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Search results for: MAMMALIAN TISSUE REGENERATION
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Mechanical properties of mosquito nets in the context of hernia repair
PublicationThe paper deals with issue of applying mosquito nets as implants in hernia repair, which have already been used in resource-poor developing countries. Uniaxial tensile tests have been conducted on polyester mosquito meshes in two orthogonal directions. Non-linear elastic constitutive laws parameters have been identified to be applied in dense net material models. Mechanical performance of tested mosquito nets has been compared...
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Efficiency comparison of selected endoscopic video analysis algorithms
PublicationIn the paper, selected image analysis algorithms were examined and compared in the task of identifying informative frames, blurry frames, colorectal cancer and healthy tissue on endoscopic videos. In order to standardize the tests, the algorithms were modified by removing from them parts responsible for the classification, and replacing them with Support Vector Machines and Artificial Neural Networks. The tests were performed in...
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Modeling of light propagation in canine gingiva
PublicationThis study is a preliminary evaluation of the effectivenes of laser-based surgery of maxillary and mandibular bone in dogs. Current methods of gingivial surgery in dogs require the use of general anaesthesia.1, 2 The proposed methods of laser surgery can be performed on conscious dogs, which substantially reduces the associated risks. Two choices of lasers, Nd:YAG and a 930 nm semiconductor lasers were evaluated. The former is...
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Thermodynamic Cycle Concepts for High-Efficiency Power Plans. Part A: Public Power Plants 60+
PublicationAn analysis was carried out for different thermodynamic cycles of power plants with air turbines. Variants with regeneration and different cogeneration systems were considered. In the paper, we propose a new modification of a gas turbine cycle with the combustion chamber at the turbine outlet. A special air by-pass system of the combustor was applied and, in this way, the efficiency of the turbine cycle was increased by a few points....
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Urban space recovery. Landscape-beneficial solutions in new estates built in post-industrial and post-military areas in Bristol, Poznań and Gdańsk
PublicationThe limitation of territorial expansion and the implementation of the idea of a compact city are generally accepted paradigms of spatial development of contemporary cities. In consequence, actions are taken to improve the quality of city landscape and revitalise vacant areas. This study approaches the process of city regeneration as transformation and supplementation of the existing urban structure as well as creation of multifunctional, structurally,...
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Allergic reactions as a defense of the organism to the influence of implants components made of stainless steel
PublicationDue to the increasing number of cases of hypersensitivity caused by direct contact with metals, as well as the increasing demand for implants in humans all ages numerous studies on the effects of the impact of implant components are being carried out. The paper presents the phenomenon of etiology of allergy in general terms and in relation to the biomaterials used in medicine. There have been characterized in terms of impact on...
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A new finite element with variable Young's modulus
PublicationThe Finite Element Method (FEM) is a numerical technique that is well-established in the field of engineering. However, in biological sciences, it is justtaking its first steps. Bone tissue is an example of biological material which isexposed to high loads in its natural environment. Practically every movementof the body results in changing stress levels in the bone. Nature copes with thisvery well but when human intervention is...
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Public spaces connecting cities. Green and Blue Infrastructures potential.
PublicationA city fragmentation causes a lot of negative effects in urban environment such as: disconnecting the environmental, functional and compositional relations, a loss of urban compactness, chaotic development, visual chaos, a domination of technical landscape, reduction of security. This is why one of main challenges for urban planners is to connect the fragmented structures by creating friendly, attractive and safe public space....
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Cellulose Nanomaterials in Biomedical, Food, and Nutraceutical Applications: A Review
PublicationNanotechnology with bionanomaterials have tremendous potential to enhance and utilize for nutrient and bioactive absorption, drug delivery systems, pharmaceutical, and nutraceutical field through various applications. Cellulose nanomaterials are green materials that are obtained from renewable sources and possess exceptional mechanical strength and biocompatibility. The associated unique physical and chemical properties have made...
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Thermoplastic elastomer filaments and their application In 3D printig
PublicationThe paper provides an overview on the materials used in the 3D printing technology (the Polish and foreign market) with a particular focus on flexible filaments and their possible application in the industry. There are described the techniques of 3D printing and modern filaments available on the market. There is observed the increase of interest in the production of products from filaments based on thermoplastic elastomers (TPE),...
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Allergic Reactions as a Defense of the Organism to the Influence of Implants Components Made of Stainless Steel
PublicationDue to the increasing number of cases of hypersensitivity caused by direct contact with metals, as well as the increasing demand for implants in humans all ages numerous studies on the effects of the impact of implant components are being carried out. The paper presents the phenomenon of etiology of allergy in general terms and in relation to the biomaterials used in medicine. There have been characterized in terms of impact on...
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Behavioral state classification in epileptic brain using intracranial electrophysiology
PublicationOBJECTIVE: Automated behavioral state classification can benefit next generation implantable epilepsy devices. In this study we explored the feasibility of automated awake (AW) and slow wave sleep (SWS) classification using wide bandwidth intracranial EEG (iEEG) in patients undergoing evaluation for epilepsy surgery. APPROACH: Data from seven patients (age [Formula: see text], 4 women) who underwent intracranial depth electrode...
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Metody wykorzystania energii z rekuperacji w transporcie szynowym
PublicationW artykule przedstawiony został przegląd metod wykorzystania energii pochodzącej z hamowania odzyskowego. Wśród znanych i stosowanych w praktyce metod wymieniono wykorzystanie odzyskanej energii na nietrakcyjne potrzeby własne pojazdu, magazynowanie odzyskanej energii w zasobnikach (pokładowych lub stacjonarnych) i wykorzystywanie jej w razie potrzeby, transformację i zwrot odzyskanej energii do krajowej sieci zasilania, a także...
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Antifungal Effect of Penicillamine Due to the Selective Targeting of L-Homoserine O-Acetyltransferase
PublicationDue to the apparent similarity of fungal and mammalian metabolic pathways, the number of established antifungal targets is low, and the identification of novel ones is highly desirable. The results of our studies, presented in this work, indicate that the fungal biosynthetic pathway of L-methionine, an amino acid essential for humans, seems to be an attractive perspective. The MET2 gene from Candida albicans encoding L-homoserine...
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A Novel Cryptic Clostridial Peptide That Kills Bacteria by a Cell Membrane Permeabilization Mechanism
PublicationThis work reports detailed characteristics of the antimicrobial peptide Intestinalin (P30), which is derived from the LysC enzyme of Clostridium intestinale strain URNW. The peptide shows a broader antibacterial spectrum than the parental enzyme, showing potent antimicrobial activity against clinical strains of Gram-positive staphylococci and Gram-negative pathogens and causing between 3.04 ± 0.12 log kill for Pseudomonas aeruginosa...
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Mechanochemical Energy Transduction during the Main Rotary Step in the Synthesis Cycle of F1-ATPase
PublicationF1-ATPase is a highly efficient molecular motor that can synthesize ATP driven by a mechanical torque. Its ability to function reversibly in either direction requires tight mechanochemical coupling between the catalytic domain and the rotating central shaft, as well as temporal control of substrate binding and product release. Despite great efforts and significant progress, the molecular details of this synchronized and fine-tuned...
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A Fast Method of Separation of the Noisy Background from the Head-Cross Section in the Sequence of MRI Scans
PublicationThe paper presents a new method of removing the noisy background from the sequence of magnetic resonance imaging (MRl) scans. The sequence of scans is required in order to monitor a passage of a contrast agent through the brain tissue. The scans contain the noisy head-cross data and also the noisy background data. The latter has to be removed and excluded from a further analysis. It is achieved by applying some basic morphological...
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Polysaccharides-Based Hybrid Materials for Bio- and Non-Bio Sectors. Edytorial
PublicationThis special edition spotlights the recent research in the design, development, and emerging applications of polysaccharides-based hybrid materials for biotechnological and biomedical purposes. All the articles published in this issue underscore the significance of materials derived from cellulose, alginate, chitosan, starch, and carrageenan for various applications, including enzyme production, encapsulation, targeted drug delivery,...
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Isogeometric Shell FE Analysis of the Human Abdominal Wall
PublicationIn this paper a nonlinear isogeometric Kirchhoff-Love shell model of the human abdominal wall is proposed. Its geometry is based on in vivo measurements obtained from a polygon mesh that is transformed into a NURBS surface, and then used directly for the finite element analysis. The passive response of the abdominal wall model under uniform pressure is considered. A hyperelastic membrane model based on the Gasser-Ogden-Holzapfel...
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The influence of image masks definition onsegmentation results of histopathological imagesusing convolutional neural network
PublicationAbstract—In the era of collecting large amounts of tissue materials, assisting the work of histopathologists with various electronic and information IT tools is an undeniable fact. The traditional interaction between a human pathologist and the glass slide is changing to interaction between an AI pathologist with a whole slide images. One of the important tasks is the segmentation of objects (e.g. cells) in such images. In this...
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Wpływ stopowania laserowego z użyciem nanorurek węglowych stopu Ti13Nb13Zr do zastosowań biomedycznych na jego wybrane własności mechaniczne
PublicationDo eksperymentu użyto stopu tytanu Ti13Nb13Zr, który ze względu na swój skład chemiczny i właściwości mechaniczne stanowi materiał do zastosowań w inżynierii medycznej. Celem pracy była ocena wpływu stopowania laserowego stopu Ti13Nb13Zr z powłoką z wielościennych nanorurek węglowych na jego właściwości mechaniczne (chropowatość, nanotwardość, moduł Younga). Do wytworzenia powłoki węglowej wykorzystano metodę osadzania elektroforetycznego (EDP)....
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Tereny zdegradowane w UE: skala problemu, przyczyny powstawania i zasady zrównoważonej rewitalizacji = Brownfields in the EU : Scale of the problem, reasons of generation and principles of sustainable revitalization
PublicationRosnąca liczba terenów zdegradowanych staje się istotnym problemem w wielu krajach na całym świecie. Celem pracy jest przedstawienie holistycznego podejścia do zarządzania terenami zdegradowanymi rozwijanego w ramach europejskiego projektu HOMBRE (Holistic Management of Brownfield Regeneration). Koncepcja koncentruje się na osiągnięciu najwyższych możliwych korzyści ekonomicznych z uwzględnieniem zasad zrównoważonego rozwoju oraz...
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Sustainable urban planning in the context of studentification of the inner city areas
PublicationThe social dimension of urban planning as well as the importance of local communities and civic participation are often underlined in contemporary urban renewal and revitalisation programmes based on the principles of sustainable development. British Urban Renaissance is one the most far-reaching and widely discussed urban regeneration strategies which aims at repopulation and social diversification of inner city areas and land...
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Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse
PublicationThe MRL/MpJ mouse is an inbred laboratory strain of Mus musculus, known to exhibit enhanced autoimmunity, increased wound healing, and increased regeneration properties. We report the full-length mitochondrial DNA (mtDNA) sequence of the MRL mouse (Accession # EU450583), and characterize the discovery of two naturally occurring heteroplasmic sites. The first is a T3900C substitution in the TpsiCloop of the tRNA methionine gene...
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Zrównoważona rewitalizacja „modelowego” terenu zdegradowanego z wykorzystaniem rozwiązań projektu Unii Europejskiej Hombre
PublicationRosnąca liczba terenów zdegradowanych stanowi rosnący problem wielu krajów w Europie i na świecie. Celem pracy jest przedstawienie koncepcji zrównowazonej rewitalizacji modelowego terenu zdegradowanego w oparciu o narzędzia opracowane w ramach projektu HOMBRE (VII EU PR). Koncepcja koncentruje się na osiągnięciu najwyższych możliwych zysków ekonomicznych uwzgledniając zasady zrównowazonego rozwoju i potrzeby lokalnej społeczności....
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Konkursy studenckie jako narzędzie w określaniu potencjału rewitalizacyjnego miejskich terenów zdegradowanych.
PublicationZgodnie z zasadami prowadzenia działań rewitalizacyjnych określonych w ustawie o rewitalizacji obowiązującej od 9 października 2015 r. oraz horyzontalnych wytycznych w zakresie rewitalizacji w programach operacyjnych na lata 2014-2020 faza przygotowawcza procesu rewitalizacji powinna zawierać wielopłaszczyznowe analizy zakończone wnioskami aplikacyjnymi ujętymi w gminnych programach rewitalizacji obszarów zurbanizowanych. Artykuł...
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IN VIVO DEGRADATION OF BIOMATERIALS
PublicationThe material designed to be introduced into the human tissue should be biocompatible and biofunctional. Unless it is so, the body may respond to the implant in different ways. An inflammation reaction may appear such as: parting of items of the implant surface resulting from fraction or pressure. The condition of the surface has an important influence on the usefulness of the implant. The required values depend on the implant function...
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Parametric versus nonparametric modelling of dynamic susceptibility contrast enhanced MRI based data
PublicationDynamic tracking of a bolus of a paramagnetic agent (dynamic susceptibility contract - DSC) in MRI (magnetic resonance imaging) measurements is successfully used for assessment of the tissue perfusion and the other features and functions of the brain (i.e. cerebral blood flow - CBF, cerebral blood volume - CBV, mean transit time - MTT). The parametric and nonparametric approaches to the identification of MRI models are presented...
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Graphene Production and Biomedical Applications: A Review
PublicationGraphene is a two-dimensional nanomaterial composed of carbon atoms with sp2 hybrid orbitals. Both graphene and graphene-based composite have gained broad interest among researchers because of their outstanding physiochemical, mechanical, and biological properties. Graphene production techniques are divided into top-down and bottom-up synthesis methods, of which chemical vapor deposition (CVD) is the most popular. The biomedical...
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Structural and Material Determinants Influencing the Behavior of Porous Ti and Its Alloys Made by Additive Manufacturing Techniques for Biomedical Applications
PublicationOne of the biggest challenges in tissue engineering is the manufacturing of porous structures that are customized in size and shape and that mimic natural bone structure. Additive manufacturing is known as a sufficient method to produce 3D porous structures used as bone substitutes in large segmental bone defects. The literature indicates that the mechanical and biological properties of scaffolds highly depend on geometrical features...
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Three-Dimensional Printing of Bone Models
PublicationThe trabecular bone occurs, for example, in the femoral heads. Understanding the phenomenon of bone tissue degeneration can be the basis for the possibility of looking for alternative methods of surgical treatment of bone loss. The paper presents the results of the trabecular bone model, which was produced in additive manufacturing method with fused filament fabrication technology. The verification of the mechanical behavior of...
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LCT, PIV and IR Imaging Detection in Selected Technical and Biomedical Applications
PublicationThermochromic liquid crystals (TLC), Particle Image Velocimetry (PIV) and Infrared Imaging Themography (IR) have been successfully used in non-intrusive technical, industrial and biomedical studies and applications. These four tools (based on the desktop computers) have come together during the past two decades to produce a powerful advanced experimental technique as a judgment of quality of information that cannot be obtained...
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Carnivorous plants used for green synthesis of silver nanoparticles with broad-spectrum antimicrobial activity
PublicationIn this study, we exploit the anti-oxidative potential of four carnivorous plants to produce uniform and biologically active silver nanoparticles. The use of polyvinylpyrrolidone promoted syn-thesis of quasi-spherical nanoparticles characterized by stability and high uniformity. Their activity was tested against three human pathogens and three species of plant pathogenic bacteria. The study demonstrates the influence of synthesis...
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Liquid Crystals, PIV and IR-Photography in Selected Technical and Biomedical Applications
PublicationThermochromic liquid crystals (TLC), Particle Image Velocimetry (PIV), Infrared Imaging Themography (IR) and True-Colour Digital Image Processing (TDIP) have been successfully used in non-intrusive technical, industrial and biomedical studies and applications. These four tools (based on the desktop computers) have come together during the past two decades to produce a powerful advanced...
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Thermal and mechanical properties of polyurethanes modified with L-ascorbic acid
PublicationIn this study we report the thermal and mechanical properties of polyurethanes modified with ascorbic acid (AA). Ascorbic acid was used as a modifier at concentration of 1 or 2 mass%. The antioxidative properties of AA may improve the biocompatibility of the obtained materials, which were designed for biomedical applications. In this paper we describe characterization of obtained unmodified and ascorbic acid modified polyurethanes...
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VOCs absorption from gas streams using deep eutectic solvents – A review
PublicationVolatile organic compounds (VOCs) are one of the most severe atmospheric pollutants. They are mainly emitted into the atmosphere from anthropogenic sources such as automobile exhaust, incomplete fuel combustion, and various industrial processes. VOCs not only cause hazards to human health or the environment but also adversely affect industrial installation components due to their specific properties, i.e., corrosive and reactivity....
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On the Possibility of the Amphotericin B-Sterol Complex Formation in Cholesterol- and Ergosterol-Containing Lipid Bilayers: A Molecular Dynamics Study
PublicationAmphotericin B (AmB) is a well-known membrane-active antibiotic that has been used to treat systemicfungal infections for more than 45 years. Therapeutic application of AmB is based on the fact that it is moreactive against ergosterol-containing membranes of fungal cells than against mammalian membranes withcholesterol. In this paper, we examine the hypothesis according to which the selectivity of the AmB's membraneaction originates...
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Dual-Activity Fluoroquinolone-Transportan 10 Conjugates offer alternative Leukemia therapy during Hematopoietic Cell Transplantation
PublicationHematopoietic cell transplantation (HCT) is often considered a last resort leukemia treatment, fraught with limited success due to microbial infections, a leading cause of mortality in leukemia patients. To address this critical issue, we explored a novel approach by synthesizing antileukemic agents containing antibacterial substances. This innovative strategy involves conjugating fluoroquinolone antibiotics, such as ciprofloxacin...
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Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site
PublicationAn important stage in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) life cycle is the binding of the spike (S) protein to the angiotensin converting enzyme-2 (ACE2) host cell receptor. Therefore, to explore conserved features in spike protein dynamics and to identify potentially novel regions for drugging, we measured spike protein variability derived from 791 viral genomes and studied its properties by molecular...
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Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities
PublicationRecent studies have shown that modified human lactoferrin 20−31 fragment, named HLopt2, possesses antibacterial and antifungal activity. Thus, we decided to synthesize and evaluate the biological activity of a series of conjugates based on this peptide and one of the antimicrobials with proven antibacterial (ciprofloxacin, CIP, and levofloxacin, LVX) or antifungal (fluconazole, FLC) activity. The drugs were covalently connected...
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Emerging anticancer activity of candidal glucoseamine-6-phosphate synthase inhibitors upon nanoparticle-mediated delivery
PublicationNumerous glutamine analogues have been reported as irreversible inhibitors of the glucosamine-6-phosphate (GlcN-6-P) synthase in pathogenic Candida albicans in the last 3.5 decades. Among the reported inhibitors, the most effective N3-(4-methoxyfumaroyl)-L-2,3- diaminopropanoic acid (FMDP) has been extensively studied in order to develop its more active analogues. Several peptide−FMDP conjugates were tested to deliver FMDP to its...
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Superhydrophobic and superoleophilic melamine sponges impregnated with deep eutectic solvents for oil spill cleanup
PublicationThe extensive extraction of oil from the bottom of seas and oceans and its transportation by tankers increase the risk of potential environmental disasters associated with hydrocarbon fractions entering water reservoirs. Therefore, this paper presents the preparation of a simple impregnation of a melamine sponge with deep eutectic solvents (DES), which can be obtained from natural sources, including coconut oil, palm kernel oil,...
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Transcriptomic responses to wounding: meta-analysis of gene expression microarray data
PublicationBackground A vast amount of microarray data on transcriptomic response to injury has been collected so far. We designed the analysis in order to identify the genes displaying significant changes in expression after wounding in different organisms and tissues. This meta-analysis is the first study to compare gene expression profiles in response to wounding in as different tissues as heart, liver, skin, bones, and spinal cord, and...
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The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma-Recent Findings and Review
PublicationThe inflammatory process plays a significant role in the development of colon cancer (CRC). Intestinal cytokine networks are critical mediators of tissue homeostasis and inflammation but also impact carcinogenesis at all stages of the disease. Recent studies suggest that inflammation is of greater importance in the serrated pathway than in the adenoma-carcinoma pathway. Interleukins have gained the most attention due to their...
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Bacterial cellulose in the field of wound healing and regenerative medicine of skin: recent trends and future prospectives
PublicationIn this overview, we focused on the bacterial cellulose (BC) applications, described in recently published scientific papers, in the field of skin regenerative medicine and wound care industry. Bacterial cellulose was proven to be biocompatible with living tissues. Moreover, its mechanical properties and porous structure are considered to be suitable for biomedical applications. It is due to the fact that porous structure of bacterial...
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PERFORMANCE OF ENDOSCOPIC IMAGE ANALYSIS ALGORITHMS IN LARGE BOWEL VIDEOS PROCESSING
PublicationComputer-assisted endoscopy is a rapidly developing eld of study. Many image anal- ysis algorithms exist, achieving very high rates of eciency at processing single endoscopic images. However, most of them were never tested in processing real-life endoscopic videos. In the article such tests of 16 endoscopy image analysis algorithms are presented and dis- cussed. Tests were performed on two real-life endoscopic videos of a human...
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Rating mathematical models for first-pass of tracer in pCT lung studies
PublicationThis paper presents a comparison of model based on the Gauss function and the most commonly used Gamma-variate model in perfusion computed tomography (pCT) lung studies. It also verifies whether used model affects value of blood volume parameter. Three mean concentration-time curves were created from actual pCT measurements: arterial input function, blood vessels in lungs and lung parenchyma. On the basis of these mean curves we...
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Impact of surface skin temperature change on blood flow characteristics in palm
PublicationHeating a human palm during 3 minutes period causes changes in superficial skin temperature and leads to thermoregulation system response. The response time and level of flow characteristics change depend on the subject hand size and health of his vascular tree. A solution of Pennes bioheat propagation model was analyzed in order to see how much heat has to be transferred into the tissue to extort the observable reaction. The reflective...
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Obtaining a Well-Trained Artificial Intelligence Algorithm from Cross-Validation in Endoscopy
PublicationThe article shortly discusses endoscopic video analysis problems and artificial intelligence algorithms supporting it. The most common method of efficiency testing of these algorithms is to perform intensive cross-validation. This allows for accurately evaluate their performance of generalization. One of the main problems of this procedure is that there is no simple and universal way of obtaining a specific instance of a well-trained...
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Bioactive core material for porous load-bearing implants
PublicationSo far state of knowledge on biodegradable materials is reviewed. Among a variety of investigated materials, those composed of polymers and ceramics may be considered as only candidates for a core material in porous titanium alloy. The collagen and chitosan among natural polymers, polyhydroxy acids among synthetic polymers, and hydroxyapatite and tricalcium phosphate among ceramics are proposed for further research. Three essential...