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A Convenient Way to Methylated 2-Imidazolines. Syntheses of Fluorene and Triazine Cyclic Diamidines
PublicationOne N-methyl- and 4-substituted 2-imidazolines are described. Fluorene bisimidazolines were obtained in good yield (64-92%), starting from 2,7-dicyanofluorene and ammonium sulfide. In a two-step procedure the crude bisthioamide was reacted with excess diaminoalkane-ethanol (1:1 mixt.) in an oil bath. This new procedure is superior over std. methods. For the sake of comparison, a new triazine bisimidazoline (I) was prepd. by...
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Structural Factors Affecting Cytotoxic Activity of (E)-1-(Benzo[d ][1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-one Derivatives
PublicationDerivatives of (E)-1-(5-alkoxybenzo[d][1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-one (1) demonstrated exceptionally high in vitro cytotoxic activity, with IC50 values of the most active derivatives in the nanomolar range. To identify structural fragments necessary for the activity, several analogs deprived of selected fragments were prepared, and their cytotoxic activity was tested. It was found that the activity depends on combined effects...
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Computational studies of friction forces for hard tissue cultivation in bioreactor.
PublicationPonieważ wymiana naturalego stawu na endoprotezę może być dokonywana 2-3 razy w życiu, problem leczenia przez transplantację tkanek chrzęstnych nabiera dużego znaczenia. Przeszczepów tkanki można dokonywać z sukcesem wiele razy. W bioreaktorach, środowisko hydrodynamiczne kształtuje hodowlę tkanek in vitro w obecności sił tarcia, poprzez bezpośrednie działanie na morfologię komórek a także poprzez pośrednie działanie na tkankę...
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The activity of latent benzoperimidine esters to inhibit P-glycoprotein and multidrug resistance-associated protein 1 dependent efflux of pirarubicin from several lines of multidrug resistant tumor cells.
PublicationZaprezentowano wyniki badań biologicznych przeprowadzonych dla nowej grupy związków: estrów benzoperymidyny z zastosowaniem wybranych linii komórek nowotworowych: wrażliwych i opornych o oporności P-gp-zależnej, MRP1-zależnej i o oporności związanej z nadekspresją białek MRP1/LRP. Metodą spektrofluorymetryczną zbadano zdolność estrów benzoperymidyny do hamowania eksportu aktywnego pirarubicyny z komórek opornych. Estry benzoperymidyny...
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Culturable bacteria community development in postglacial soils of Ecology Glacier, King George Island, Antarctica
PublicationGlacier forelands are excellent sites in which to study microbial succession because conditions change rapidly in the emerging soil. Development of the bacterial community was studied along two transects on lateral moraines of Ecology Glacier, King George Island, by culture-dependent and culture-independent approaches (denaturating gradient gel electrophoresis). Environmental conditions such as cryoturbation and soil composition...
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A New Expression System Based on Psychrotolerant Debaryomyces macquariensis Yeast and Its Application to the Production of Cold-Active β-D-Galactosidase from Paracoccus sp. 32d
PublicationYeasts provide attractive host/vector systems for heterologous gene expression. The currently used yeast-based expression platforms include mesophilic and thermotolerant species. A eukaryotic expression system working at low temperatures could be particularly useful for the production of thermolabile proteins and proteins that tend to form insoluble aggregates. For this purpose, an expression system based on an Antarctic psychrotolerant...
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Enhancing colloidal stability of nanodiamond via surface modification with dendritic molecules for optical sensing in physiological environments
PublicationPre-treatment of diamond surface in low-temperature plasma for oxygenation and in acids for carboxylation was hypothesized to promote the branching density of the hyperbranched glycidol polymer. This was expected to increase the homogeneity of the branching level and suppress interactions with proteins. As a result, composite nanodiamonds with reduced hydrodynamic diameters that are maintained in physiological environments were...
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The ability to overcome multidrug resistance of tumor cell lines by novel acridine cytostatics with condensed heterocyclic rings
PublicationZbadano aktywność cytotoksyczną, in vitzo dwóch nowych grup cytostatyków akrydynowych zawierających skondensowane pierścienie heterocykliczne w stosunku do komórek nowotworowych linii wrażliwych i opornych. Otrzymane wyniki potwierdziły naszą wcześniejszą hipotezę o istotnej roli pierścieni hetero-cyklicznych w pokonywaniu krzyżowej oporności wielolekowej.
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Green porous benzamide-like nanomembranes for hazardous cations detection, separation, and concentration adjustment
PublicationGreen biomaterials play a crucial role in the diagnosis and treatment of diseases as well as health-related problem-solving. Typically, biocompatibility, biodegradability, and mechanical strength are requirements centered on biomaterial engineering. However, in-hospital therapeutics require an elaborated synthesis of hybrid and complex nanomaterials capable of mimicking cellular behavior. Accumulation of hazardous cations like...
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Cząsteczki mikroRNA - nowy biologicznie aktywny składnik mleka kobiecego
PublicationCząsteczki mikroRNA są krótkimi, niekodującymi oligonukleotydami odpowiadającymi za potranskrypcyjną regulację ekspresji genów. W wyniku ich aktywności kontrolowanych jest wiele procesów komórkowych oraz szlaków sygnalizacyjnych. Od 2010 roku wiadomo, że wchodzą one w skład mleka kobiecego, które obecnie uznaje się za jedno z najbogatszych pokarmowych źródeł mikroRNA. Funkcje tych cząsteczek w organizmie karmionego mlekiem matki...
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Centrum Rewitalizacji Budowli Miejskich w Politechnice Gdańskiej.
PublicationPodano informację o utworzeniu na Politechnice Gdańskiej Centrum Rewitalizacji Budowli Miejskich CURE, działającego w ramach V Programu Unii Europejskiej, akcja kluczowa ''City of Tomorrow and Cultural Heritage''. Opisano działalność Centrum CURE w dziedzinie badań naukowych, transferu technologii i współpracy Naukowo-technicznej.
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Rozdział 2.2.1. Strukturalizacja przyrodnicza obszaru województwa pomors-kiego. W: [Praca zbiorowa] Materiały do monografii przyrodniczej regionu gdańskiego. Gdańsk: Marpress**2002 s. 18-31, 1 rys. Tom 8 Diagnoza stanu i koncepcja ochrony środowiska przyrodniczo-kulturowe- go w województwie pomorskim. Diagnosis of natural-cultural environment´scondition and the idea of its protection in Pomeranian Voivodship. Red. A.Kostarczyk, M. Przewoźniak.
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Rozdział 2.1. Metoda zintegrowanej waloryzacji środowiska przyrodniczo-kul-turowego. W: [Praca zbiorowa] Materiały do monografii przyrodniczej regionu gdańskiego. Gdańsk: Marpress**2002 s. 16-18.Tom 8 Diagnoza stanu i koncepcja ochrony środowiska przyrodniczo-kulturowe- go w województwie pomorskim. Diagnosis of natural-cultural environment´scondition and the idea of its protection in Pomeranian Voivodship. Red. A.Kostarczyk, M. Przewoźniak.
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KM supported process improvement
PublicationThe corporate universe nowadays is full of change initiatives andimprovement philosophies. However,only few have proved successful enough to be integrated into regular operations a worldwide leading companies.In this context Six Sigma projects and Lean action workouts emerge as he most effective practices.In this paper we argue that there is a considerable potential to enhance them using Knowledge Management methodology and benefit...
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REVIEW OF CURRENT RESEARCH ON CHITOSAN AS A RAW MATERIAL IN THREE-DIMENSIONAL PRINTING TECHNOLOGY IN BIOMEDICAL APPLICATIONS
PublicationThree-dimensional (3D) biomaterial manufacturing strategies show an extraordinary driving force for the development of innovative solutions in the biomedical sector, including drug delivery systems, disease modelling and tissue and organ engineering. Due to its remarkable and promising biological and structural properties, chitosan has been widely studied for decades in several potential applications in the biomedical field. However,...
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Inhibitors of angiogenesis in cancer therapy – synthesis and biological activity
PublicationAngiogenesis is the process of formation of new capillaries from preexisting blood vessels. Angiogenesis is involved in normal physiological processes, and plays an important role in tumor invasion and development of metastases. Vascular endothelial growth factor (VEGF) plays a key role in angiogenesis. VEGF is a mitogen for vascular endothelial cells and stimulates their proliferation. By inhibiting the biological activity of...
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Haemocompatibility of Modified Nanodiamonds
PublicationThis study reports the interactions of modified nanodiamond particles in vitro with human blood. Modifications performed on the nanodiamond particles include oxygenation with a chemical method and hydrogenation upon chemical vapor deposition (CVD) plasma treatment. Such nanodiamonds were later incubated in whole human blood for different time intervals, ranging from 5 min to 5 h. The morphology of red blood cells was assessed along...
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Synthesis and antimicrobial activity of 6-sulfo-6-deoxy-D-glucosamine and its derivatives
Publication6-Sulfo-6-deoxy-D-glucosamine (GlcN6S), 6-sulfo-6-deoxy-D-glucosaminitol (ADGS) and their N-acetyl and methyl ester derivatives have been synthesized and tested as inhibitors of enzymes catalyzing reactions of the UDP-GlcNAc pathway in bacteria and yeasts. GlcN6S and ADGS at micromolar concentrations inhibited glucosamine-6-phosphate (GlcN6P) synthase of microbial origin. The former was also inhibitory towards fungal GlcN6P N-acetyl...
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Reactions on the surface of the implant under the influence of biofilm
PublicationThe contact of a biomaterial with the biological environment in in vitro and in vivo tests leads to the production of a particular ecosystem in which the active roles perform both, the material surface and the extracellular matrix protein forming a biofilm. Proteins affect cell and bacteria adhesion processes, biological activity of cells and activation of inflammatory response.The knowledge of the reaction mechanisms active on...
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Corrosion of titanium biomaterials, mechanisms, effects and modelisation
PublicationBadania in vivo oraz in vitro wskazują na bardzo małą szybkość korozji biostopów tytanu.Najczęstsza przycyną jest korozja ogólna i lokalna oraz korozja frettingowa. Trzy możliwe mechanizmy to: rozpuszczanie warstwy tlenku tytanu, dyfuzja pierwiastków przez warstwę tlenkową oraz reakcje elektrochemiczna w środowisku korozyjnym odsłoniętego metalu. Procesy korozyjne prowadzą do obluzowania implantów i poważnych schorzeń. Standardowe...
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Voriconazole-Based Salts Are Active against Multidrug-Resistant Human Pathogenic Yeasts
PublicationVoriconazole (VOR) hydrochloride is unequivocally converted into VOR lactates and valinates upon reaction with silver salts of organic acids. This study found that the anticandidal in vitro activity of these compounds was comparable or slightly better than that of VOR. The Candida albicans clinical isolate overexpressing CaCDR1/CaCDR2 genes, highly resistant to VOR, was apparently more susceptible to VOR salts. On the other hand,...
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Projektowanie, synteza oraz badanie aktywności biologicznej nowych inhibitorów sulfatazy steroidowej (STS) na bazie amidosiarczanowych pochodnych triazoli i oksadiazoli
PublicationNiniejsza dysertacja dotyczy szeregu badań z wykorzystaniem technik modelowania molekularnego oraz metod syntezy nowych inhibitorów STS opartych o rdzenie pierścieni heterocyklicznych 1,2,3-triazolu oraz 1,2,4-oksadiazolu. Aktywność inhibicyjna otrzymanych pochodnych została oznaczona w testach in vitro z wykorzystaniem enzymu wyizolowanym z łożyska ludzkiego oraz znakowanym radioizotopowo siarczanem estronu, a także w teście komórkowych...
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Synthesis, physical properties and preliminary investigation of hemocompa-tibility of polyurethanes from aliphatic resources with castor oil participation
PublicationWykonano syntezy PUR z oligoeterodiolu, dioli małocząsteczkowych, oleju rycynowego i 4,4´diizocyjanianudicykloheksylometanu. Oznaczono właściwości mechaniczne PUR, kąty zwilżania i napięcie powierzchniowe. Opisano wstępne badania zgodności PUR z ludzką krwią oraz kalcyfikacji powierzchni PUR w warunkach statycznych in vitro. Napięcie powierzchniowe otrzymanych PUR jest zbliżone do napięcia powierzchniowego naturalnych powierzchni...
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Revitalized Mill Island in Bydgoszcz - the identity of the place created by the Brda River and its tributary named Młynowka
PublicationMill Island in Bydgoszcz, Poland is an example of downtown public space where a meander of the Młynówka creates the identity of the area.Before 2005, the only outstanding local feature was the fact that its south and west ends resembled the Venetian canals. The way the other parts of Mill Island were managed was inappropriate for a downtown.A comprehensive revitalization programme is returning Mill Island public space to residents,...
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Electrophoretic deposition and characterization of composite chitosan/Eudragit E 100 or poly(4-vinylpyridine)/mesoporous bioactive glass nanoparticles coatings on pre-treated titanium for implant applications
PublicationTitanium implants are surface-modified to achieve bioactivity and often antibacterial properties. Such surface coatings may increase corrosion degradation and be weakly attached to the substrate. In the present research, biodegradable composite coatings, investigated so far as smart environment-sensitive, slowly releasing silver to the implant neighborhood, were produced as a combination of chitosan (CS) with Eudragit E 100 (EE100)...
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Obliczanie nośności i osiadania pali pojedynczych na podstawie badań sondą Statyczną CPT.
PublicationOmówiono metodę obliczania nośności i osiadania pali z uwzględnieniem bezpośredniego wykorzystania wyników badań sondą statyczną CPT. Dla oceny krzywej osiadania zastosowano funkcje transformacyjne. Przedstawiono analizę wykorzystując wyniki próbnych obciążeń statycznych dla 94 pali Vibro-Fundex. Zaproponowane korelacje zostały zweryfikowane przy wykorzystaniu procedury weryfikacji hipotez statystycznych.
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Philosophy of Symbolic Forms and a Mystery of “Appearing Itself ”. Cassirer in the Context of Phenomenology
Publicationin the publications concerning Cassirer, whose number has been increasing for about a dozen years, more and more space is devoted to the genesis of his philosophy, and more attention is paid to its linkage to Neo-Kantian Marburg school. Also, in addition to Kantian, Hegelian and Goethean heritage in Cassirer’s philosophy is indicated, while its discovered philosophical foundations make it possible to regard the author of The Philosophy...
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Antimicrobial Activity of Chimera Peptides Composed of Human Neutrophil Peptide 1 (HNP-1) Truncated Analogues and Bovine Lactoferrampin
PublicationThree chimera peptides composed of bovine lactoferrampin and the analogue of truncated human neutrophil peptide 1 were synthesized by the solid-phase method. In two compounds peptide chains were connected via isopeptide bond, whereas in the third one disulfide bridge served as a linker. All three chimeras displayed significantly higher antimicrobial activity than the constituent peptides as well as their equimolar mixtures. The...
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Structural factors affecting affinity of cytotoxic oxathiole-fused chalcones toward tubulin
PublicationSynthesis, in vitro cytotoxic activity, and interaction with tubulin of (E)-1-(6-alkoxybenzo[d][1,3]oxathiol- 5-yl)-3-phenylprop-2-en-1-one derivatives (2) are described. Some of the compounds demonstrated cytotoxic activity at submicromolar concentrations, and the activity could be related to interaction with tubulin at the colchicine binding site. Interaction of selected derivatives with tubulinwas evaluated using molecular modeling,...
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Badania bioaktywności z wykorzystaniem komórek kościotwórczych na tytanie pokrytym chitozanem = Bioactivity studies using osteogenic cells on titanium coated with chitosan
PublicationChitosan is a natural polymer from the group of polysaccharides, which has found wide application in biomedical applications to induce bioactivity of implant. The studies described were carried out test imposition of chitosan membranes with varying degrees of deacetylation on the surface of titanium, and then check the bioactivity of the material in vitro, using osteogenic cells MC3T3-E1. Titanium surface before imposition of...
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Molecular Umbrella as A Nanocarrier for Antifungals
PublicationA molecular umbrella composed of two O‐sulfated cholic acid residues was applied for the construction of conjugates with cispentacin, containing a “trimethyl lock” (TML) or o‐dithiobenzylcarbamoyl moiety as a cleavable linker. Three out of five conjugates demonstrated antifungal in vitro activity against C. albicans and C. glabrata but not against C. krusei, with MIC90 values in the 0.22–0.99 mM range and were not hemolytic. Antifungal...
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Studies of the effects of antifungal cationic derivatives of amphotericin B on human erythrocytes.
PublicationBadano nową grupę kationowych pochodnych amfoterycyny B pod kątem zależności pomiędzy ich zdolnością do asocjacji i selektywną toksycznością. We wszystkich przypadkach stosowano amfoterycynę B jako związek odniesienia. Jako miarę efektu toksycznego in vitro badanych związków stosowano wypływ wewnątrzkomórkowego potasu oraz hemolizę. Miarą aktywności przeciwgrzybowej był MIC i utrata potasu wewnatrzkomórkowego. Do oceny stopnia...
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The function of the sculpture in public space and its reception occupants of the city
PublicationSculpture has been with people for thousands of years. Its destiny, subject and scale have changed over the centuries. Public art, along with sculpture, began to appear in a new form (not only to commemorate important figures and events) only in the 1960s. This paper aims to answer what functions are currently performed by the sculptures located in a public space and how they are perceived by the inhabitants of the city.
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Assessment of usefulness of different tacks in laparoscopic ventral hernia repair
PublicationLaparoscopic ventral hernia repair is becoming a popular technique with good results and fast postoperative recovery. The mesh is placed directly under the peritoneum and anchored with transabdominal sutures and tacks. However, the ideal size of the mesh covering the hernia orifice is know, nor the ideal type or amount of tacks has to be described.
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Smart acoustic band structures
PublicationSmart acoustic band structures exhibit very interesting and non-standard physical properties due to the periodic nature of their certain characteristic on different scale levels. They manifest mostly in their frequency spectra as socalled frequency band-gaps or stop-bands, what has a great impact on the behaviour of these structures in relation to the propagation of vibro-acoustic signals that can be transmitted through the structures...
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Educating planners in Europe: A review of 21st century study programmes
PublicationEducation for urban, regional and spatial planning has become a regular subject throughout most European nations; this can be attributed in part to European policies promoting planning and spatially balanced development, but also to the recognition that planning can support sustainability. Nevertheless, there is lingering and justifiable concern about the status, profile and recognition of planning as a profession in its own right...
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Cell Density-Dependent Cytological Stage Profile and Its Application for a Screen of Cytostatic Agents Active Toward Leukemic Stem Cells
PublicationProliferation and expansion of leukemia is driven by leukemic stem cells (LSCs). Multidrug resistance (MDR) of LSCs is one of the main reasons of failure and relapses in acute myeloid leukemia (AML) treatment. In this study, we show that maintaining HL-60 at low cell culture density or applying a 240-day treatment with anthrapyridazone (BS-121) increased the percentage of primitive cells, which include LSCs determining the overall...
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Commercial function as a treat to the monument - 25 years of experience in the commercialization of monuments in Gdansk, Poland
PublicationThe principles of the market economy adopted in Poland in the nineties have significantly touched the resources of immovable monuments. As a result, monuments have become a product of culture subject to the rules of the free market; and state ownership, patronage and decision-making practice has now been replaced by private interest. Practical monument use has also changed with the shift in ownership of objects after privatization...
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Alternative methods for dark fermentation course analysis
PublicationDark fermentation course analysis is crucial, as complexed matrix of gaseous components may be formed and revealed during the process. The paper considers key issues related to the microbiological process in which complex organic substances are transformed into hydrogen. For the purposes of hydrogen generation, the application of wastewater mixed sludge pre-treated according to Faloye method (Faloye et al. in Int J Hydrog Energy...
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Rozdz. 4 Kształtowanie struktury przyrodniczo kulturowej. W: [Praca zbio-rowa] Materiały do monografii przyrodniczej regionu gdańskiego.Gdańsk: Mar- press**2002 s. 72-88 + zał. 1 mapa. Tom 8. Diagnoza stanu i koncepcja ochrony środowiska przyrodniczo-kulturo- wego w województwie pomorskim. Diagnosis of natural-cultural environment´s condition and the idea of its protction in Pomeranian Voivodship. Red. A. Kostarczyk, M. Przewoźniak.
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Rozdział 3.3. Prognoza skutków dalszego utrzymywania obecnego stanu dlaochrony wartości przyrodniczo-kulturowych. W: [Praca zbiorowa] Materiały domonografii przyrodniczej regionu gdańskiego. Gdańsk: Marpress**2002 s. 70- 71. Tom 8 Diagnoza stanu i koncepcja ochrony środowiska przyrodniczo-kulturowe-go w województwie pomorskim. Diagnosis of natural-cultural environment´scondition and the idea of its protection in Pomeranian Voivodship. Red. A.Kostarczyk, M. Przewoźniak.
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Rozdział 4.3. Układ funkcjonalny, strategia realizacyjna i koncepcja moni- toringu. W: [Praca zbiorowa] Materiały do monografii przyrodniczej regionu gdańskiego. Gdańsk: Marpress**2002 s. 84-89. Tom 8 Diagnoza stanu i koncepcja ochrony środowiska przyrodniczo-kulturowe- go w województwie pomorskim. Diagnosis of natural-cultural environment´s condition and the idea of its protection in Pomeranian Voivodship. Red. A. Kostarczyk, M. Przewoźniak.
PublicationRozdziały zawierają analizę prognozowanych problemów wdrożenia planowanego systemu ochrony środowiska przyrodniczo - kulturowego w woj. pomorskim, ze szczególnym uwzględnieniem problemów rangi regionalnej. Przedstawiono także wieloaspektową argumentację za wdrożeniem planowanego systemu oraz koncep- cję jego monitorowania.
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Revitalization of Sopot - The Seaside Spa Town in Poland
PublicationSopot is a Polish seaside resort. In the past - as early as at the beginning of the 20th century - this town was famous for the healing opportunities they created: good conditions for resting and recreation. This town was places where everyone with enough selfesteem was willing to be seen. Since the post-war reconstruction until 1989 (establishment of local governments in Poland), not much has happened in Polish cities in terms...
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Trust triggers and barriers in intercultural teams
PublicationIntercultural teams are more and more popular nowadays — they constitute a serious challenge in terms of effective cooperation and trust building, however. The article presents the potential problems that can affect intercultural cooperation and stresses the power of trust in cultural diversity conditions. The ten-factor model of intercultural team trust is presented. The main aim was to answer the questions: what are the differences...
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High resolution optical and acoustic remote sensing datasets of the Puck Lagoon
PublicationThe very shallow marine basin of Puck Lagoon in the southern Baltic Sea, on the Northern coast of Poland, hosts valuable benthic habitats and cultural heritage sites. These include, among others, protected Zostera marina meadows, one of the Baltic’s major medieval harbours, a ship graveyard, and likely other submerged features that are yet to be discovered. Prior to this project, no comprehensive high-resolution remote sensing...
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Induction of the common-sense hierarchies in lexical data
PublicationUnsupervised organization of a set of lexical concepts that captures common-sense knowledge inducting meaningful partitioning of data is described. Projection of data on principal components allow for dentification of clusters with wide margins, and the procedure is recursively repeated within each cluster. Application of this idea to a simple dataset describing animals created hierarchical partitioning with each clusters related...
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Social activities in The Vistula Marshlands
PublicationSocial activities in The Vistula Marshlands favouring development in this part of the Pomeranian Voivodeship and preserving its specific character have recently been a domain of Local Activity Groups, clubs and societies, as well as cultural centres and local schools. The activation of local environment is supported by the possibility of gaining EU grants, particularly 4 LEADER Axis from the Rural Development Programme for years...
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Przegląd instrumentów pochodnych polskiego rynku walutowego.
PublicationCoraz szersza gama instrumentów pochodnych rynku walutowego świadczy o dokonujących się na nim przemianach natury jakościowej.Oferowane instrumenty śą coraz lepiej dostosowane do indywidualnych potrzeb klientów. Artykuł przybliża następujące z nich: kontrakty terminowe forward i futures, opcje oraz swapy.
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Determination of the bearing capacity of pile foundations based on CPT test results
PublicationAnalityczne określanie pełnej krzywej obciążenie - osiadanie na podstawie parametrów geotechnicznych wciąż stanowi bardzo trudne zadanie naukowe i inżynierskie. W pracy przedstawiono metodę bezpośredniego wykorzystania oporów na stożku sondy statycznej do określania pełnej krzywej osiadania dla pali Vibro-Fundex. W sumie jako materiał weryfikacyjny wykorzystano 94 próbne obciążenia statyczne pali.
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Street Art and Urban Regeneration. Case Study Gdansk and Rome.
PublicationStreet art plays an important role in urban planning as a transforming engine to regenerate the public spaces and in the processes of participation. The article analyzes two main topics. The first one focuses on the urban serving as a support for spatial and cultural strategies in urban redevelopment projects. The second one is related to the potential of micro urban interventions as a strategy for a wider involvement of inhabitants...