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Search results for: HUMAN-INDUCED VIBRATION
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Temozolomide and sorafenib as programmed cell death inducers of human glioma cells
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IMPLANT USED IN HERNIA REPAIR UNDER PHYSIOLOGICAL MOVEMENTS OF HUMAN ABDOMEN
PublicationThe study deals with the mechanical behaviour of implant used in repair of abdominal hernia. The influence of orientation of the orthotropic implants in different areas of abdominal wall is studied.
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Multimodal human-computer interfaces based on advanced video and audio analysis
PublicationMultimodal interfaces development history is reviewed briefly in the introduction. Examples of applications of multimodal interfaces to education software and for the disabled people are presented, including interactive electronic whiteboard based on video image analysis, application for controlling computers with mouth gestures and the audio interface for speech stretching for hearing impaired and stuttering people. The Smart...
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The Influence of The Light-Activated Titania P25 on Human Breast Cancer Cells
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Numerical contribution to the viscoelastic magnetic lubrication of human joint in periodic motion.
PublicationPraca przedstawia rozwiązania problemu smarowania stawów człowieka w układzie współrzędnych ortogonalnych krzywoliniowych dla ruchu nieustalonego okresowego w polu magnetycznym. Uwzględnia się lepkosprężyste właściwości cieczy synowialnej w trakcie smarowania
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Studies of the effects of antifungal cationic derivatives of amphotericin B on human erythrocytes.
PublicationBadano nową grupę kationowych pochodnych amfoterycyny B pod kątem zależności pomiędzy ich zdolnością do asocjacji i selektywną toksycznością. We wszystkich przypadkach stosowano amfoterycynę B jako związek odniesienia. Jako miarę efektu toksycznego in vitro badanych związków stosowano wypływ wewnątrzkomórkowego potasu oraz hemolizę. Miarą aktywności przeciwgrzybowej był MIC i utrata potasu wewnatrzkomórkowego. Do oceny stopnia...
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Methodology for incorporating the human and organizational factors inqualitative and quantative risk assessments
PublicationZaproponowano metodykę systematycznego uwzględniania czynników ludzkich i organizacyjnych w jakościowych i ilościowych modelach ryzyka stosując hierarchiczne diagramy wpływu (HID). Współczynniki wagowe i skalowe czynników wpływu w HID określone są odpowiednio na podstawie wiedzy ogólnej i audytu danego systemu. Metodykę zaimplementowano w programie komputerowym zaprojektowanym do obliczeń złożonych HID
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Risk analysis and functional safety assessment with regard to human andorganisational factors
PublicationReferat poświęcono wybranym zagadnieniom analizy ryzyka i zarządzania bezpieczeństwem funkcjonalnym systemów związanych z bezpieczeństwem. Systemy takie, zawierające coraz częściej jednostki programowalne, są potencjalnie narażone na błędy człowieka, które mają swoje źródło w uchybieniach organizacyjnych. W procesie analizy ryzyka takich systemów proponuje się stosować metody jakościowe i ilościowe. Potencjalne błędy człowieka...
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Measurements of surface roughness of heads of human hip joints in lubrication aspects
PublicationW niniejszej pracy przedstawiono wyniki pomiarów chropowatości chrząstki stawowej na powierzchniach głów kostnych stawu biodrowego człowieka. Pomiarów dokonano przy pomocy czujników mechanicznych i laserowych. Praca zawiera wyniki analizy statystycznej.
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Procedure of determination of volatile trihalomethanes in human urine with perwaporation and gas chromatography
PublicationPraca przedstawia wyznaczanie podstawowych parametrów walidacyjnych nowej procedury oznaczania lotnych związków chlorowcoorganicznych z grupy trihalometanów w próbkach moczu ludzkiego, opartej na zastosowaniu:- techniki perwaporacji na etapie izolacji i wzbogacania analitów;- bezpośredniego dozowania próbek ekstraktów (permeatu) do kolumny chromatograficznej;- chromatograficznego rozdzielanie mieszaniny na poszczególne składniki;-wykorzystaniu...
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A novel chemiluminescent immunoassay for detection of Toxoplasma gondii IgG in human sera
PublicationThis study describes Toxoplasma gondii IgG chemiluminescent immunoassay (CLIA) based on the use of a novel immunochemical reagents in the form of the conjugates of original acridinium ester (AE) labels attached to antibodies and SAG2-GRA1-ROP1L chimeric antigen and shows that this test is useful for diagnostic purposes.
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Numerical Model of the Aortic Valve Implanted Within Real Human Aorta
PublicationCardiovascular system diseases are the main cause of deaths in developed and developing countries. The main reasons are myocardial infarction, heart failure, stroke and valvular diseases. These are caused mainly by arteriosclerosis. The valvular diseases involve a significant burden for the health care system and their frequency is rising with the patient age. This work describes the tools and numerical models appropriate for modeling...
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Investigations to realize thermal, humid and human comfort in modern living houses.
PublicationPrzedstawiono badania nad komfortem cieplnym, wilgotnościowym i psychicznym w domkach mieszkalnych. Wykonano pomiary oraz przeprowadzono ankiety. Zastosowano różne sposoby wentylacji.
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The Effect of Mechanical Vibration during Transport under Model Conditions on the Shelf-Life, Quality and Physico-Chemical Parameters of Four Apple Cultivars
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Application of neural networks for identification of forcedness having effect on magnitude of turbine rotor vibration using pressure distribution in blade tip clearance.
PublicationW pracy sprawdzono, czy zastosowanie sieci neuronowych umożliwia identyfikację wymuszeń powstających w wyniku funkcjonowania maszyny jak i zależnych od jej stanu mechanicznego przy zastosowaniu rozkładu ciśnienia w uszczelnieniu nadbandażowym. Przeprowadzono pomiary rozkładu ciśnienia dla różnych warunków pracy, uwzględniając zmianę mimośrodu oraz zmianę skośnego ustawienia osi wirnika względem osi korpusu. Dokonano analiz przy...
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A novel chemiluminescent immunoassay based on original acridinium ester labels as better solution for diagnosis of human toxoplasmosis than conventional ELISA test
PublicationToxoplasma gondii infection is one of the most common human zoonosis. Laboratory diagnosis of this disease is mainly based on the results of serological methods detecting specific antibodies in the patient’s sera. In this study we aimed to evaluate the performance of a chemiluminescence immunoassay (CLIA) based on the use of a novel immunochemical reagent in the form of the conjugate of original acridinium label (AL) attached to...
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Experimental study on earthquake-induced pounding between structural elements made of different building materials
PublicationCelem artykułu jest pokazanie wyników dwóch eksperymentów dotyczących zderzeń pomiędzy elementami wykonanymi z różnych materiałów budowlanych, takich jak: stal, beton, drewno i ceramika. Pierwszy z nich polegał na zrzucaniu kul na płaską powierzchnię, drugi dotyczył zderzeń modeli konstrukcji poddanych wymuszeniom sejsmicznym na stole wstrząsowym. Wyniki testów pokazują, iż wpływ materiału elementów kolidujących ze sobą na zachowanie...
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Phase Transitions and Structural Changes in DPPC Liposomes Induced by a 1-Carba-Alpha-Tocopherol Analogue
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Periodicity-induced effects in the scattering and absorption of light by infinite and finite gratings of circular silver nanowires
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Influence of cathodic-protection-induced hydrogenation on mechanical properties of two ship hull plate steels
PublicationPrzedstawiono wyniki próby rozciągania i udarowej Charpy V dla stali zwykłej wytrzymałości (kategorii A) i podwyższonej wytrzymałości (kat. AH32) zarówno w stanie dostawy jak i po nawodorowaniu (protektor Zn w słonej wodzie). Nawodorowanie obydwu stali zwiększyło nieco granicę plastyczności (Re) i wydłużenie (A), nie zmieniając (atal A) lub nieco zmniejszając przewężenie (Z). Wpływ nawodorowania na udarność był ewidentnie pozytywny...
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Protective Effect of Black Tea Against Ethanol-Induced Oxidative Modifications of Liver Proteins and Lipids
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Wave‐Induced Surge Motion and Collisions of Sea Ice Floes: Finite‐Floe‐Size Effects
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Integrative multiomics study for validation of mechanisms in radiation-induced ischemic heart disease in Mayak workers
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Kras mutations and PU.1 promoter methylation are new pathways in murine radiation-induced AML
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Both activating and inhibitory Fc gamma receptors mediate rituximab-induced trogocytosis of CD20 in mice
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Effect of selective doping on the spatial dispersion of donor-induced quantum dots in Si nanoscale transistors
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The Increase of Triterpene Saponin Production Induced by Trans-Anethole in Hairy Root Cultures of Panax quinquefolium
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Proteome Analysis of PC12 Cells Reveals Alterations in Translation Regulation and Actin Signaling Induced by Clozapine
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Ovocystatin Induced Changes in Expression of Alzheimer’s Disease Relevant Proteins in APP/PS1 Transgenic Mice
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Is there any association between HCV multiplication and iron induced liver injury in chronic hepatitis C?
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Ab Initio Analysis of a Quantum Dot Induced by a Local External Potential in a Semiconducting Carbon Nanotube
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Cold atmospheric plasma-induced chemical vapor generation in trace element analysis by spectrometric methods
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Cadmium-Induced Oxidative Stress in Plants, Cadmium Toxicity, and Tolerance in Plants: From Physiology to Remediation
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Prolonged Quercetin Administration Diminishes the Etoposide-Induced DNA Damage in Bone Marrow Cells of Rats
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Renoprotective and Cardioprotective Potential of Moricandia sinaica (Boiss.) against Carbon Tetrachloride-Induced Toxicity in Rats
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pH-Induced modification to stratum corneum lipids investigated using thermal, spectroscopic, and chromatographic techniques
PublicationZbadano jakim zmianom jakościowym i ilościowym ulegają indywidualne klasy lipidów w Stratum Corneum (tkanka rogowa skóry) pod wpływem środowiska o zmiennym pH.
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Analytical and experimental determination of parameters for the non-linear viscoelastic model of earthquake-induced structural pounding
PublicationNieliniowy model lepko-sprężysty umożliwia dokładną symulację siły zderzenia w czasie oraz symulację odpowiedzi konstrukcji podatnej na zderzanie podczas trzęsień ziemi. Jednym z celów niniejszego artykułu jest wyprowadzenie wzoru na zależność pomiędzy liczbą tłumienia zderzenia (parametr wspomnianego modelu), a współczynnikiem odbicia. Kolejnym celem jest wyznaczenie zakresu wartości współczynników odbicia oraz współczynników...
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DNA Methylation Changes Induced by Redox-Active Compounds—Choosing the Right PCR-Based Method
PublicationThe impact of catechins on the expression profile of redox-related genes in HT29 cell line has been studied recently by our group using Oxidative Stress RT2 Profiler PCR Array. Within the examined panel of 84 genes, the down-regulation of SRXN1 gene was unique among other up-regulated genes. We hypothesized that the observed down-regulation resulted from DNA methylation and have exploited this observation to choose the proper strategy...
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The Dominant Influence of Plastic Deformation Induced Residual Stress on the Barkhausen Effect Signal in Martensitic Steels
PublicationThe paper presents the results of investigation of the influence of plastic deformation on the magnetic properties of martensitic steel (P91 grade). The properties of the hysteresis loops as well as of the Barkhausen effect (BE) signal are analysed for both tensile and compressive loading up to ε = 10% of plastic deformation. The choice of the steel and of the deformation range is unique, since for such combination one can expect...
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Modeling of Common Mode Currents Induced by Motor Cable in Converter Fed AC Motor Drives
PublicationInvestigation of conducted EMI generation in AC motor fed by pulse width modulated frequency converters requires to consider parasitic capacitances in converters, motor windings and feeding cables to be taken into account. Motor voltage transients and related common mode currents are significantly correlated with resonance effects occurring in load circuits. An analysis of frequency converter load impedance-frequency characteristics...
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Three-dimensional modeling and automatic analysis of the human nasal cavity and paranasal sinuses using the computational fluid dynamics method
PublicationPurpose The goal of this study was to develop a complete workflow allowing for conducting computational fluid dynam- ics (CFD) simulation of airflow through the upper airways based on computed tomography (CT) and cone-beam computed tomography (CBCT) studies of individual adult patients. Methods This study is based on CT images of 16 patients. Image processing and model generation of the human nasal cavity and paranasal sinuses...
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Occurrence and levels of polybrominated diphenyl ethers (PBDEs) in house dust and hair samples from Northern Poland; an assessment of human exposure
PublicationPolybrominated diphenyl ethers (PBDEs) are among most ubiquitous compounds to be found in indoor environment and ingestion of household dust is considered an important route of exposure to PBDEs, especially in toddlers and young children. The present work reported concentration levels of PBDE congeners (PBDE-28, -47, -99, -100, -153, -154, -183 and -209) in hair and dust samples from selected households from Northern Poland. The...
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Numerical study on pounding between two adjacent buildings under earthquake excitation
PublicationSeismic excitation, which results in large horizontal relative displacements, may cause collisions between two adjacent structures due to insufficient separation distance between them. Such collisions, known as earthquake-induced structural pounding, may induce severe damages. In this paper, the case of pounding between two adjacent buildings is studied by the application of single degree-of-freedom structural models. Impact is...
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Discovery of small-molecule regenerative drugs using a model of complex tissue injury in mice. Transcriptomic responses of neurodevelopmental genes during pharmacologically induced regeneration
PublicationDespite significant development in regenerative medicine, there is a deficit of effective therapies for wound healing and tissue regeneration. Research performed using animal wound models allows for a better understanding of this complex process, searching for compounds with pro-regenerative properties, and assessing their efficacy and safety. Unfortunately, the lack of adequate preclinical models proves to be an issue as no animal...
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A new human IgG avidity test, using mixtures of recombinant antigens (rROP1, rSAG2, rGRA6), for the diagnosis of difficult-to-identify phases of toxoplasmosis
PublicationThe preliminary diagnostic utility of two mixtures of Toxoplasma gondii recombinant antigens (rROP1+rSAG2 and rROP1+rGRA6) in IgG ELISA and IgG avidity test has been evaluated. A total of 173 serum samples from patients with toxoplasmosis and seronegative people were examined. The sensitivity of IgG ELISA for rROP1+rSAG2 and rROP1+rGRA6 was 91.1% and 76.7%, respectively, while the reactivity for sera from patients where acute toxoplasmosis...
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No Evidence for Sex-specificity in Vitamin C, E and Fatty Acid Content of Human Milk from Healthy Polish Mothers
PublicationHuman milk (HM) is a complex fluid that meets the nutritional needs of infants. Its composition idrfs associated with environmental, maternal, and foetal variables. It provides nutrients and bioactive substances, including cytokines, immunoglobulins, and constituents with antioxidative properties. Boys are reportedly more susceptible to oxidative stress. This study aimed to determine the relationship between infant sex and the...
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Imidazoacridinone antitumor agent C-1311 as a selective mechanism- based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.
Publication5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311), a promising antitumor agent that is also active against autoimmune diseases, was determined to be a selective inhibitor of the cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1311 might modulate the effectiveness of other drugs used in multidrug therapy. The present work aimed to identify the mechanism of the observed C-1311-mediated inactivation of CYP1A2...
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Rapid Characterization of the Human Breast Milk Lipidome Using a Solid-Phase Microextraction and Liquid Chromatography-Mass Spectrometry-Based Approach.
PublicationHuman breast milk (HBM) is a biofluid consisting of various biomolecules such as proteins, lipids, carbohydrates, minerals and bioactive substances. Due to its unique and complex composition, HBM provides not only nutritional components required for the growth of the infant, but also additional protection against infections. Global insight into the composition of HBM is crucial to understanding the health benefits infants receive...
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Antitumor DNA-Damaging C-1748 is a New Inhibitor of Autophagy that Triggers Apoptosis in Human Pancreatic Cancer Cell Lines
PublicationDespite the enormous progress that has been made over the past decades in diagnosis, treatment and prevention of many types of tumors, survival rates in pancreatic cancer still remain poor. Pancreatic cancer is one of the most malignant and chemoresistant tumors and the profound mechanism supporting these phenomena is the constitutively activated prosurvival autophagy. The antitumor 1-nitroacridine derivative C-1748 belongs to...
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Metabolic activity of tree saps of different origin towards cultured human cells in the light of grade correspondence analysis and multiple regression modeling
PublicationTree saps are nourishing biological media commonly used for beverage and syrup production. Although the nutritional aspect of tree saps is widely acknowledged, the exact relationship between the sap composition, origin, and effect on the metabolic rate of human cells is still elusive. Thus, we collected saps from seven different tree species and conducted composition-activity analysis. Saps from trees of Betulaceae, but not from...