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Cellular Effects of Selected Unsymmetrical Bisacridines on the Multicellular Tumor Spheroids of HCT116 Colon and A549 Lung Cancer Cells in Comparison to Monolayer Cultures
PublikacjaMulticellular tumor spheroids are a good tool for testing new anticancer drugs, including those that may target cancer stem cells (CSCs), which are responsible for cancer progression, metastasis, and recurrence. Therefore, we applied this model in our studies of highly active antitumor unsymmetrical bisacridines (UAs). We investigated the cellular response induced by UAs in 2D and 3D cultures of HCT116 colon and A549 lung cancer...
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Optimization of Chemical Functionalities of Indole-2-carboxamides To Improve Allosteric Parameters for the Cannabinoid Receptor 1 (CB1)
Publikacja5-Chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide (1; ORG27569) is a prototypical allosteric modulator for the cannabinoid type 1 receptor (CB1). Here, we reveal key structural requirements of indole-2-carboxamides for allosteric modulation of CB1: a critical chain length at the C3-position, an electron withdrawing group at the C5-position, the length of the linker between the amide bond and the phenyl ring...
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Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells
PublikacjaAndrogen receptor (AR) plays a crutial role in prostate cancer (PCa) development and metastasis. Here, we reported potent anti-PCa activity of a small molecule imidazoacridinone C-1311. In AR-positive PCa cells, C-1311 was found to inhibit the transcriptional activity of AR uncovering a novel mechanism that may be relevant for its anticancer effect. Mechanistically, C-1311 decreased AR binding to prostate-specific antigen (PSA)...
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Układ informatyczny systemu diagnostycznego ciągników kołowych
PublikacjaPodstawowym elementem systemu diagnostycznego jest komputer pokładowy Fujitsu FUTRO S100 z chłodzeniem pasywnym w wykonaniu odpornym na drgania i wstrząsy, z pamięcią Compact Flesh 16Gb. Do komputera dołączony jest monitor dotykowy NVOX LCD 10" VGA/FVAT. Oprogramowanie komputera obejmuje system operacyjny Windows XP-2000, driver konwertera USB/DeviceNet oraz opracowany program diagnostyczny. Komputer połączony jest łączem USB z...
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The antitumor compound triazoloacridinone C-1305 inhibits FLT3 kinase activity and potentiates apoptosis in mutant FLT3-ITD leukemia cells.
PublikacjaAim: FMS-like receptor tyrosine kinase (FLT3) is expressed in some normal hematopoietic cell types and plays an important role in the pathogenesis of acute myeloid leukemia (AML). In this study, we examined the effects of triazoloacridinone C-1305, an antitumor compound, on AML cells with different FLT3 status in vitro. Methods: A panel of human leukemic cell lines with different FLT3 status was used, including FLT3 internal tandem...
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Technical diagnostics and monitoring of traction current collectors
PublikacjaNew evaluation methods of the technical condition of rolling stock current collectors are proposed in this paper. The method of automatic measurement of the pantograph static force characteristic, realized when the vehicle runs through the test section of the track with especially prepared overhead line height distribution, has been practically implemented by the Polish Railways. The method of testing the slipper spring suspension...
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Application of Structural Control Systems for the Cables of Cable-Stayed Bridges: State-of-the-Art and State-of-the-Practice
PublikacjaStay cables are one of the key elements of cable-stayed bridges and are characterized by lightweight, low inherent damping, and high flexibility. They are continuously subjected to small-to large-amplitude vibrations due to various types of dynamic loads that may, in the long term, cause fatigue and fracture problems for the cable system, and may eventually compromise the safety of cable-stayed bridges. Thus, several countermeasures...
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Investigation of stability and limit load of a truss overhead opened bridge
PublikacjaThe paper presents selected methods of determining stability and limit load of a truss top chord in opened bridges. These methods include linear buckling and non-linear static analysis based on the finite element method and algorithms based on design code procedures. The described methods were tested on an example of a steel footbridge situated in Straszyn. The results of stability analysis are compared. The results of geometrical...
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Identification of the mechanical properties of the skin by electromechanical impedance analysis of resonant piezoelectric actuator
PublikacjaThis paper is devoted to the analysis and verification of developed piezoelectric sensor/actuator for measuring the mechanical properties of soft tissues, especially human skin. The key element of the measurement structure is an electromechanical system that uses both the reverse piezoelectric effect (vibration generation – stimulation of the tissues in the appropriate frequency range) and direct piezoelectric effect (system response...
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THE MODELLING OF ACCUMULATION AND DISSIPATION OF ENERGY IN MECHANICAL DRIVE SYSTEM
PublikacjaThis paper presents a modelling of accumulation and dissipation energy in simple drive system. The simple drive system is presented by laboratory stand designed for calculate fatigue life of material for bending and rotation tests pieces. The laboratory stand was prepared to diagnosis of fatigue life of material by use energetic methods. This idea was submitted as utility model to Polish Patent Office. This laboratory stand gives...
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Merging extremum seeking and self-optimizing narrowband interference canceller - overdetermined case
PublikacjaActive cancellation systems rely on destructive interference to achieve rejection of unwanted disturbances entering the system of interest. Typical practical applications of this method employ a simple single input, single output arrangement. However, when a spatial wavefield (e.g. acoustic noise or vibration) needs to be controlled, multichannel active cancellation systems arise naturally. Among these, the so-called overdetermined...
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In-service measurement of the small wind turbine test stand for structural health monitoring
PublikacjaThis paper presents the research activity performed on a Small Wind Turbine (SWT) test stand. Commercially available turbine was modified towards incorporation of the sensors system for condition monitoring. Installed sensors measure angular shaft position, torque applied from the wind loads, vibration accelerations and last but not least rotational speed. All gathered data are then transferred and processed in Test.Lab by means...
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Numerical Study on Seismic Response of a High-Rise RC Irregular Residential Building Considering Soil-Structure Interaction
PublikacjaThe objective of the present study is to investigate the importance of soilstructure interaction effects on the seismic response of a high-rise irregular reinforced-concrete residential building. In order to conduct this research, a detailed three-dimensional structure model was subjected to various earthquake excitations, also including a strong mining tremor. Soil-foundation flexibility was represented using the spring-based...
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A higher order transversely deformable shell-type spectral finite element for dynamic analysis of isotropic structures
PublikacjaThis paper deals with certain aspects related to the dynamic behaviour of isotropic shell-like structures analysed by the use of a higher order transversely deformable shell-type spectral finite element newly formulated and the approach known as the Time-domain Spectral Finite Element Method (TD-SFEM). Although recently this spectral approach is reported in the literature as a very powerful numerical tool used to solve various...
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Effective Gap Size Index for Determination of Optimum Separation Distance Preventing Pounding between Buildings during Earthquakes
PublikacjaSeismic excitations may lead to collisions between adjacent civil engineering structures causing major damage. In this paper, an effective equation for calculating the gap size index is proposed so as to provide the optimum separation distance preventing structural pounding during different earthquakes. Evaluation of the best prediction of the required separation distance between two adjacent buildings was carried out by using...
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Effects of Surface Energy and Surface Residual Stresses on Vibro-Thermal Analysis of Chiral, Zigzag, and Armchair Types of SWCNTs Using Refined Beam Theory
PublikacjaIn this article, vibration characteristics of three different types of Single-Walled Carbon Nanotubes (SWCNTs) such as armchair, chiral, and zigzag carbon nanotubes have been investigated considering the effects of surface energy and surface residual stresses. The nanotubes are embedded in the elastic substrate of the Winkler type and are also exposed to low and high-temperature environments. A new refined beam theory namely, one-variable...
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High Resolution Sea Ice Floe Size and Shape Data from Knox Coast, East Antarctica
PublikacjaThis dataset contains floe size distribution data from a very high resolution (pixel size: 0.3 m) optical satellite image of sea ice, acquired on 16 Feb. 2019 off the Knox Coast (East Antarctica). The image shows relatively small ice floes produced by wave-induced breakup of landfast ice between Mill Island and Bowman Island. The ice floes are characterised by a narrow size distribution and angular, polygonal shapes, typical...
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Detection of defects in PMMA beam using shear waves - numerical simulation and experiment
PublikacjaTest doświadczalny falami sprężystymi jest częścią systemu diagnostycznego belek. Autorzy badają pole przyspieszeń wywołane przepływem fal ultradźwiękowych i jego modyfikacje wynikające z wprowadzonych uszkodzeń belki. Artykuł porównuje wyniki eksperymentalne z symulacjami numerycznymi MES. The experimental test introduced in the paper is the part of the diagnostic system utilizing the elastic waves. The authors investigate the...
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Magnetism and charge density waves in RNiC2(R=Ce,Pr,Nd)
PublikacjaWe have compared the magnetic, transport, galvanomagnetic, and specific-heat properties of CeNiC2, PrNiC2, and NdNiC2 to study the interplay between charge density waves (CDW) and magnetism in these compounds. The negative magnetoresistance in NdNiC2 is discussed in terms of the partial destruction of charge density waves and an irreversible phase transition stabilized by the field-induced ferromagnetic transformation is reported....
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VUV irradiation studies of plasmid DNA in aqueous solution
PublikacjaInteractions of VUV light and DNA samples in aqueous solutions are reported. The damage induced by such radiation is quantified by monitoring both loss of supercoiled DNA and formation of single and double strand breaks using agarose gel electrophoresis. Irradiations were performed using synchrotron VUV photons of 130, 150, 170 and 190 nm. VUV irradiation experiments revealed enhanced damage upon irradiation with 170 nm photons...
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Wpływ imperfekcji geometrycznych na bezpieczeństwo montażu i naprawy zbiorników cylindrycznych metoda podbudowy
PublikacjaW pracy zajęto się wyznaczeniem nośności granicznej zbiorników stalowych o osi pionowej montowanych lub naprawianych z zastosowaniem hydraulicznego systemu podnoszenia konstrukcji. Podniesiony zbiornik jest szczególnie narażony na utratę stateczności, a obciążenie wiatrem utrudnia prowadzenie prac. Jakiekolwiek deformacje blach, szczególnie w pobliżu zamocowań podnośników mogą w znacznym stopniu obniżyć obciążenie krytyczne konstrukcji....
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Pomiar sił w wantach mostu podwieszonego
PublikacjaW artykule przedstawiono metodę oraz wyniki badań sił w wantach Mostu III Tysiąclecia im. Jana Pawła II w Gdańsku. Do identyfikacji sił wykorzystano trzy metody: wibracyjną; z wykorzystaniem siłownika jednosplotowego (lift-off) oraz pomiaru strzałki ugięcia. Przedstawione wyniki badań dowodzą, że wszystkie metody mogą być z powodzeniem wykorzystywane do identyfikacji rzeczywistej siły w wancie. Każda z metod ma jednak ograniczenia...
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CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells
PublikacjaHigh CYP3A4 expression sensitizes tumor cells to certain antitumor agents while for others it can lower their therapeutic ef fi cacy. We have elucidated the in fl uence of CYP3A4 overexpression on the cellular response induced by antitumor acridine derivatives, C-1305 and C-1748, in two hepatocellular carcinoma (HepG2) cell lines, Hep3A4 stably transfected with CYP3A4 isoenzyme, and HepC34 expressing empty vector. The compounds...
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Pounding Between Superstructure Segments in Multi-Supported Elevated Bridge with Three-Span Continuous Deck Under 3D Non-Uniform Earthquake Excitation
PublikacjaReports after severe ground motions show that the earthquake-induced structural pounding may lead to significant damage in elevated bridges. The aim of this paper is to analyse pounding between superstructure segments of a highway elevated bridge with three-span continuous deck under 3D non-uniform earthquake excitation, which is induced by spatial seismic effects related to the propagation of seismic wave. The conditional stochastic...
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Redox State Sensitive Spectroscopy of the Model Compound [(H-dcbpy)(2)Ru-II(NCS)(2)](2-) (dcbpy=2,2 '-Bipyridine-4,4 '-dicarboxylato)
PublikacjaThe charge transfer reaction mechanism in a ruthenium polypyridine model complex with isothiocyanato ligands, i.e., [(H-dcbpy)(2)Ru(NCS)(2)](2-) 2Bu(4)N(+) (Ru2H) (dcbpy = 2,2'-bipyridine-4,4'-dicarboxylato), has been investigated by combining UV-vis absorption, resonance Raman spectroscopy, and electrochemical methods. Understanding the photophysics of light-harvesting complexes of this class is an indispensable prerequisite to...
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Analysis of temporary steel grandstand with different bracing systems exposed to crowd load
PublikacjaGrandstands are structures which are regularly subjected to dynamic loads generated by crowd motions. It is a dangerous situation when spectators induce rhythmic jumping, dancing, stamping, etc. If the synchronized movement of spectators excites a natural frequency of the structure, resonant response might occur. To avoid such situations, temporary steel grandstands are commonly strengthened using additional elements that create...
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Formaldehyde detection with chemical gas sensors based on WO3 nanowires decorated with metal nanoparticles under dark conditions and UV light irradiation
PublikacjaWe report results of formaldehyde gas (CH2O) detection under dark conditions and UV light irradiation with pristine tungsten trioxide nanowires (WO3 NWs) and metal nanoparticles decorated WO3 NWs gas sensing layers. The resistive layers were deposited by one step aerosol assisted chemical vapor deposition (AACVD) on commercial alumina substrates with 10-pair interdigitated platinum electrodes. The elaborated gas sensors, based...
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Effect of oxidation and in vitro intestinal hydrolysis on phospholipid toxicity towards HT29 cell line serving as a model of human intestinal epithelium
PublikacjaOxidation of food-derived phospholipids (PLs) can influence nutrient digestion and induce oxidative stress in gastrointestinal epithelium. In this study, hen egg yolk PL fraction was used to evaluate the effect of lipoxygenase (LOX)-induced PL oxidation on the rate of PL hydrolysis catalyzed by pancreatic phospholipase A2 (PLA2) in the presence of bile salts (BSs). Then, PL/BS solutions containing native or oxidized PLs were used...
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Corrosion and Cavitation Resistances of Low Alloy Steel After Frictional-Mechanical Treatment
PublikacjaPaper presents the results of the studies of wear, corrosion and cavitation resistances of the S355J2 low alloy medium carbon steel subjected to surface modification by friction-mechanical treatment, as tested in sea water simulated solution. To evaluate the effect of the surface treatment, the comparative studies of the corrosive properties of the steel before and after treatment have been considered. The treatment due to a severe...
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Numerical study on seismic response of a base-isolated building modelled with shell elements
PublikacjaSeismic isolation is counted among the most popular and effective means of protecting structures against earthquake forces. Base isolators, like Lead-Rubber Bearings (LRB), High-Damping Rubber Bearings (HDB) or Friction Pendulum Systems (FPS) are extensively used in practice in many earthquake-prone regions of the world. The present paper reports the results obtained from the numerical study on seismic response of a base-isolated...
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FURTHER REMARKS ON THE SURFACE VIS IMPRESSA CAUSED BY A FLUID-SOLID CONTACT
PublikacjaIt is well-known that, nano-mechanics should take into account not only physical phenomena occuring within the bulk but, first of all, the physical phenomena appropriate for a surface of two materials contact. The huge volume density of internal surfaces as well countours lines located within the nanomaterial results in our interest in, apart from classical form of mass, momentum and entropy transport, those modes of transportation...
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Application of fracture mechanics for energetic effects predictions while wood sawing
PublikacjaIn the classical approach, energetic effects (cutting forces and cutting power) of wood sawing process are generally calculated on the basis of the specific cutting resistance, which is in the case of wood cutting the function of more or less important factors. On the other hand, cutting forces (power) could be considered from a point of view of modern fracture mechanics. Cutting forces may be employed to determine not only toughness...
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Navier number and transition to turbulence
PublikacjaThe motivation behind this article is to explain a role of the Navier number (Na -dimensionless slip-length) in prediction of closures for laminar to turbulent transition undergoing via eddies detachment from the slip layer in nano-cannals. Additionally the role of the Navier number Na in universal modeling of phenomenon of enhanced mass flow rate reported in micro- and nano-channels has been explained. The Na number should be...
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Pressure drop of HFE7000 and HFE7100 during flow condensation in minichannels
PublikacjaAttention is focused on the issues of flow resistance and pressure drop of perspective refrigeration fluids during condensation in the two-phase flow in minichannels. The case of the flow through a cylindrical single channel of 2.3 mm inner diameter was carefully analyzed. Pressure drop tests have been performed in diabatic flow conditions. The effect of heat flux, mass flux, vapour quality and saturation temperature on the two-phase...
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Tire/Road Noise On Poroelastic Road Surfaces - Results Of Laboratory Measurements
PublikacjaTire/road noise is the most important part of traffic noise for medium and high speed driving both in the case of passenger cars and trucks. The potential to make modification of tires that significantly reduce tire/road noise in nearly over, at least for conventional tires so the only promising action is to improve road pavements. One of the innovative solutions is poroelastic road pavement (PERS) that reduces airflow related...
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Estimation of fracture toughness and shear yield stress of orthotropic materials in cutting with rotating tools
PublikacjaThe cutting force is an energetic effect of splitting material, and might be considered from a point of view of modern fracture mechanics. Forecasting of the shear plane angle in cutting broaden possibilities for modelling of the cutting process even for thin uncut chips. Such mathematical model has been developed here for description of the orthotropic materials’ cutting on the base of fracture theory, and includes work of separation...
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Zirconia ceramics with additions of Alumina for advanced tribological and biomedical applications
PublikacjaThe results of an investigation on slip cast and sintered Y2O3 (3 wt%)- stabilized ZrO2 with additions of 5, 10, 15 wt% Al2O3 are reported. The surface roughness, porosity and density of the samples were measured. The hardness HRc and Hv, fracture toughness K1C, and friction coefficients were also measured using standard methods. The structural properties of the samples were observed by Scanning Electron Microscopy (SEM). The surface...
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Research and applications of active bearings: A state-of-the-art review
PublikacjaControllable/active bearings are mainly associated with active magnetic bearings (AMBs), whereas active bearing control is also found in many types of bearings, e.g. fluid, gas and hybrid bearings. The article presents a review of the literature describing the structure and results of studies of active bearings. Active control brings a number of benefits resulting in the fact that their use as a support for rotors becomes increasingly...
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Ocena wpływu pokarmowych kwasów nukleinowych i ich komponentów na replikacyjną i naprawczą syntezę DNA w modelach komórek ludzkiego układu pokarmowego
PublikacjaKwasy nukleinowe, do których należą DNA i RNA, są podstawowymi elementami każdej komórki niezbędnymi do prawidłowego funkcjonowania organizmu. Pomimo, że cząsteczki te stanowią również nieodłączne składniki produktów żywnościowych spożywanych przez człowieka, to badania na temat ich zawartości w żywności oraz wartości odżywczej są ograniczone. Wyniki uzyskane w niniejszej pracy doktorskiej pokazały istotne różnice w ilości, wielkości...
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Combined environmental testing device for picosatellites
PublikacjaAs access to space conditions becomes more available, both technically and economically, scientists’ interest in launching finer and more sophisticated experiments grows. To be qualified for launch, such experiments need to be carefully tested prior to the event. The tests should represent actual launch conditions as closely and in a detailed manner. Typical tests for payload include: vibration tests, thermal and vacuum tests,...
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A Study in Experimental Methods of Human-Computer Communication for Patients After Severe Brain Injuries
PublikacjaExperimental research in the domain of multimedia technology applied to medical practice is discussed, employing a prototype of integrated multimodal system to assist diagnosis and polysensory stimulation of patients after severe brain injury. The system being developed includes among others: eye gaze tracker, and EEG monitoring of non-communicating patients after severe brain injuries. The proposed solutions are used for collecting...
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Issues of Measuring the Course of Batch Production Processes
PublikacjaIn order to meet demands induced by development of manufacturing processes and production systems, new criteria and indicators that would allow a multiple aspect and realistic rating of batch production process courses are necessary. The objective of this paper is to present the correlation between production processes measurement, its rating and production control, basing on case study analysis from production enterprise. A new...
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Effects of Xanthan Gum Biopolymer on the Permeability, Odometer, Unconfined Compressive and Triaxial Shear Behavior of a Sand
PublikacjaBiopolymers, which are microbially induced polymers, can be used as an alternative material to improve engineering performance of soils. In this paper, a laboratory study of 0.075-1.0 mm size sand and biopolymer (i.e., xanthan gum) mixtures with various mix ratios (0%, 0.5%, 1.0%, and 1.5%) was performed. The materials, specimen preparation, and test methods are described, as are the results of a suite of permeability, odometer, unconfined...
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Consideration of the safety of bungee jumping in relation to mechanical properties of the instalation based on a jump accident in Gdynia
PublikacjaThis paper considers a bungee jumping accident that took place in July 2019 in Gdynia, Poland. The authors conducted an investigation to determine the cause of the bungee rope failure. It was based on mechanical tests concerning the strength of the rope as well as the calculation of the force induced in the rope during the jump. Based on the theoretical and experimental results, the rope safety factor was estimated. It appeared...
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Induction motor bearings diagnostic indicators based on MCSA and normalized triple covariance
PublikacjaInduction motors are one of the most widely used electrical machines. Statistics of bearing failures of induction motors indicate, that they constitute more than 40% of induction motor damage. Therefore, bearing diagnosis is so important for trouble-free work of induction motors. The most common methods of bearing diagnosis are based on vibration signal analysis. The main disadvantage of those methods is the need for physical access...
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MCSA with Normalized Triple Covariance as a bearings diagnostic indicator in an induction motor
PublikacjaStatistics of bearing failures in induction motors indicate, that they constitute more than 40% of IM damage, therefore bearing diagnosis is very important. Vibration methods for bearing diagnostics have one major disadvantage - they require the availability of the machine for sensors installation. This is the reason for seeking new methods based on motor supply current analysis. Diagnosis of induction motors, conducted remotely...
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EMPIRICAL ASSESMENT OF THE MAIN DRIVING SYSTEM OF THE CIRCULAR SAWING MACHINE
PublikacjaThe producers of panel saws tend to improve sawing accuracy and minimise a level of vibrations, to increase their competitiveness at the market. Mechanical vibrations in the main saw driving system, which level depend on a plethora independent factors, may really affect sawing accuracy and general machine tool vibrations. The objective of the research was to explore vibrations signals of the main spindle system, and to extract...
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Modelling and Measurement of Folk Guitar: Truss Rod and Strings in Numerical Analysis of Tone
PublikacjaThe study makes an attempt to model a complete vibrating guitar including its non-linear features, specifically the tension-compression of truss rod and tension of strings. The purpose of such a model is to examine the influence of design parameters on tone. Most experimental studies are flawed by uncertainties introduced by materials and assembly of an instrument. Since numerical modelling of instruments allows for deterministic...
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Eulerian motion magnification applied to structural health monitoring of wind turbines
PublikacjaSeveral types of defects may occur in wind turbines, as physical damage of blades or gearbox malfunction. A wind farm monitoring and damage prediction system is built to observe abnormal vibrations of elements of wind turbine: blades, nacelle, and tower. Contactless methods are developed which do not require turbine stopping. In this work, structural health monitoring of a wind turbine is evaluated using a conversion from the captured...
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The conception of energetic investigations of the multisymptom fatigue of the simple mechanical systems' constructional materials
PublikacjaThe article presents the basic assumptions of the research project aimed, as the main scientific purpose, an identification of the slow-changeable energy processes surrounding the high-cycle fatigue of constructional materials within the plain mechanical system, especially the marine one, for diagnostic purposes. There is foreseen an application of alternative diagnostic methods based on energetic observations of the multi-symptom,...