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Wyniki wyszukiwania dla: peptide profile
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Serum fatty acid profile in psoriasis and its comorbidity
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Aromagramy - profile zapachowe w ocenie jakości żywności.
PublikacjaKażdy produkt ma charakterystyczny i unikalny zestaw lotnych składników. Ich identyfikacja i ocena ilościowa może stać się źródłem informacji na temat jakości zdrowotnej żywności na którą składa się zarówno jakość organoleptyczna, jak i bezpieczeństwo dla zdrowia konsumenta. W pracy opisano nowe trendy w oznaczaniu substancji zapachowych opierajace sie na tworzeniu aromagramów, czyli profili zapachowych produktów spożywczych, z...
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Simulation of the profile wear of the tool in double wheel lapping
PublikacjaPrzedstawiono założenia modelowe do wyznaczenia zużycia profilowego narzędzia w docieraniu dwutarczowym. Rozkłady istotnych czynników kinematycznych (prędkości docierania i przyspieszenia stycznego) wpływających na zużycie docieraka zaprezentowane zostały dla różnych typów zakreślanych trajektorii.
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Simulation of the profile wear of the tool in double wheel lapping
PublikacjaW pracy przedstawiono model zużycia narzędzia w docieraniu dwutarczowym. Wyprowadzono równania opisujące kontakt przedmiotu z narzędziem. Przedstawiono wyniki analiz symulacyjnych dla różnych parametrów kinematycznych - dla układu współbieżnego i przeciwbieżnego.
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CLASSIFICATION OF RESTRAINTS IN THE OPTIMIZATION PROBLEM OF A COLD-FORMED PROFILE
PublikacjaThis work describes the restraints in the optimization problem. This is an important and complicated issue because it requires taking into account a vast range of information related to the design and production. In order to describe the relations of a specific optimization problem, it is essential to adopt appropriate criteria and to collect information on all kinds of restraints, i.e. boundary conditions. The following paper...
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A novel sensor for measuring temperature profile during the thermoablation
PublikacjaAbstract — A novel approach for monitoring a temperature distribution inside a tissue during thermoablation is presented in the paper. A thermal profile is measured using a set of serially connected thermistors each bypassed by a capacitor. This technique allows a two-wire and simultaneous multi- point measurements using a multi-frequency measurement of electrical impedance. It is...
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A Highly Selective Biosensor Based on Peptide Directly Derived from the HarmOBP7 Aldehyde Binding Site
PublikacjaThis paper presents the results of research on determining the optimal length of a peptide chain to eectively bind octanal molecules. Peptides that map the aldehyde binding site in HarmOBP7 were immobilized on piezoelectric transducers. Based on computational studies, four Odorant Binding Protein-derived Peptides (OBPPs) with dierent sequences were selected. Molecular modelling results of ligand docking with selected peptides were...
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Peptydy przeciwgrzybowe
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AMCA to TAMRA long range resonance energy transfer on a flexible peptide
PublikacjaFörster resonance energy transfer between 7-amino-4-methyl-3-coumarinylacetic acid, (AMCA, donor) and 5- carboxytetramethylrhodamine, (TAMRA, acceptor) bound to Lys(AMCA)-Gly-Pro-Arg-Ser-Leu-Ser-Gly-Lys (TAMRA)-NH2 peptide is demonstrated by various spectroscopic techniques in glycerol at room temperature. In particular, nonexponential character of fluorescence intensity decay evidences the distance distribution between the donor...
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Interactions in aqueous solutions of K-peptide and DMSO – spectroscopic and calorimetric studies
PublikacjaIntroduction K-peptide (GILQINSRW) – short 9 amino acid fragment of the hen egg white lysozyme has the ability to form amyloid structures. Dimethyl sulfoxide (DMSO) is an osmolyte which can alter this ability. Our goal was to get an insight into the mechanism of Kpeptide-DMSO interactions in aqueous solutions. Such a knowledge can be helpful to understand processes leading to various neurodegenerative diseases. Methods ATR-FTIR...
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Evaluation of Receptor Affinity, Analgesic Activity and Cytotoxicity of a Hybrid Peptide, AWL3020
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Triple helical collagen-like peptide interactions with selected polyphenolic compounds
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Antimicrobial and conformational studies of the active and inactive analogues of the protegrin-1 peptide
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Double amino acid – A novel molecule enabling peptide interpenetrating structures
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Synthesis and Evaluation of Biological Activity of Antimicrobial – Pro-Proliferative Peptide Conjugates
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Increased Urinary C-Peptide and Albumin Excretion in Juvenile Borderline Hypertensives
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Modified Peptide Molecules As Potential Modulators of Shelterin Protein Functions; TRF1
PublikacjaIn this work, we present studies on relatively new and still not well-explored potential anticancer targets which are shelterin proteins, in particular the TRF1 protein can be blocked by in silico designed "peptidomimetic" molecules. TRF1 interacts directly with the TIN2 protein, and this protein-protein interaction is crucial for the proper functioning of telomere, which could be blocked by our novel modified peptide molecules....
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Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid
PublikacjaThe series of 16 novel amino acid and peptide mycophenolic acid (MPA) derivatives was obtained as potential antibacterial agents. Coupling of MPA with respective amines was optimized with condensing reagents such as EDCI/DMAP and T3P/TEA. Amino acid analogs were received both as methyl esters and also with the free carboxylic group. The biological activity of the products was tested on five references bacterial strains: Klebsiella...
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Aromagrams - aromatic profiles in the appreciation of food quality
PublikacjaW ostatnich latach obserwuje się coraz powszechniejsze stosowanie analizy instrumentalnej do oceny jakości organoleptycznej produktów spożywczych. Nowe podejście polega na tworzeniu profili zapachowych, swego rodzaju "aromagramów" charakterystycznych dla danego produktu. Do najczęściej stosowanych technik pozwalających na tworzenie i rozpoznawanie "aromagramów" należą techniki chromatograficzne, w szczególności chromatografia gazowa...
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Molecular basis of TRF proteins and their interactions with peptides
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Pegylated Fluorescent Peptides as Substrates of Proteolytic Enzymes
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Growth Orientation and the Profile of Micro-Entrepreneurs From the Pomorskie Province
PublikacjaThe article begins with the presentation of the concept of Entrepreneurial Orientation. Entrepreneurial Orientation assumes that some enterprises, regardless of size, behave in an entrepreneurial way and are proactive, innovative and willing to take risks. The relationships between Entrepreneurial Orientation and the results of enterprises are also subject to research, although its results are not clear – mainly due to the different...
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Serum mass profile signature as a biomarker of early lung cancer
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Ewaluation of a PCR Melting Profile technique for bacterial strain differentiation
PublikacjaBadano przydatność techniki PCR MP w efektywnym typowaniu szczepów w badaniach epidemiologicznych zakażeń szpitalnych. Technika oparta jest na użyciu niskiej temperatury denaturacji podczas LM PCR. Badaniu zostały poddane izolaty Escherichia coli pochodzące od pacjentów Szpitala Klinicznego w Gdańsku. Wykazano, że technika jest szybka, o wysokim potencjale różnicującym i bardzo dobrej powtarzalności i może być zastosowana w badaniach...
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Anti-inflammatory Activity and Phytochemical Profile of Galinsoga Parviflora Cav.
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Comprehensive analysis of microRNA expression profile in malignant glioma tissues
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Stereometry of turned surfaces in a frequency-domain formulation of profile irregularities
PublikacjaPrzedstawiono częstotliwościowe składowe nierówności powierzchni toczonych. Ponieważ nierówności mają charakter szerokopasmowy, trudny do wartościowania parametrami normatywnymi, zastosowano ich analizę amplitudowo-częstotliwościową, opartą na szybkiej transformacie Fouriera. Przedstawiono kształtowanie nierówności wzdłużnych dla toczenia. Zaproponowano oryginalny układ pomiaru sygnału przemieszczeń narzędzia względem przedmiotu...
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The Effects of Pin Profile on HDPE Thermomechanical Phenomena during FSW
PublikacjaFriction stir welding (FSW) of polymeric materials has recently attracted significant attention. Herein, we present the effect of the tool pin profile on the FSW of high-density polyethylene (HDPE) joints through joint experimental analysis and thermomechanical simulations. For analysis of pin profile effects on the thermomechanical properties of HDPE joints, frustum (FPT), cubic (CPT), and triangular (TPT) pin shapes were selected...
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Extending the Shibboleth identity management model with a networked user profile
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Maternal smoking Modulates Fatty Acid Profile of Breast Milk
PublikacjaAIM: We hypothesized that the fatty acid composition of breast milk can be affected by a smoking habit in the mother. Consequently, this study verified whether maternal smoking modulates, and if so to what extent, the breast milk fatty acid profile. METHODS: The study included 20 postpartum women who declared smoking more than five cigarettes daily throughout a period of pregnancy and lactation, and 136 non-smoking postpartum women....
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Profile irregularities of turned surfaces as a result of machine tool interactions
PublikacjaThe paper describes the influence of the machining operation on a surface, which disturbs the projection of the tool profile in the form of its relative movements with respect to the object. The elements of the machine tool undergo constant wear during the machining process, it is therefore important to recognize the effects of their influence on the surface's irregularities. Amplitude-frequency analysis of lateral profiles has...
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Prediction of Bioactive Peptides From Chicken Feather and Pig Hair Keratins Using In Silico Analysis Based on Fragmentomic Approach
PublikacjaBackground: Keratin is among the most abundant structural proteins of animal origin, however it remains broadly underutilized. Objective: Bioinformatic investigation was performed to evaluate selected keratins originating from mass-produced waste products, i.e., chicken feathers and pig hair, as potential sources of bioactive peptides. Methods: Pepsin, trypsin, chymotrypsin, papain, and subtilisin were used for in silico keratinolysis...
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Autonomus hydroacoustics sound velocity profiler.
PublikacjaPraca zawiera opis bezpośredniej zasady pomiarowej i struktury wersji autonomicznego miernika pomiarów rozkładów prędkości dźwięku w akwenach przeznaczonych do stosowania na okrętach nawodnych, podwodnych i opuszczanych antenach sonarowych śmigłowców i okrętów nawodnych.
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Determination of terpene profiles in potential superfruits
PublikacjaThe aim of this work was to characterize and compare the profiles of volatile terpenes in four potential superfruits. These profiles were determined using headspace solid-phase microextraction coupled with comprehensive two-dimensional gas chromatography linked to time-of-flight mass spectrometry. The proposed technique allowed the separation and identification of 79 terpenes present in cape gooseberry, crabapple, cherry silver...
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PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke
PublikacjaIschemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the pro-viable activity of cell-penetrating peptides: arginine-rich Tat(49–57)-NH2 (R49KKRRQRRR57-amide) and its less basic analogue, PTD4 (Y47ARAAARQARA57-amide). Our model included glucose...
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Imunofan—RDKVYR Peptide—Stimulates Skin Cell Proliferation and Promotes Tissue Repair
PublikacjaRegeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today’s science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical specialties. In this study, we...
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Imunofan - RDKVYR peptide - stimulates skin cell proliferation and promotes tissue repair
PublikacjaRegeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today's science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical...
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Rapid PD-L1 detection in tumors with PET using a highly specific peptide
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Hydrazone Linker as a Useful Tool for Preparing Chimeric Peptide/Nonpeptide Bifunctional Compounds
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A Novel Cryptic Clostridial Peptide That Kills Bacteria by a Cell Membrane Permeabilization Mechanism
PublikacjaThis work reports detailed characteristics of the antimicrobial peptide Intestinalin (P30), which is derived from the LysC enzyme of Clostridium intestinale strain URNW. The peptide shows a broader antibacterial spectrum than the parental enzyme, showing potent antimicrobial activity against clinical strains of Gram-positive staphylococci and Gram-negative pathogens and causing between 3.04 ± 0.12 log kill for Pseudomonas aeruginosa...
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The Effect of Conjugation with Octaarginine, a Cell-Penetrating Peptide on Antifungal Activity of Imidazoacridinone Derivative
PublikacjaAcridine cell-penetrating peptide conjugates are an extremely important family of compounds in antitumor chemotherapy. These conjugates are not so widely analysed in antimicrobial therapy, although bioactive peptides could be used as nanocarriers to smuggle antimicrobial compounds. An octaarginine conjugate of an imidazoacridinone derivative (Compound 1-R8) synthetized by us exhibited high antifungal activity against reference...
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Biodegradation of nodularin and other nonribosomal peptides by the Baltic bacteria
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Targeting melanocortin receptor type 1 with small peptides
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Meat and fermented meat products as a source of bioactive peptides
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Hydration of Simple Model Peptides in Aqueous Osmolyte Solutions
PublikacjaThe biology and chemistry of proteins and peptides are inextricably linked with water as the solvent. The reason for the high stability of some proteins or uncontrolled aggregation of others may be hidden in the properties of their hydration water. In this study, we investigated the effect of stabilizing osmolyte–TMAO (trimethylamine N-oxide) and destabilizing osmolyte–urea on hydration shells of two short peptides, NAGMA (N-acetyl-glycine-methylamide)...
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Effect of ectoine on hydration spheres of peptides–spectroscopic studies
PublikacjaIn this paper, we use FTIR spectroscopy to characterize the hydration water of ectoine, its interactions with two peptides–diglycine and NAGMA, and the properties of water molecules in the hydration spheres of both peptides changed by the presence of the osmolyte. We found that the interaction of ectoine with the peptide hydration shells had no effect on its own hydration sphere. However, the enhanced hydration layer of the osmolyte...
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AC and DC global electric circuit and the height profile of atmospheric conductivity
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Whole-Body Cryotherapy Alters Circulating MicroRNA Profile in Postmenopausal Women
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Changes of heavy metals concentrations in the profile of sewage slugde in reed beds
PublikacjaW Polsce pojawiły się jedynie pilotowe obiekty trzcinowe unieszkodliwiające osady ściekowe. Natomiast w Danii są one eksploatowane w pełnej skali w dużych oczyszczalniach ścieków. Materiał badawczy pobrano z czterech duńskich obiektów o długim czasie eksploatacji wynoszącym od 7 do 15 lat. Obiekty te zlokalizowane były na terenie oczyszczalni: Rudkobing, Vallo, Naskov i Helsinge koło Kopenhagi obsługujących od 9 000 do 40 000 mieszkańców....
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The cytokine profile of mature milk from smoking and non-smoking mothers
PublikacjaZweryfikowano wpływ palenia kobiet na poziom cytokin (IL-1α, IL-1β, IL-6, IL-8, IL-10 i TNF-α) w mleku ludzkim w 30-32 dni po porodzie. Badana grupa składała się z 24 kobiet po porodzie, które deklarowały palenie więcej niż pięciu papierosów dziennie. Grupę kontrolną stanowiło 45 niepalących kobiet. W porównaniu do kobiet niepalących w mleku kobiet palących stwierdzono znacznie wyższe stężenia cytokiny IL-1α (P = 0,04). Nie stwierdzono...