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Wyniki wyszukiwania dla: GENETIC POLYMORPHISM
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Andrzej Chybicki dr inż.
OsobyZ wykształcenia informatyk, absolwent Wydziału Elektroniki, Telekomunikacji i Informatyki Politechniki Gdańskiej, doktor nauk technicznych w dziedzinie informatyka specjalizujący się w przetwarzaniau danych przestrzennych w rozproszonych systemach informatycznych. Ukierunkowany na wykorzystywanie osiągnięć i wiedzy zakresu prowadzonych badań w przemyśle. Współpracował z szeregiem podmiotów przemysłu informatycznego, geodezyjnego...
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Electron-Induced Decomposition of 5-Bromo-4-thiouracil and 5-Bromo-4-thio-2′-deoxyuridine: The Effect of the Deoxyribose Moiety on Dissociative Electron Attachment
PublikacjaWhen modified uridine derivatives are incorporated into DNA, radical species may form that cause DNA damage. This category of molecules has been proposed as radiosensitizers and is currently being researched. Here, we study electron attachment to 5-bromo-4-thiouracil (BrSU), a uracil derivative, and 5-bromo-4-thio-20 -deoxyuridine (BrSdU), with an attached deoxyribose moiety via the N-glycosidic (N1-C) bond. Quadrupole mass spectrometry...
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Dissociative Electron Attachment to 5-Iodo-4-thio-2′-deoxyuridine: A Potential Radiosensitizer of Hypoxic Cells
PublikacjaIn the search for effective radiosensitizers for tumor cells, halogenated uracils have attracted more attention due to their large cross section for dissociation upon the attachment of low-energy electrons. In this study, we investigated dissociative electron attachment (DEA) to 5-iodo-4-thio-2'-deoxyuridine, a potential radiosensitizer using a crossed electron-molecule beam experiment coupled with quadrupole mass spectrometry....
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Therapeutic intervention by the simultaneous inhibition of DNA repair and type I or type II DNA topoisomerases: one strategy, many outcomes
PublikacjaMany anticancer drugs reduce the integrity of DNA, forming strand breaks. This can cause mutations and cancer or cell death if the lesions are not repaired. Interestingly, DNA repair-deficient cancer cells (e.g., those with BRCA1/2 mutations) have been shown to exhibit increased sensitivity to chemotherapy. Based on this observation, a new therapeutic approach termed 'synthetic lethality' has been developed, in which radiation...
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APPLICATION OF APRIORI ALGORITHM IN THE LAMINATION PROCESS IN YACHT PRODUCTION
PublikacjaThe article specifies the dependence of defects occurring in the lamination process in the production of yachts. Despite great knowledge about their genesis, they cannot be completely eliminated. Authentic data obtained through cooperation with one of the Polish yacht shipyards during the years 2013–2017 were used for the analysis. To perform a simulation, the sample size was observed in 1450 samples, consisting of 6 models of...
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Comparison of heat transfer characteristics in surface cooling with boiling microjets of water, ethanol and HFE7100
PublikacjaThe basis of microjet technology is to produce jets which impinge the surface at the stagnation point with a very high kinetic energy. Main objective of this paper was to investigate the physical phenomena occurring on solid surfaces upon impingement of the single microjet in case of three fluids, namely water, ethanol and HFE7100. Intense heat transfer in the impact zone of microjet has been examined and described with precise...
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Analysis of the regenerative braking process for the urban traffic conditions
PublikacjaIn a regular drive system, with an internal combustion engine, vehicle braking is connected with the unproductive dissipation of kinetic and potential energy accumulated in the mass of the vehicle into the environment. This energy can constitute up to 70% of the energy used to drive a vehicle under urban conditions. Its recovery and reuse is one of the basic advantages of hybrid and electric vehicles. Modern traffic management...
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Heat transfer characteristics of hybrid microjet – Microchannel cooling module
PublikacjaThe paper presents experimental investigation of heat transfer intensification in a microjet–microchannel cooling module. Applied technology takes benefits from two very attractive heat removal techniques. When jets are impinging on the surface, they have a very high kinetic energy at the stagnation point, also in microchannels boundary layer is very thin allowing to obtain very high heat fluxes. Main objective of this paper was...
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Model-Based Evaluation of N2O Production Pathways in the Anammox-Enriched Granular Sludge Cultivated in a Sequencing Batch Reactor
PublikacjaA mechanistic model was developed as an extension of the Activated Sludge Model No. 1 to describe three nitrous oxide (N2O) production pathways in a laboratory-scale anammox-enriched granular sequencing batch reactor. Heterotrophic denitrification and two processes mediated by ammonia oxidizing bacteria (AOB), that is, ammonia (NH4+) oxidation via hydroxylamine (NH2OH) and autotrophic denitrification, were considered. A systematic...
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How proteins bind to DNA: target discrimination and dynamic sequence search by the telomeric protein TRF1
PublikacjaTarget search as performed by DNA-binding proteins is a complex process, in which multiple factors contribute to both thermodynamic discrimination of the target sequence from overwhelmingly abundant off-target sites and kinetic acceleration of dynamic sequence interrogation. TRF1, the protein that binds to telomeric tandem repeats, faces an intriguing variant of the search problem where target sites are clustered within short fragments...
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THE APPLICATION OF KALMAN FILTERING TO PREDICT VERTICAL RAIL AXIS DISPLACEMENTS OF THE OVERHEAD CRANE BEING A COMPONENT OF SEAPORT TRANSPORT STRUCTURE
PublikacjaAs the devices designed to transport materials, the overhead cranes should meet certain geometric requirements for their operation to be safe. The presently available geodetic equipment, in particular total stations, provides opportunities for precise 3D measurements of coordinates of the controlled points. These coordinates make a basis for correcting the height of crane runway axes. The paper presents a method to calculate position...
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Principles and Developments of Solid-Phase Microextraction
PublikacjaSample preparation has been commonly considered a critical step of the analytical process. In this sense, remarkable efforts have been made to develop efficient sample preparation techniques which could overcome the limitations of conventional approaches. Since its inception in the early 1990’s, solid-phase microextraction (SPME) has become a widespread miniaturized sample preparation technique for extraction and preconcentration...
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Molecular Targets for Anticandidal Chemotherapy
PublikacjaA relatively small number of anticandidal chemotherapeutics used in clinical practice is at least in part consequence of a limited number of their molecular targets: ergosterol in the membrane, lanosterol demethylase, b(1!3) glucan synthase, and DNA/RNA biosynthesis. Much more potential novel targets have been revealed by the comparative genomic studies identifying essential genes unique for Candida albicans or resulted from recognition...
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Numerical investigation of multiphase blood flow coupled with lumped parameter model of outflow
PublikacjaPurpose The purpose of this paper is the application of the computational fluid dynamics model simulating the blood flow within the aorta of an eight-year-old patient with Coarctation of Aorta. Design/methodology/approach The numerical model, based on commercial code ANSYS Fluent, was built using the multifluid Euler–Euler approach with the interaction between the phases described by the kinetic theory of granular flow (KTGF). Findings A...
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Identification and cloning of C. albicans SC5314 genes encoding L-methionine biosynthetic pathway enzymes.
Dane BadawczeEnzymes of fungal L-methionine biosynthetic pathway: homoserine O-acetyltransferase (Met2p), O-acetylhomoserine sulfhydrylase (Met15p) and cystathionine-γ-synthase (Str2p) could be exploited as molecular targets for antifungal chemotherapy. The goal of the study was to identify and clone genes encoding mentioned above enzymes. MET2, MET15 and STR2 genes...
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The structure of 70(2Bi2O3-V2O5) - 30SrBO7 measured with X-ray diffraction and SEM methods
Dane BadawczeThe structure changes of 70(2Bi2O3-V2O5)-30SrB4O7 glass occurred during increase in temperature was measured by XRD and SEM.
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A novel cold-active beta-D-galactosidase from the Paracoccus sp. 32d - gene cloning, purification and characterization
PublikacjaBeta-D-galactosidase (EC 3.2.1.23) catalyze the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. Cold-active beta-D-galactosidases have recently become a focus of attention of researchers and dairy product manufactures owing to theirs ability to: (I) eliminate of lactose from refrigerated milk for people afflicted with lactose intolerance, (II) convert lactose to glucose and galactose which...
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ANALIZA I PROJEKTOWANIE UKŁADÓW STEROWANIA STERAMI STRUMIENIOWYMI STATKÓW Z ZASTOSOWANIEM SYSTEMU Z BAZĄ WIEDZY
PublikacjaŚwiatowa literatura dostarcza przykładów wskazujących na aktualność tematyki związanej z wykorzystaniem elementów sztucznej inteligencji w zastosowaniach morskich. Komisja Europejska finansuje projekty mające na celu poprawę konkurencyjności przemysłu okrętowego. W rozprawie podjęto tematykę związaną ze wspomaganiem projektowania podsystemów elektroenergetycznych statków. W rozprawie udowodniono przyjętą na wstępie tezę pracy:...
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Designing acoustic scattering elements using machine learning methods
PublikacjaIn the process of the design and correction of room acoustic properties, it is often necessary to select the appropriate type of acoustic treatment devices and make decisions regarding their size, geometry, and location of the devices inside the room under the treatment process. The goal of this doctoral dissertation is to develop and validate a mathematical model that allows predicting the effects of the application of the scattering...
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Implementing artificial intelligence in forecasting the risk of personal bankruptcies in Poland and Taiwan
PublikacjaResearch background: The global financial crisis from 2007 to 2012, the COVID-19 pandemic, and the current war in Ukraine have dramatically increased the risk of consumer bankruptcies worldwide. All three crises negatively impact the financial situation of households due to increased interest rates, inflation rates, volatile exchange rates, and other significant macroeconomic factors. Financial difficulties may arise when the...
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Fusion of Taq DNA polymerase with single-stranded DNA binding-like protein of Nanoarchaeum equitans—Expression and characterization
PublikacjaDNA polymerases are present in all organisms and are important enzymes that synthesise DNA molecules. They are used in various fields of science, predominantly as essential components for in vitro DNA syntheses, known as PCR. Modern diagnostics, molecular biology and genetic engineering need DNA polymerases which demonstrate improved performance. This study was aimed at obtaining a new NeqSSB-TaqS fusion DNA polymerase from the...
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Polysaccharide-based Nanocomposites for Biomedical Applications: A Critical Review
PublikacjaPolysaccharides (PSA) are taking specific position among biomaterials for advanced applications in medicine. Nevertheless, poor mechanical properties is known as the main drawback of PSA, which highlights need for PSA modification. Nanocomposites PSA (NPSA) are a class of biomaterials widely used as biomedical platforms, but despite their importance and worldwide use have not been reviewed. Herein we critically reviewed application...
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Machining process sequencing and machine assignment in generative feature-based CAPP for mill-turn parts
PublikacjaProcess selection and sequencing, as one of the most complex issues when evaluated from a mathematical point of view and crucial in CAPP, still attract research attention. For the current trend of intelligent manufacturing, machining features (MFs) are the information carriers for workpiece geometry and topology representation. They are basically derived from CAD models and are used by downstream engineering applications. A feature-based...
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Optimization of hydrodynamic vortex separator for removal of sand particles from storm water by computational fluid dynamics
PublikacjaStorm water treatment has been gradually acknowledged for the removal of pollutants from urban areas using the hydro cyclone separation technique. The separation efficiency of the hydrodynamic vortex separator (HDVS) is a complex phenomenon. With the aim enhance the separation potency of HDVS for storm runoff to get rid of sand particles, the HDVS with different structural configurations was studied by computational fluid dynamics....
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Mathematical modelling of two-step nitrification-denitrification for treatment of sludge digester liquors: influence of nitrite (NO2-N) on the process kinetics
PublikacjaSeparate treatment of the sludge digester liquors is an alternative for expansion of the mainstream treatment line. In order to reduce the oxygen demand for nitrification and organic carbon demand for denitrification, a shortcut in the nitrogen conversion pathway has been promoted in recent years, i.e. nitrification-denitrification via NO2-N instead of NO3-N. Although NO2-N is a common intermediate product of nitrification and...
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Heat transfer characteristics of hybrid microjet -microchannel cooling module
PublikacjaThe paper presents the experimental investigation of heat transfer intensification in a microjet- microchannel cooling module. Applied technology takes benefits from two very attractive heat removal techniques. When jets are impinging on the surface, they have a very high kinetic energy at the stagnation point, also in microchannels boundary layer is very thin allowing to obtain very high heat fluxes. Main objective of this paper...
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Heterogeneity of quaternary structure of glucosamine-6-phosphate deaminase from Giardia lamblia
PublikacjaThe oligoHis-tagged versions of glucosamine-6- phosphate deaminase from Giardia lamblia (GlmNagB-HisN, GlmNagB-HisC) were constructed and purified to hear homogeneity, and their kinetic and structural properties were compared to those of the wild-type enzyme (GlmNagB). Introduction of the oligoHis tag at the GlmNagB C-terminus resulted in almost complete loss of the catalytic activity, while the catalytic properties of GlmNagB-HisN...
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Thermal visualization of Ostwald-de Waele liquid in wavy trapezoidal cavity: Effect of undulation and amplitude
PublikacjaThe present study is concerned with the numerical simulations of Ostwald-de Waele fluid flow in a wavy trapezoidal cavity in the presence of a heated cylinder situated at the center of the cavity. The work consists in characterizing the mixed convection as a function of the intensity of heat flow. The flow behaviour and temperature distribution in a cavity are the main focus of this study. The lower wall of the cavity is fixed...
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Experimental and numerical investigation of mercury removal from flue gas by sorbent polymer composite
PublikacjaThis paper presents an experimental and numerical investigation of the performance of a sorbent polymer composite (SPC) material used for removing mercury from the flue gases in a full-scale industrial installation. The investigated material is an attractive alternative to activated carbon, which is commonly used for this purpose. While the application of the SPC is characterized by high capital expenditures, this technology offers...
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Why Are Left-Handed G-Quadruplexes Scarce?
PublikacjaG-quadruplexes (G4s) are nucleic acid structures crucial for the regulation of gene expression and genome maintenance. While they hold promise as nanodevice components, achieving desired G4 folds requires understanding the interplay between stability and structural properties, like helicity. Although right-handed G4 structures dominate the experimental data, the molecular basis for this preference over left-handed helicity is unclear....
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BACTERIAL INACTIVATION VIA LASER-DRIVEN GOLD NANOPARTICLE HEATING: SIMULATION AND ANALYSIS
PublikacjaThis study utilizes CFD technique to simulate the inactivation of E. coli bacteria within a microfluidic chamber, employing gold nanoparticles irradiated by a laser beam. Employing a single-phase model, the presence of bacteria is considered by treating thermal properties in the governing equations as effective, combining those of water and bacteria using established correlations from scientific literature. The conversion of light...
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Installation of GNSS receivers on a mobile railway platform – methodology and measurement aspects
PublikacjaDetermining the course of a railway track axis using satellite methods relies on ensuring the precise assembly of GNSS receivers in dedicated measuring devices. Depending on the number of receivers, solutions that are based on placing the apparatus directly above the railway track axis (as well as in eccentric positions) are used to indirectly obtain data to form the basis of the desired results. This publication describes the...
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Stone cutting industry waste-supported zinc oxide nanostructures for ultrasonic assisted decomposition of an anti-inflammatory non-steroidal pharmaceutical compound
PublikacjaPowdered stone waste (PSW) obtained from a stone cutting industrial unit was applied as support for the immobilization of nano-sized ZnO to be utilized as an effective catalyst for the catalytic conversion of acetaminophen (ACE) under ultrasonication. The incorporation of ZnO nanostructures into PSW structure enhanced the specific surface area and pore volume of the as-prepared nanocompound. The change in the value of zero point...
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Experimental validation of pressure drop models during flow boiling of R134a – effect of flow acceleration and entrainment
PublikacjaA crucial step to assure proficient work of power and process apparatus is their proper design. A wide array of those devices operates within boiling or condensation of the working fluid to benefit from high heat transfer rates. Two-phase flows are associated with high heat transfer coefficients because of the latent heat of evaporation and high turbulence level between the liquid and the solid surface. Predicting heat transfer...
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Analiza właściwości rozszerzonego obserwatora prędkości maszyny indukcyjnej
PublikacjaRozszerzony obserwator prędkości został zaproponowany przez prof. Krzemińskiego i jest oparty na rozszerzonym modelu maszyny indukcyjnej, gdzie wprowadzona został nowa zmienna ζ. Jest to nowe podejście do estymacji zmiennych stanu maszyny indukcyjnej i nie wszystkie problemy zostały do tej pory rozwiązane. Zaproponowano wykorzystanie algorytmów ewolucyjnych do doboru wzmocnień obserwatora. W celu redukcji nakładów obliczeniowych...
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Paweł Tysiąc dr inż.
Osobydr inż. Paweł Tysiąc Urodził się 25 marca 1992 w Gdańsku. Po ukończeniu Gimnazjum nr 32 uczęszczał do VIII Liceum Ogólnokształcącego im. Komisji Edukacji Narodowej w Gdańsku, klasy o profilu matematyczno-geograficznym, uzyskując w 2011 roku świadectwo dojrzałości. Następnie w latach 2011-2016 kontynuował naukę na Wydziale Inżynierii Lądowej i Środowiska Politechniki Gdańskiej. Ukończył studia I stopnia w specjalności Geodezja...
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Using UAV Photogrammetry to Analyse Changes in the Coastal Zone Based on the Sopot Tombolo (Salient) Measurement Project
PublikacjaThe main factors influencing the shape of the beach, shoreline and seabed include undulation, wind and coastal currents. These phenomena cause continuous and multidimensional changes in the shape of the seabed and the Earth’s surface, and when they occur in an area of intense human activity, they should be constantly monitored. In 2018 and 2019, several measurement campaigns took place in the littoral zone in Sopot, related to...
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H2AX phosphorylation, its role in DNA damage response and cancer therapy
PublikacjaDouble-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired, may have severe consequences for cell survival, as they lead to chromosome aberrations, genomic instability, or cell death. Various physical, chemical, and biological factors are involved in DSB induction. Cells respond to DNA damage by activating the so-called DNA damage response (DDR), a complex molecular mechanism developed to detect...
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CFD COUPLING OF VOF MODEL WITH ARRHENIUS EQUATION FOR ANALYSIS OF LASER-INDUCED THERMAL DEACTIVATION OF E. COLI
PublikacjaUnderstanding bacterial deactivation at the micro-scale, particularly with E. coli, is crucial for advancing microbiology and has promising applications in biomedical research. In this research contribution, we investigate the thermal inactivation of E. coli bacteria using gold nanoparticles irradiated by a green 1-W laser within a microfluidic chamber. The microfluidic device comprises a fluidic chamber filled with a thin film...
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INVESTIGATION OF THE CHARACTERISTICS OF A LOWEMISSION GAS TURBINE COMBUSTION CHAMBER OPERATING ON A MIXTURE OF NATURAL GAS AND HYDROGEN
PublikacjaT his article is devoted to the investigation of the characteristics of a low-emission gas turbine combustion chamber, which can be used in Floating Production, Storage and Offloading (FPSO) vessels and operates on a mixture of natural gas and hydrogen. A new approach is proposed for modelling the processes of burning out a mixture of natural gas with hydrogen under preliminary mixing conditions in gaseous fuel with an oxidizer...
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Manufacturing and Recycling Impact on Environmental Life Cycle Assessment of Innovative Wind Power Plant Part 2/2
PublikacjaThe process of conversion of wind kinetic energy into electricity in innovative wind power plant emits practically no harmful substances into the environment. However, the production stage of its components requires a lot of energy and materials. The biggest problem during production plan-ning process of an innovative wind power plant is selection of materials and technologies and, consequently, the waste generated at this stage....
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Double-diffusive natural convection energy transfer in magnetically influenced Casson fluid flow in trapezoidal enclosure with fillets
PublikacjaThe prime motive of this disquisition is to deal with mathematical analysis of natural convection energy transport driven by combined buoyancy effects of thermal and solutal diffusion in a trapezoidal enclosure. Casson fluid rheological constitutive model depicting attributes of viscoelastic liquids is envisioned. The influence of the inclined magnetic field governed by Lorentz field law is also considered. To raise the essence...
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Molecular dynamics simulations reveal the balance of forces governing the formation of a guanine tetrad—a common structural unit of G-quadruplex DNA
PublikacjaG-quadruplexes (G4) are nucleic acid conformations of guanine-rich sequences, in which guanines are arranged in the square-planar G-tetrads, stacked on one another. G4 motifs form in vivo and are implicated in regulation of such processes as gene expression and chromosome maintenance. The structure and stability of various G4 topologies were determined experimentally; however, the driving forces for their formation are not fully...
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Kinematyczne pomiary GNSS na linii kolei wąskotorowej w Koszalinie
PublikacjaW artykule opisano metodę kinematycznych pomiarów geodezyjnych GNSS zastosowaną dla inwentaryzacji trasy kolejowej w terenie silnie zalesionym. W badaniach wskazano możliwości wykorzystania tej metody dla inwentaryzacji układu geometrycznego trasy kolei wąskotorowej w Koszalinie. Opisano najważniejsze różnice pomiędzy koleją o rozstawie szyn 1000 mm a 1435 mm oraz przyszłościowe zagadnienie planowanej rewitalizacji tego odcinka....
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Linezolid-resistant Enterococcus faecium strains isolated from one hospital in Poland –commensals or hospital-adapted pathogens?
PublikacjaOne of the most pressing problems of enterococci infections is occurring resistance to linezolid, which is an antibiotic used in the treatment of infections caused by vancomycin-resistant strains (VRE). The main objective of our research was to investigate the relationship of 19 linezolid-resistant E. faecium isolates from 18 patients hospitalized at Clinical Hospital in Gdansk (Poland). One of the LZDREF was isolated in 2003...
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TDOA versus ATDOA for wide area multilateration system
PublikacjaThis paper outlines a new method of a location service (LCS) in the asynchronous wireless networks (AWNs) where the nodes (base stations) operate asynchronously in relation to one another. This method, called asynchronous time difference of arrival (ATDOA), enables the calculation of the position of the mobile object (MO) through the measurements taken by a set of non-synchronized fixed nodes and is based on the measurement of...
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Yade-open DEM: an open-source software using a discrete element methodto simulate granular material
PublikacjaPurpose - YADE-OPEN DEM is an open source software based on the Discrete Element Method which uses object oriented programming techniques. The paper describes the softwarearchitecture.Design/methodology/approach - The DEM chosen uses position, orientation, velocity and angular velocity as independent variables of simulated particles which are subject to explicit leapfrog time-integration scheme (Lagrangian method). The three-dimensional...
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Knowledge‐Intensive Business Services (KIBS) and Their Role in the Knowledge‐Based Economy
PublikacjaThe importance of the knowledge‐intensive business services sector for the development of the economy is growing. In the 80s and 90s this sector became the fastest growing sector in the OECD countries (OECD, 2001). Many publications stress its close relationship to the levels of innovation and performance of the whole economy (e.g. Hipp, 1999; Tomlinson, 1999; Aslesen and Isaksen, 2007). It is an increasingly common belief that...
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Low-cost performance-driven modelling of compact microwave components with two-layer surrogates and gradient kriging
PublikacjaUtilization of electromagnetic (EM) simulation tools has become indispensable for reliable evaluation of microwave components. As the cost of an individual analysis may already be considerable, the computational overhead associated with EM-driven tasks that require massive simulations (e.g., optimization) may turn prohibitive. One of mitigation methods is the employment of equivalent network models. Yet, they are incapable of accounting...
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Train the trainer course
PublikacjaThis chapter presents the concept, evaluation and evaluation results for the train the trainer. This concept of train the trainers is prepared within Workpackage 5 of EU-funded project: MASTER BSR (Erasmus+ Strategic Partnership Programme). Due to the nature of adult learning the content is designed for the use of participatory methods (involved, active). This method uses various techniques of active learning e.g. group work,...