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Search results for: CELLULAR NETWORKS
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Applying artificial intelligence for cellular networks optimization
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Accuracy analysis of a mobile station location in the cellular networks
PublicationJakość usług lokalizacyjnych oferowanych w sieciach komórkowych zależy od efektywności estymacji położenia terminala ruchomego. Dokładność obecnie stosowanych metod lokalizacyjnych jest niewystarczająca, szczególnie w odniesieniu do wywołań w niebezpieczeństwie. Modyfikacja istniejących algorytmów może istotnie wpłynąć na zwiększenie dokładności lokalizowania terminala ruchomego przy jednocześnie niewielkich nakładach finansowych....
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Efficient methods for radio location service in cellular communication networks
PublicationW artykule przedstawiono dwie oryginalne metody lokalizowania terminala ruchomego w sieciach komórkowych trzeciej generacji. Metody te podczas estymacji położenia terminala nie wymagają znajomości różnicy czasów w synchronizacji poszczególnych stacji bazowych, przez co są tanie w implementacji. Przedstawiono wyniki badań symulacyjnych zaproponowanych metod.
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Study on transmission quality in cellular 4G and 5G networks between 2019–2021: Impact of the COVID-19 pandemic on the level of provided services by operating base transceiver stations
PublicationThe COVID-19 pandemic has significantly limited user mobility, not least among students. Remote learning had a particular impact on resource allocation in relation to using terrestrial cellular networks, especially 4G systems in urban agglomerations. This paper presents the results of a quality evaluation of an outdoor environment, carried out between 2019 and 2021 on the campus of a technical university. Annual studies are conducted...
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IEEE International Workshop on Cellular Nanoscale Networks and Applications
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Piotr Rajchowski dr inż.
PeoplePiotr Rajchowski (Member, IEEE) was born in Poland, in 1989. He received the E.Eng., M.Sc., and Ph.D. degrees in radio communication from the Gdańsk University of Technology (Gdańsk Tech), Poland, in 2012, 2013, and 2017, respectively. Since 2013, he has been working at the Department of Radiocommunication Systems and Networks, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, as a IT...
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Jacek Stefański prof. dr hab. inż.
PeopleJJacek Stefański received M.Sc., Ph.D. and D.Sc. degrees in telecommunications engineering from Gdansk University of Technology (GUT), Poland, in 1993, 2000 and 2012, respectively. Awarded title of Professor by the President of Poland in 2020. Currently, he works as a professor at the Department of Radio Communication Systems and Networks (DRCSN) in GUT. From 2005 to 2009, he worked as an assistant professor in the National Institute...
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Communication Networks in the Service of the Environmental Monitoring
PublicationIn the paper selected issues relating to communication networks in the services of the environmental monitoring (EM) have been described. It is divided into three main parts: introduction, wire and wireless networks. At the beginning of the basic definitions were explained. The wire part focuses on a plain old telephone service (POTS), an integrated services digital network (ISDN), a digital subscriber line (DSL) and a fiber-optic...
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Cellular network quality evaluation at a university campus on the eve of 5G
PublicationThanks to the availability of mobile devices and the spread of broadband access around the world, the number of network users continues to grow. This has raised user awareness when it comes to the quality of content they consume. Many service providers and operators focus on monitoring QoN (Quality of Network) and QoS (Quality of Service) parameters, particularly those influenced by bandwidth and latency. However, for most end-users,...
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Path Loss Modelling for Location Service Applications
PublicationThe aim of this paper is the path loss modeling for the radiolocation services in radiocommunication networks, particularly in cellular networks. The main results of the measurements obtained in the physical layer of the UMTS are introduced. A new method for the utilization of the multipath propagation phenomenon to improve the estimation of the distance between the mobile station (MS) and the base station (BS) is outlined. This...
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Design of Cost-Efficient Optical Fronthaul for 5G/6G Networks: An Optimization Perspective
PublicationCurrently, 5G and the forthcoming 6G mobile communication systems are the most promising cellular generations expected to beat the growing hunger for bandwidth and enable the fully connected world presented by the Internet of Everything (IoE). The cloud radio access network (CRAN) has been proposed as a promising architecture for meeting the needs and goals of 5G/6G (5G and beyond) networks. Nevertheless, the provisioning of cost-efficient...
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Radio Link Measurement Methodology for Location Service Applications
PublicationThe aim of this paper is the methodology of measurements executed in a radio link for the realization of radiolocation services in radiocommunication networks, particularly in cellular networks. The main results of the measurements obtained in the physical layer of the universal mobile telecommunications system (UMTS) are introduced. A new method for the utilization of the multipath propagation phenomenon to improve the estimation...
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Wirtualne sieci 5G, NGN i następne. Radioinformatyczna metamorfoza sieci komórkowych
PublicationPrzedstawiono problematykę ewolucyjnej, a w zasadzie rewolucyjnej, metamorfozy komórkowych systemów radiokomunikacyjnych w kontekście architektury sieci 5G, zasad jej działania oraz nowych możliwości implementacyjnych usług sieci NGN. Artykuł dotyczy w szczególności istoty działania sieci 5G, łączącej w sobie cechy sieci radiokomunikacyjnych poprzednich generacji, zwłaszcza 4G, oraz nowe właściwości charakterystyczne dla 5G. Dotyczą...
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Symposium on Cellular Automata
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Low Cost Method for Location Service in the WCDMA System
PublicationA new and low cost method for a location service (LCS) in the Wideband Code Division Multiple Access (WCDMA) system is outlined. This method, which is called TDOA + RTT, enables calculation of the geographical position of a mobile station (MS) without knowledge of relative time differences (RTDs) between base stations (BSs). The TDOA+RTT method is based on the measurement of round trip times (RTTs) between the MS and the serving...
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Detection of the First Component of the Received LTE Signal in the OTDoA Method
PublicationIn a modern world there is a growing demand for localization services of various kinds. Position estimation can be realized via cellular networks, especially in the currently widely deployed LTE (Long Term Evolution) networks. However, it is not an easy task in harsh propagation conditions which often occur in dense urban environments. Recently, time-methods of terminal localization within the network have been the focus of attention,...
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Study on CPU and RAM Resource Consumption of Mobile Devices using Streaming Services
PublicationStreaming multimedia services have become very popular in recent years, due to the development of wireless networks. With the growing number of mobile devices worldwide, service providers offer dedicated applications that allow to deliver on-demand audio and video content anytime and everywhere. The aim of this study was to compare different streaming services and investigate their impact on the CPU and RAM resources, with respect...
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New First - Path Detector for LTE Positioning Reference Signals
PublicationIn today's world, where positioning applications reached a huge popularity and became virtually ubiquitous, there is a strong need for determining a device location as accurately as possible. A particularly important role in positioning play cellular networks, such as Long Term Evolution (LTE). In the LTE Observed Time Difference of Arrival (OTDOA) positioning method, precision of device location estimation depends on accuracy...
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Digital Gaps and Economic Inequalities in MENA Countries: An Empirical Investigation
PublicationThis research contributes to the present state of the art by examining changes in cross-country inequalities in digital technologies deployment and economic performance. Our empirical target builds on the hypothesis that rapid global diffusion of digital technologies unequivocally leads to gradual eradication of cross-country digital gaps and cross-country inequalities in terms of deployment of ICT; the technology convergence occurs....
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Estimation of transmission quality in cellular systems based on indicators measured by the radio module
PublicationThe article presents a measurement stand for testing transmission quality in cellular systems such as LTE, NB-IoT, UMTS and GSM. The results of BLER and throughput measurements for various propagation conditions as well as results of quality indicators appropriate for mentioned technologies measured by commercial radio module are presented. Those measurements were utilized to analyze the possibility of estimating the transmission...
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Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the antitumor imidazoacridinone C-1311 in human hepatoma cells
PublicationThere is increasing evidence that the expression level of drug metabolic enzymes affects the final cellular response following drug treatment. Moreover, anti-tumour agents may modulate enzymatic activity and/or cellular expression of metabolic enzymes in tumour cells. We investigated the influence of CYP3A4 overexpression on the cellular response induced by the anti-tumour agent C-1311 in hepatoma cells. C-1311-mediated CYP3A4...
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Comparison of Redox Properties of Flavonoid Aglycones and Corresponding Glycosides and Their Mixtures in the Cellular Model
PublicationFlavonoids are polyphenolic compounds commonly found in plants. As dietary components, they have been shown to exhibit numerous pro-health properties that are believed to be associated with their antioxidant effects. In this study, the antioxidant activity of four flavonoid compounds was determined by cellular antioxidant activity assay using HT29 cells as a model of the alimentary tract. The strongest impact on cellular redox...
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Application of a cellular automaton to simulations of granular flow in silos
PublicationA cellular automaton based on a gas model of hydrodynamics was used to calculate the kinematics of non-cohesive granular materials during confined flow in a mass flow and funnel flow model silo. In the model, collisions of particles were taken into account during granular flow. In addition, a simplified automaton was used wherein granular flow was assumed as an upward propagation of holes through a lattice composed of cells representing...
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Human UDP-Glucuronosyltransferases: Effects of altered expression in breast and pancreatic cancer cell lines.
PublicationIncreased aerobic glycolysis and de novo lipid biosynthesis are common characteristics of invasive cancers. UDP-glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that in normal cells possess the ability to glucuronidate these lipids and speed their excretion; however, de-regulation of these enzymes in cancer cells can lead to an accumulation of bioactive lipids, which further fuels cancer progression. We hypothesize...
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Enhanced Activity of P4503A4 and UGT1A10 Induced by Acridinone Derivatives C-1305 and C-1311 in MCF-7 and HCT116 Cancer Cells: Consequences for the Drugs’ Cytotoxicity, Metabolism and Cellular Response
PublicationActivity modulation of drug metabolism enzymes can change the biotransformation of chemotherapeutics and cellular responses induced by them. As a result, drug-drug interactions can be modified. Acridinone derivatives, represented here by C-1305 and C-1311, are potent anticancer drugs. Previous studies in non-cellular systems showed that they are mechanism-based inhibitors of cytochrome P4503A4 and undergo glucuronidation via UDP-glucuronosyltranspherase...
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Application of advanced spectroscopic methods in the assessment of the leachability degree of hazardous elements from the matrix of cellular concretea
PublicationDue to its structure, autoclaved cellular concrete exhibits good insulating properties with relatively high compressive strength values. It is increasingly used in construction because of its economic attractiveness. Autoclaved cellular concrete is mainly used in interior structure layers, and therefore its potential exposure to heavy metal leaching from the matrix may be related to the presence of a high pH medium from other materials...
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Development of Safirinium dyes for new applications: fluorescent staining of bacteria, human kidney cells, and the horny layer of the epidermis
PublicationLow-molecular synthetic fluorophores are convenient tools in bioimaging applications. Several derivatives of Safirinium dyes as well as their reactive N-hydroxysuccinimide (NHS) esters bearing diverse substituents were synthesized and evaluated experimentally in terms of their lipophilicity by means of reverse-phase and immobilized artificial membrane high-performance liquid chromatography. Subsequently, the selected compounds...
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Image-based numerical modeling of the tensile deformation behavior and mechanical properties of additive manufactured Ti–6Al–4V diamond lattice structures
PublicationThis work concerns the numerical modeling of the deformation process and mechanical properties of structures obtained by the additive method laser power bed fusion (LPBF). The investigation uses diamond structures of Ti–6Al–4V titanium implantation alloy with various relative densities. To model the process of tensile deformation of the materials, geometric models were used, mapping the realistic shape of the examined structures....
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Analysis of elementary cellular automata using the theory of conflict
PublicationThe paper contains decomposition of elementary cellular automata (ECA in short) to subsystems that are defined according to a new theory called theory of conflict (ToC in short). The decomposition is a completely new approach to analysis of ECA and complex systems in general.
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Enhanced susceptibility of SARS-CoV-2 spike RBD protein assay targeted by cellular receptors ACE2 and CD147: Multivariate data analysis of multisine impedimetric response
PublicationSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the cells through the binding of spike protein to the host cell surface-expressing angiotensin-converting enzyme 2 (ACE2) or by endocytosis mediated by extracellular matrix metalloproteinase inducer (CD147). We present extended statistical studies of the multisine dynamic electrochemical impedance spectroscopy (DEIS) revealing interactions between Spike RBD and...
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Quantum Dots as a Good Carriers of Unsymmetrical Bisacridines for Modulating Cellular Uptake and the Biological Response in Lung and Colon Cancer Cells
PublicationNanotechnology-based drug delivery provides a promising area for improving the efficacy of cancer treatments. Therefore, we investigate the potential of using quantum dots (QDs) as drug carriers for antitumor unsymmetrical bisacridine derivatives (UAs) to cancer cells. We examine the influence of QD–UA hybrids on the cellular uptake, internalization (Confocal Laser Scanning Microscope), and the biological response (flow cytometry...
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CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells
PublicationHigh CYP3A4 expression sensitizes tumor cells to certain antitumor agents while for others it can lower their therapeutic ef fi cacy. We have elucidated the in fl uence of CYP3A4 overexpression on the cellular response induced by antitumor acridine derivatives, C-1305 and C-1748, in two hepatocellular carcinoma (HepG2) cell lines, Hep3A4 stably transfected with CYP3A4 isoenzyme, and HepC34 expressing empty vector. The compounds...
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ANALYSIS OF THE p53 PROTEIN GENE EXPRESSION MODEL
PublicationWe study the asymptotic behaviour of the solutions of the p53-Mdm2 model proposed by Monk (2003). The p53 gene is crucial for cellular inhibition of the angiogenesis process, while Mdm2 is a negative regulator of the p53 tumor-suppressor. We investigate the stability of the positive steady state and perform some numerical experiments.
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Push-to-talk als eine der ersten voip - applikationen in mobilfunknetzen
PublicationW pracy przedstawiono wybrane aspekty realizacji multimediów w sieciach komórkowych. Dokonano analizy protokołu SIP ze szczególnym uwzględnieniem pomiarów systemów rzeczywistych. Oceniono nową usługę PoC (Push-to-Talk over Cellular)- pierwszą aplikację typu VoIP realizowaną w sieciach komórkowych
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Amphotericin B and Its New Derivatives - Mode of Action
PublicationAmphotericin B (AmB) is a well known antifungal and antiprotozoal antibiotic used in the clinic for several decades. Clinicalapplications of AmB, however, are limited by its nephrotoxicity and many other acute side effects which are not acceptable by patientswhen their life is not threaten. In order to improve the therapeutic index of this drug, lipid formulations have been introduced and manyefforts have been made to obtain less...
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Modified Peptide Molecules As Potential Modulators of Shelterin Protein Functions; TRF1
PublicationIn this work, we present studies on relatively new and still not well-explored potential anticancer targets which are shelterin proteins, in particular the TRF1 protein can be blocked by in silico designed "peptidomimetic" molecules. TRF1 interacts directly with the TIN2 protein, and this protein-protein interaction is crucial for the proper functioning of telomere, which could be blocked by our novel modified peptide molecules....
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Endocrine Disrupting Compounds – Problems and Challenges
PublicationIn this chapter, information about some of the estrogenic compounds and their environmental fate and biological influence can be found. Special attention is paid to the review of the analytical approaches used at the stages of detection and determination of Endocrine Disrupting Compounds (EDCs) in the environmental samples. Also, a brief characterization of both cellular and non-cellular bioassays is presented. The discovery of...
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Implementation of high-speed data transmission technological demonstrator using software defined radio technology
PublicationIn the article implementation of high-speed data transmission technological demonstrator using software defined radio technology is presented. A system architecture design including asymmetric framing transmission organization, which differs from the ones used in cellular systems is described. The construction of technological demonstrator consisting of management unit, radio unit and programmable multithreaded software performing...
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Implementation of high-speed data transmission technological demonstrator using software defined radio technology
PublicationIn the article implementation of a high-speed data transmission technological demonstrator using software defined radio technology is presented. A system architecture design including asymmetric framing transmission organization, which differs from the ones used in cellular systems is described. The construction of technological demonstrator consisting of a management unit, radio unit and programmable multi-threaded software performing...
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Biopolymer-based composites for tissue engineering applications: A basis for future opportunities
PublicationBiomimetic scaffolds supporting tissue regeneration are complex materials with multifunctional characteristics. The unique biocompatibility and biodegradability of biopolymers make them excellent candidates for tissue engineering and regenerative medicine. Biopolymers, which have a wide range of properties, can be obtained from different natural sources. Depending on the target tissue, biopolymers can be engineered to meet a series...
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From tryptophan to novel mitochondria-disruptive agent, synthesis and biological evaluation of 1,2,3,6-tetrasubstituted carbazoles
PublicationMitochondrial targeting plays an important role in anticancer therapy. The Mn(III)-promoted cyclization of 5- (1H-indol-3-yl)-3-oxopentanoic acid allow to obtain novel substituted carbazole derivatives that can act as mitochondria-disruptive agents. The starting materials used for the synthesis of these new aminocarbazoles are oxopentanoate derivatives of tryptophan. The scope and limitation of this method of synthesis are determined...
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Chemical and biological evaluation of antioxidant activity of endogenous redox-active compounds compared to plant-derived exogenous antioxidants
PublicationThe research conducted so far has shown that endogenous antioxidants, despite being regarded as the first line of antioxidant defense, may not be sufficient to maintain redox homeostasis in cells exposed to oxidative stress. The results obtained in the doctoral dissertation show that endogenous redox-active compounds were moderate or weak scavengers of ABTS and DPPH radicals, while in cellular setting, their impact on the reducing...
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The Unfolded Protein Response: A Double-Edged Sword for Brain Health
PublicationEfficient brain function requires as much as 20% of the total oxygen intake to support normal neuronal cell function. This level of oxygen usage, however, leads to the generation of free radicals, and thus can lead to oxidative stress and potentially to age-related cognitive decay and even neurodegenerative diseases. The regulation of this system requires a complex monitoring network to maintain proper oxygen homeostasis. Furthermore,...
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c-Myc Protein Level Affected by Unsymmetrical Bisacridines Influences Apoptosis and Senescence Induced in HCT116 Colorectal and H460 Lung Cancer Cells
PublicationUnsymmetrical bisacridines (UAs) are highly active antitumor compounds. They contain in their structure the drugs previously synthesized in our Department: C-1311 and C-1748. UAs exhibit different properties than their monomer components. They do not intercalate to dsDNA but stabilize the G-quadruplex structures, particularly those of the MYC and KRAS genes. Since MYC and KRAS are often mutated and constitutively expressed in cancer...
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Acid–Base Equilibrium and Self-Association in Relation to High Antitumor Activity of Selected Unsymmetrical Bisacridines Established by Extensive Chemometric Analysis
PublicationUnsymmetrical bisacridines (UAs) represent a novel class of anticancer agents previously synthesized by our group. Our recent studies have demonstrated their high antitumor potential against multiple cancer cell lines and human tumor xenografts in nude mice. At the cellular level, these compounds affected 3D cancer spheroid growth and their cellular uptake was selectively modulated by quantum dots. UAs were shown to undergo metabolic...
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Interactions between polyphenolic antioxidants quercetin and naringenin dictate the distinctive redox-related chemical and biological behaviour of their mixtures
PublicationFood synergy concept is suggested to explain observations that isolated antioxidants are less bioactive than real foods containing them. However, mechanisms behind this discrepancy were hardly studied. Here, we demonstrate the profound impact of interactions between two common food flavonoids (individual: aglycones quercetin—Q and naringenin—N− or their glycosides rutin—R and naringin—N+ vs. mixed: QN− and RN+) on their electrochemical...
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Effect of oxidation and in vitro intestinal hydrolysis on phospholipid toxicity towards HT29 cell line serving as a model of human intestinal epithelium
PublicationOxidation of food-derived phospholipids (PLs) can influence nutrient digestion and induce oxidative stress in gastrointestinal epithelium. In this study, hen egg yolk PL fraction was used to evaluate the effect of lipoxygenase (LOX)-induced PL oxidation on the rate of PL hydrolysis catalyzed by pancreatic phospholipase A2 (PLA2) in the presence of bile salts (BSs). Then, PL/BS solutions containing native or oxidized PLs were used...
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Encapsulation of an anticancer drug Isatin inside a host nano-vehicle SWCNT: a molecular dynamics simulation
PublicationThe use of carbon nanotubes as anticancer drug delivery cargo systems is a promising modality as they are able to perforate cellular membranes and transport the carried therapeutic molecules into the cellular components. Our work describes the encapsulation process of a common anticancer drug, Isatin (1H-indole-2,3-dione) as a guest molecule, in a capped single-walled carbon nanotube (SWCNT) host with chirality of (10,10). The...
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CHEMOTHERAPY-MEDIATED COMPLICATIONS OF WOUND HEALING. AN UNDERSTUDIED SIDE EFFECT
PublicationSignificance: Chemotherapy is a primary method to treat cancer, but while cytotoxic drugs are designed to target rapidly dividing cancer cells, they can also affect other cell types, including dermal cells and macrophages involved in wound healing, which often leads to the development of chronic wounds. The situation becomes even more severe when chemotherapy is combined with surgical tumor excision. Recent advances: Despite its...
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Dissimilar autogenous TIG joint of Alloy 617 and AISI 304H steel for AUSC application
PublicationTo reduce costs and improve high-temperature performance in Advanced Ultra Super Critical (AUSC) boilers, it is necessary to weld austenitic steel to Inconel alloy. In this study, the autogenous tungsten inert gas (TIG) welding process was used to join Alloy 617 and an austenitic AISI 304H steel plate of thickness 5 mm. Microstructural analysis showed that the microstructure formation was uneven along the weldments, with columnar...