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Search results for: BLOOD VESSEL TUMORS
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Endometrial nitric oxide production and nitric oxide synthases in the equine endometrium: Relationship with microvascular density during the estrus cycle
PublicationNitric oxide (NO) plays an important role in angiogenesis and in the regulation of the blood flow. This study was carried out to investigate (i) the effects of endogenous estrogens and progestins and exogenous progesterone (P(4)) (5 ng/ml or 1 microg/ml) or estradiol 17beta (E(2)beta) (50 pg/ml or 1 microg/ml) on in vitro endometrial NO synthesis; (ii) the presence of different isoforms of NO synthase;...
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Path planning algorithm for ship collisions avoidance in environment with changing strategy of dynamic obstacles
PublicationIn this paper a path planning algorithm for the ship collision avoidance is presented. Tested algorithm is used to determine close to optimal ship paths taking into account changing strategy of dynamic obstacles. For this purpose a path planning problem is defined. A specific structure of the individual path and fitness function is presented. Principle of operation of evolutionary algorithm and based on it dedicated application...
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Combined Close Range Photogrammetry and Terrestrial Laser Scanning for Ship Hull Modelling
PublicationThe paper addresses the fields of combined close-range photogrammetry and terrestrial laser scanning in the light of ship modelling. The authors pointed out precision and measurement accuracy due to their possible complex application for ship hulls inventories. Due to prescribed vitality of every ship structure, it is crucial to prepare documentation to support the vessel processes. The presented methods are directed, combined...
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The Use of Unmanned Surface Vessels in Bathymetric Measurements of Waterbodies with Highly Dynamic Seafloor Relief
PublicationThe early 21st century is a time when unmanned surface vessels (USV) are used in various measurement applications. Modern autonomous and unmanned vessels are increasingly often used in bathymetric measurements whose aim is to measure the seafloor with the sufficient positioning accuracy. Therefore, the use of USVs in hydrography can be seen as the beginning of a new era in this regard. This paper presents bathymetric measurements...
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The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation
PublicationC-1311 is a small molecule, which has shown promise in a number of preclinical and clinical studies. However, the biological response to C-1311 exposure is complicated and has been reported to involve a number of cell fates. Here, we investigated the molecular signaling which determines the response to C-1311 in both cancer and non-cancer cell lines. For the first time we demonstrate that the tumor suppressor, p53 plays a key role...
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Synthesis and biological activity of mycophenolic acid-amino acid derivatives
PublicationIn search of new immunosuppressants, mycophenolic acid (MPA) was coupled with amino acid methyl esters followed by hydrolysis to analogs bearing free carboxylic groups. The obtained compunds were tested in vitro as growth inhibitors of lymphoid cell line (Jurkat) and human peripheral blood mononuclear cells (PBMC) from healthy donors. According to obtained results recovering of free carboxylic group increased their activity. Additionally,...
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Modelling of Diffusing Capacity Measurement Results in Lung Microangiopathy Patients. A novel Diagnostic Suppport
PublicationLung microangiopathy is a little known negative influence of diabetes mellitus on the functioning of the lungs. The aim of this study is to design a supportive method for diagnosing lung microangiopathy. This will be based on routinely performed pulmonary measurements as well as on investigation process modelling and data processing. A model of the diffusion of oxygen from the alveoli to the blood has been described with a set...
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Synthesis and antiproliferative activity of new mycophenolic acid conjugates with adenosine derivatives
PublicationNew conjugates of mycophenolic acid (MPA) and adenosine derivatives were synthesized and assessed as potential immunosuppressants on Jurkat cell line and peripheral blood mononuclear cells (PBMC) from healthy donors. As compared to MPA, all compounds were found to be more active against Jurkat cell line. The antiproliferative activities were compared with MPA and adenosine, in both 2′,3′-O-isopropylidene protected and free hydroxyl...
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Determination of thiocyanate (biomarkers of ETS) and other inorganic ions in human nasal discharge samples using ion chromatography
PublicationEnvironmental tobacco smoke (ETS) is a mixture of air and tobacco smoke containing more than 4000 chemical substances. In view of the health risks of many of these substances, studies are needed to determine biomarkers of exposure to ETS constituents in people who actively or passively are exposed to the toxic compounds. The methodologies for determining most biomarkers from saliva, urine and blood samples are known, but methods...
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Diesel electric a new trend on the ship propulsion
PublicationW artykule przedstawiono rozwój napędu "diesel elektrycznego" oraz argumentację zastosowania tego napędu na różnych typach statków. Referat zawiera również rozwiązania układu transmisji mocy oraz sprawność, jaka cechuje napęd elektryczny. W artykule zawarto również zalety tego napędu, oraz zwrócono uwagę na nowe koncepcje i rozwiązania korzystne dla wytwarzania i transmisji mocy w napędzie elektrycznym.This article presents development...
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Classification of Sea Going Vessels Properties Using SAR Satellite Images
PublicationThe aim of the project was to analyze the possibility of using machine learning and computer vision to identify (indicate the location) of all sea-going vessels located in the selected area of the open sea and to classify the main attributes of the vessel. The key elements of the project were to download data from the Sentinel-1 satellite [1], download data on the sea vessels [2], then automatically tag data and develop a detection...
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The hydrodynamic pressure field of the ship Zodiak, measurements and calculations
PublicationThe article presents the results of measurements of the slowly changing hydrodynamic pressure field HPF generated by the movement of the ship, Zodiak, in the Bay of Gdansk. The measurement results have been obtained in the framework of the program of the work in Siramis, under the auspices of the European Defence Administration of the EU, by the research team of the Naval Academy in Gdynia. The measurement results were compared with...
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RAMAN DIAGNOSTICS OF CVD DIAMOND GROWTH
PublicationDevelopment of Raman spectroscopic system for diagnostics of growth of diamond and BDD (Boron- Doped-Diamond) thin films during μPA CVD (Microwave Plasma Assisted Chemical Vapour Deposition) process is described. Raman studies of such films were carried out as in-situ monitoring of film deposition as ex-situ measurements conducted for a sample outside the reaction vessel after manufacturing process. Modular system for the in-situ...
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VARIANT DESIGNING IN the PRELIMINARY SMALL SHIP DESIGN PROCESS
PublicationShip designing is a complex process, as the ship itself is a complex, technical multi-level object which operates in the air/water boundary environment and is exposed to the action of many different external and internal factors resulting from the adopted technical solutions, type of operation, and environmental conditions. A traditional ship design process consists of a series of subsequent multistage iterations, which gradually...
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Ship’s de-perming process using coils lying on seabed
PublicationA ship built from ferromagnetic steel disturbs the uniformity of the Earth’s magnetic field. Changes of ship’s signature are due to the magneto-mechanical interaction of the hull with the Earth’s magnetic field. The ship’s magnetic field can be detected by a magnetic naval mine. For this reason, the vessel has to be demagnetized. There are several methods of ship’s de-perming. The results of experimental and computer simulations...
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The Accuracy of a Marine Satellite Compass under Terrestrial Urban Conditions
PublicationWhen used at sea, satellite compasses are capable of determining the course of a sailing vessel with high accuracy. It is dicult to verify the accuracy declared by the device manufacturer under such conditions, as it is dicult to define a reliable reference. This study analyses the accuracy of the satellite compass in an urban setting, with the satellite signal being obscured to various extents. It is an important point in the...
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Modeling of Accidental Bunker Oil Spills as a Result of Ship's Bunker Tanks Rupture - a Case Study
PublicationAIS (Automatic Identification System) data analysis is used to define ship domain for grounding scenarios. The domain has been divided into two areas as inner and outer domains. Inner domain has clear border, which is based on ship dynamic characteristics. Violation of inner domain makes the grounding accident unavoidable. Outer domain area is defined with AIS data analyzing. Outer domain shows the situation of own ship in compare...
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Common methods for the chiral determination of amphetamine and related compounds I. Gas, liquid and thin-layer chromatography
PublicationThis article reviews the most common, useful methods for the chiral determination of amphetamine (AM) and AM-deriveddesigner drugs in different of matrix, including blood, hair, urine, medicaments or standard solutions, taking into considerationarticles published in the past 15 years. We consider chromatographic methods (e.g., gas, liquid, high-performance liquid, and thinlayer). We describe several types of chiral derivatization...
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New PCR test for detection of Candida glabrata based on the molecular target chosen by the RAPD technique
PublicationRapid, reliable diagnosis is a necessary condition for the successful treatment of infections. Such diagnostic assays are continually being developed. #e paper presents a method for selecting the molecular target for PCR-based diagnostics based on the comparison of RAPD patterns. A sequence encoding Candida glabrata CBS138 hypothetical protein was selected. The limit of detection for PCR and real-time PCR reactions with DNA extracted...
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Medical Image Dataset Annotation Service (MIDAS)
PublicationMIDAS (Medical Image Dataset Annotation Service) is a custom-tailored tool for creating and managing datasets either for deep learning, as well as machine learning or any form of statistical research. The aim of the project is to provide one-fit-all platform for creating medical image datasets that could easily blend in hospital's workflow. In our work, we focus on the importance of medical data anonimization, discussing the...
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CARDIOVASCULAR RISK FACTORS AMONG POLISH EMPLOYEES OF UNIFORMED SERVICES
PublicationObjectives: Employees of uniformed services (EoUS) were screened for cardiovascular risk factors. Material and Methods: A total of 1138 EoUS (age M±SD 49.9±6.0 years) and 263 controls (age M±SD 54.4±9.7 years) under the care of the cardiology clinic in Gdańsk, Poland,were included in the study. Medical history and blood samples were collected, and a physical examination was performed. Ten-year cardiovascular risk of death was...
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Vitamin B12 deficiency anaemia, unspecified - Male, 52 - Cell image [7120730007975601]
Open Research DataThis is the histopathological image of HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS cell sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: VS200 Olympus slide scanner (40x magnification) and saved to DICOM format.
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Diamond-based protective layer for optical biosensors
PublicationOptical biosensors have become a powerful alternative to the conventional ways of measurement owing to their great properties, such as high sensitivity, high dynamic range, cost effectiveness and small size. Choice of an optical biosensor's materials is an important factor and impacts the quality of the obtained spectra. Examined biological objects are placed on a cover layer which may react with samples in a chemical, biological...
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Iron deficiency anaemia, unspecified - Female, 34 - Cell image [7120730007984591]
Open Research DataThis is the histopathological image of HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS cell sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: VS200 Olympus slide scanner (40x magnification) and saved to DICOM format.
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Analytical procedures for determination of cocaine and its metabolites in biological samples
PublicationThe dangerous effects and increased usage of illicit drugs have inspired the development of analytical methodologies. We based our review of analytical procedures for determination of cocaine (COC) and its metabolites on literature from the past two decades. Our main aim was to compare the capabilities of different analytical techniques. The diversity of matrices from which COC is determined (e.g., blood, hair, saliva, plasma,...
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Thermal sequences database of the skin flaps in breast reconstruction and burns
PublicationThis paper presents a database of Active Dynamic Thermography (ADT) thermal sequences gathered throughout 6 year study on ADT application in skin flap blood perfusion monitoring and burn wounds diagnosis. For skin flap monitoring the database comprises of data collected during three different breast reconstruction procedures. The patients were monitored pre, intra and post surgically within 90 days period. The sequences were used...
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Thermal sequences database of the skin flaps in breast reconstruction and burns
PublicationThis paper presents a database of Active Dynamic Thermography (ADT) thermal sequences gathered throughout 6 year study on ADT application in skin flap blood perfusion monitoring and burn wounds diagnosis. For skin flap monitoring the database comprises of data collected during three different breast reconstruction procedures. The patients were monitored pre, intra and post surgically within 90 days period. The sequences were used...
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Stress Detection of Children With ASD Using Physiological Signals
PublicationThis paper proposes a physiological signal-based stress detection approach for children with autism spectrum disorder (ASD) to be used in social and assistive robot inter- vention. Electrodermal activity (EDA) and blood volume pulse (BVP) signals are collected with an E4 smart wristband from children with ASD in different countries. The peak count and signal amplitude features are derived from EDA signal and used in order to detect...
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Mixed germ cell tumor - Male, 31 - Tissue image [6060730023672131]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Mixed germ cell tumor - Male, 31 - Tissue image [6060730023676811]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Mixed germ cell tumor - Male, 31 - Tissue image [6060730023678671]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Mixed germ cell tumor - Male, 31 - Tissue image [6060730023679211]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Mixed germ cell tumor - Male, 31 - Tissue image [606073002367551]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Mixed germ cell tumor - Male, 31 - Tissue image [6060730023673761]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Mixed germ cell tumor - Male, 31 - Tissue image [6060730023674071]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Mixed germ cell tumor - Male, 31 - Tissue image [606073002367571]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Mixed germ cell tumor - Male, 31 - Tissue image [6060730023671541]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Mixed germ cell tumor - Male, 31 - Tissue image [6060730023673321]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Mixed germ cell tumor - Male, 31 - Tissue image [6060730023678721]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Mixed germ cell tumor - Male, 31 - Tissue image [6060730023676491]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Mixed germ cell tumor - Male, 31 - Tissue image [6060730023674471]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Mixed germ cell tumor - Male, 31 - Tissue image [6060730023675861]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Mixed germ cell tumor - Male, 31 - Tissue image [6060730023675651]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Mixed germ cell tumor - Male, 31 - Tissue image [7040247104939551]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Mixed germ cell tumor - Male, 31 - Tissue image [6060730023679851]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Mixed germ cell tumor - Male, 31 - Tissue image [6060730023674551]
Open Research DataThis is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Multibeam Echosounder and LiDAR in Process of 360-Degree Numerical Map Production for Restricted Waters with HydroDron
PublicationIn order to increase the safety of inland navigation and facilitate the monitoring of the coastal zone of restricted waters, a model of multi-sensory fusion of data from hydroacoustic and optoelectronic systems mounted on the autonomous survey vessel HydroDron will be developed. In the research will be used the LiDAR laser scanner and multibeam echosounder. To increase the visual quality and map accuracy, additionally side scan...
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Towards Improving Optimised Ship Weather Routing
PublicationThe aim of the paper is to outline a project focusing on the development of a new type of ship weather routing solution with improved uncertainty handling, through better estimation of ship performance and responses to sea conditions. Ensemble forecasting is considered to take into account the uncertainty levels that are typical of operations in a stochastic environment. Increased accuracy of weather prediction is achieved through...
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Modelling charge transfer processes in C2+ -tetrahydrofuran collision for ion-induced radiation damage in DNA building blocks
PublicationInvestigations of collision-induced processes involving carbon ions and molecules of biological interest in particular DNA building blocks, are crucial to model the effect of radiation on cells in order to improve medical treatments for cancer therapy. Using carbon ions appears to be one of the most efficient ways to increase biological effectiveness to damage cancerous cells by irradiating deep-seated tumors. Therefore, interest...
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Mechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by antitumor triazoloacridinone C-1305.
Publication5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone, C-1305, is a promising antitumor therapeutic agent with high activity against several experimental tumors. It was determined to be a potent and selective inhibitor of liver microsomal and human recombinant cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1305 might modulate the effectiveness of other drugs used in multidrug therapy. The objective of this study was...