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Kwas mykofenolowy i jego analogi. Synteza i aktywność biologiczna = Mycophenolic acid (MPA) and its analogues. Synthesis and biological activity
PublikacjaW artykule opisano kwas mykofenolowy (MPA)oraz jego analogi. Kwas MPA został odkryty ponad 100 lat temu i nadal pozostaje atrakcyjnym celem badań biologicznych. Z uwagi na bardzo dużą tendencję do ulegania glukuronidyzacji in vivo, ograniczone są jego możliwości zastosowań jako potencjalnego chemoterapeutyka. Otrzymane dotychczas analogi m.in. zawierające różne cykliczne ugrupowania, monocykliczne fenole i niefenolowe analogi oraz...
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Experimental research on water lubricated three layer sliding bearing with lubrication grooves in the upper part of the bush and its comparison with a rubber bearing
Publikacjacomposite. Eachofitslayershasanimportantfunction.Speciallypreparedslidingsurfaceensures minimum resistance.Followingrunning-initssmoothnessbecomesveryhighandthebearingmay continue workingunder fluid lubricationregime.NBRlayerensuresbearingelasticity,goodvibration damping propertiesandinsusceptibilitytoshaftaxismisalignment.Theexternalbrasslayermakes fitting thebearingeasier. Experiment resultsoftheconductedresearchwerecomparedwiththoseforarubberbearingof similar...
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Zieleń miejska Gdyni okresu międzywojennego oraz problematyka jej zachowania = Urban greenery of Gdynia of interwar period and the issues of its retaining
PublikacjaURBAN GREENERY OF GDYNIA OF INTERWAR PERIOD AND THE ISSUES OF ITS RETAINING The subject of this article is the urban greenery arrangement in interwar Gdynia and the issues of its retaining after the II World War. The article will concern retaining the authenticity and integrity of the historic urban greenery of Gdynia, both greenery layouts and the plant material creating it. The author of the article will present in what...
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Recycling of Industrial Waste as Soil Binding Additives—Effects on Soil Mechanical and Hydraulic Properties during Its Stabilisation before Road Construction
PublikacjaTo improve the in situ soil stabilization, different chemical additives are used (ion exchange compounds, additives based on H2SO4 or vinyl polymers, and organic additives using lignosul- fonates). One interesting alternative is the production of additives from various waste materials. The extensive testing of waste-based blends with soil was performed; the mechanical (unconfined compressive strength (UCS)) and hydraulic (capillary...
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Transient States during Short-circuit in a Line Powered by UPS and its Impact on Earth Fault Loop Impedance Measurement and Power Quality
PublikacjaThe short-circuit in a line powered by Uninterruptible Power Supply (UPS) during different UPS operation modes is presented in the article. The transient state condition related to the short-circuit in a line fed from double conversion On-line UPS is discussed in detail. The results of the measurements of earth fault loop impedance (FLI) in circuits powered by UPS with the instruments of various manufacturers are presented. The...
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The microbial community, its biochemical potential, and the antimicrobial resistance of Enterococcus spp. in Arctic lakes under natural and anthropogenic impact (West Spitsbergen)
PublikacjaThe sustainable management of small human communities in the Arctic is challenging. In this study, both a water supply system (Lake 1) under the natural impact of a bird-nesting area, and a wastewater receiver (Lake 2) were analysed in the vicinity of the Polish Polar Station on West Spitsbergen. Microbial community composition, abundance and activity were assessed in samples of the treated wastewater, lake water and sediments...
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Insights into the microbial community of treated wastewater, its year-round variability and impact on the receiver, using cultivation, microscopy and amplicon-based methods
PublikacjaApart from chemical constituents, wastewater treatment plant (WWTP) effluents also release microorganisms that can be important to the receiving water bodies either from a sanitary point of view, or taking to the account the biogeochemical potential of the recipients. However, little is known about the treated wastewater microbial community, its composition, seasonal changes, functions and fate in the waters of the receiver. Thus,...
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The effect of sunscreen 4‐methylbenzylidene camphor in different and reproductive models, its bioaccumulation and molecular effects on ligand‐receptor interaction, and protein expression
Publikacja4-Methylbenzylidene camphor (4-MBC) is a photo-absorbing UV filter prevalently used in cosmetics, which can be absorbed into circulation and cause systemic effects. 4-MBC is continued to be released in the environment despite the growing knowledge about its bioaccumulation and endocrine disrupting effects. Previous reviews have mentioned UV-filter together but this review considers 4-MBC alone, due to its prevalence and concerning...
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Aspekty techniczno-ekonomiczne postulowanego rozwoju zastosowania turbin gazowych w polskiej elektroenergetyce. Prace IMiUE i ITC P. Śl.**2002 s. 167-177, 3 rys. bibliogr. 12 poz. II Konferencja Naukowo-Techniczna 2002 ENERGETYKA GAZOWA [Szczyrk].
PublikacjaRozważając możliwość zastosowania turbin gazowych w polskiej elektroenerge-tyce, zwrócono uwagę na wpływ aktualnej struktury wytwarzania energii elek-trycznejna perspektywy zastosowania turbin gazowych. Pod tym względem, pod-dano analizie z jednej strony elektrownie zawodowe, z drugiej strony, elek-trownie komunalne i przemysłowe.
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The effect of hybridization of fire retarded epoxy/flax-cotton fiber laminates by expanded vermiculite: Structure-property relationship study
PublikacjaThe study describes the hybridization of epoxy/flax-cotton (EP/FF) composites containing ammonium polyphosphate (APP) with micrometric expanded vermiculite (VMT) (1–10 wt%). The efficiency of hybridization of flame retarded epoxy/flax-cotton composites was assessed by performing static tensile and flexural strength evaluation, supplemented by impact strength measurements of the composites. Moreover, thermal and thermomechanical...
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Analiza cyklu życia modułu słonecznego i jego wpływ na środowisko = Life cycle analysis of a solar module and its ecological impact
PublikacjaSystemy fotowoltaiczne są odnawialnym źródłem energii elektrycznej, które w czasie eksploatacji nie emitują żadnych szkodliwych substancji, hałasu, nie zwiększają również efektu cieplarnianego. Wpływ każdego produktu na środowisko naturalne, w tym także systemów fotowoltaicznych, musi uwzględniać końcową fazę istnienia - okres po zakończeniu eksploatacji. Obecnie produkowane moduły ogniw fotowoltaicznych mają 25÷30-letnią gwarancję...
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Chemical Reduction of 2,4,6-Tricyano-1,3,5-triazine and 1,3,5-Tricyanobenzene. Formation of Novel 4,4‘,6,6‘-Tetracyano-2,2‘-bitriazine and Its Radical Anion
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A biocompatible poly(amidoamine) (PAMAM) dendrimer octa-substituted with α-cyclodextrin towards the controlled release of doxorubicin hydrochloride from its ferrocenyl prodrug
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Carvacrol as a Stimulant of the Expression of Key Genes of the Ginsenoside Biosynthesis Pathway and Its Effect on the Production of Ginseng Saponins in Panax quinquefolium Hairy Root Cultures
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A DFT/TD DFT study of the structure and spectroscopic properties of 5-methyl-2-(8-quinolinyl)benzoxazole and its complexes with Zn(II) ion
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A method for evaluating the performance of a marine piston internal combustion engine used as the main engine on a ship during its voyage in different sailing conditions
PublikacjaPrzedstawiono metodę oceny działania tłokowych silników spalinowych napędu głównego staków morskich, nazywanych silnikami głównymi, działających w typowych warunkach ich eksploatacji. Warunki te zostały opisane z uwzględnieniem pola osiągów tego rodzaju silników. Metoda ta umożliwia obliczenie wartości działania w wyniku zastosowania rachunku całkowego. Znamienne jest to, że działanie wspomnianych silników spalinowych zostało przyrównane...
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Impact of High Pressure on Metallophilic Interactions and Its Consequences for Spectroscopic Properties of a Model Tetranuclear Silver(I)–Copper(I) Complex in the Solid State
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Chemometric modeling of aquatic toxicity of contaminants of emerging concern (CECs) in Dugesia japonica and its interspecies correlation with daphnia and fish: QSTR and QSTTR approaches
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Synthesis of UiO-66-OH zirconium metal-organic framework and its application for selective extraction and trace determination of thorium in water samples by spectrophotometry
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Highly Sensitive Determination of Bisphenol A in Bottled Water Samples by HPLC after Its Extraction by a Novel Th-MOF Pipette-Tip Micro-SPE
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The semi-Markov model of energy state changes of the main marine internal combustion engine and method for evaluating its operation during ships voyage
PublikacjaPrzedstawiono metodę oceny działania tłokowych silników spalinowych napędu głównego statków morskich, nazywanych silnikami głównymi, działających w różnych warunkach ich eksploatacji. Metoda ta umożliwia obliczenie wartości działania w wyniku zastosowania teorii procesów semimarkowskich i statystyki matematycznej. Znamienne jest to, że działanie wspomnianych silników spalinowych zostało przyrównane do wielkości fizycznej, którą...
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High-temperature oxidation of the Crofer 22 H ferritic steel with Mn1.45Co1.45Fe0.1O4 and Mn1.5Co1.5O4 spinel coatings under thermal cycling conditions and its properties
PublikacjaThe aim of the presented study was to deposit protective-conducting Mn1.45Co1.45Fe0.1O4 and Mn1.5Co1.5O4 spinel coatings on the Crofer 22 H ferritic steel by means of electrophoresis and to evaluate their physicochemical properties after high-temperature oxidation under thermal cycling conditions. When the Crofer 22 H steel – whether uncoated or coated with the two spinels – was oxidized in 48-h cycles involving a temperature of...
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A new Toxoplasma gondii chimeric antigen containing fragments of SAG2, GRA1, and ROP1 proteins—impact of immunodominant sequences size on its diagnostic usefulness
PublikacjaThis study presents the first evaluation of new Toxoplasma gondii recombinant chimeric antigens containing three immunodominant regions of SAG2, GRA1, and one of two ROP1 fragments differing in length for the serodiagnosis of human toxoplasmosis. The recombinant chimeric antigens SAG2-GRA1-ROP1L (with large fragment of ROP1, 85-396 amino acid residues) and SAG2-GRA1-ROP1S (with a small fragment of ROP1, 85-250 amino acid residues)...
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Architektura współczesnego muzeum i jej znaczenie dla tożsamości krajobrazu miasta = The Architecture of Contemporary Museum and its Significance for the Identity of the Urban Landscape
PublikacjaArtykuł dotyczy architektury współczesnych muzeów, które pod koniec XX w. przeszły znaczący rozwój jako instytucje publiczne. Oprócz specyficznych wymagań technicznych, funkcjonalnych, estetycznych i kulturowych, ich charakterystyczną cechą jest wzrastające zapotrzebowanie na przestrzeń dodatkową służącą edukacji, odpoczynkowi, rozrywce i strefie komercyjnej (handlu i usług). Atrakcyjna przestrzeń publiczna zapewnia dostęp do wszystkich...
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The forecasted values of cutting power for sawing on band sawing machines for Polish Scots pine wood (Pinus sylvestris L.) in a function of its provenance.
PublikacjaIn this paper the predicted values of cutting power for band sawing machine (EB 1800, f. EWD), which is used in the Polish sawmills, were showed. The values of cutting power were forecasted for Scots pine (Pinus sylvestris L.) wood of five provenances from Poland. These values were determined using an innovative method of predicting the cutting power, which takes into account of elements of fracture mechanics. The resulting predictions...
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Discussion on “Dynamic soil-structure interaction: A three-dimensional numerical approach and its application to the Lotung case study”. Poor performance of the HSS model
PublikacjaThe Hardening Soil Small (HSS) is a constitutive model being extension to the well established Hardening Soil Model (HS) accounting for the nonlinearity of small strain stiffness. It is implemented in commercial finite element computer codes for geotechnical analyses and used widely in research and design. The article deals with a problem known as overshooting after very small load reversals. It induces much higher stiffness than...
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Improved cytotoxicity and preserved level of cell death induced in colon cancer cells by doxorubicin after its conjugation with iron-oxide magnetic nanoparticles
PublikacjaA promising strategy for overcoming the problem of limited efficacy in antitumor drug delivery and in drug release is the use of a nanoparticle-conjugated drug. Doxorubicin (Dox) anticancer chemotherapeutics has been widely studied in this respect, because of severe cardiotoxic side effects. Here, we investigated the cytotoxic effects, the uptake process, the changes in cell cycle progression and the cell death processes in the...
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Rediscovering Automatic Detection of Stuttering and Its Subclasses through Machine Learning—The Impact of Changing Deep Model Architecture and Amount of Data in the Training Set
PublikacjaThis work deals with automatically detecting stuttering and its subclasses. An effective classification of stuttering along with its subclasses could find wide application in determining the severity of stuttering by speech therapists, preliminary patient diagnosis, and enabling communication with the previously mentioned voice assistants. The first part of this work provides an overview of examples of classical and deep learning...
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The influence of the type of halogen substituent and its position on the molecular conformation, intermolecular interactions and crystal packing for a series of 1-benzoyl-3-(halogenophenyl)thioureas
PublikacjaBy the reaction of benzoyl chloride, potassium isothiocyanate and the appropriate halogenoaniline, i.e. 2/3/4-(bromo/iodo)aniline, we have obtained five new 1-benzoyl-3-(halogenophenyl)thioureas, namely, 1-benzoyl-3-(2-bromophenyl)- thiourea and 1-benzoyl-3-(3-bromophenyl)thiourea, C14H11BrN2OS, and 1-benzoyl-3-(2-iodophenyl)thiourea, 1-benzoyl-3-(3-iodophenyl)thiourea and 1-benzoyl-3-(4-iodophenyl)thiourea, C14H11IN2OS. Structural...
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Detoxification of the tricyclic antidepressant opipramol and its analog – IS-noh by UGT enzymes before and after activation by phase I enzymes in rat liver microsomes
PublikacjaThe present studies were carried out to evaluate the simultaneous one-pot metabolism of opipramol (IS-opi) and analog (IS-noh) by phase I and phase II enzymes present in rat liver microsomes (RLM) as an alternative to separate testing with recombinant enzymes. This approach allows for more time-saving and cost-effective screening of the metabolism of newly discovered drugs. We also considered that the lack of results for phase...
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N-(1-Piperidinepropionyl)amphotericin B methyl ester (PAME) - a new derivative of the antifungal antibiotic amphotericin B: Searching for the mechanism of its reduced
PublikacjaZ zastosowaniem techniki monowarstw Langmuira zbadano naturę oddziaływań pochodnej antybiotyku przeciwgrzybowego amfoterycyny B o obniżonej toksyczności tj. estru metylowego N-(1-piperydynopropionylo)amfoterycyny B (PAME) z komponentami błon biologicznych takich jak: ergosterol, cholesterol i modelowy fosfolipid DPPC i stwierdzono, że zróżnicowanie tych oddziaływań jest podstawą obniżonej toksyczności związku.
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Mohammad Malikan dr inż.
OsobyMohammad Malikan studied Ph.D. at the Department of Mechanics of Materials and Structures at the Gdańsk University of Technology. He was the first person who graduated in the new form of the doctoral education system of Poland (Doctoral School). He has worked as a mechanical engineer and designer for several years in CAD/CAE fields in various industries, such as feed production lines, machinery, elevator, oil, etc. His main research...
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Andrzej Wardziński dr inż.
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ACM SIGPLAN Workshop on Types in Language Design and Implementation (was TIC)
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International Conference on Digital Content, Multimedia Technology and its Applications
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Fabrication of a Molecularly Imprinted Polymer Adsorbent for Pipette Tip Micro Solid-phase Extraction of Levofloxacin from Aqueous Samples Prior to its Spectrophotometric Determination
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Advanced oxidation (H2O2 and/or UV) of functionalized carbon nanotubes (CNT-OH and CNT-COOH) and its influence on the stabilization of CNTs in water and tannic acid solution
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Molecular Characterization of a Novel Lytic Enzyme LysC from Clostridium intestinale URNW and Its Antibacterial Activity Mediated by Positively Charged N-Terminal Extension
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Co-microprecipitation/flotation of trace amounts of cadmium from environmental samples through its complexation with iodide and neutralization with cetyltrimethylammonium bromide in the presence of perchlorate ions
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Deformation of the Titanium Plate Stabilizing the Lateral Ankle Fracture Due to Its Overloading in Case of the Young, Obese Patient: Case Report Including the Biomechanical Analysis
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Determination of free tyrosine in equestrian supplements by LC–MS/MS and comparison of its quantity with total free amino acids content in view of doping control
PublikacjaThe reports on the probable beneficial impact of tyrosine (TYR) supplementation on performance enhancement have contributed to the growth of interest in TYR in equestrian sports field and related industries, such as the manufacture of dietary and nutritional supplements. In this study, the first attempt to the assessment of horses exposure to TYR during nutritional supplementation was demonstrated by quantification of unbound TYR...
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Cellulose and its derivatives, coffee grounds, and cross-linked, β-cyclodextrin in the race for the highest sorption capacity of cationic dyes in accordance with the principles of sustainable development
PublikacjaIn this study, seven different materials were analyzed and includes coffee grounds (CG), two types of cellulose (CGC and CC), two types of modified cellulose (CT and CTCD), and cross-linked β-cyclodextrin (CD-1 and CD-2) were tested as adsorbents for the removal of dyes from the wastewater. The composition, morphology, and presence of functional groups in the obtained sorption materials were characterized by elemental analysis,...
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Limiting distribution of the three-state semi-Markov model of technical state transitions of ship power plant machines and its applicability in operational decision-making.
PublikacjaThe article presents the three-state semi-Markov model of the process {W(t): t 0} of state transitions of a ship power plant machine, with the following interpretation of these states: s1 – state of full serviceability, s2 – state of partial serviceability, and s3 – state of unserviceability. These states are precisely defined for the ship main engine (ME). A hypothesis is proposed which explains the possibility of application...
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Determination of bromhexine and its metabolites in equine serum samples by liquid chromatography – Tandem mass spectrometry: Applicability to the elimination study after single oral dose
PublikacjaBromhexine (BH), expectorant used in the treatment of respiratory disorders associated with viscid or excessive mucus, is not permitted for use in the competing horse by many authorities in horseracing and Olympic disciplines. Metabolic studies are of the great importance in anti-doping field because they allow for updating the selection of the most appropriate markers for prohibited substances, such as metabolites present at higher...
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Urban city lights. Light pollution as one of the effects of incorrectly designed external illumination. How can a successful lighting masterplan diminish its impact?
PublikacjaIn the modern world, artificial lighting brings many tangible benefits such as the ability to extend working hours and so increase production, recreational use of the city after dark, or the possibility to travel regardless of the time of day. However, this flexibility comes at a price and negatively impacts on the environment. One such negative phenomenon is Light Pollution ‐ a term used to describe excessive nighttime artificial...
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Comparative in vitro studies on liposomal formulations of amphotericin Band its derivative, N-methyl-N-D-fructosyl amphotericin B methyl ester (MFAME)
PublikacjaMFAME, ester metylowy N-metylo-N-D-fruktozylo amfoterycyny B jest półsyntetyczną pochodną antybiotyku przeciwgrzybowego amfoterycyny B (AMB). W przeciwieństwie do wyjściowego antybiotyku pochodna ta jest nietoksyczna dla komórek zwierzęcych oraz tworzy rozpuszczalne sole rozpuszczalne w wodzie. Przeprowadzono badania porównawcze aktywności biologicznej wolnego antybiotyku i wolnej pochodnej oraz ich preparatów liposomalnych. Stosowano...
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Characterization of exceptionally thermostable single-stranded DNA-binding proteins from Thermotoga maritima and Thermotoga neapolitana
PublikacjaBACKGROUND: In recent years, there has been an increasing interest in SSBs because they find numerous applications in diverse molecular biology and analytical methods.RESULTS: We report the characterization of single-stranded DNA binding proteins (SSBs) from the thermophilic bacteria Thermotoga maritima (TmaSSB) and Thermotoga neapolitana (TneSSB). They are the smallest known bacterial SSB proteins, consisting of 141 and 142 amino...
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Sylwester Kaczmarek dr hab. inż.
OsobySylwester Kaczmarek ukończył studia w 1972 roku jako mgr inż. Elektroniki, a doktorat i habilitację uzyskał z technik komutacyjnych i inżynierii ruchu telekomunikacyjnego w 1981 i 1994 roku na Politechnice Gdańskiej. Jego zainteresowania badawcze ukierunkowane są na: sieci IP QoS, sieci GMPLS, sieci SDN, komutację, ruting QoS, inżynierię ruchu telekomunikacyjnego, usługi multimedialne i jakość usług. Aktualnie jego badania skupiają...
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Artur Piekarczuk dr hab. inż. prof. ITB
OsobyMy professional activity includes issues related to the examination and evaluation of construction products and the preparation of academic, technical and expert opinions on building construction structures as well as scientific articles in the field of buildings. My interests were focused on the use of modern methods of numerical analysis in research and expert works. I am currently the Manager of the Durability Testing Laboratory...
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ICT in Management 2020
Kursy OnlineICT in Management for Bachelor in Management students