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Search results for: anti-candida activity
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Xanthone synthetic derivatives with high anticandidal activity and positive mycostatic selectivity index values
PublicationWith the current massive increases in drug-resistant microbial infection as well as the significant role of fungal infections in the death toll of COVID-19, discovering new antifungals is extremely important. Natural and synthetic xanthones are promising derivatives, although only few reports have demonstrated their antifungal mechanism of action in detail. Newly synthetized by us xanthone derivative 44 exhibited strong antifungal...
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Fabrication of anti-corrosion nitrogen doped graphene oxide coatings by electrophoretic deposition
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Parallel in vitro and in silico investigations into anti-inflammatory effects of non-prenylated stilbenoids
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Milky Sap of Greater Celandine (Chelidonium majus L.) and Anti-Viral Properties
PublicationThe milky juice of the greater celandine herb has been used in folk medicine and in homeopathy for treatment of viral warts for years. However, classical medicine fails to use properties of celandine herbs in treatment of diseases induced by papilloma viruses. Nevertheless, dermatological outpatient clinics are regularly visited by patients reporting efficacy of milky sap isolated from celandine herb in treatment of their own...
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Silybum marianum glycerol extraction for the preparation of high-value anti-ageing extracts
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Effect of the Sorption Layer on the Protection Time Provided by Anti-Smog Half-Masks
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Developing electrochemical measurements in order to assess anti-corrosive coatings more effectively
PublicationCelem pracy było sprawdzenie powtarzalności wyników uzyskanych metodą pomiaru szumu (Electrochemical Noise method - ENM) elektrochemicznego wykonanych na powłokach organicznych w konfiguracji bez połączenia z podłożem metalowym (NOCS - No Connection to the Substrate). NOCS polega na wykonaniu pomiarów na trzech teoretycznie takich samych obszarach badanego układu. W takim układzie nie jest wymagane połączenie elektryczne z metalowym...
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SYNTHESIS OF PHOSPHORUS TACRINE ANALOGUES AS A NEW POTENTIAL ANTI-ALZHEIMER’S DISEASE AGENTS
PublicationA series of novel phosphorus tacrine derivatives was obtained in three steps, including synthesis of 9-chlorotacrine, connection of 9-chlorotacrine with hexamethylenediamine, 1,8-diaminooctane and 1,12-diaminododecane linkers and reaction of obtained tacrine diamine analogues with corresponding acid ester to give nine tacrine organophosphorus compounds. All of the obtained final structures were characterized by 1H NMR, 13C NMR,...
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Glucose oxidase as an important yet overlooked factor determiningthe antibacterial activity of bee pollen and bee bread
PublicationBee pollen (BP) and bee bread (BB) have attracted great attention due to their biological activities including antibacterial activity. However, the mechanism of antibacterial activity is largely unknown. Therefore, we aimed to characterise the antibacterial effect of BP and BB aqueous extracts against bacterial pathogens (Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis and Enterococcus faecalis)...
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Elderly persons professional activity - substantive issues and methodological challenges
PublicationPopulation ageing in Europe and mass withdrawal from professional activity leads to a number of adverse phenomena, such as increased public spending, reduced consumer demand and the growing problem of social exclusion. The study focuses on the problems of population ageing in Europe as well as on the feasible steps that may be taken with a view to professional activation of the elderly. The first part is concerned with the trends...
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Structure-activity relationship studies on the antimicrobial activity of novel edeine a and d analogues
PublicationOpisano syntezę 4 nowych analogów peptydowego antybiotyku, edeiny a i d z wykorzystaniem klasycznej syntezy w roztworze. Stosowano metodę estrów aktywnych oraz metodę azydową do tworzenia wiązań peptydowych. Zbadano także aktywność przeciwgrzybową i przeciwbakteryjną opisanych połączeń.
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Sławomir Milewski prof. dr hab. inż.
PeopleSławomir Milewski, born in 1955 in Puck, Poland, graduated in 1979 in Chemistry from the Faculty of Chemistry, Gdańsk University of Technology (GUT). In 1984 was employed at the Department of Pharmaceutical Technology and Biochemistry. In 1985 he got his PhD, in 1994 became a DSc (habilitation) and in 2002 got the professorship in chemical sciences. Currently he is a full professor and Head of the Department of Pharmaceutical Technology...
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Novel 5-Substituted 2-(Aylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl)benzenesulfonamides: Synthesis, Molecular Structure, Anticancer Activity, Apoptosis-Inducing Activity and Metabolic Stability
PublicationA series of novel 5-substituted 2-(arylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl) benzenesulfonamide derivatives 27–60 have been synthesized by the reaction of aminoguanidines with an appropriate phenylglyoxal hydrate in glacial acetic acid. A majority of the compounds showed cytotoxic activity toward the human cancer cell lines HCT-116, HeLa and MCF-7, with IC50 values below 100 M. It was found that for the analogues 36–38...
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Comparison of the content of phenolic compounds and antioxidant activity of white, red and black currants (Ribes sp.) extracts
PublicationThe aim of this study was to compare the content of antioxidant compounds and the antioxidant activity of extracts from white, red and black currants (Ribes sp.). The chemical properties verified included determinations of anthocyanins and other phenols by HPLC-DAD-MS, total antioxidant activity by standard spectrophotometric tests (ABTS, DPPH and FCR), and profiles of antioxidants by TLC with visualization reagents (ABTS, DPPH,...
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INFLUENCE OF TEMPERATURE ON THE ACTIVITY OF ANAMMOX GRANULAR BIOMASS - SHORT AND LONG-TERM ASPECT
PublicationThe aim of this study was to determine a short-term and long-term effect of temperature on the anammox process rate and determination of temperature coefficients in the Arrhenius and Ratkowski equations. The short-term effects of temperature on the anammox biomass were investigated in batch tests at ten different temperatures in the range of 10-55 ̊C. The maximum rate 1.3 gN (gVSS·d)-1 observed at 40 ̊C. The minimum rate, close...
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Professional activity and women entrepreneurship in Poland – Europe 2020 Strategy perspective
PublicationThe level of economic activity of women in Poland is the lowest among Baltic Sea Region countries. The analysis of Europe 2020 targets, shows that at least 3 of the 5 main objectives relate, more or less, to women (e.g. participation in labor market). The objective concerning social inclusion assumes the increase in the employment rate of men and women (aged 20-64) in Poland up to 71%. To achieve this goal, support programs to...
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Study of proapoptotic activity of anthraquinone derivatives towards H226 cancer cells using flow cytometry
Open Research DataThis study presents the fluorescence intensity of Annexin V/7AAD and caspase 3/7 which correspond to the proapoptotic activity of anthraquinone derivatives towards H226 cancer cells.
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Study of proapoptotic activity of anthraquinone derivatives towards A549 cancer cells using flow cytometry
Open Research DataThis study presents the fluorescence intensity of Annexin V/7AAD and caspase 3/7 which correspond to the proapoptotic activity of anthraquinone derivatives towards A549 cancer cells.
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A strategy for GPS data processing in a precise local network during high solar activity
PublicationThis paper presents the analyses connected with reduction of errors from ionospheric refraction using GPS data from local satellite networks. This is particularly essential during rising solar activity. The Bernese GPS Software v. 4.2 was used, as an analytical tool. The test data included measurements from a geodynamic network SUDETES situated in the Sudety Mountains across the border between the Czech Republic and Poland. A local...
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Anna Zielińska-Jurek prof. dr hab. inż.
People2018 DSc in technical sciences in the field of chemical technology Chemical Faculty, Gdansk University of Technology, Title: “Functionalized titanium(IV) oxide as a photocatalyst for environmental purification” 2011 Ph. D. in technical sciences in the field of chemical technology Chemical Faculty, Gdansk University of Technology, Title of the dissertation:...
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Effect of antitumor compounds on the yeast topoisomerase II relaxation activity
Open Research DataThe datasets contain results of antitumor compounds* (known inhibitors of human topoisomerase alpha II) inhibitory activity against yeast topoisomerase II. DNA topoisomerases (Topo) are enzymes that catalyze changes in the spatial structure of DNA and play an important role in replication, transcription and recombination. Beyond their normal functions,...
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Carbon activity coefficients of SOFC and SOFC with LSCNT layer fueled by biogas mixture at 750 C - longterm
Open Research DataThe dataset contains the calculated carbon activity coefficient for the SOFC and SOFC with LSCNT layer (La0.27Sr0.54Ce0.09Ni0.1Ti0.9O3-s) fueled by synthetic biogas mixture (60:40 CH4:CO2). The outlet concentration of the gases from SOFC were measured using novel FTIR-based unit.
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Influence of accelerometer signal pre-processing and classification method on human activity recognition
PublicationA study of data pre-processing influence on accelerometer-based human activity recognition algorithms is presented. The frequency band used to filter-out the accelerometer signals and the number of accelerometers involved were considered in terms of their influence on the recognition accuracy. In the test four methods of classification were used: support vector machine, decision trees, neural network, k-nearest neighbor.
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Electrochemical Activity and Electrical Properties of Optimized Polypyrrole Coatings on Iron
PublicationIn this work, electrochemical activity and electrical properties of polypyrrole (PPy) coated iron electrodes have been investigated. PPy film was electrochemically polymerized from sodium salicylate aqueous solution under conditions, which provided an increase of iron corrosion resistance. It was noticed that the pH of the solution and the applied electrode potential range during the study of the polymer properties had an influence...
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Activity-based payments: alternative (anonymous) online payment model
PublicationElectronic payments are the cornerstone of web-based commerce. A steady decrease in cash usage has been observed, while various digital payment technologies are taking over. They process sensitive personal information raising concerns about its potentially illicit usage. Several payment models that confront this challenge have been proposed. They offer varying levels of anonymity and readiness for adoption. The aim of this study...
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Influence of Additional Loads on Chosen Gait Parameters and Muscles Activity
PublicationThis paper is devoted to human motion analysis and comparison of chosen kinematics parameters during normal gait with and without additional load in a form of backpack. A stability in both cases were compared in both frontal and sagittal planes, by applying a video tracking system. Experimental tests performed on treadmill, passive markers, placed on volunteers bare skin were used. Additionally, an infra-red camera was employed...
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Power of the SMR brainwaves in the mental imagery experiment in sport: the "Fitness Activity" scenario.
Open Research DataThe data were collected to perform research on the neural oscillation during mental imagery in sport. The main aim of the study was to examine the cortical correlates of imagery depending on instructional modality (guided vs self-produced) using various sport-related scripts. The research was based on the EEG signals recorded during the session with...
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Synthesis and antimicrobial activity of 6-sulfo-6-deoxy-D-glucosamine and its derivatives
Publication6-Sulfo-6-deoxy-D-glucosamine (GlcN6S), 6-sulfo-6-deoxy-D-glucosaminitol (ADGS) and their N-acetyl and methyl ester derivatives have been synthesized and tested as inhibitors of enzymes catalyzing reactions of the UDP-GlcNAc pathway in bacteria and yeasts. GlcN6S and ADGS at micromolar concentrations inhibited glucosamine-6-phosphate (GlcN6P) synthase of microbial origin. The former was also inhibitory towards fungal GlcN6P N-acetyl...
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Bacteriophage–Ciprofloxacin Combination Effectiveness Depends on Staphylococcus aureus–Candida albicans Dual-Species Communities’ Growth Model
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Investigations of the optical activity of nonlinear crystals by means of dual-wavelength polarimeter
PublicationA dual-wavelength method in high accuracy polarimetry has been successfully tested and applied to measure optical activity (OA) of nonlinear crystals. In proposed polarimetric scheme two neighboring semiconductor laser wavelengths (635 and 650 nm) are used, which increases number of parameters measured simultaneously and improves the data processing. By neglecting dispersion of eigen wave ellipticity in crystals, more efficient...
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Journal of Imagery Research in Sport and Physical Activity
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International Journal of Behavioral Nutrition and Physical Activity
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Myrosinase activity in different plant samples; optimisation of measurement conditions for spectrophotometric and pH-stat methods
PublicationMyrosinase found in Brassicaceae plants, is the enzyme responsible for hydrolysis of glucosinolates. As a result a variety of biologically active metabolites are liberated, whose importance in crop protection and especially in cancer chemoprevention is rapidly gaining recognition. The growing practical application of glucosinolate degradation products requires that sensitive and reliable methods of myrosinase activity determination...
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Activity of Patents in Fuel Cells and Hydrogen Production in the Context of Passenger Car Fleet in the V4 Countries
PublicationThe hydrogen market in the world today is capable ovule and em-pirical evidence on activity of patents in fuel cells and hydrogen production islimited so far. Patent applications in zero-emission mobility in the aspect of fuelcells include: DAFC/DMFC&DMFC, PEMFC, SOFC, AFC, PAFC. As for thepatents relating to the hydrogen production, they concern low carbon, electrol-ysis and inorganic. The purpose of the study was to investigate...
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Design, synthesis, and biological evaluation of tetrahydroquinolinones and tetrahydroquinolines with anticancer activity
PublicationColorectal cancer (CRC) is the most commonly diagnosed cancer in Europe and the United States and the second leading cause of cancer related mortality. A therapeutic strategy used for the treatment of CRC involves targeting the intracellular levels of reactive oxygen species (ROS). In this study, we synthesized a series of novel tetrahydroquinolinones and assessed their ability to inhibit CRC growth and proliferation by evoking...
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A Novel IoT-Perceptive Human Activity Recognition (HAR) Approach Using Multi-Head Convolutional Attention
PublicationTogether with fast advancement of the Internet of Things (IoT), smart healthcare applications and systems are equipped with increasingly more wearable sensors and mobile devices. These sensors are used not only to collect data, but also, and more importantly, to assist in daily activity tracking and analyzing of their users. Various human activity recognition (HAR) approaches are used to enhance such tracking. Most of the existing...
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Relationship between the betalain composition in Opuntia ficus indica and Beta vulgaris varieties and biological activity of their extracts
PublicationBetalains are a class of pigments that are much less com- monly found in nature than anthocyanins or carotenoids. They occur only in a few edible plants such as red beetroot (Beta vulgaris), prickly pears (Opuntia ficus indica), amaranth (Amaranthus sp.) and some mushrooms. This group of pig- ments can be divided into two major groups: yellow vulgax- anthins and red betanins. Despite their structural similarity to compounds from...
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Dual-wavelength polarimeter application in investigations of the optical activity of a langasite crystal
PublicationA method of high accuracy polarimetry, which includes optical activity measurements systematic errors, was realized with dual-wavelength polarimeter for two wavelengths of 635 and 650 nm. Simultaneous measurements with neighboring wavelengths significantly improved the data processing, by increasing the amount of data to eliminate the systematic errors. For langasite crystal La3Ga5SiO14 we measured temperature dependence of the...
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Fulminant hepatic failure in woman with iron and non-steroidal anti-inflammatory drug intoxication
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In vitro antioxidant, anti-inflammatory activities and acetylcholinesterase inhibition properties of selected plant extracts
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The enhancement of anti-staphylococcal potential of plant derived naphthoquinones as a result of combination with silver nanoparticles
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Large nonsaturating magnetoresistance, weak anti-localization, and non-trivial topological states in SrAl2Si2
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Anti-Inflammatory and Antiviral Effects of Cannabinoids in Inhibiting and Preventing SARS-CoV-2 Infection
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Ornamental Flowers Grown in Human Surroundings as a Source of Anthocyanins with High Anti-Inflammatory Properties
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Polyoxygenated cyathane diterpenoids from the mushroom Cyathus africanus, and their neurotrophic and anti-neuroinflammatory activities
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Non-steroidal anti-inflammatory drugs are safe with respect to the transcriptome of human dermal fibroblasts
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Non-destructive inspection of anti-corrosion protective coatings using optical coherent tomography
PublicationW artykule przedstawiono zastosowanie optycznej tomografii koherentnej (OCT) do badania antykorozyjnych powłok ochronnych. Omówiono właściwości optycznej interferometrii niskokoherentnej jako zastosowanej metody pomiarowej, opisano budowę pomiarowego systemu OCT, zbudowanego w Katedrze Metrologii i Optoelektroniki WETI PG. Przy pomocy zrealizowanego systemu przebadano grupę powierzchni metalicznych pokrytych różnymi powłokami antykorozyjnymi....
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Gdańsk University of Technology graduates’ form of employment or business activity – years 2011-2014
Open Research DataThe dataset includes data from the survey on the Gdańsk University of Technology graduates' from the years 2011-2014 on the form of their employment or business activity. The survey was conducted in the period from 2013 to 2016, two years after the respondents obtained graduate status. The research sample included 5025 respondents. To summarize, the...
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Gdańsk University of Technology graduates’ form of employment or business activity – years 2015-2018
Open Research DataThe dataset includes data from the survey on the Gdańsk University of Technology graduates' from the years 2015-2018 on the form of their employment or business activity. The survey was conducted in the period from 2017 to 2020, two years after the respondents obtained graduate status. The research sample included 7409 respondents. To summarize, the...
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The form of employment or business activity of the Gdańsk University of Technology graduates – years 2010-2018
Open Research DataThe dataset includes data from the survey on the Gdańsk University of Technology graduates from years 2010-2018 on their form of employment or business activity. The survey was conducted in the period from 2012 to 2020, two years after the respondents obtained graduate status. The research sample included 12776 respondents. To summarize, the most popular...