Search results for: BIOLOGICAL ACTIVITY
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Distinct cellular uptake patterns of two anticancer unsymmetrical bisacridines and their metabolic transformation in tumor cells.
PublicationUnsymmetrical bisacridines (UAs) represent a novel class of anticancer agents. Their high cytotoxicity towards multiple human cancer cell lines and inhibition of human tumor xenograft growth in nude mice signal their potential for cancer treatment. Therefore, the mechanism of their strong biological activity is broadly investigated. Here, we explore the efflux and metabolism of UAs, as both strongly contribute to the development...
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Impact of enhanced pretreatment on biological nutrient removal in municipal wastewater treatment plants
PublicationThe aim of this study was to determine the effect of enhanced primary treatment on: increasing primary sludge production for increased biogas production; reducing the organic load on downstream biological treatment processes and thereby reducing energy consumption for aeration; denitrification and enhanced biological phosphorus removal (EBPR) rates in the activated sludge system. For this purpose, three commercial organic polymers...
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Photosensitive and pH-dependent activity of pyrazine-functionalized carbazole derivative as promising antifungal and imaging agent
PublicationCarbazole skeleton plays a significant role as a structural scaffold of many pharmacologically active compounds. Pyrazine-functionalized carbazole derivative was constructed by coupling 2-amino-5-bromo-3-methylaminepyrazine (ABMAP) into 3 and 6 positions of the carbazole ring. Multi-experimental methods were used, e.g., potentiometric, spectroscopic (ATR, UV, XRD powder,1H and13C NMR), electrochemical (cyclic voltammetry), and...
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Partial characterization of three Korean white lotus cultivars
PublicationThe nutritional and bioactive values of Korean white lotus cultivars (Muan, Chungyang, and Garam)extracted with methanol, water, and acetone solvents were evaluated by the contents of their bioactive compounds and antioxidant activity determined by ABTS, CUPRAC, FRAP, DPPH, and β-carotene-linoleic acid assays. HPLC, fluorometry, and FTIR spectroscopy were employed for evaluation of polyphenols and fatty acids. All lotus cultivar...
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A new approach to designing control of dissolved oxygen and aeration system in sequencing batch reactor by applied backstepping control algorithm
PublicationThe Wastewater Treatment Plant (WWTP) is a very complex system, due to its nonlinearity, time-variance, and multiple time scales in its dynamics among others. The most important control parameter in a WWTP is the Dissolved Oxygen (DO) concentration. The tracking problem of the DO concentration is one of the most fundamental issues in biological wastewater treatment. Proper DO concentration control is necessary to achieve adequate...
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Optoelectronic investigation of nanodiamond interactions with human blood
PublicationWe present optoelectronic investigation of in vitro interactions of whole human blood with different nanodiamond biomarkers. Plasmo-chemical modifications of detonation nanodiamond particles gives the possibility for controlling their surface for biological applications. Optical investigations reveal the biological activity of nanodiamonds in blood dependent on its surface termination. We compare different types of nanodiamonds:...
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Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties
PublicationCemented arthroplasty is a common process to fix prostheses when a patient becomes older and his/her bone quality deteriorates. The applied cements are biocompatible, can transfer loads, and dampen vibrations, but do not provide antibacterial protection. The present work is aimed at the development of cement with antibacterial effectivity achieved with the implementation of nanoparticles of different metals. The powders of Ag,...
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Novel 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives as potent anticancer agents – Synthesis, molecular structure, QSAR studies and metabolic stability
PublicationA series of new 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cancer MCF-7. The obtained results indicated that these compounds display prominent cytotoxic effect. The best anticancer properties have been observed for derivatives...
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Modifications at the C(5) position of pyrimidine nucleosides
PublicationThis review summarizes the state of knowledge on the chemical methods of C(5)-modifications of uridine and cytidine derivatives and may serve as a useful tool for synthetic chemists to choose an appropriate reaction protocol. The synthesis of 5-substituted uracil derivatives is gaining an increasing interest because of their possible applications in medicine and pharmacy. Modifications at the C(5) position of pyrimidine nucleosides...
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The impact of lipophilicity on environmental processes, drug delivery and bioavailability of food components
PublicationLipophilic properties of the compound allow to predict its fate in living organisms and to propose the models of chemicals transport and accumulation in the ecosystem. Lipophilicity is also useful as the characteristic of chemicals in respect to their optimal attributes for specific biological and non-biological tasks. The lipophilicity descriptors define the potency of endo- and xenobiotics to metabolic transformations and their...
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Assessment of the usefulness of bacterial cellulose produced by Gluconacetobacter xylinus E25 as a new biological implant
PublicationBionanocellulose (BNC) is a clear polymer produced by the bacterium Gluconacetobacter xylinus. In our current study, “Research on the use of bacterial nanocellulose (BNC) in regenerative medicine as a function of the biological implants in cardiac and vascular surgery”, we carried out material analysis, biochemical analysis, in vitro tests and in vivo animal model testing. In stage 1 of the project, we carried out physical and...
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Determination of thiocyanate as a biomarker of tobacco smoke constituents in selected biological materials of human origin
Publicationn order to protect human health, it is necessary to biomonitor toxic substances originating from tobacco smoke in biological materials sampled from persons with different exposures to tobacco smoke constituents. Thiocyanate anion is a biomarker of exposure to tobacco smoke components which is characterized by a relatively long half‐life in the human body, i.e. 6 days. In this work, we present the results of thiocyanate determinations...
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Analytical methods for exhaustive characterization of Brassica plants and dietary products based on them
PublicationGlucosinolates (GLs), and particularly two classes of their degradation products - isothiocyanates (ITC) and indoles - released upon myrosinase catalyzed hydrolysis, belong to the most promising chemopreventive dietary components. Despite their wide use in plant research, studies on chemopreventive mechanisms and industrial utilization in the production of e.g. dietary supplements, the methods of reliable characterization of myrosinase-GLs...
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Antimicrobal and ostheointegration activity of bone cement contains nanometals
PublicationPurpose: One of the major problems in bone surgery are infections – especially thoseoccurring in the course of the operating on the patients with lowered immunity system,because they carry the danger of complications. In the Mechanical Department of TechnicalUniversity of Gdansk, there has been carried the research with the use of bone cement andmetal nanoparticles.Design/methodology/approach: The bone cement was used without supplement...
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The use of fosmid metagenomic libraries in preliminary screening for various biological activities
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ADCP Observations of Diel Vertical Migration of Biological Layers in Gulf of Gdańsk
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Chapter 13. Immunological determination of the pharmaceutical diclofenac in environmental and biological samples
PublicationOpracowano wysoce specyficzną i czułą metodę immunologiczną oznaczania przeciwzapalnego leku diklofenaku. Jest to jeden z najczęściej wykrywanych farmaceutyków w środowisku. Granicę wykrywalności oraz wartość IC50 określono na poziomie 6 ng/L oraz 60 ng/L dla wody wodociągowej, odpowiednio. W badaniu porównawczym, stosując test ELISA oraz GC-MS określono poziomy stężeń diklofenaku w wodach ściekowych z 21 oczyszczalni ścieków i...
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In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine
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Analytical applications of membrane extraction for biological and environmental liquid sample preparation
PublicationW niniejszej pracy przedstawiono informacje dotyczące technik ekstrakcji membranowej wykorzystywanych do oznaczania związków organicznych w ciekłych próbkach środowiskowych i biologicznych. Szczególną uwagę poświęcono podstawom teoretycznym tych technik, możliwości połączenia z technikami oznaczeń końcowych oraz obszarom praktycznego ich wykorzystania.
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Microbiological and biological aspects of wastewater tretment plant Wschód in Gdańsk Operation.
PublicationW pracy wykazano, iż w oczyszczalni Wschód w Gdańsku, pracującej w zmodyfikowanym systemie UCT, zanieczyszczenia bakteriologiczne ze ścieków są usuwane w granicach od 92% do ponad 99%, a zanieczyszczenia parazytologiczne niemal całkowicie. Pomimo tego odpływy są nadal dość znacznie zanieczyszczone bakteriologicznie o czym świadczy liczba bakterii wskaźnikowych oraz okresowa obecność bakterii z rodzaju Salmonella. Ustalono, iż...
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The efficiency of biological nutrients removal in WWTP`s "Wschód" in Gdańsk (Poland)
PublicationRozbudowana w latach 1997-99 oczyszczalnia ścieków Wschód w Gdańsku zapewnia wysokoefektywne oczyszczanie ścieków odprowadzanych do wód Zatoki Gdańskiej Morza Bałtyckiego. Zrealizowany układ technologiczny biologicznego oczyszczania ścieków o przepustowości 180 tys. m3 na dobę jest złożony z sześciu reaktorów MUCT, z których każdy współpracuje z dwoma osadnikami wtórnymi. W artykule podsumowano okres pierwszych trzech lat eksploatacji...
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Biological fluids as a source of information on the exposure of man to envinonmental chemical agents.
PublicationWiele związków (min. lotne związki chlorowcoorganiczne, metale) ma szkodliwy wpływ na tkanki i narządy organizmu ludzkiego, wywołując nieodwracalne zmiany chorobowe. W celu określenia zagrożenia zawodowego coraz częściej wykonuje się pomiar stężeń substancji chemicznych i ich metabolitów w płynach biologicznych - moczu, krwi, rzadziej w mleku matki, żółci, ślinie, czy też spermie. Aby oznaczyć poziomy tych stężeń, pobrane próbki...
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Effect of carbonate substitution on physicochemical and biological properties of silver containing hydroxyapatites
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Accumulation and fate of selected heavy metals in biological wastewater treatment system
PublicationBadano akumulację oraz stopień usuwania metali ciężkich (Cd, Cu, Pb, Zn) w systemie biologicznego oczyszczania ścieków. Porównano zawartość wybranych metali w ściekach surowych i oczyszczonych, a także ich stężenie w osadzie czynnym przed i po beztlenowej stabilizacji.
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Phytochemical Constituents, Biological Activities, and Health-Promoting Effects of the Melissa officinalis
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Receptor for advanced glycation end‐products: Biological significance and imaging applications
PublicationThe receptor for advanced glycation end-products (RAGE or AGER) is a transmembrane, immunoglobulin-like receptor that, due to its multiple isoform structures, binds to a diverse range of endo- and exogenous ligands. RAGE activation caused by the ligand binding initiates a cascade of complex pathways associated with producing free radicals, such as reactive nitric oxide and oxygen species, cell proliferation, and immunoinflammatory...
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Full scattering profile of circular optical phantoms mimicking biological tissue
PublicationHuman tissue is one of the most complex optical media since it is turbid and nonhomogeneous. In our poster, we suggest a new type of skin phantom and an optical method for sensing physiological tissue condition, basing on the collection of the ejected light at all exit angles, to receive the full scattering profile. Conducted experiments were carried out on an unique set-up for noninvasive encircled measurement. Set-up consisted...
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Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters
PublicationThe biological activity of Cd compounds has been investigated scarce since Cd has been recognized as a human carcinogen. However, the toxicity of cadmium is comparable to the toxicity of noble metals such as Pt and Pd. The paradigm of metal toxicity has been challenged suggesting that metal toxicity is not a constant property, yet it depends on many factors like the presence of appropriate ligands. Studies on anticancer activity...
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Silver-modified titania with enhanced photocatalytic and antimicrobial properties under UV and visible light irradiation
PublicationCommercial titania photocatalysts were modified with 2 wt% of silver by photodeposition. The properties of the samples were characterized by DRS, XPS, XRD, FE-SEM and STEM. The modified samples exhibited activity under visible light and enhanced activity under UV irradiation for 2-propanol and acetic acid oxidation, respectively. The time-resolved microwave conductivity (TRMC) analysis indicated that enhanced activity (2.5–8-fold...
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Task Scheduling – Review of Algorithms and Analysis of Potential Use in a Biological Wastewater Treatment Plant
PublicationThe idea of task scheduling is to increase the efficiency of a system by minimising wasted time, evenly loading machines, or maximising the throughput of machines. Moreover, the use of appropriate scheduling algorithms often leads to a reduction in the energy costs of the process. Task scheduling problems are found in a variety of industrial areas, and their scale changes significantly depending on the problem. This review shows...
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The Caucasian flora: a still-to-be-discovered rich source of antioxidants
PublicationCellular redox homeostasis is a state of balance between the formation of Usually Reactive Oxygen and / or Nitrogen Species (ROS/RNS), endogenous antioxidant defence systems, and exogenous dietary antioxidants. The disturbance of redox homeostasis, by the overproduction of endogenous ROS/RNS, may increase the risk of development of so-called civilisation diseases. The solution seems to be either the increased production of endogenous...
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The influence of sterilization with EnbioJet Microwave Flow Pasteurizer on composition and bioactivity of aronia and blue-berried honeysuckle juices
PublicationIn this study, fruit juices that are rich sources of anthocyanins, obtained from aronia (Am. chokeberry, Aronia melanocarpa) and blueberry honeysuckle (Lonicera caerulea L. var. edulis) were used to examine the preservation of plant phytochemicals and bioactivity upon sterilization -either thermal, or with an EnbioJet microwave flow pasteurizer. The chemical properties verified included determinations of anthocyanins and other...
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Modeling hydrolysis of slowly biodegradable organic compounds in biological nutrient removal activated sludge systems
PublicationHydrolysis is an important process in biological wastewater treatment and is known to be the ratelimiting step in organic carbon removal from municipal or industrial wastewater. The influence of the readily biodegradable chemical oxygen demand fraction in biological wastewater treatment systems has been extensively investigated, but little is known about the effects of slowly biodegradable substrate (XS) on denitrification and...
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Beata Krawczyk dr hab.
PeopleBeata Krawczyk, PhD, Professor Academic degrees, education, qualifications: B. Krawczyk earned his master degree in Biology at the University of Gdansk, Biology Faculty, in 1986, and her PhD in Molecular Biology at the University of Gdansk, Biology Faculty, in 1996. Postdoctoral degree (habilitation) in biological sciences in the discipline biology, Faculty of Natural Sciences, University of Szczecin, Szczecin, in 2009. In 2012...
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A research on the optimal conditions for separation and identyfication of the components from the Droseraceae extracts by column liquid chromatography
PublicationThe isolation of the components with anticipated biological properties i.e. antimicrobial, fungicidal, antioxidant and perhaps anticancer activity is for many years a one of the biggest issues of modern separation science. Their obtaining based on the isolation of the components with the biological activity from in vitro cultured plants by extraction techniques is often more difficult than their production by the chemical synthesis.The...
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An overview of the cognitive and biological effects of city nighttime illumination including a London case study
PublicationCurrent scientific research demonstrates how critical the effects of city nighttime illumination are upon cognitive and biological health1 – which needs to be adequately acknowledged, understood and addressed by conscious cities and the plans they develop. Until recent decades, the design of nighttime lighting was determined mostly by electrical engineers who often applied technical standards to meet the requirements of vehicle-focused...
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Environmental risk assessment of Polish wastewater treatment plant activity
PublicationWastewater treatment plants (WWTPs) play an extremely important role in shaping modern society's environmental wellbeing and awareness, however only well operated and supervised systems can be considered as environmentally sustainable. For this reason, an attempt was undertaken to assess the environmental burden posed by WWTPs in major Polish cities by collecting water samples prior to and just after wastewater release points....
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Characteristics and fate of organic nitrogen in municipal biological nutrient removal wastewater treatment plants
PublicationThe aim of this study was to investigate the occurrence and fate of colloidal and dissolved organic nitrogen (CON and DON) across biological nutrient removal (BNR) activated sludge bioreactors. Primary and secondary effluent total nitrogen (TN) measurements and component fractionation, CON and DON concentration profiles across BNR bioreactors, and laboratory batch experiments with the process mixed liquor were carried out at several...
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Optical, colloidal and biological properties of up-converting nanoparticles embedded in polyester nanocarriers
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CRF1 receptor splicing in epidermal keratinocytes: Potential biological role and environmental regulations
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Significant Down-Regulation of “Biological Adhesion” Genes in Porcine Oocytes after IVM
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Application of pH measurements for the following the course of biological treatment of wastewater and its control
PublicationZaprezentowano wyniki badań przeprowadzonych w skali laboratoryjnej w reaktorze imitującym działanie reaktora SBR. Oczyszczaniu poddano ścieki syntetyczne z dodatkiem glukozy. W trakcie oczyszczania ścieków monitorowano zmiany pH, redox, przewodności oraz stężenia azotu amonowego, azotanów i fosforanów. Stwierdzono korelację między pH i zmianami stężenia fosoranów oraz brak podobnej zależności dla związków azotowych.
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LC-ESI-MS profiling of Potentilla norvegica and evaluation of its biological activities
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Analysis of Potential Exposure to Components of Municipal Solid Waste in a Mechanical Biological Treatment
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Comparison of the Toxicity of Pristine Graphene and Graphene Oxide, Using Four Biological Models
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Gallic Acid-Functionalized, TiO2-Based Nanomaterial—Preparation, Physicochemical and Biological Properties
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Preliminary investigations on biological treatment of aqueous phase separated from cutting fluids
PublicationZaprezentowano wyniki fizykochemicznego podczyszczania przepracowanych cieczy obróbkowych pochodzących z różnych źródeł. Emulsje przepracowanych cieczy obróbkowych zostały rozdzielone na fazę organiczną i wodną z wykorzystaniem różnych koagulantów. Wydzielona faza wodna została następnie poddana biologicznemu oczyszczaniu z wykorzystaniem osadu czynnego. W wyniku oczyszczania ścieków uzyskano 59-88% obniżenie wartości ChZT.
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Physical, Chemical and Biological Changes in the Gulf of Gdańsk Ecosystem (Southern Baltic Sea).
PublicationPrzedstawiono fizyczne, chemiczne i biologiczne zmiany zachodzące w ekosystemie Zatoki Gdańskiej (Południowy Bałtyk. Opisano klimat (temp. wody, opady poziom morza, zasolenie), fluktuację stężeń związków biogennych (azotany,fosforany, krzemiany), poziom organicznych zanieczyszczeń (POP´s, PcB´, pestycydy, WWA) oraz zmiany w biologicznym życiu morza.
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Rational design, synthesis and biological evaluation of thiadiazinoacridines: a new class of antitumor agents.
PublicationZsyntetyzowano serię związków o potencjalnej zdolności do wiązania się z DNA z grupy tiadiazinoakrydyn poprzez cyklizację odpowiednich pochodnych 9-imino-4-nitro-9,10-dihydroakrydyny. Zbadano ich zdolność do wiązania się z DNA oraz cytotoksyczność względem kilku linii komórek nowotworwych. Badania aktywności przeciwnowotworowej wobec białaczki P388 wskazały na zgodność tych wyników z wynikami cytotoksyczności in vitro. Wykazano,...
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Scaffolds Loaded with Dialdehyde Chitosan and Collagen—Their Physico-Chemical Properties and Biological Assessment
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