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ENERGY ANALYSIS OF THE PROPULSION SHAFT FATIGUE PROCESS IN A ROTATING MECHANICAL SYSTEM PART II IDENTIFICATION STUDIES – DEVELOPING THE FATIGUE DURABILITY MODEL OF A DRIVE SHAFT
PublikacjaThe article presents a continuation of research carried out concerning identification of energy consequences of mechanical fatigue within a propeller shaft in a rotating mechanical system, while working under conditions of the loss of the required alignment of shaft lines. Experimental research was carried out on a physical model reflecting a full-sized real object: i.e., the propulsion system of the ship. It is proven, by means...
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Imunofan—RDKVYR Peptide—Stimulates Skin Cell Proliferation and Promotes Tissue Repair
PublikacjaRegeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today’s science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical specialties. In this study, we...
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Novel 2-alkythio-4-chloro-N-[imino(heteroaryl)methyl]benzenesulfonamide Derivatives: Synthesis, Molecular Structure, Anticancer Activity and Metabolic Stability
PublikacjaA series of novel 2-alkythio-4-chloro-N-[imino-(heteroaryl)methyl]benzenesulfonamide derivatives, 8–24, were synthesized in the reaction of the N-(benzenesulfonyl)cyanamide potassium salts 1–7 with the appropriate mercaptoheterocycles. All the synthesized compounds were evaluated for their anticancer activity in HeLa, HCT-116 and MCF-7 cell lines. The most promising compounds, 11–13, molecular hybrids containing benzenesulfonamide...
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Functionalized Peptide Fibrils as a Scaffold for Active Substances in Wound Healing
PublikacjaTechnological developments in the field of biologically active peptide applications in medicine have increased the need for new methods for peptide delivery. The disadvantage of peptides as drugs is their low biological stability. Recently, great attention has been paid to self-assembling peptides that can form fibrils. Such a formulation makes bioactive peptides more resistant to enzymatic degradation and druggable. Peptide fibrils...
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The Substantial Improvement of Amphotericin B Selective Toxicity Upon Modification of Mycosamine with Bulky Substituents
PublikacjaAbstract: Background: It is assumed that the unfavorable selective toxicity of an antifungal drug Amphotericin B (AmB) can be improved upon chemical modification of the antibiotic molecule. Objective: The aim of this study was verification of the hypothesis that introduction of bulky substituents at the amino sugar moiety of the antibiotic may result in diminishment of mammalian vitro toxicity of thus prepared AmB derivatives. Methods:...
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Comprehensive Evaluation of the Biological Properties of Surface-Modified Titanium Alloy Implants
PublikacjaAn increasing interest in the fabrication of implants made of titanium and its alloys results from their capacity to be integrated into the bone system. This integration is facilitated by different modifications of the implant surface. Here, we assessed the bioactivity of amorphous titania nanoporous and nanotubular coatings (TNTs), produced by electrochemical oxidation of Ti6Al4V orthopedic implants’ surface. The chemical composition...
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Internet photogrammetry for inspection of seaports
PublikacjaThis paper intends to point out the possibility of using Internet photogrammetry to construct 3D models from the images obtained by means of UAVs (Unmanned Aerial Vehicles). The solutions may be useful for the inspection of ports as to the content of cargo, transport safety or the assessment of the technical infrastructure of port and quays. The solution can be a complement to measurements made by using laser scanning and traditional...
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Theoretical modelling of efficient fire safety water networks by certified domination
PublikacjaThis paper explores a new way of designing water supply networks for fire safety using ideas from graph theory, focusing on a method called certified domination. Ensuring a good water supply is crucial for fire safety in communities, this study looks at the rules and problems in Poland for how much water is needed to fight fires in different areas and how this can be achieved at a lowest possible cost. We present a way to plan...
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Thermal cooling process by nanofluid flowing near stagnating point of expanding surface under induced magnetism force: A computational case study
PublikacjaThis paper is dedicated to the exam of entropy age and research of the effect of mixing nanosolid additives over an extending sheet. In this review, Newtonian nanofluid version turned into researched at the actuated appealing field, heat radiation and variable heat conductivity results. With becoming modifications, the proven PDEs are moved into popular differential situations and paintings mathematically making use of a specific...
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Highly-Miniaturized Dual-Mode Bandpass Filter Based on Quarter-Mode Substrate Integrated Waveguide with Wide Stopband
PublikacjaThis paper presents a novel design of a highly-miniaturized dual-mode bandpass filter (BPF) employing a quarter-mode substrate integrated waveguide (QMSIW). The QMSIW resonator is based on a square cavity with metallic vias along two sides, and open-ended edges at the remaining sides that contain orthogonal feed lines. An open slot is introduced along the two sides of the square cavity with metallic vias to form a magnetic wall....
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The potential interaction of environmental pollutants and circadian rhythm regulations that may cause leukemia
PublikacjaTumor suppressor genes are highly affected during the development of leukemia, including circadian clock genes. Circadian rhythms constitute an evolutionary molecular machinery involving many genes, such as BMAL1, CLOCK, CRY1, CRY2, PER1, PER2, REV-ERBa, and RORA, for tracking time and optimizing daily life during day-night cycles and seasonal changes. For circulating blood cells many of these genes coordinate their proliferation,...
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Novel molecules containing structural features of NSAIDs and 1,2,3-triazole ring: Design, synthesis and evaluation as potential cytotoxic agents
PublikacjaFor the first time the template containing structural features of more than one NSAIDs and the 1,2,3-triazole ring was explored for the identification of potential cytotoxic agents. These new and complex molecules were predicted to be effective inhibitors of PDE4B by molecular modelling studies in silico. The multi-step synthesis of these compounds were carried out starting from the well-known drug nimesulide and involved the use...
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Structure, Physicochemical and Biological Properties of an Aqua (2,2′,2′′-Nitrilotriacetato)-oxidovanadium(IV) Salt with 4-Methylpyridinium Cation
PublikacjaThe crystal structure of a nitrilotriacetate (nta) oxidovanadi-um(IV) salt with 4-methylpyridinium cation, [4-Me(Py)H]+, of [4-Me(Py)H][VO(nta)(H2O)] stoichiometry was determined. The com-plex comprises a discrete mononuclear [VO(nta)(H2O)]–coordinationentity that can be rarely found among other known compounds con-taining nitrilotriacetate oxidovanadium(IV) moieties. The complex wascharacterized by spectroscopic (IR and EPR) methods,...
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Analysis of the influence of polystyrene microplastics and their derivatives on the DNA of human colon epithelial cells HT29 with the comet assay
PublikacjaWe have been using plastic for almost a century and nowadays a lot of them circulates as pollutants in the environment and still defragmenting to micro and nanoscale. The exposition through the food chain and its precise impact on human health is still not clear. In our study, we tested real food packaging after contact with food products and real thermoinsulation and environmental samples of polystyrene in different model liquids,...
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The complete lists of 1D reversible number-conserving cellular automata with radius one of up to 7 states
Dane BadawczeThis dataset contains complete lists of all one-dimensional reversible number-conserving k-ary cellular automata with radius one of up to 7 states, i.e. with state sets {0,1}, {0,1,2}, {0,1,2,3}, {0,1,2,3,4}, {0,1,2,3,4,5} and {0,1,2,3,4,5,6}.
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Magnetic flux leakage signals of near side defects measured with different velocities
Dane BadawczeThe dataset contains raw signals measured with the use of the magnetic flux leakage (MFL) technique. Linear Hall effect sensors A1324 were used to measure magnetic flux leakage. Three voltage signals were measured: Bx sensor output, Bz1 sensor output, and difference of Bz1 and Bz2 outputs. An output of a Bx sensor was directly proportional to the tangential...
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Magnetic flux leakage signals of far side defects measured with different velocities
Dane BadawczeThe dataset contains raw signals measured with the use of the magnetic flux leakage (MFL) technique. Linear Hall effect sensors A1324 were used to measure magnetic flux leakage. Three voltage signals were measured: Bx sensor output, Bz1 sensor output, and difference of Bz1 and Bz2 outputs. An output of a Bx sensor was directly proportional to the tangential...
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Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine
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Analiza drgań przewodów jezdnych sieci trakcyjnej w aspekcie oceny jej stanu technicznego
PublikacjaW pracy przedstawiono możliwości wykorzystania analizy drgań przewodów jezdnych sieci trakcyjnej do oceny jej stanu technicznego. Zaprezentowano wyniki badań laboratoryjnych, w których rejestrowano drgania odcinka przewodu jezdnego o zróżnicowanym stopniu zużycia i przy różnych warunkach jego zawieszenia. Na bazie przeprowadzonych analiz w dziedzinie czasu i częstotliwości, wskazano zależności między stanem sieci a wybranymi parametrami...
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Diagnostyka analogowych filtrów wielosekcyjnych oparta na klasyfikato-rach neuronowych z dwucentrowymi funkcjami bazowymi
PublikacjaPrzedmiotem artykułu jest zastosowanie klasyfikatora z dwucentrowymi funkcjami bazowymi do lokalizacji uszkodzeń w wielosekcyjnych torach analogowych elektronicznych systemów wbudowanych sterowanych mikrokontrolerem. Przedstawiono szczegóły procedury pomiarowej oraz metody detekcji i lokalizacji uszkodzeń toru analogowego z wykorzysta-niem klasyfikatora DB zaimplementowanego w postaci algorytmicznej w kodzie programu mikrokontrolera....
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Fenomenologia form symbolicznych. Podstawowe pojęcia i inspiracje "późnej" filozofii Ernsta Cassirera
PublikacjaMonografia rekonstruuje system filozofii Ernsta Casirera w oparciu o nieznane do niedawna teksty jego spuścizny rekopiśmienniczej. Jest pierwszym w języku polskim kompleksowym opracowaniem całości filozofii tego myśliciela.
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Magnetic field maps of an astable multivibrator in frequency range from 30 MHz to 3 GHz – selective detection
Dane BadawczeThe data presents a result of near field measurements of electromagnetic emissions radiated from the PCB of a small electronic device. An efficient method of modelling the magnetic and electric field emissions is the measurements in the near field using electric and magnetic probes. The attached files contain magnetic field maps created on based measurements...
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Imunofan - RDKVYR peptide - stimulates skin cell proliferation and promotes tissue repair
PublikacjaRegeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today's science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical...
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Coastal cliff erosion as a source of toxic, essential and nonessential metals in the marine environment
PublikacjaDue to the rising environmental awareness, emissions and releases of pollutants, including metals, have been considerably reduced in the last decades. Therefore, the remobiliza-tion of natural and anthropogenic contaminants is gaining importance in their biogeochemical cycle. In the marine coastal zone, this process occurs during the erosion of a shore, especially the most vulnerable cliffs. The research was conducted in the...
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RE-SHAPING THE LAND AND WATER CONNECTIONS AND ITS ROLE IN ACHIEVING LANDSCAPE AND ECOLOGICAL SYSTEMS’ CONTINUITY ON THE POST-INDUSTRIAL TERRITORIES
PublikacjaThis paper delves into recently applied strategies of creating new water areas and modifying the existing ones as a part of the transformation processes of post-industrial territories. It proves that while the pursuit for unique architectural and urban space values remains an important factor contributing to such modifications, they may also play an important role in reclaiming ecological systems continuity. On the basis of theoretical...
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Fast Low-fidelity Wing Aerodynamics Model for Surrogate-Based Shape Optimization
PublikacjaVariable-fidelity optimization (VFO) can be efficient in terms of the computational cost when compared with traditional approaches, such as gradient-based methods with adjoint sensitivity information. In variable-fidelity methods, the directoptimization of the expensive high-fidelity model is replaced by iterative re-optimization of a physics-based surrogate model, which is constructed from a corrected low-fidelity model. The success...
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CYP3A4 overexpression enhances apoptosis induced by anticancer agent imidazoacridinone C-1311, but does not change the metabolism of C-1311 in CHO cells
PublikacjaWe examine whether CYP3A4 overexpression influences the rate and pattern of antitumor imidazoacridinone C-1311 metabolism, in relation to the impact of this overexpression on cell cycle progression and final cellular response of CHO cells following C-1311 treatment. Methods: Three CHO cell lines: CHO-WT, wild type, CHO-HR, overexpressing cytochrome P450 reductase (CPR) and CHO-HR-3A4, coexpressing CPR and CYP3A4 were applied....
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Reactions of cobalt(ii) chloride and cobalt(ii) acetate with hemisalen-type ligands: ligand transformation, oxidation of cobalt and complex formation. Preliminary study on the cytotoxicity of Co(ii) and Co(iii) hemisalen complexes
PublikacjaSeveral molecular cobalt(II) complexes, one Co(II) coordination polymer, and one ionic cobalt(III) complex with imine hemisalen ligands were synthesized. The hemisalen ligands were synthesized from o-vanillin (oVP) and diverse aminopyridines (compounds HL1–HL4) or aminophenol (compound HL5). It was observed that cobalt(II) chloride in dry acetonitrile catalyzes a transformation of HL1 and HL3 instead of complex formation. The conversion...
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Successive cytotoxicity control by evolutionary surface decorated electronic push-pull green ZnCr-LDH nanostructures: Drug delivery enlargement for targeted breast cancer chemotherapy
PublikacjaThe reason for the increasing bioavailability and biocompatibility of the porous nanomaterials in the presence of different (bio)molecules is still unknown. The role of difference functional groups and their interactions with the potential bioavailability and biocompatibility is of great importance. To investigate the potential contribution of the electronic effects (especially on the surface of the porous nanomaterials) on their...
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Flow Maps and Flow Patterns of R1233zd(E) in a Circular Minichannel at Low, Medium and High Values of Saturation Pressure
PublikacjaThere is a gap in knowledge regarding the flow pattern of low-boiling working fluids in the range of high saturation temperatures (above 120°C) and medium and high reduced pressures (0.5-0.9). Data are present in the literature for similar values of reduced pressures, but for lower values of saturation temperature. This is due to the existing refrigeration applications of these working fluids. At high values of reduced pressure,...
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Charge Transfer, Complexes Formation and Furan Fragmentation Induced by Collisions with Low-Energy Helium Cations
PublikacjaThe present work focuses on unraveling the collisional processes leading to the fragmentation of the gas-phase furan molecules under the He+ and He2+ cations impact in the energy range 5–2000 eV. The presence of different mechanisms was identified by the analysis of the optical fragmentation spectra measured using the collision-induced emission spectroscopy (CIES) in conjunction with the ab initio calculations. The measurements of...
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Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity
PublikacjaSeven conjugates composed of well-known fluoroquinolone antibacterial agents, ciprofloxacin (CIP) or levofloxacin (LVX), and a cell-penetrating peptide transportan 10 (TP10-NH2) were synthesised. The drugs were covalently bound to the peptide via an amide bond, methylenecarbonyl moiety, or a disulfide bridge. Conjugation of fluoroquinolones to TP10-NH2 resulted in congeners demonstrating antifungal in vitro activity against human...
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Design, synthesis and high antitumor potential of new unsymmetrical bisacridine derivatives towards human solid tumors, specifically pancreatic cancers and their unique ability to stabilize DNA G-quadruplexes
PublikacjaNew promising unsymmetrical bisacridine derivatives (UAs), have been developed. Three groupsincluding 36 compounds were synthesized by the condensation of 4-nitro or 4-methylacridinone, imi-dazoacridinone and triazoloacridinone derivatives with 1-nitroacridine compounds linked with anaminoalkyl chain. Cytotoxicity screening revealed the high potency of these compounds against severaltumor cell lines. Particularly, imidazoacridinone-1-nitroacridine...
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Impact of Work on the Well-Being of Police Officers and Firefighters
PublikacjaWork is one of the most important spheres of human functioning and has a significant impact on individual overall well-being. The purpose of this study is to assess the positive and negative impact of the work of police officers and firefighters on their well-being in different spheres of life. In particular, the study examines the relationship between the type of occupation and the elements that generate a feeling of well-being,...
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Neutral Dissociation of Pyridine Evoked by Irradiation of Ionized Atomic and Molecular Hydrogen Beams
PublikacjaThe interactions of ions with molecules and the determination of their dissociation patterns are challenging endeavors of fundamental importance for theoretical and experimental science. In particular, the investigations on bond-breaking and new bond-forming processes triggered by the ionic impact may shed light on the stellar wind interaction with interstellar media, ionic beam irradiations of the living cells, ion-track nanotechnology,...
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Chemical analysis of low carbon content coals and their applications as dye adsorbent
PublikacjaCoal is primarily a fuel material but lately it has been utilized as an adsorbent for removing toxic metal ions. However, its usage for removing organic pollutants is not well studied. We report here a systematic study on the use of coal samples of varying carbon contents as adsorbents for removing Basic Blue 41 as a model cationic dye. The coal samples were collected from coal mines and were thoroughly characterized. The concentrations...
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Analysis of energy efficiency of suburban railway transport network
PublikacjaRising numbers of agglomeration residents cause increased need for people movement on daily basis. Because of congestion of local roads, air pollution and limited parking space, providing mass transit based on electric traction is reasonable. While the electric rail vehicles are considered highly efficient in themselves, they need to be analyzed as a part of a transport network, because energy consumption depends on operating conditions...
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Mathematical Modeling of Ice Dynamics as a Decision Support Tool in River Engineering
PublikacjaThe prediction of winter flooding is a complicated task since it is affected by many meteorological and hydraulic factors. Typically, information on river ice conditions is based on historical observations, which are usually incomplete. Recently, data have been supplemented by information extracted from satellite images. All the above mentioned factors provide a good background of the characteristics of ice processes, but are not...
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Monitoring strategy for industrially contaminated rivers - A study of all year round behaviour of Klodnica river catchment, upper Silesia, Poland
PublikacjaThe study was undertaken to thoroughly characterise the contamination of water in industrially influenced river Klodnica, in order to explore monitoring strategies in case of limited analytical capacity. Statistical analysis undertaken after a short study was found to be helpful in reducing monitoring efforts in the future.Klodnica river is located within area of dominating coal mining, metallurgy, and additionally being influenced...
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Multistatyczny, Dopplerowski System określania położenia i prędkości ruchomych celów w wodzie
PublikacjaW omawianym w pracy multistatycznym, dopplerowskim systemie określania położenia i prędkości ruchomych celów w wodzie źródłem sygnału są dwa nadajniki emitujące sinusoidalne, akustyczne fale ciągłe o różnych częstotliwościach, które po odbiciu od ruchomego celu są obierane przez cztery hydrofony. W artykule przedstawiono analize teoretyczna efektu Dopplera, na którym oparte jest działanie systemu oraz metodę rozwiązania głównych...
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Analiza drgań przewodu jezdnego sieci trakcyjnej w aspekcie oceny jej stanu technicznego.
PublikacjaGórna sieć trakcyjna jest nadal najefektywniejszym sposobem zasilania kolejowych pojazdów elektrycznych. Sieć jezdna nie ma możliwości technicznych redundancji, co wymaga okresowej oceny stanu technicznego w celu zapewnienia prawidłowej współpracy z odbierakami prądu pojazdów. W artykule przedstawiono aspekty oceny stanu technicznego górnej sieci trakcyjnej na podstawie modelowania matematycznego i wybranych badań laboratoryjnych....
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Sieć sensorowa do rejestracji drgań górnej sieci trakcyjnej w celach diagnostyki eksploatacyjnej
PublikacjaWraz ze wzrostem prędkości kolejowych pojazdów elektrycznych zwiększają się wymagania utrzymania sieci trakcyjnej w odpowiednim stanie technicznym. Ciągły monitoring i diagnostyka pozwalają wykrywać pogarszającą się jakość odbioru prądu z sieci jezdnej. Jedną z metod jest umieszczenie czujników przyspieszenia na przewodzie jezdnym. Analiza przebiegu przyspieszenia pozwala określić jakość współpracy sieci jezdnej z pantografem....
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Hat problem on odd cycles
PublikacjaThe topic is the hat problem in which each of n players is randomly fitted with a blue or red hat. Then everybody can try to guess simultaneously his own hat color by looking at the hat colors of the other players. The team wins if at least one player guesses his hat color correctly, and no one guesses his hat color wrong; otherwise the team loses. The aim is to maximize the probability of a win. In this version every player can...
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A construction for the hat problem on a directed graph
PublikacjaA team of n players plays the following game. After a strategy session, each player is randomly fitted with a blue or red hat. Then, without further communication, everybody can try to guess simultaneously his own hat color by looking at the hat colors of the other players. Visibility is defined by a directed graph; that is, vertices correspond to players, and a player can see each player to whom he is connected by an arc. The...
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On the hat problem on a graph
PublikacjaThe topic of this paper is the hat problem in which each of n players is uniformly and independently fitted with a blue or red hat. Then everybody can try to guess simultaneously his own hat color by looking at the hat colors of the other players. The team wins if at least one player guesses his hat color correctly, and no one guesses his hat color wrong; otherwise the team loses. The aim is to maximize the probability of winning....
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Sterowanie predykcyjne i fuzja danych w systemie dynamicznego pozycjonowania statku
PublikacjaRozprawa doktorska poświęcona jest badaniu zastosowania fuzji danych oraz sterowania predykcyjnego w systemie dynamicznego pozycjonowania statku. W pierwszej części pracy przedstawiono historię rozwoju systemów dynamicznego pozycjonowania, różne metody estymacji położenia statku, metody sterowania oraz cel i tezę pracy. Następnie zaprezentowano model matematyczny statku, kinematykę oraz dynamikę. W kolejnej części przedstawiono...
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System monitoringu odbieraków prądu pojazdów kolejowych w aspekcie bezpieczeństwa i ciągłości ruchu.
PublikacjaOmówiono metodę monitorowania stanu technicznego odbieraków prądu w oparciu o pomiar uniesienia przewodów jezdnych sieci trakcyjnej w czasie przejazdu pociągu. Opisano konstrukcję i zasadę działania wdrożonego na linii kolejowej pilotażowego stanowiska monitoringu. Przedstawiono metodę analizy i sposób wizualizacji wyników pomiarów. Zastosowany algorytm szacowania siły statycznej odbieraka uwzględnia prędkości pociągu i działanie...
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ROBOT TYPU QUADROCOPTER STEROWANY MIKROKONTROLERAMI O NIEWIELKIEJ MOCY OBLICZENIOWEJ
PublikacjaWspółczesna robotyka rozwija się bardzo dynamicznie. Coraz więcej osób prywatnych i inżynierów konstruuje różnego rodzaju pojazdy mobilne. Dlatego autorzy niniejszego referatu postawili sobie następującą tezę: możliwa jest budowa latającego robota mobilnego na bazie kontrolera o niskiej mocy obliczeniowej oraz prostego regulatora, i podjęli się jej udowodnienia.
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Badania eksperymentalne i symulacyjne dynamiki modelowego odcinka sieci trakcyjnej
PublikacjaW pracy przedstawiono główne założenia i strukturę opracowanego modelu matematycznego odcinka kolejowej górnej sieci trakcyjnej, opartego na metodzie energetycznej Lagrange’a. W celu wyznaczenia wybranych parametrów modelu, jak również dla oceny stopnia zgodności odwzorowania przez utworzony program symulacyjny stanów statycznych i dynamicznych sieci zbudowano laboratoryjny model odcinka sieci jezdnej z użyciem rzeczywistych jej...
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Calculations of the resistance values of 20 thermistors at 100°C
Dane BadawczeThe presented data set is part of the research aimed at determining the actual characteristics of each thermistor in a package of twenty NTC10k type sensors.