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Wyniki wyszukiwania dla: drug delivery devices
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Enhanced Activity of P4503A4 and UGT1A10 Induced by Acridinone Derivatives C-1305 and C-1311 in MCF-7 and HCT116 Cancer Cells: Consequences for the Drugs’ Cytotoxicity, Metabolism and Cellular Response
PublikacjaActivity modulation of drug metabolism enzymes can change the biotransformation of chemotherapeutics and cellular responses induced by them. As a result, drug-drug interactions can be modified. Acridinone derivatives, represented here by C-1305 and C-1311, are potent anticancer drugs. Previous studies in non-cellular systems showed that they are mechanism-based inhibitors of cytochrome P4503A4 and undergo glucuronidation via UDP-glucuronosyltranspherase...
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Daniel Gromadzki Phd., Eng., Assistant Professor dr inż.
OsobyPhD in Macromolecular Chemistry of the Academy of Sciences of the Czech Republic and Charles University in Prague Teacher and educator in chemistry Expert evaluator in panels on biodegradable nanoparticles for medicine (European Commission) Reviewer in polymer chemistry for international journals Human rights advocate in Europe and Canada Languages: Polish, English, German, French, Czech, Dutch, Lithuanian, Bulgarian
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A model for agribusiness supply chain risk management using fuzzy logic. Case study: Grain route from Ukraine to Poland
PublikacjaIn order to establish new logistics routes, it is necessary to address several technical and organizational issues, among others. One of the most important criteria for evaluating the performance of a supply chain is the delivery time, proactive consideration of potential hazards and associated uncertainties that may occur along the route. However, the existing solutions are often passive and reactive, based on statistics, thus...
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Improvement of opipramol base solubility by complexation with β-cyclodextrin
PublikacjaOpipramol (OPI), a tricyclic antidepressant and anxiolytic compound, is administered orally in the form of a dihydrochloride. Salt form of the drug has a higher solubility in water and hence bioavailability and stability. A similar effect can be achieved by closing the hydrophobic part of the drug molecule in the cyclodextrin cavity. The paper presents opipramol inclusion complexes with beta-cyclodextrin (β-CD) in 1:1 molar ratio....
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A taxonomy of challenges to resilient message dissemination in VANETs
PublikacjaInter-vehicular communications is seen as a promising solution to a number of issues related with public road safety, road congestion management, and infotainment. However, Vehicular Ad-hoc NETworks (VANETs) characterized by high mobility of vehicles and facing a number of other issues related with high frequency wireless communications and network disconnections, encounter major challenges related with reliability of message delivery....
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Number of active users of the mobile banking application (only a mobile phone) - 2017
Dane BadawczeCustomers using mobile devices can use their bank account via the bank's website or a separate application. Such a solution allows for easier logging in (usually no customer number is required, but only a password) and a number of additional functions (from a more extensive interface to a larger number of possible operations - making a transfer, opening...
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Urządzenia Peryferyjne - 22/23
Kursy OnlineUP/PD 2023 {mlang pl}Przedmiot Urządzenia Peryferyjne i jego angielska wersja Peripheral Devices przeznaczony jest dla studentów II stopnia na specjalności Komputerowe Systemy Elektroniczne (Computer Electronic Systems). Tematem przedmiotu są różnorodne zagadnienia dotyczące urządzeń peryferyjnych systemów komputerowych, głównie umożliwiających komunikację człowiek-komputer, oraz ich prototypowanie i podstawowe podzespoły.{mlang} {mlang...
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Urządzenia Peryferyjne 2023/24
Kursy OnlineUP/PD 2023 {mlang pl}Przedmiot Urządzenia Peryferyjne i jego angielska wersja Peripheral Devices przeznaczony jest dla studentów II stopnia na specjalności Komputerowe Systemy Elektroniczne (Computer Electronic Systems). Tematem przedmiotu są różnorodne zagadnienia dotyczące urządzeń peryferyjnych systemów komputerowych, głównie umożliwiających komunikację człowiek-komputer, oraz ich prototypowanie i podstawowe podzespoły.{mlang} {mlang...
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Urządzenia Peryferyjne 2024/25
Kursy OnlineUP/PD 2023 {mlang pl}Przedmiot Urządzenia Peryferyjne i jego angielska wersja Peripheral Devices przeznaczony jest dla studentów II stopnia na specjalności Komputerowe Systemy Elektroniczne (Computer Electronic Systems). Tematem przedmiotu są różnorodne zagadnienia dotyczące urządzeń peryferyjnych systemów komputerowych, głównie umożliwiających komunikację człowiek-komputer, oraz ich prototypowanie i podstawowe podzespoły.{mlang} {mlang...
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Wiktor Sieklicki dr inż.
OsobyTytuł magistra oraz inżyniera uzyskał w specjalności Automatyka i Robotyka w Katedrze Mechaniki i Wytrzymałości Materiałów Wydziału Mechanicznego Politechniki Gdańskiej (2006). Tytuł doktora nauk technicznych w dyscyplinie Budowa Maszyn uzyskał w 2010 roku na Wydziale Mechanicznym PG (2010). Od 2010 roku zatrudniony na stanowisku Adiunkta w Katedrze Mechaniki i Mechatroniki Wydziału Mechanicznego PG. W latach 2011-2013 zatrudniony...
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Integrated circuit structure surface images obtained with contact capacitive imaging technique
Dane BadawczeThe measurements were done using NTEGRA Prima (NT-MDT) device. CSG 10Pt probe.
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Assessing Roadside Hybrid Energy Absorbers Using the Example of SafeEnd
PublikacjaA combination of crash cushion and end-terminal, hybrid energy absorbing devices have been in use worldwide for a few years already. They include SafeEnd, a system Poland has recently introduced. Some road authorities have raised concerns as regards the operating conditions of the devices and how they work together with safety barriers. The objective of this research is to clarify the concerns and answer the following questions:...
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Integration and Dependency in Software Lifecycle Based on Jazz Platform
PublikacjaSoftware delivery organizations are being asked to meet goals that seem mutually exclusive. Teams are asked to increase product quality, accelerate time to market, and meet increasing mandates from regulatory bodies. As software solutions and software development environments become rapidly more complex. Many business drivers compound these challlenges.
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The mechanism of internalization study of QDgreen−CD−FA−C−2028 conjugate at IC80 value to cancer (H460, Du-145, and LNCaP) and normal (MRC-5 and PNT1A) cells
Dane BadawczeThe influence of different endocytosis inhibitors on the internalization of QDgreen−CD−FA−C−2028 conjugate at IC80 value in cancer (H460, Du-145, and LNCaP) and normal (MRC-5 and PNT1A) cells. First, the cells were preincubated with: drug-free medium (no inhibitor), at 4 °C, 5 µM Cytochalasin D, 30 µM Amiloride, 80 µM Dynasore, 25 µM Pitstop 2 and 1.5...
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Modeling of pharmaceuticals mixtures toxicity with deviation ratio and best-fit functions models
PublikacjaThe present study deals with assessment of ecotoxicological parameters of 9 drugs (diclofenac (sodium salt), oxytetracycline hydrochloride, fluoxetine hydrochloride, chloramphenicol, ketoprofen, progesterone, estrone, androstenedione and gemfibrozil), present in the environmental compartments at specific concentration levels, and theirmutual combinations by couples against Microtox® and XenoScreen YES/YAS® bioassays. As the quantitative...
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Integration of protein tethering in a rapid and label-free SERS screening platform for drugs of abuse
PublikacjaSurface enhanced Raman spectroscopy (SERS) has emerged as a promising technique for the rapid and ultrasensitive detection of molecular species such as drugs of abuse in biofluids. Yet, it remains a significant challenge to create a viable screening tool for multiple drug classes, owing to the lack of affinity of certain species for the SERS substrate and to the matrix interference in complex media. Here we report a protein tethering...
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Antibacterial Porous Systems Based on Polylactide Loaded with Amikacin
PublikacjaThree porous matrices based on poly(lactic acid) are proposed herein for the controlled release of amikacin. The materials were fabricated by the method of spraying a surface liquid. Description is given as to the possibility of employing a modifier, such as a silica nanocarrier, for prolonging the release of amikacin, in addition to using chitosan to improve the properties of the materials, e.g., stability and sorption capacity....
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Utilizing Genome-Wide mRNA Profiling to Identify the Cytotoxic Chemotherapeutic Mechanism of Triazoloacridone C-1305 as Direct Microtubule Stabilization
PublikacjaRational drug design and in vitro pharmacology profiling constitute the gold standard in drug development pipelines. Problems arise, however, because this process is often dicult due to limited information regarding the complete identification of a molecule’s biological activities. The increasing aordability of genome-wide next-generation technologies now provides an excellent opportunity to understand a compound’s diverse eects...
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Influence of the electrosynthesis conditions on the spontaneous release of anti-inflammatory salicylate during degradation of polypyrrole coated iron for biodegradable cardiovascular stent
PublikacjaIn this work, the spontaneous release of anti-inflammatory salicylate from polypyrrole (PPy) coated iron has been studied during degradation of the material in phosphate buffer saline at 37 C. The sodium salicylate was incorporated into PPy in a one-step electropolymerization process. The influence of the synthesis conditions such as sodium salicylate concentration, pyrrole concentration and deposition charge on drug release profile...
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Supporting First Year Students Through Blended-Learning - Planning Effective Courses and Learner Support
PublikacjaHigher education has been actively encouraged to find more effective and flaxible delivery models to provide all students with access to good quality learning experiences. This paper describes students opinion about using e-learning techniques and their participation in courses provided in different ways as additional help and expectations of first year students.
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The II phase metabolism of endogenous and exogenous compounds, including antitumor chemotherapeutics
PublikacjaThe II phase metabolism, it is a set of metabolism and excretion pathways of endogenous as well as exogenous compounds including xenobiotics. UDP-glucuronyltransferases (UGTs; EC 2.4.1.17) are the most crucial representatives of II phase enzymes, which are responsible for the transformation of bilirubine and bile acids, steroids and thyroid hormones and lipids. Exogenous compounds, including drugs, carcinogens, environmental pollutants...
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Shrinking-shifting and amplifying-shifting device using transformation optics
PublikacjaBased on transformation optics (TO), this paper uses geometric divisions and linear coordinate transformations to design “shrinking-shifting—and reshaping”, and “amplifying-shifting—and reshaping” devices. The proposed devices can reshape the sizes and locations of the wrapped-objects inside the core-region. The shrinking-shifting device shrinks the larger object into a smaller one and shifts it to different location, whereas the...
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Overview of DC–DC Converters Dedicated to HVdc Grids
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Estimation of Parameters Associated With Individual Sources of Voltage Fluctuations
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Lagrangian model of an isolated dc-dc converter with a 3-phase medium frequency transformer accounting magnetic cross saturation
PublikacjaThis article presents a nonlinear equivalent circuit model of an isolated dc-dc converter with a 3-phase medium frequency transformer. The model takes into account the magnetic cross saturation of the 3-phase core-type magnetic circuit. The model is suitable in detailed electromagnetic transient simulations of power systems involving isolated dc-dc converters. The model is developed using the Lagrange energy method. It involves...
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Modified Preisach model of hysteresis in multi air gap ferrite core medium frequency transformer
PublikacjaThis article presents the modified Preisach model of hysteresis for a 3-phase medium frequency transformer in a 100 kW dual active bridge converter. The transformer magnetic core is assembled out of ferrite I-cores, which results in multiple parasitic air gaps. For this transformer, the hysteresis loops were measured and parameters of the Preisach model were determined. The Preisach distribution function is approximated with a...
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The transition of HIV within and between affected populations in Poland
PublikacjaThe aim of the paper is the estimation of probabilities that describe the transition of HIV within and between the following three populations: homosexual and bisexual men, injecting drug users and heterosexual persons in Poland in the years 1995-2006
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Condition monitoring of energy installations IDESII
Kursy OnlineMeasurement errors and uncertainties. Industrial measurements in the energy industry. Measuring devices. The basics of control in industry. Measurement characteristics in complex energy systems. Distributed Control System (DCS) (KSR).
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Clinical situations text database for Polish language
Dane BadawczeDataset contains a database of anonymized texts in Polish for the purposes of building a medical speech corpus, for clinical situations in the following areas: medical interview, interview and description of the result of an oncological examination, description of a radiological examination, description of a pathomorphological examination, description...
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Improving sensitivity of residual current transformers to high frequency earth fault currents
PublikacjaFor protection against electric shock in low voltage systems residual current devices are commonly used. However, their proper operation can be interfered when high frequency earth fault current occurs. Serious hazard of electrocution exists then. In order to detect such a current, it is necessary to modify parameters of residual current devices, especially the operating point of their current transformer. The authors proposed...
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Sensing of anesthetic drugs in blood with Raman spectroscopy
PublikacjaA proof-of-concept study of a Raman spectroscopy-based approach for measuring the content of anesthesia drugs in blood is presented. Spectra of spiked blood from several patients exhibit prominent changes in regions associated with the drug.
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Stable nanoconjugates of transferrin with alloyed quaternary nanocrystals Ag–In–Zn–S as a biological entity for tumor recognition
PublikacjaOne way to limit the negative effects of anti-tumor drugs on healthy cells is targeted therapy employing functionalized drug carriers. Here we present a biocompatible and stable nanoconjugate of transferrin anchored to Ag-In-Zn-S quantum dots modified with 11-mercaptoundecanoic acid (Tf-QD) as a drug carrier versus typical anticancer drug, doxorubicin. Detailed investigations of Tf-QD nanoconjugates without and with doxorubicin...
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Applying a Mesoscopic Transport Model to Analyse the Effects of Urban Freight Regulatory Measures on Transport Emissions—An Assessment
PublikacjaSustainable urban freight management is a growing challenge for local authorities due to social pressures and increasingly more stringent environmental protection requirements. Freight and its adverse impacts, which include emissions and noise, considerably influence the urban environment. This calls for a reliable assessment of what can be done to improve urban freight and meet stakeholders’ requirements. While changes in a transport...
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Electrochemistry meets enzymes: Investigation of the biotransformation pathway of C-1311 based on electrochemical simulation in comparison to in vitro methods.
PublikacjaThe knowledge of the metabolic pathways and the biotransformation of new drugs is one of the major challenges in pharmaceutical research. It is crucial for elucidation of degradation routes of the new biologically active compounds, especially in the area of possible toxicity. Conventional in vitro drug metabolism studies are based on incubating drug candidate with e.g. hepatocytes or, most importantly, liver cell microsomes and...
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Visualization of the surface of the Nafion membrane
Dane BadawczeFuel cells use the chemical energy of hydrogen or other fuels to produce electricity. If the fuel is hydrogen, the only products are electricity, water and heat. Fuel cells are unique in the variety of their potential applications, they can use a wide variety of fuels. They are also highly scalable devices that can power both cars and mobile phones....
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A Set of Low-power Microcontroller-based Modules Used for Testing of Small Energy Measurement Methods
PublikacjaEstimation of energy consumption of low-power devices is not widely discussed in the scientific literature, but this topic is getting more and more popular. Evaluation process of newly developed methods and instrumentation requires carefull treatment. In order to fulfill this niche, the set of micro-power microcontroller based devices was proposed. The devices represent typical energy consuption profiles and allow experimental verification...
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Jakub Jan Chabik dr inż.
OsobyBiogram Jakub Chabik jest absolwentem Politechniki Wrocławiskiej oraz studiów MBA na Uniwersytecie Ekonomicznym w Poznaniu. Posiada stopień naukowy doktora zarządzania. Kariera zawodowa Od 30 lat pracuje w międzynarodowych firmach na stanowiskach związanych z technologiami informatycznymi i zarządzaniem. W przesżłości prowadził projekt połaczenia dwóch instytucji finansowych, prowadząc fundamentalną zmianę kulturową w okresie szybkiego...
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Chemosensitization of multidrug resistant Candida albicans by the oxathiolone fused chalcone derivatives
PublikacjaThree structurally related oxathiolone fused chalcone derivatives appeared effective chemosensitizers, able to restore in part sensitivity to fluconazole of multidrug-resistant C.albicans strains. Compound 21 effectively chemosensitized cells resistant due to the overexpression of the MDR1 gene, compound 6 reduced resistance of cells overexpressing the ABC-type drug transporters CDR1/CDR2 and derivative 18 partially reversed fluconazole...
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Magnetization reversal process in flat and patterned exchange-biased CoO/[Co/Pd] thin films
PublikacjaNanostructured magnetic materials have gained great interest due to their possible technological applications in electronic and spintronic devices or in medicine as drug carriers. The key issue which decides on their potential industrial utilization is an exhibited type of a magnetization reversal process. Two main approaches used to describe the switching mechanism are the domain wall motion and coherent magnetization rotation,...
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The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748
PublikacjaDrug resistance is one of the major cause of pancreatic cancer treatment failure. Thus, it is still imperative to develop new active compounds and novel approach to improve drug efficacy. Here we present 9-amino-1-nitroacridine antitumor agent, C-1748, developed in our laboratory, as a candidate for pancreatic cancer treatment. We examined (i) the cellular response of pancreatic cancer cell lines: Panc-1, MiaPaCa-2, BxPC-3 and...
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Modeling of TiO2-Based Electron-Selective Contacts for Crystalline Silicon Solar Cells
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Frequency compensation for two-stage operational amplifiers with improved PSRR characteristic
PublikacjaW pracy została opisana nowa metoda kompensacji częstotliwościowej dwustopniowych wzmacniaczy operacyjnych. Metoda kompensacji gwarantuje uzyskanie stabilnej pracy wzmacniacza operacyjnego przy założeniu że wzmocnienie układu z zamkniętą pętlą sprzężenia zwrotnego jest ograniczone do wartości kilkunastu decybeli. W porównaniu do innych znanych metod kompensacji, zaproponowana metoda umożliwia co najmniej dziesięciokrotne poszerzenie...
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Supply current spectrum estimation of digital cores at early design
PublikacjaPrzedstawiono nową aproksymacyjną metodę obliczania widma prądu zasilania układów cyfrowych. Metoda oparta jest na charakterystyce impulsów prądowych w kategoriach ich czasu narastania, opadania i długości impulsu. Górną granicę widma (obwiednię) można obliczyć posługując się gęstością prawdopodobieństwa zmian stanu sygnałów w węzłach układu cyfrowego. W odróżnieniu od znanych metod, metoda proponowana wykorzystuje ograniczoną...
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Output-capacitorless low-dropout regulator using a cascoded flipped voltage follower
PublikacjaPrzedstawiono udoskonaloną konfigurację wtórnika napięciowego w odwróconej konfiguracji oraz jej zastosowanie w regulatorze o małym spadku napięcia. W pracy przedstawiono teoretyczną analizę podstawowych parametrów wtórnika oraz regulatora napięcia. Ponadto przedstawiono wyniki pomiarów parametrów prototypowego układu scalonego wykonanego z użyciem technologii CMOS 0.35 um. Uzyskane wyniki porównano z rezultatami uzyskanymi w innych...
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Accurate Computation of IGBT Junction Temperature in PLECS
PublikacjaIn the article, a new method to improve the accuracy of the insulated-gate bipolar transistor (IGBT) junction temperature computations in the piecewise linear electrical circuit simulation (PLECS) software is proposed and described in detail. This method allows computing the IGBT junction temperature using a nonlinear compact thermal model of this device in PLECS. In the method, a nonlinear compact thermal model of the IGBT is...
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Metrological analysis of precision of the system of delivering a water capsule for explosive production of water aerosol
PublikacjaIn this paper an analysis of precision of the system controlling delivery by a helicopter of water-capsule designed for extinguishing large scale fires is presented. The analysis was performed using the numerical method of distribution propagation (Monte Carlo method) supplemented with results of application of the uncertainty propagation method. In addition the optimum conditions for the airdrop are determined to ensure achievement...
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The influence of ILs on TiO2 microspheres activity towards 5-FU removal under artificial sunlight irradiation
PublikacjaIn this work, the effect of various ionic liquids (ILs), namely, choline chloride [Chol][Cl], hexadecylpyridynium chloride [HDPy][Cl], and tributylmethylammonium chloride [TBMA][Cl], on the morphology, surface compo-sition in relation to photocatalytic oxidation of 5-fluorouracil (5-FU) and phenol in the presence of TiO2 pho-tocatalysts under artificial sunlight conditions was investigated. The highest photoactivity towards cytostatic...
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Quantification of unconjugated and total ibuprofen and its metabolites in equine urine samples by gas chromatography–tandem mass spectrometry: Application to the excretion study
PublikacjaIbuprofen (IBU) is a widely used nonsteroidal anti-inflammatory drug (NSAID) in human and also veterinary medicine. NSAIDs are usually highly metabolized compounds in horses; they are often present in equine urine, mostly in their conjugated forms (glucuronides). Thus, hydrolysis to cleave the glucuronide linkage prior to anti-doping analysis is often necessary for improving detection. In this study, unconjugated and total IBU...
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Synthesis of disubstituted 1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids derivatives
Publikacja1,3,4,9-tetrahydropyrano[3,4-b ]indole-1-acetic acid derivatives are of interest for pharmaceutical research as a core structure for synthesis of biological active substance - Etodolac (selective Cyclooxygenase-2 inhibitor, which belongs to the Non-steroidal Anti-inflammatory Drug, NSAID, that shows a clin-ically effective analgesic and anti-inflammatory activity). Here the way of synthesis of two 1,3,4,9-tetrahydropyrano[3,4-b...
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Comparative molecular modelling of biologically active sterols
PublikacjaMembrane sterols are targets for a clinically important antifungal agent – amphotericin B. The relatively specific antifungal action of the drug is based on a stronger interaction of amphotericin B with fungal ergosterol than with mammalian cholesterol. Conformational space occupied by six sterols has been defined using the molecular dynamics method to establish if the conformational features correspond to the preferential interaction...