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Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma
PublikacjaPURPOSE: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO2)-Pro-Lys-Thr-OCH3]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocytes, neurons) of neuroectodermal origin, and both are tumors with high heterogeneity and unsatisfactory susceptibility to chemotherapies....
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How to achieve sustainability?-Employee's point of view on company's culture and CSR practice
PublikacjaThe people are the company. This study aims to examine the structure of relationships between company culture, performance, corporate social responsibility (CSR), and reputation, as seen from the employee's perspective, to determine which company culture factors most influence CSR practice and, as a result, sustain a company's development and improve its performance. To accomplish this goal, we conducted a survey among employees...
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Evaluation of Analytes Characterized with Potential Protective Action after Rat Exposure to Lead
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Starch-grafted-N-vinylformamide copolymers manufactured by reactive extrusion: synthesis and characterization
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Elimination of clicks from archive speech signals using sparse autoregressive modeling
PublikacjaThis paper presents a new approach to elimination of impulsivedisturbances from archive speech signals. The proposedsparse autoregressive (SAR) signal representation is given ina factorized form - the model is a cascade of the so-called formantfilter and pitch filter. Such a technique has been widelyused in code-excited linear prediction (CELP) systems, as itguarantees model stability. After detection of noise pulses usinglinear...
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Action of an Antiserum to a-Tocoquinone on Photosystem II-Particle Preparations of N icotiana tabacum
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The effect of electromagnetic field on reactive oxygen species production in human neutrophilsin vitro
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Study of pozzolanic action of ground waste expanded perlite by means of thermal methods
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Experimental economics in business education: Using simple games to achieve multifaceted effects
PublikacjaEconomics differs from other sciences not only because of its normative part, but also because of very limited use of experiments. In this way, economics is often perceived as being methodologically more similar to astronomy or meteorology rather than physics or chemistry. Over last decades, however, experimental economics has been significantly developed. This chapter presents some of the possibilities for academic teachers to...
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Effect of native air-formed oxidation on the corrosion behavior of AA7075 aluminum alloys
PublikacjaThe microstructure of aluminum alloys plays a key role in their corrosion resistance. In particular, the presence of intermetallic precipitates differing in the potential from the alloy matrix induces local corrosion. The study presents the effect of native air-formed oxidation on the corrosion behavior of AA 7075 aluminum alloy. Various microscopic and spectroscopic techniques were used to examine the changes occurring in the...
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Localization of impulsive disturbances in archive audio signals using predictive matched filtering
PublikacjaThe problem of elimination of impulsive disturbances from archive audio signals is considered and its new solution, called predictive matched filtering, is proposed. The new approach is based on the observation that a large percentage of noise pulses corrupting archive audio recordings have highly repetitive shapes that match several typical “patterns”, called click templates. To localize noise pulses, click templates can be correlated...
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The community involvement of courts: an action research study in the context of the Polish justice system
PublikacjaPurpose – As a rule, common courts are hermetic organizations, separated from their stakeholders by procedures based on legal provisions. For these reasons, they are often perceived as unreliable and non-transparent, and as such, they do not inspire trust among stakeholders. The authors posit that the court’s community involvement may lead to the increased accountability and legitimacy of courts, which should in turn result in...
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Elimination of Impulsive Disturbances From Archive Audio Signals Using Bidirectional Processing
PublikacjaIn this application-oriented paper we consider the problem of elimination of impulsive disturbances, such as clicks, pops and record scratches, from archive audio recordings. The proposed approach is based on bidirectional processing—noise pulses are localized by combining the results of forward-time and backward-time signal analysis. Based on the results of specially designed empirical tests (rather than on the results of theoretical analysis),...
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Unsteady aerodynamic forces acting on the rotor blades in the turbine stagewith steam extraction.
PublikacjaPrzeprowadzono analizę niestacjonarnych wymuszeń działających na łopatki wirnikowe w stopniu z upustem turbiny 13UC100. Niestacjonarne siły zostały wyznaczone dla 4 punktów pracy upustu. Wskazano na możliwą przyczynę zaistniałego zniszczenia łopatek wirnikowych turbiny.
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Reactive extrusion of biodegradable aliphatic polyesters in the presence of free-radical-initiators: A review
PublikacjaNowadays, growing attention is being paid to the environment and sustainability, what fully justified research works focused on modification of biodegradable polymers and their composites. In this field of research reactive extrusion seems to be the most promising approach, which fits well to sustainable development strategy. In In the present work, the in-situ modification of biodegradable aliphatic polyesters and the compatibilization...
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Chain Action - How Do Countries Add Value Through Digital Government?
PublikacjaThis study examineshow countries develop and benefit from Digital Government(DG).The literature proposes various conceptualizations of the value-adding logic of DG, but the benchmarking practice is not respondingto such proposals.For instance, the United Nations’E-Government Surveycombines the readiness and uptake indicatorsand failsto cover any impactindicators;thus,its diagnostic valueis limited. To overcome...
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An MTA-phosphorylase gene discovered in the metagenomic library derived from Antarctic top soil during screening for lipolytic active clones confers strong pink fluorescence in the presence of rhodamine B.
PublikacjaIn this work, we present the construction of a metagenomic library in Escherichiacoli using the pUC19 vector and environmental DNA directly isolated fromAntarctic topsoil and screened for lipolytic enzymes. Unexpectedly, the screeningon agar supplemented with olive oil and rhodamine B revealed one unusual pinkfluorescent clone (PINKuv) out of 85 000 clones. This clone harbored a plasmid,pPINKuv, which has an insert of 8317 bp that...
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Identyfikacja i izolacja genu kodującego zaadaptowaną do zimna β-galaktozydazę Paracoccus sp. = Identification and izolation of the gene encoding cold-active β-galactosidase from paracoccus sp.
PublikacjaZaprezentowane badania były prowadzone u eehi wyizolowania ze środo¬wiska organizmu psychrofilnego, zdolnego do hydrolizy laktozy w niskiej tempe¬raturze, oraz zidentyfikowania genu kodującego (i-galaktozydazę zaadaptowaną do zimna.Poszukiwan gen został w izolowany z psychrofilnego szczepu autarkicz¬nego Paracoccus sp. 321). Na podstawie sekwencji nukleotydowej genu kodują¬cego fS-galaktozdaze ustalono skład aminokwasów),...
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Salinity enhances high optically active L-lactate production from co-fermentation of food waste and waste activated sludge: Unveiling the response of microbial community shift and functional profiling
PublikacjaLactic acid (LA), a versatile platform molecule, can be fermented from organic wastes, such as food waste and waste activated sludge. In this study, an efficient approach using salt, a component of food waste as an additive, was proposed to increase LA production. The LA productivity was increased at 10 g NaCl/L and optical pure L-lactate was obtained at 30 g NaCl/L. The enhancement of LA was in accordance with the increased solubilization...
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Synthesis and biological evaluation of 2,7-Dihydro-3H-dibenzo[de,h]cinnoli- ne-3,7-done derivatives a novel group of anticancer agents active on a multidrug resistance cell line.
PublikacjaZsyntezowano serię pochodnych pirydazonu z jednym lub dwoma łańcuchami bocznymi w różnych pozycjach chromoforu tetracyklicznego. Związki wykazały aktywność cytoksyczną na mysią białaczkę L1210 i ludzką k562 oraz na linii komórkowej oporności krzyżowej MDR (k562/DX). Dwa najbardziej aktywne związki przetestowano in vivo na mysiej białaczce P388. Wykazały one aktywność przeciwnowotworową porównywalną z aktywnością Mitoxantronu.
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Voltage and Reactive Power Load Flow Optimization in the Power System Using Fuzzy Logic
PublikacjaThe paper presents issues related to voltage control in the power system. An original method of reactive power flow optimization is considered, which leads to improved voltages in the power system and reduced active power losses. The optimization method is based on a procedure that employs fuzzy logic and is supported by a gradient search algorithm. The method has been implemented in PLANS software and verified.
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Robust Parameter Estimation and Output Prediction for Reactive Carrier-Load Nonlinear Dynamic Networks
PublikacjaIn this paper an extension of on-line model simplification technique for a class of networked systems, namely reactive carrier-load nonlinear dynamic networked system (RCLNDNS), kept within point-parametric model (PPM) framework is addressed. The PPM is utilised to acquire a piece wise constant time-varying parameter linear structure for the RCLNDNS suitable for the on-line one step ahead prediction that may be applied to monitoring...
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Platelets in fetal growth restriction: role of reactive oxygen species, oxygen metabolism, and aggregation.
PublikacjaFetal growth restriction (FGR) is mainly caused by failure of the uteroplacental unit. Theexact pathogenesis remains unclear. The cause is thought to be related to abnormal platelet activation,which may...
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Thermal Self-Action Effects of Acoustic Beam in a Gas with Reversible or Irreversible Chemical Reaction
PublikacjaThermal self-action of acoustic beam in a gas where an exothermic chemical reaction takes place, is studied. This kind of thermal self-action differs from that in a newtonian fluid. In dependence on the type of a chemical reaction, reversible or not, heating or cooling of a medium occurs. A beam in the case of the irreversible reaction may be unusually self-focusing. The self-action effects relating to wave beams containing shock...
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Effect of native air-formed oxidation on the corrosion behavior of AA 7075 aluminum alloys
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Numerical Simulation of Temperature Field in Steel under Action of Electron Beam Heating Source
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Linking the diversity of native flora to land cover heterogeneity and plant invasions in a river valley
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Multispecies invasion reduces the negative impact of single alien plant species on native flora
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A Ship Domain-Based Method of Determining Action Distances for Evasive Manoeuvres in Stand-On Situations
PublikacjaA ship encounter can be considered safe if neither of ships’ domains (defined areas around ships) is intruded by other ships. Published research on this includes optimising collision avoidancemanoeuvres fulfilling domain-based safety conditions.However, until recently there was no method, using ship’s domain to determine exact moment when a particular collision avoidance manoeuvre can still be successfully performed. The authors...
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Reactive extrusion of bio-based polymer blends and composites – Current trends and future developments
PublikacjaReactive extrusion is a cost-effective and environmentally-friendly method to produce new materials with enhanced performance properties. At present, reactive extrusion allows in-situ polymerization, modification/functionalization of polymers or chemical bonding of two (or more) immiscible phases, which can be carried out on commonly used extrusion lines. Although reactive extrusion has been known for many years, its application...
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Deep learning model for automated assessment of lexical stress of non-native english speakers
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Erratum to: Coarse-grained model of the native cellulose Iα and the transformation pathways to the Iβ allomorph
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Reactive Extrusion of Waste Plastics with Compatibilizer and Lightly Pyrolyzed Crumb Rubber for Asphalt Modification
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Structural analogues of reactive intermediates as inhibitors of glucosamine-6-phosphate synthase and phosphoglucose isomerase
PublikacjaCentra aktywne izomerazy fosfoglukozowej (PGI) oraz domeny izomerazowej (HPI) syntazy glukozamino-6-fosforanu (GlcN-6-P), wykazują podobieństwo ułożenia przestrzennego kluczowych reszt aminokwasowych, z wyjątkiem reszty Arg272 PGI i reszt Lys603 i Lys485 HPI. Dziesięć pochodnych D-heksitolo-6-P, kwasu 5-fosfoarabonowego i kwasu 6-fosfoglukonowego, strukturalnych analogów cis-enolaminy lub cis-enolanu, przypuszczalnych stanów przejściowych...
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Starch‐graft copolymers of N‐vinylformamide and acrylamide modified with montmorillonite manufactured by reactive extrusion
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Rodzinna Europa jako peryferie Czesława Miłosza ["Native Realm" as Czesław Milosz's Periphery]
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State action aimed at limiting financial exclusion in Poland in terms of sustainable and inclusive development
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Kinetic flux vector splitting scheme for solving non-reactive multi-component flows
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Wpływ smarowności na działania układu tribologicznego (impact of lubricity on the tribological system action)
Publikacjathe paper presents analysis and evaluation, based on tests results, of the impact of lubricity of the used lubricating oils (shell argina t 40) on the action of boundary layer of sulzer 6zl40/48 engines aboard the ''włocławek'' sea-going ship. for comparison purposes, the same oils were tested with the ceramizer four-stroke engine (all types of the vidar four-stroke engines) regeneration agent added. so understood boundary layer...
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THE POSSIBILITIES OF ESTIMATING THE RELIABILITY OF SHIP PIPELINES’ ELEMENTS INCLUDING DESTRUCTIVE PHENOMENA ACTING ON THEM
PublikacjaIn the article an approach to the problem of estimating reliability data based on physical models is proposed. The possibility of reliability assessment for selected elements of ship pipelines, based on the recognition of the destructive physical phenomena taking place in them, is discussed. To do this, an overview of these phenomena has been made. In addition, a preliminary review of existing measures of destruction of materials...
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Thermal self-action effects for acoustic beams containing fronts in a Maxwell relaxing fluid
PublikacjaThis paper examines the thermal self-action of acoustic beams in a Maxwell relaxing fluid. This type of thermal self-action differs from that in a Newtonian fluid and behaves differently depending on a ratio of sound period and time of thermodynamic relaxation. The self-action which relates to sound beams containing shock fronts is also discussed. In addition, stationary and non-stationary types of self-action are considered.
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Flame-Retardant Polymer Materials Developed by Reactive Extrusion: Present Status and Future Perspectives
PublikacjaThe development of flame retardant polymer materials has two roots, one in materials design, and the other in materials processing. Over recent decades, different types and classes of flame retardant polymer materials have been commercialized to meet safety requirements in the construction, automotive, and coatings industries. In the vast majority of cases, the design and fabrication of new materials presenting low fire hazards...
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Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor
PublikacjaInositol requiring enzyme 1 alpha (IRE1α) is one of three signaling sensors in the unfolding protein response (UPR) that alleviates endoplasmic reticulum (ER) stress in cells and functions to promote cell survival. During conditions of irrevocable stress, proapoptotic gene expression is induced to promote cell death. One of the three signaling stressors, IRE1α is an serine/threonine-protein kinase/endoribonuclease (RNase) that...
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The Action Mechanisms, Anti-Cancer and Antibiotic-Modulation Potential of Vaccinium myrtillus L. Extract
PublikacjaHerbal medicinal products containing Vaccinium myrtillus L. (bilberry) fruits and fruit extracts are widely available in the market. Although bilberry leaves and stems are considered as bio-waste, they contain much higher levels of phenolic compounds than fruits. The study aimed to investigate the antimicrobial and anticancer potential of aerial part extracts from Vaccinium myrtillus L. (V. myrtillus, VM) plants harvested at high...
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Automated detection of pronunciation errors in non-native English speech employing deep learning
PublikacjaDespite significant advances in recent years, the existing Computer-Assisted Pronunciation Training (CAPT) methods detect pronunciation errors with a relatively low accuracy (precision of 60% at 40%-80% recall). This Ph.D. work proposes novel deep learning methods for detecting pronunciation errors in non-native (L2) English speech, outperforming the state-of-the-art method in AUC metric (Area under the Curve) by 41%, i.e., from...
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Detection of Lexical Stress Errors in Non-Native (L2) English with Data Augmentation and Attention
PublikacjaThis paper describes two novel complementary techniques that improve the detection of lexical stress errors in non-native (L2) English speech: attention-based feature extraction and data augmentation based on Neural Text-To-Speech (TTS). In a classical approach, audio features are usually extracted from fixed regions of speech such as the syllable nucleus. We propose an attention-based deep learning model that automatically de...
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Weakly-Supervised Word-Level Pronunciation Error Detection in Non-Native English Speech
PublikacjaWe propose a weakly-supervised model for word-level mispronunciation detection in non-native (L2) English speech. To train this model, phonetically transcribed L2 speech is not required and we only need to mark mispronounced words. The lack of phonetic transcriptions for L2 speech means that the model has to learn only from a weak signal of word-level mispronunciations. Because of that and due to the limited amount of mispronounced...
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Overcoming Challenges of Virtual Scrum Teams: Lessons Learned Through an Action Research Study
PublikacjaAfter the COVID-19 breakout, agile teams found themselves in situations that “pure agilists” and textbooks on agile methods had preferred to ignore. Whereas agile mindsets helped them to quickly shift to remote work, mere virtualization of agile practices often proved insufficient, and several challenges emerged. This paper reports on an Action Research project carried out in Lufthansa Systems Poland with the aim of (1) revisiting...
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Simulation Studies of Control Systems for Doubly Fed Induction Generator Supplied by the Current Source Converter
PublikacjaThe control system for a Doubly Fed Induction Generator (DFIG) supplied by a grid-connected Current Source Converter (CSC) is presented in this paper. Nonlinear transformation of DFIG model to the multi-scalar form is proposed. The nonlinear control strategy of active and reactive power of DFIG is realized by feedback linearization. In the proposed control scheme, the DFIG model and CSI parameters are included. Two Proportional-Integral...
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Feedback Control of Doubly-Fed Generator Connected to Current Source Converter
PublikacjaDoubly-fed induction generator (DFIG) system supplied by current source converter (CSC) is considered in this article. The DFIG can work in two independent modes: AC grid connection and stand-alone mode. The DFIG is connected to the ac grid directly through its stator and the CSC links the rotor side. In this mode, the active and reactive powers of the DFIG must be controlled. This article proposes two control system structures...