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Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice
PublicationThe ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna...
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Discovery of small-molecule regenerative drugs using a model of complex tissue injury in mice. Transcriptomic responses of neurodevelopmental genes during pharmacologically induced regeneration
PublicationDespite significant development in regenerative medicine, there is a deficit of effective therapies for wound healing and tissue regeneration. Research performed using animal wound models allows for a better understanding of this complex process, searching for compounds with pro-regenerative properties, and assessing their efficacy and safety. Unfortunately, the lack of adequate preclinical models proves to be an issue as no animal...
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Toward Mechanosynthesis of Diamondoid Structures: X. Commercial Capped CNT SPM Tip as Nowadays Available C2 Dimer Placement Tool for Tip-Based Nanofabrication
PublicationAccording to Drexler, advanced mechanosynthesis will employ advanced nano-machines, but advanced nano-machines will themselves be products of advanced mechanosynthesis. This circular relationship must be broken via TBN technology development. In this article, the possibility of using easily available commercial CNT tips to assemble carbon-based intermediate generations of nano-devices is considered. Mechanosynthesis of a target...
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Novel primosomal protein B from Clostridium pastuerianum
PublicationPriB is a primosomal protein that catalyzes DNA replication in Procaryota. The replication pathway starts with PriA protein - the initiator protein that binds to a DNA replication fork, unwinds double-stranded DNA and role of PriB is to stabilize PriA on the DNA. However there are many biochemical differences in replication mechanism in bacteria and only some of them use PriB proteins. A few of PriB proteins were published and...
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Structure and the space vector modulation for a medium-voltage power-electronic-transformer based on two seven-level cascade H-bridge inverters
PublicationThis study presents the structure and the space vector pulse-width modulation (SVPWM) for power electronic transformer (PET) based on two seven-level cascade H-bridge (CHB) inverters. The DC links of CHB inverters are coupled with nine dual-active bridge (DAB) converters with medium-frequency transformers. The DC-link voltages are equalised with two methods – through the control of DAB voltages...
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From Scores to Predictions in Multi-Label Classification: Neural Thresholding Strategies
PublicationIn this paper, we propose a novel approach for obtaining predictions from per-class scores to improve the accuracy of multi-label classification systems. In a multi-label classification task, the expected output is a set of predicted labels per each testing sample. Typically, these predictions are calculated by implicit or explicit thresholding of per-class real-valued scores: classes with scores exceeding a given threshold value...
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Temperature and potential-dependent structural changes in Pt cathode electrocatalyst viewed by in situ XAFS
PublicationW pracy przedstawiono wyniki badań widm absorpcji promieniowania rentgenowskiego nano-platyny używanej jako katalizator w katodach polimerowych ogniw paliwowych (PEM FC). Badania XAFS realizowane były w warunkach pracy ogniwa paliwowego. Wysokiej jakości widma, uzyskane za pomocą specjalnie przygotowanej do pomiarów XAFS in situ komórki FC, umożliwiły przeprowadzenie zaawansowanej analizy obrazującej zmiany w lokalnej strukturze...
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Fuzzy regresion approach to road safety analysis at regional level
PublicationRoad safety modelling on regional level of NUTS 2 in the EU is the complex issue and authors of this article indicate this in previous publications. NUTS 2 are basic regions for the application of regional policies (0.8-3 m inhabitants). During multivariate models development they discovered that it is difficult to make regression model well described all regions, even if they are from one country. In the first step Poisson model...
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Cubane Like Structure of a Silanethiol Primary Amine Assembly a Novel, Unusual Hydrogen Bond Pattern.
PublicationMetodą rentgenowskiej analizy strukturalnej wyznaczono struktury krystaliczne i cząsteczkowe trzech soli amoniowych: (t-BuO)3SiS(-)H3N(+)Bu-t, (i-PrO)3SiS(-)H3N(+)Bu-t i (t-BuO)3SiS(-)H3N(+)(CH2)2CH(CH3)2. Wszystkie trzy związki w ciele stałym tworzą tetramery w których atomy S i N wyznaczają w przybliżeniu naroża sześcianu. Trwałość tych agregatów, oprócz sił elektrostatycznego przyciągania, zapewnia sieć wiązań wodorowych N-H
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Cultural heritage preservation - the engineers´ contribution
Publication10 lat dokonań w zakresie popularyzacji dziedzictwa kultury, szczególnie w aspekcie Rekomendacji Rady Europy No. R(90) 20 w sprawie ochrony i konserwacji dziedzictwa techniki, przemysłu i inżynierii budowlanej. Sprawozdanie z konferencji PIH-Go w 1993 i 1995, projektu ''Technology & Heritage" w 1997 oraz PEH-GO 2000 w 1999 r. Informacja metodyczna o przedmiocie humanistycznym ''Kulturotwórcze aspekty budownictwa'', realizowanym...
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BADANIA KOMPOZYTOWEGO MOSTU DLA PIESZYCH
PublicationThe paper presents in situ load testing of the innovative footbridge of FOBRIDGE grant mounted at Gdansk University of Technology. The span of composite sandwich structure (GFRP skins, PET core) and the scope of static and dynamic tests are presented. The selected, representative results of in situ measurements and data obtained from the SHM monitoring system are discussed. Besides the standard testing procedures on the full scale...
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Ernst Cassirer’s Idea of the Critique of Knowledge
PublicationThe article analyses systematically and historically the specific idea of transcenden-talism developed in the Marburg School of Neo-Kantianism. The unique line of the Marburg’s School interpretation of Kant’s critical philosophy consists in contrasting critical (relational) and dogmatic (substantial) understandings of basic philosophical concepts. This line is characteristic of the Marburg School...
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Measurement of expenditure efficiency of Polish cities with county rights in the context of quality of life
PublicationThe article is devoted to the measurement of efficiency of overall expenditures. The purpose of the study is to evaluate the efficiency of use of budget resources by local government units in the context of fostering quality of life. The subject of the study is 65 Polish cities with county rights (county status). Calculations were carried out using Data Envelopment Analysis (DEA). The results of analysis confirm the two research...
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The Leaderless Bacteriocin Enterocin K1 Is Highly Potent against Enterococcus faecium: A Study on Structure, Target Spectrum and Receptor
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Collagen type II–hyaluronan interactions – the effect of proline hydroxylation: a molecular dynamics study
PublicationHyaluronan–collagen composites have been employed in numerous biomedical applications. Understanding the interactions between hyaluronan and collagen is particularly important in the context of joint cartilage function and the treatment of joint diseases. Many factors affect the affinity of collagen for hyaluronan. One of the important factors is the ratio of 3- or 4-hydroxy proline to proline residues. This article presents...
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THE IMPACT OF ENVIRONMENTAL TAXES ON TRANSPORTATION AND STORAGE ENTERPRISES’ DEVELOPMENT – THE CASE OF BALKAN COUNTRIES
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Calix[4]arenes appended with thioamide moieties as powerful tool for heavy metals recognition
PublicationSelectivity of new thioamide derivatives was assessed using those ligands as sensor materials in ion-selective membrane electrodes and tested towards Pb2+ - selectivity. The influence of the nature of the thioamide function (linear, branched or cyclic substituents) on their ionophoric properties was investigated. Electrodes based on cyclic thioamide moieties are promising analytical tools for monitoring Pb2+ concentration in natural...
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Health-Promoting Effects of Ethylene-Treated Kiwifruit ‘Hayward’ from Conventional and Organic Crops in Rats Fed an Atherogenic Diet
PublicationKiwifruit is a subtropical fruit that is very popular among consumers. Kiwifruit ‘Hayward’ (Actinidia deliciosa C.F. Liang et A.R. Ferguson) is an important source of bioactive compounds and possesses high antioxidant capacity, but its value can be changed during ripening. The aim of this study was to compare the levels of total polyphenols (TP), ascorbic acid (AA), and total antioxidant capacities (TACs) of ethylene-treated and...
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Zewnętrzna stolarka drzwiowa Gdańska-Wrzeszcza na przełomie XIX i XX wieku
PublicationDzielnica Gdańska Wrzeszcz ukształtowała się na przełomie XIX i XX w. Liczba mieszkańców Wrzeszcza wzrosła z około 2500 w 1884 r. do około 35 000 w 1914 r. W tym czasie powstało kilkaset jednorodzinnych i wielorodzinnych budynków mieszkalnych oraz najważniejsze obiekty użyteczności publicznej, jak zespół Politechniki, szkoły, szpitale i kościoły. Wrzeszcz – w odróżnieniu od śródmieścia Gdańska – w niewielkim tylko stopniu ucierpiał...
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The biological activity of new tuftsin derivatives - induction of phagocytosis
PublicationFagocytoza odgrywa ważną rolę w ochronie organizmu przed różnymi mikroorganizmami. Proces ten może być indukowany przez różne czynniki np. endogenny immunomodulator jakim jest tuftsyna czy muramylo-dipeptyd (MDP), najmniejszy syntetyczny glikopeptyd bakteryjnej ściany komórkowej. Zsyntetyzowano nowe analogi MDP i nor-MDP z tuftsyną i retro-tuftsyną, które są zdolne do indukowania fagocytozy. Najbardziej obiecujące okazały się dwa...
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Zmiany w poziomie dochodów gmin województwa pomorskiego w latach 1999-2004
PublicationW artykule analizie poddana została strona dochodowa budżetów gmin wchodzących w skład województwa pomorskiego. Ze względu na dużą niestałość przepisów prawnych dotyczących funkcjonowania samorządów terytorialnych, w szczególności ich gospodarki finansowej, okres badawczy zawężono do lat 1999-2004, charakteryzujących się względną stabilnością. Badanie nie ograniczyło się do przedstawienia podstawowych wskaźników, tj. dochodów ogółem...
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the assessment of the noise-induced harmful effects based on the properties of human hearing system
PublicationA new way of assessment of noise-induced harmful effects on human hearing system is presented in the paper. The method takes into consideration properties of the human hearing system. The pro-posed method determines the cumulative impact on hearing system produced by the excessive noise. Based on the predicted effects of the noise exposure, the new types of noise indicators were developed. The evaluation of these indicators was...
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The noise-induced harmful effect assessment based on the properties of the human hearing system
PublicationA new way of assessment of noise-induced harmful effects on human hearing system is presented in the paper. The method takes into consideration properties of the human hearing system. The pro-posed method determines the cumulative impact on hearing system produced by the excessive noise. Based on the predicted effects of the noise exposure, the new types of noise indicators were developed. The evaluation of these indicators was...
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Hierarchical random models in road transport safety
PublicationIn this paper multilevel approach to the issue of road safety level on the road network of European regions, classified as NUTS 2 in statistical databases of the EU, has been presented. The risk calculated as the number of death casualties in road accidents per 100,000 inhabitants of a given region has Poisson distribution. Therefore, generalized Poisson model has been assumed in the modelling process. Multilevel stochastic analysis...
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Falling accident risk in Poland.
PublicationFor the last few years we observe optimistic tendencies in traffic risk development in Poland - the number of fatalities decreases about 10% per year, bringing Poland closer to European Union standards. Nevertheless in 2001 we observed the unexpected, and bigger than forecasted, fatality reduction. The reason was the economic downturn suffered across the country, resulting in reduced demand for transportation. The danger lies in...
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Wdrażanie zarządzania środowiskiem w małych i średnich przedsiębiorstwach - bariery i sugestie rozwiązań
PublicationKonieczność wzmocnienia polskiej gospodarki i dostosowania jej do standardów światowych wymaga między innymi, zmian w systemach zarządzania firmą. W artykule przedstawiono spostrzeżenia i wnioski jakie nasunęły się wykonawcom w trakcie realizacji projektu pt. ''Przyjazny środowisku przemysł stoczniowy'' (Pro-ecological polish shipyard industry), którego zasadniczym celem była pomoc polskim przedsiębiorstwom we wdrażaniu systemu...
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In silico approaches for better understanding cysteine cathepsin-glycosaminoglycan interactions
PublicationCysteine cathepsins constitute the largest cathepsin family, with 11 proteases in human that are present primarily within acidic endosomal and lysosomal compartments. They are involved in the turnover of intracellular and extracellular proteins. They are synthesized as inactive procathepsins that are converted to mature active forms. Cathepsins play important roles in physiological and pathological processes and, therefore, receive...
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Simplified saturation modelling in three-leg power transformer for the system stability analisys
PublicationThe paper presents a simplified method for modelling non-linearity of the magnetic circuit of the power transformer. The saturation effect is implemented by describing the self and mutual inductances as a function of the magnetic flux. The most important element of this function is the saturation coefficient which is calculated based on transient state during the unloaded transformer switch on. The transformer model is described...
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Zmodyfikowana metoda prognozowania rezultatów nadzorowania drgań narzędzie--przedmiot obrabiany. W: Projektowanie mechatroniczne. Zagadnienia wybrane. Praca zbiorowa pod red. T. Uhla. Kraków: Kated. Robotyki i Dynam. Masz.AGH**2003 s. 125-134, 3 rys. 1 tab. bibliogr. 6 poz.
PublicationW pracy przedstawiono zmodyfikowaną metodę prognozowania rezultatów nadzoro-wania drgań narzędzie-przedmiot obrabiany za pomocą sterowanej programowo prędkości obrotowej wrzeciona. Istotą modyfikacji jest uwzględnienie w mode-lu złożoności geometrycznej narzędzia oraz efektu rozproszenia energii pro-cesu skrawania. Podano opis dynamiki skrawania niestacjonarnego modelu obli-czeniowego, oraz sposobu nadzorowania. Zamieszczono...
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Falling accident risk in Poland.
PublicationFor the last few years we observe optimistic tendencies in traffic risk development in Poland the number of fatalities decreases about 10% per year, bringing Poland closer to European Union standards. Nevertheless in 2001 we observed the unexpected, and bigger than forecasted, casualty reduction. The reason was the economic downturn suffered across the country, resulting in reduced demand for transportation. The danger lies in...
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Gold nanoparticles and their coatings, their effect on cells and their interaction with radiation
PublicationTwo nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or polyethylene glycolamine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous skin and breast tissues. In addition to the observed intrinsic cancer-selective chemotoxicity, these AuNPs acted as radiosensitisers in combination with...
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Philosophy of Symbolic Forms and a Mystery of “Appearing Itself ”. Cassirer in the Context of Phenomenology
Publicationin the publications concerning Cassirer, whose number has been increasing for about a dozen years, more and more space is devoted to the genesis of his philosophy, and more attention is paid to its linkage to Neo-Kantian Marburg school. Also, in addition to Kantian, Hegelian and Goethean heritage in Cassirer’s philosophy is indicated, while its discovered philosophical foundations make it possible to regard the author of The Philosophy...
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Changes in the addiction prevalence in Polish population between 1990-2019: Review of available data
PublicationThe 1989 collapse of the socialist political system in Poland initiated an avalanche of modifications regarding healthcare policy resulting with new institutions and programs dedicated to monitoring and preventing addiction. In the current article, we look at the available data allowing to track changes in (1) the prevalence of exposure to addictive substances and behaviors, and (2) changes of addictions prevalence in Poland...
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Study on extraction and characterization of anchote (Coccinia abyssinica) starch and reinforced enset (Ensete ventricosum) fiber for the production of reinforced bioplastic film
PublicationPopulation expansion is causing an increase in dependence on plastic materials. The worst aspects of conventional plastics were their inability to biodegrade, their poor capacity to transmit water vapor, and their production of greenhouse gases. Usages of bioplastics are necessary for the advancement of a green economy and environment in order to eradicate these drawbacks of traditional plastics. In this study, reinforced bioplastic...
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Hybrid constructed wetlands for the National Parks in Poland - a case study, requirements, dimensioning, preliminary results
PublicationWater and wastewater management, especially in rural areas, greatly affects loads of nutrients discharged to the Baltic Sea. In Poland, this management is unbalanced because of the dispersed development and in many locations con struction of sewerage system is uneconomic or even impossible. For this reason, a significant part of sewage from single-family houses in rural areas must be discharged into domestic sewage systems. The...
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A Generalized Framework Towards Structural Mechanics of Three-layered Composite Structures
PublicationThree-layered composite structures find a broad application. Increasingly, composites are being used whose layer thicknesses and material properties diverge strongly. In the perspective of structural mechanics, classical approaches to analysis fail at such extraordinary composites. Therefore, emphasis of the present approach is on arbitrary transverse shear rigidities and structural thicknesses of the individual layers. Therewith...
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Przęsło łukowe kolejowego obiektu mostowego. Wpływ schematu statycznego i rozwiązań konstrukcyjnych na właściwości dynamiczne
PublicationW pracy przedstawiono kompleksową analizę optymalizacyjną kolejowego wiaduktu łukowego. Szczególną uwagę zwrócono na zachowanie dynamiczne konstrukcji. Odpowiedź dynamiczna przęsła pod obciążeniem taboru Kolei Dużych Prędkości (KDP) jest jednym z kluczowych elementów podlegających ocenie przy projektowaniu obiektów wzdłuż KDP. Drgania przęsła ograniczane są ze względu na trwałość i bezpieczeństwo konstrukcji oraz komfort pasażerów....
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Association of Genes Related to Oxidative Stress with the Extent of Coronary Atherosclerosis
PublicationOxidative stress is believed to play a critical role in atherosclerosis initiation and progression. In line with this, in a group of 1099 subjects, we determined eight single nucleotide polymorphisms (SNPs) related to oxidative stress (PON1 c.575A>G, MPO c.463G>A, SOD2 c.47T>C, GCLM c.590C>T, NOS3 c.894G>T, NOS3 c.786T>C, CYBA c.214C>T, and CYBA c.932A>G) and assessed the extent of atherosclerosis in coronary arteries based on...
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Prediction of protein assemblies, the next frontier: The CASP14‐CAPRI experiment
PublicationWe present the results for CAPRI Round 50, the 4th joint CASP-CAPRI protein assembly prediction challenge. The Round comprised a total of 12 targets, including 6 dimers, 3 trimers, and 3 higher-order oligomers. Four of these were easy targets, for which good structural templates were available either for the full assembly, or for the main interfaces (of the higher-order oligomers). Eight were difficult targets for which only distantly...
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An Efficient Noisy Binary Search in Graphs via Median Approximation
PublicationConsider a generalization of the classical binary search problem in linearly sorted data to the graph-theoretic setting. The goal is to design an adaptive query algorithm, called a strategy, that identifies an initially unknown target vertex in a graph by asking queries. Each query is conducted as follows: the strategy selects a vertex q and receives a reply v: if q is the target, then =, and if q is not the target, then v is a...
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Ni-WC/Al2O3 and Ni-WC/MgWO4/MgAl2O4 catalysts for resource recovery via pyrolysis combined with the dry reforming of plastics (PCDR)
PublicationPlastic waste (PW) is currently one of an environmental threat. Despite the increasing share of recycled plastics, their disposal remains high. Therefore, there is a high demand for new PW management systems. Among them, pyrolysis combined with dry reforming (PCDR) is an advantageous solution because it allows for resource recovery in the form of gas and liquid fuels, with simultaneous utilization of CO2. To date, catalysts based...
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Investigating trip and parking characteristics of hospitals: A case study from Tri-City, Poland
PublicationThis research aims to investigate public hospitals’ trip and parking characteristics based on the study conducted in Poland in September 2021 on the example of the Tri-City agglomeration. The main objective of the research was to build models of the relationship between the number of trips during peak transport hours and the number of beds. The second research element was the analysis of transport behavior in these areas. The research...
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Lignin-based carbon fibers for renewable and multifunctional lithium-ion battery electrodes
PublicationLignin-based carbon fibers (LCFs) from the renewable resource softwood kraft lignin were synthesized via oxidative thermostabilization of pure melt-spun lignin and carbonization at different temperatures from 1000°C to 1700°C. The resulting LCFs were characterized by tensile testing, scanning electron microscopy (SEM), X-ray diffraction (XRD) and confocal Raman spectroscopy. The microstructure is mainly amorphous carbon with some...
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Tool Wear Monitoring Using Improved Dragonfly Optimization Algorithm and Deep Belief Network
PublicationIn recent decades, tool wear monitoring has played a crucial role in the improvement of industrial production quality and efficiency. In the machining process, it is important to predict both tool cost and life, and to reduce the equipment downtime. The conventional methods need enormous quantities of human resources and expert skills to achieve precise tool wear information. To automatically identify the tool wear types, deep...
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Accurate Lightweight Calibration Methods for Mobile Low-Cost Particulate Matter Sensors
PublicationMonitoring air pollution is a critical step towards improving public health, particularly when it comes to identifying the primary air pollutants that can have an impact on human health. Among these pollutants, particulate matter (PM) with a diameter of up to 2.5 μ m (or PM2.5) is of particular concern, making it important to continuously and accurately monitor pollution related to PM. The emergence of mobile low-cost PM sensors...
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The effect of transglutaminase on the properties of salmon skin-gelatin films
PublicationCelem pracy była enzymatyczna modyfikacja folii otrzymanych z żelatyny rybnej. Źródłem żelatyny były surowe i wędzone skóry łososia. Stwierdzono, że czas żelowania roztworu żelatyny ulegał skróceniu w obecności transglutaminazy w badanym zakresie 0,1-0,2 mg/ml. Enzymatyczne modyfikacje prowadziły do obniżenia rozpuszczalności folii, jednakże w różnym stopniu zależnym od źródła białka. Obecność DTT lub cysteiny w mieszaninie reakcyjnej...
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Experimental Tests Of Sandwich Beams In The Design Process Of GFRP Shell Footbridge Structure
PublicationThe paper includes selected aspects of the study to elaborate architectural, material and construction design of pedestrian footbridge spans made of composite materials. The considered footbridge is a sandwich-type shell structure. The cooperation of PET foam core with outer lining surfaces is crucial for its load bearing capacity. The paper is aimed to experimental investigation of sandwich beams subjected to bending loading....
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ECG-based prediction of ventricular fibrillation by means of the PCA
PublicationA Sudden Cardiac Death (SCD) is a death resulting from cardiac failure with no significant symptoms earlier than one hour before occurrence. It is the cause of for approximately 400000 deaths per year in United States and millions of deaths worldwide. The proposed system, including two-stage algorithm and wearable diagnostic device allows for SCD risk estimation and continuous monitoring of high risk patients. A single channel...
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Face detection in image sequences using a portable thermal camera
PublicationFace detection is often a first step in quantitative analysis of face images. It is an important research area for visible images and recently also for thermography. Due to technological developments thermal cameras may be embedded into wearable devices to provide remote healthcare. In this paper, we compared three algorithms for face detection in thermal images by testing execution time, accuracy, symmetry ratio and false-positives....
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Music Genre Recognition in the Rough Set-Based Environment
PublicationThe aim of this paper is to investigate music genre recognition in the rough set-based environment. Experiments involve a parameterized music data-base containing 1100 music excerpts. The database is divided into 11 classes cor-responding to music genres. Tests are conducted using the Rough Set Exploration System (RSES), a toolset for analyzing data with the use of methods based on the rough set theory. Classification effectiveness...