P–OH groups and protonation of the...
-
Evaluation of Gas Chromatography Stationary Phases Based on Morpholinium Ionic Liquids by McReynolds Constants and Activity Coefficients at Infinite Dilution
PublikacjaIn this work, four ionic liquids (ILs) based on the N-alkyl-N-methylmorpholinium cation ([Mor1,R], in which R = 2, 4, 8, or 10) and bis (trifluoromethanesulfonyl)imide anion were synthesized. Using GLC, a number of parameters describing the sorption properties of the investigated ILs were determined. The values of Kovats indices, McReynolds constants, and activity coefficients at infinite dilution were the basis for the evaluation...
-
Activation of the C=P bond in phosphanylphosphaalkenes C=P–P bond system) in the reaction with nucleophilic reagents: MeLi, nBuLi and tBuLi
PublikacjaThree reactions of phosphanylphosphaalkene (1) with nucleophiles were performed to activate the diphosphorus monomer. We observed similar results in the reactions with MeLi and nBuLi, in which the P–P bond is cleavaged and triphosphorus systems [P(Me)2–CH(biph)–CH(biph)–P–(PtBu 2)]- (1a'') and [P(nBu)2–CH(biph)–CH(biph)–P–(PtBu 2)]- (1b''), respectively, are formed depending on the nucleophilic reagent (biph ¼ biphenyl). In the...
-
Convenient and efficient N-methylation of secondary amines under solvent-free ball milling conditions
PublikacjaIn the present work, we report the development of a rapid, efcient, and solvent-free procedure for the N-methylation of secondary amines under mechanochemical conditions. After optimization of the milling parameters, a vibrational ball mill was used to synthesize 26 tertiary N-methylated amine derivatives in a short time of 20 min (30 Hz frequency) and high yields ranging from 78 to 95%. An exception was compounds having a hydroxyl...
-
Międzynarodowa konferencja IATUL Seminar 2019 „Organizacyjne i prawne aspekty Otwartej Nauki” / International IATUL Seminar 2019 "Organizing the Open Science Framework – Strategies and Legal Aspects”
PublikacjaIATUL Seminar 2019 was held in Gdańsk/Sopot, Poland (December 10-11th, 2019). The theme of the Seminar was „Organizing the Open Science Framework – Strategies and Legal Aspects”. The event was co-organized by Gdańsk University of Technology Library and International Association of University Libraries (IATUL). IATUL Seminar 2019 event attracted delegates, including directors and senior managers of university and research libraries...
-
Theory versus experiment for vacuum Rabi oscillations in lossy cavities
PublikacjaThe 1996 experiment by Brune et al. [Phys. Rev. Lett. 76, 1800 (1996)] on vacuum Rabi oscillation is analyzed by means of alternative models of atom-reservoir interaction. Agreement with experimental Rabi oscillation data can be obtained if one defines jump operators in the dressed-state basis and takes into account thermal fluctuations between dressed states belonging to the same manifold. Such low-frequency transitions could...
-
Al-Kindi’s “The Real One”: Considerations of a mathematician or of a metaphysician?
PublikacjaThe aim of the article is to analyze Al-Kindi’s concept of the True (Essential) One and certain additional issues, also taking into account the influence on his position from both classical philosophy and source texts of Islam. In the opening part of the article, Al-Kindi’s innovative approach to the application of mathematics in research in other areas of knowledge is discussed. In the next part,...
-
Size effect at aggregate level in microCT scans and DEM simulation – Splitting tensile test of concrete
PublikacjaThe paper describes an experimental and numerical study of size effect on concrete cylindrical specimens in splitting tensile test. Own experimental campaign was performed on specimens with 5 various diameters from D = 74, 105, 150, 192 and 250 mm with hardboard loading strips (distributed load according to standard methods) scaled proportionally to the specimen diameter. The crack opening-control system was applied to obtain the...
-
Maxillary sinus aeration analysis using computational fluid dynamics
PublikacjaThe maxillary sinus aeration using the computational fluid dynamics (CFD) method based on individual adult patients’ computed tomography (CT) scans were analyzed. The analysis was based on CT images of 4 patients: one with normal nose anatomy and three with nasal septal deviation (NSD) and concha bullosa (CB). The CFD simulation was performed using the Reynolds-Average Simulation approach and turbulence closure based on linear...
-
Dynamic model of nuclear power plant turbine
PublikacjaThe paper presents the dynamic multivariable model of Nuclear Power Plant steam turbine. Nature of the processes occurring in a steam turbine causes a task of modeling it very difficult, especially when this model is intended to be used for on-line optimal process control (model based) over wide range of operating conditions caused by changing power demand. Particular property of developed model is that it enables calculations...
-
THE EFFECT OF NOTCH DEPTH ON CTOD VALUES IN FRACTURE TESTS OF STRUCTURAL STEEL ELEMENTS
PublikacjaIn elements of steel structures working at low temperatures, there is a risk of appearance of brittle fracture. This risk is reduced through the use of certified materials having guaranteed strength at a given temperature. A method which is most frequently used to determine brittle fracture toughness is the Charpy impact test, preformed for a given temperature. For offshore structures intended to work in the arctic climat e, the...
-
Data governance: Organizing data for trustworthy Artificial Intelligence
PublikacjaThe rise of Big, Open and Linked Data (BOLD) enables Big Data Algorithmic Systems (BDAS) which are often based on machine learning, neural networks and other forms of Artificial Intelligence (AI). As such systems are increasingly requested to make decisions that are consequential to individuals, communities and society at large, their failures cannot be tolerated, and they are subject to stringent regulatory and ethical requirements....
-
Changes of microbiological quality of water in distribution system. Zmiany mikrobiologicznej jakości wody w sieci dystrybucyjnej.
PublikacjaW artykule przedstawiono mikrobiologiczną jakość wody podziemnej uzdatnianej w dwóch stacjach oczyszczania wody (WTP I i WTP II), w sieci dystrybucyjnej. Obie stacje uzdatniania stosują dezynfekcję za pomocą dwutlenku chloru. Badania wykazały wzrost ogólnej liczby bakterii w miarę zwiększania się odległości od stacji uzdatniania.In the paper microbiological quality of water in distribution system produced in two ground water treatment...
-
CFD COUPLING OF VOF MODEL WITH ARRHENIUS EQUATION FOR ANALYSIS OF LASER-INDUCED THERMAL DEACTIVATION OF E. COLI
PublikacjaUnderstanding bacterial deactivation at the micro-scale, particularly with E. coli, is crucial for advancing microbiology and has promising applications in biomedical research. In this research contribution, we investigate the thermal inactivation of E. coli bacteria using gold nanoparticles irradiated by a green 1-W laser within a microfluidic chamber. The microfluidic device comprises a fluidic chamber filled with a thin film...
-
Review of the Usefulness of Various Rotational Seismometers with Laboratory Results of Fibre-Optic Ones Tested for Engineering Applications
PublikacjaStarting with descriptions of rotational seismology, areas of interest and historical field measurements, the fundamental requirements for rotational seismometers for seismological and engineering application are formulated. On the above basis, a review of all existing rotational seismometers is presented with a description of the principles of their operation as well as possibilities to fulfill formulated requirements. This review...
-
Specific Binding of Cholesterol to the Amyloid Precursor Protein: Structure of the Complex and Driving Forces Characterized in Molecular Detail
PublikacjaC99 is the C-terminal membrane-bound fragment of the amyloid precursor protein that is cleaved by γ-secretase to release Aβ peptides, the hallmark of Alzheimer’s disease (AD). Specific interactions of C99 with cholesterol have been proposed to underlie the recognized role of cholesterol in promoting amyloidogenesis. By using molecular dynamics simulations, we studied cholesterol binding to C99 in a lipid bilayer. We determined...
-
Photophysics of a Ruthenium 4H-Imidazole Panchromatic Dye in Interaction with Titanium Dioxide
PublikacjaThe photophysics of bis(4,4′-di-tert-butyl-2,2′-bipyridine-κ2N,N′)[2-(4-carboxyphenyl)-4,5-bis(p-tolylimino-κN)imidazolato]ruthenium(II) hexafluorophosphate is investigated, both in solution and attached to a nanocrystalline TiO2 film. The studied substitution pattern of the 4H-imidazole ligand is observed to block a photoinduced structural reorganization pathway within the 4H-imidazole ligand that has been previously investigated....
-
9-Cyano-10-methylacridinium hydrogen dinitrate
PublikacjaThe title compound, C15H11N2+·HN2O6−, crystallizes in the monoclinic space group C2/c with four molecules in the unit cell. The planar 9-cyano-10-methylacridinium cations lie on crystallographic twofold axes and are arranged in layers, almost perpendicular to the ac plane, in such a way that neighbouring molecules are positioned in a `head-to-tail' manner. These cations and the hydrogen dinitrate anions are linked through C—H⋯O...
-
Nitrogen oxides removal from hydrogen flue gas using corona discharge in marine boilers: Application perspective
PublikacjaThis paper focuses on the combustion of hydrogen in boilers, as it appears to be a more effective method than using fuel cells for heating purposes due to higher boiler efficiency. One of the main disadvantages of hydrogen combustion in air is NOx formation. Therefore, the authors decided to introduce corona discharge as an inno- vative technique to clean hydrogen flue gas by effectively reducing NOx levels. The method involves...
-
Progress in non-isocyanate polyurethanes synthesized from cyclic carbonate intermediates and di- or polyamines in the context of structure–properties relationship and from an environmental point of view
PublikacjaCommercially, polyurethanes are produced by the reaction of diisocyanates, polyols (polyester or polyether) and low molecular weight chain extender. Toxicity, moisture sensitivity and phosgene-based synthesis of diisocyanates resulted in investigations focused on obtaining the non-isocyanate polyurethanes (NIPUs). This work presents the review of synthesis and structure–properties relationship of non-isocyanate polyurethanes obtained...
-
Spotkanie informacyjne dla kandydatów do Szkoły Doktorskiej
WydarzeniaW dniu 29 czerwca, o godz. 11:00 (UTC+2) , odbędzie się spotkanie informacyjne dla kandydatów, dotyczące rekrutacji do Szkoły Doktorskiej PG na r.a. 2021/2022. Dostęp na hasło: PhD
-
Medium-sized cyclic bis(anisylphosphonothioyl)- disulfanes and their corresponding cyclic sulfane-structures and most characteristic reactions
PublikacjaCyclic 8-, 9-, 10-, and 12-membered bis(anisylphosphonothioyl)disulfanes were synthesized. Next, structurally related 7 to 9-membered cis and trans sulfanes were isolated as a result of sulfur atom extrusion from the parent cyclic disulfanes. The results of the desulfurization of the disulfanes were compared to the results obtained for desulfurization of the respective bis(anisylphosphodithioates). Cyclic disulfanes predominantly...
-
Mechatronic Design Towards Investigation of the Temporo-Mandibular Joint Behaviour
PublikacjaA significant problem of the temporo-mandibular joint (TMJ) research is lack of data concerning geometry and position of TMJ discs. It leads to necessity of developing a driving method of the process optimization, which is based on chosen techniques of mechatronic design. In particular, the latter concerns a technique of experimentally supported virtual prototyping. On this stage, the research is characterized by well-verified...
-
The fast identification of explosives, natcotics and other chemicals carried on board of ships or transported in containers
PublikacjaThe fast identification of explosives, narcotics and other chemicals carried on board of ships or transported in containers to the harbors is an important problem of maritime security. Raman spectroscopy is an advanced technique used in state-of-the art laboratories for fast identification of chemicals. No sample preparation is required, and identification can be carried out through transparent packing, such as plastic or glass,...
-
A comprehensive review on Ginger (Zingiber officinale) as a potential source of nutraceuticals for food formulations: Towards the polishing of gingerol and other present biomolecules
PublikacjaCurrently, ginger is one the most consumed plants when dealing with the treatments of various illnesses. So far, it is known that various biologically active molecules, such as gingerols, shogaols and zingerone, among others, are the main responsible for specific biological activities, opening a new window for its utilization as a nutraceutical in foods. In pioneering extraction processes, solvent extraction has been initially...
-
Assessment of dynamic characteristics of thin cylindrical sandwich panels with magnetorheological core
PublikacjaBased on the equivalent single-layer linear theory for laminated shells, free and forced vibrations of thin cylindrical sandwich panels with magnetorheological core are studied. Five variants of available magnetorheological elastomers differing in their composition and physical properties are considered for smart viscoelastic core. Coupled differential equations in terms of displacements based on the generalized kinematic hypotheses...
-
Investigation on Mode I Fracture Behavior of Hybrid Fiber-Reinforced Geopolymer Composites
PublikacjaRecent reports in the literature have shown that fber-reinforced geopolymer composites (FRGC) made with monofbers exhibit a signifcant enhancement in fracture energy. However, many aspects of the fracture performance of hybrid fberreinforced geopolymer composites (HFRGC) remain largely unexploited, and these are predominant for the structures. For the frst time, the mode I fracture energy of HFRGC is investigated. The mode I behavior...
-
Symbiosis of Art and Technology – From Renaissance to Interactive Art,
PublikacjaThe article presents the mutual relations between art and technology from the Renaissance to the interactive art of today. It indicates important factors influencing the possibilities of imaging and interpreting reality by artists, ranging from the development of oil painting techniques, linear perspective, the invention of printing and photography, to achievements related to the development of information technologies (computers,...
-
Reactions of the Lithiated DiphosphinetBu2P-P(SiMe3)Li with [(η6-C6H6)RuCl2]2in the Presence of Tertiary Phosphines
PublikacjatBu2P–P(SiMe3)Li reacted with [(η6-C6H6)RuCl2]2at–40 °C in the presence of PR3(PR3=PEt3,PEt2Ph, PEtPh2) by the nucleophilic addition of the tBu2P–P(SiMe3) moiety to the benzene ring to yield solely the complexes [(R3P)2Ru(Cl)-{η5-C6H6(Me3SiP–PtBu2)}] (1). These products decomposed slowly at ambient temperature to yield benzene, Ru clusters, and small amounts of the dinuclear ruthenium complexes [{(R3P)2Ru}2(μ,η2:2-P2)2Ru(PR3)2](Ru–Ru)(6)....
-
Scanning networks with cactus topology
PublikacjaThe family of Pursuit and Evasion problems is widelystudied because of its numerous practical applications,ranging from communication protocols to cybernetic andphysical security. Calculating the search number of a graphis one of most commonly analyzed members of this problemfamily. The search number is the smallest number of mobileagents required to capture an invisible and arbitrarily fastfugitive, for instance piece of malicious...
-
Development of Sulfamoylated 4‑(1-Phenyl‑1H‑1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer
PublikacjaWe present here the advances achieved in the development of new sulfamoylated 4-(1-phenyl-1H-1,2,3-triazol-4-yl)phenol derivatives as potent steroid sulfatase (STS) inhibitors for the treatment of breast cancer. Prompted by promising biological results and in silico analysis, the initial series of similar compounds were extended, appending a variety of m-substituents at the outer phenyl ring. The inhibition profiles of the newly...
-
Synthesis of Combretastatin A-4 Analogs and their Biological Activities
PublikacjaCombretastatin A-4 (CA-4) is a natural product, which consists of two phenyl rings, linked by an ethylene bridge. CA-4, inhibitor of polymerization of tubulin to microtubules, possesses a strong antitumor and anti-vascular properties both in vitro and in vivo. Previous studies showed that disodium phosphate salt of CA-4, a water-soluble prodrug is well tolerated at therapeutically useful doses. However, it should be noted that...