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Wyniki wyszukiwania dla: steroid sulfatase
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Sizes of iron hydroxide particles formed during ferric coagulation processes
PublikacjaThe aim of the study was to apply laser granulometer for measuring sizes of particles formed in iron-based coagulation process in water, which did not contain significant amounts of organic compounds. The research was conducted using tap water, obtained from underground sources. Iron sulfate in doses of 2.0–10.0 mgFe L–1 was added to water. During initial stage of flocculation, iron hydroxide particles reached dimensions between...
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ANALYSIS OF THE IMPACT OF THE PLANNED SEWAGE DISCHARGE FROM THE ‘NORTH’ POWER PLANT ON THE VISTULA WATER QUALITY
PublikacjaThe paper presents results of analysis of the industrial sewage discharge impact from the ‘North’ Power Plant on the Vistula water quality around 45+330 of the river kilometer. For the analysis, the two-dimensional models of flow, impurities and temperature transport were used. Hydrological conditions of the analyzed section of the river, characteristic flows and bathymetry of the riverbed in the first instance were defined....
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Application of persulfate-based oxidation processes to address diverse sustainability challenges: A critical review
PublikacjaOver the past years, persulfate (PS) is widely applied due to their high versatility and efficacy in decontamination and sterilization. While treatment of organic chemicals, remediation of soil and groundwater, sludge treatment, disinfection on pathogen microorganisms have been covered by most published reviews, there are no comprehensive and specific reviews on its application to address diverse sustainability challenges, including...
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Strategy towards the use of ultrafiltration and reverse osmosis for industrial water recovery and reuse as part of the Green Deal Implementation
PublikacjaIn line with the European Parliament’s Resolution of February 10th, 2021 on the new action plan for a closed economy, most of the activities undertaken in the wastewater treatment process should focus on the search for new technologies that use wastewater as a source of water and nutrients. The paper reviews the concept of water reuse in industrial installations, with special emphasis on the use of membrane technologies for this...
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Chemical, Physical, and Mechanical Properties of 95-Year-Old Concrete Built-In Arch Bridge
PublikacjaThis research aimed to determine the durability and strength of an old concrete built-in arch bridge based on selected mechanical, physical, and chemical properties of the concrete. The bridge was erected in 1925 and is located in Jagodnik (northern Poland). Cylindrical specimens were taken from the side ribs connected to the top plate using a concrete core borehole diamond drill machine. The properties of the old concrete were...
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Pochodne amfoterycyny B z zawadą przestrzenną - nowa grupa antymykotyków o niskiej toksyczności i aktywnych względem szczepów z opornością wielolekową. Badanie natury i mechanizmów ich właściwości fizykochemicznych i biologicznych
PublikacjaBadania prezentowane w ramach niniejszej rozprawy koncentrują się na poznaniu i wyjaśnieniu molekularnych mechanizmów leżących u podstaw poprawy selektywnej toksyczności pochodnych amfoterycyny B z zawadą przestrzenną jak również ich aktywności względem opornych szczepów grzybowych. Kluczowe wnioski wynikające z pracy są następujące: i) mutanty drożdżaków z defektem biosyntezy ergosterolu zachowują wrażliwość na badane związki...
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Improved degradation of etodolac in the presence of core-shell ZnFe2O4/SiO2/TiO2 magnetic photocatalyst
PublikacjaIn the present study, susceptibility to photocatalytic degradation of etodolac, 1,8-diethyl-1,3,4,9 – tetrahydro pyran - [3,4-b] indole-1-acetic acid, which is a non-steroidal anti-inflammatory drug frequently detected in an aqueous environment, was for the first time investigated. The obtained p-type TiO2-based photocatalyst coupled with zinc ferrite nanoparticles in a core-shell structure improves the separation and recovery...
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Occurrence and seasonal variations of 25 pharmaceutical residues in wastewater and drinking water treatment plants
PublikacjaThousands of tons of pharmaceuticals are introduced into the aqueous environment due to their incomplete elimination during treatment process in wastewater treatment plants (WWTPs) and water treat- ment plants (WTPs). The presence of pharmacologically active compounds in the environment is of a great interest because of their potential to cause negative effects. Furthermore, drugs can undergo different pro- cesses leading to the...
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Projektowanie synteza oraz badanie aktywności biologicznej nowych inhibitorów Sulfatazy Steroidowej (STS) na bazie związków fosforoorganicznych
ProjektyProjekt realizowany w Wydział Chemiczny zgodnie z porozumieniem UMO-2011/03/D/NZ7/03985 z dnia 2012-08-06
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Structural and spectroscopic analysis of a new family of monomeric diphosphinoboranes
PublikacjaWe present a series of amino- and aryl(diphosphino)boranes R2PB(R’’)PR’2, where R2P, R’2P = tBu2P, tBuPhP, Ph2P, Cy2P, and R’’ = iPr2N, Ph, which were obtained via the metathesis reaction of iPr2NBBr2 or PhBBr2 with selected lithium phosphides. The structures of isolated diphosphinoboranes were characterized in the solid state and in solution by means of X-ray diffraction and NMR spectroscopy, respectively. The utility of these...
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Synthesis, structural characterization and reactivity of new trisubstituted N1-acylamidrazones: solid state and solution studies
PublikacjaA series of new linear trisubstituted N1-acylamidrazones have been investigated using a variety of analytical techniques and theoretical calculations to check the influence of the type of N1-acyl substituent on the resonance forms and conformational behavior in the solid state and in solution. The 1D- and 2D-NMR experiments, supported by computational studies, revealed that in solution all amidrazones exhibit conformational syn/anti...
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Sugar matters: sugar moieties as reactivity-tuning factors in quercetin O-glycosides
PublikacjaQuercetin, one of the most abundant flavonoids in plant-based foods, commonly occurs in nature in various glycosylated forms. There is still a less explored aspect regarding the cause of its glycosides diversity, depending on the sugars moiety attached. This work focuses on four widespread quercetin glycosides—hyperoside, isoquercitrin, quercitrin and rutin—by testing property-tuning capacity of different sugar moieties and thus...
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Lattice Dynamics and Structural Phase Transitions in Eu2O3
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Enhancing nitrogen removal in the partial denitrification/anammox processes for SO4− - Rich wastewater treatment: Insights into autotrophic and mixotrophic strategies
PublikacjaThe investigation of partial denitrification/anammox (PD/anammox) processes was conducted under autotrophic (N–S cycle) and mixotrophic (N–S–C cycle) conditions over 180 days. Key findings revealed the remarkable capability of SO42--dependent systems to produce NO2− effectively, supporting anaerobic NH4+ oxidation. Additionally, SO42− served as an additional electron acceptor in sulfate reduction ammonium oxidation (SRAO). Increasing...
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Biomarkers of alcohol consumption in body fluids - possibilities and limitations of application in toxicological analysis
PublikacjaEthyl alcohol is the most popular legal drug, but its excessive consumption causes social problems. Despite many public campaigns against alcohol use, car accidents, instances of aggressive behaviour, sexual assaults and deterioration in labor productivity caused by inebriated people is still commonplace. Fast and easy diagnosis of alcohol consumption is required in order to introduce proper and effective therapy, and is crucial...
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Structural analysis and physico-chemical characterization of mononuclear manganese(II) and polynuclear copper(II) complexes with pyridine-based alcohol
PublikacjaTwo novel manganese(II) and copper(II) complexes, mononuclear [Mn(H2O)2(2-(CH2)2OHpy)2](NO3)2 (1) and polynuclear [Cu(SO4)(2-(CH2)2OHpy)2]n (2), based on 2-(hydroxyethyl)pyridine (2-(CH2)2OHpy) were synthesised and fully characterised using X-ray structure analysis as well as spectroscopic, magnetic and thermal methods. Both central metal ions Mn(1) and Cu(1) are coordinated by two N,O-donor 2-(CH2)2OHpy ligands and possess an...
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Dynamika molekularna oddziaływań przeciwgrzybowych heptaenów aromatycznych i ich izomerów all-trans ze sterolami w błonach lipidowych
PublikacjaAromatyczne heptaeny (AH) należą do grupy makrolidów polienowych o działaniu przeciwgrzybowym. Antybiotyki z tej grupy były pierwszymi, które zostały wykorzystane w terapii układowych infekcji grzybiczych. Amfoterycyna B (AmB) oraz nystatyna, czyli niearomatyczni przedstawiciele makrolidów heptaenowych, mają istotne znaczenie kliniczne w leczeniu, odpowiednio, grzybic wewnętrznych i zewnętrznych. Molekularne podstawy mechanizmu...
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Mechanism of Binding of Antifungal Antibiotic Amphotericin B to Lipid Membranes: An Insight from Combined Single-Membrane Imaging, Microspectroscopy, and Molecular Dynamics
PublikacjaAmphotericin B is a lifesaving polyene antibiotic used in the treatment of systemic mycoses. Unfortunately, the pharmacological applicability of this drug is limited because of its severe toxic side effects. At the same time, the lack of a well-defined mechanism of selectivity hampers the efforts to rationally design safer derivatives. As the drug primarily targets the biomembranes of both fungi and humans, new insights into the...
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Spatial distribution of pharmaceuticals in conventional wastewater treatment plant with Sludge Treatment Reed Beds technology
PublikacjaPharmaceutical residues are an emerging environmental problem. It is strongly confirmed that pharmaceuticals are present in soils and environmental waters (surface, marine and even groundwater), and that wastewater treatment plant (WWTP) effluents are the main source of pharmaceuticals in the watershed. The aim of this studywas to recognize the spatial distribution and seasonal changes of selected pharmaceuticals in conventional WWTP...
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One-Step Synthesis of W/O and O/W Emulsifiers in the Presence of Surface Active Agents
PublikacjaThe main goal of this study was to describe the method of the synthesis of the dodecyl-, tetradecyl-, hexadecyl- and octadecyl-propylene glycol emulsifiers in the presence of selected anionic and nonionic surfactants. Acyl propylene glycol emulsifiers were produced by esterification of propane-1,2-diol (propylene glycol, PG) with C12:0-C18:0 fatty acids in the presence of anionic sodium dodecyl sulfate (SDS) and nonionic-poly(ethylene...
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Pharmaceuticals wastewater treatment via different advanced oxidation processes: Reaction mechanism, operational factors, toxicities, and cost evaluation – A review
PublikacjaPharmaceuticals comprises different drugs used for treating different infections in human being and animals. The huge quantities of pharmaceuticals used are found to discharge into different water resources and cause different health and environmental problems. The continuous and large-scale discharge of pharmaceuticals increases their persistency which can consequently make them more toxic. The different advanced oxidation processes...
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High-performance activation of ozone by sonocavitation for BTEX degradation in water
PublikacjaThis work presents a novel advanced oxidation process (AOP) for degradation of emerging organic pollutants – benzene, toluene, ethylbenzene and xylenes (BTEXs) in water. A comparative study was performed for sonocavitation assisted ozonation under 40–120 kHz and 80–200 kHz dual frequency ultrasounds (DFUS). Based on the obtained results, the combination of 40–120 kHz i.e., low-frequency US (LFDUS) with O3 exhibited excellent oxidation...
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Degradation of tetracycline antibiotic utilizing light driven-activated oxone in the presence of g-C3N4/ZnFe LDH binary heterojunction nanocomposite
PublikacjaIn the present study, a binary heterojunction nanocomposite composed of graphitic carbon nitride (g-C3N4) and Zn/Fe-contained layered double hydroxide (ZnFe LDH) was employed as heterogeneous catalyst for the decomposition of tetracycline (TC) antibiotic utilizing Oxone and UV light irradiation. The sole use of g-C3N4/ZnFe LDH as adsorbent led to the negligible elimination of TC. In addition, the sole use of Oxone or UV (photolysis)...
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Hybrid metal and non-metal activation of Oxone by magnetite nanostructures co-immobilized with nano-carbon black to degrade tetracycline: Fenton and electrochemical enhancement with bio-assay
PublikacjaElectrochemically synthesized magnetite nanostructures (ESMNPs) as a metal activator and nano-carbon black (NCB) as a non-metal activator were co-immobilized by alginate natural polymer to activate Oxone for the degradation of tetracycline (TC) antibiotic. The formation of sulfate radical was indirectly confirmed during the Oxone/ESMNPs/NCB/alginate process via the addition of scavenging compounds. This study revealed the high...
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The Use of Organic Coagulants in the Primary Precipitation Process at Wastewater Treatment Plants
PublikacjaMeasurements for determining the effect of chemically enhanced primary treatment (CEPT) on the efficiency of pollutant removal from wastewater were carried out using conventional inorganic coagulants PIX113 with polymer A110 (Kemipol, Police, Poland) and unconventional cationic organic coagulants Cofloc (Attana, Coalville, UK) C29510 (Kemipol, Police, Poland) and Sedifloc 575 (3F Chimica, Sandrigo, Italy). The average removal efficiency...
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Corrosion Inhibition Mechanism and Efficiency Differentiation of Dihydroxybenzene Isomers Towards Aluminum Alloy 5754 in Alkaline Media
PublikacjaThe selection of efficient corrosion inhibitors requires detailed knowledge regarding the interaction mechanism, which depends on the type and amount of functional groups within the inhibitor molecule. The position of functional groups between different isomers is often overlooked, but is no less important, since factors like steric hinderance may significantly affect the adsorption mechanism. In this study, we have presented how...
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Solvothermal synthesis and structural characterization of three polyoxotitanium-organic acid clusters
PublikacjaThree new titanium oxo-clusters Ti4O2(OiPr)10(OOCPhMe)2 (I), Ti6O4(OEt)8(OOCPhMe)8 (II) and Ti6O6(OEt)6(OOCCHPh2)6 (III) were obtained by easy one-step solvothermal reactions of titanium(IV) isopropoxide, alcohols and carboxylic acids. The three compounds were characterized by single-crystal and powder X-ray diffraction, TGA/DSC, optical and electron microscopy, and FTIR and NMR spectroscopy. X-ray powder diffraction and spectroscopy...
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Phonon confinement and interface lattice dynamics of ultrathin high-k rare earth sesquioxide films: the case of Eu2O3 on YSZ(001)
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Comparison of 2D and 3D culture models in the studies of the biological response induced by unsymmetrical bisacridines in cancer cells
PublikacjaMulticellular tumor spheroids are a good tool for testing new anticancer drugs, including those that may target cancer stem cells (CSCs), responsible for cancer progression, metastasis, and recurrence. Therefore, following the initial evaluation of the impact of antitumor unsymmetrical bisacridines (UAs) on lung and colon cancer cells using traditional monolayer cultures, I extended my investigations and applied the spherical model....
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P-448 The impact of assisted reproductive technology for second births: a follow-up study
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Enhanced solar light photocatalytic performance of Fe-ZnO in the presence of H2O2, S2O82−, and HSO5− for degradation of chlorpyrifos from agricultural wastes: Toxicities investigation
PublikacjaThis study reported Fe doped zinc oxide (Fe-ZnO) synthesis to degrade chlorpyrifos (CPY), a highly toxic organophosphate pesticide and important sources of agricultural wastes. Fourier transform infrared, X-ray diffraction, scanning electron microscope, and energy-dispersive X-ray spectroscopic analyses showed successful formation of the Fe-ZnO with highly crystalline and amorphous nature. Water collected from agricultural wastes...
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Bimetallic Bi/Cu0-catalyzed persulfate-based advanced oxidation processes towards clofibric acid degradation in wastewater
PublikacjaClofibric acid (CFA), an important blood-lipid regulatory drug is an emerging organic pollutant and widely reported in water resources. A novel bimetallic, bismuth/zero valent cupper (Bi/Cu0) catalyst was prepared which showed better physiological, structural, and catalytic properties than Cu0. The Bi/Cu0 effectively catalyzed persulfate (S2O82−) and caused 85% degradation of CFA. The Bi coupling improved reusability and stability...
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Experimental Study of the Resistance to Influence of Aggressive Liquids on Lightweight Concrete
PublikacjaIn light of the scientific research, the corrosion of concrete structures is one of the main problems that may reduce their durability due to the negative impact of the natural environment. The paper analyzes the influence of the type of component on the selected properties of lightweight concrete subjected to the influence of aggressive liquids. Four concrete mixes were prepared with a granular aggregate made of foamed glass (GEGA)...
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Thermally activated natural chalcopyrite for Fenton-like degradation of Rhodamine B: Catalyst characterization, performance evaluation, and catalytic mechanism
PublikacjaIn this work, catalytic activity of natural chalcopyrite (CuFeS2) was improved by thermal activation. The modified chalcopyrite was used as efficient catalyst for degradation of organic dye Rhodamine B (RhB) through advanced oxidation process (AOP). Effects of catalyst dosage, H2O2 concentration, reaction temperature, solution pH, anions, and natural organic matter on the degradation efficiency of RhB were investigated. This study...
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Effect of bio-polyol molecular weight on the structure and properties of polyurethane-polyisocyanurate (PUR-PIR) foams
PublikacjaThe increasing interest in polyurethane materials has raised the question of the environmental impact of these materials. For this reason, the scientists aim to find an extremely difficult balance between new material technologies and sustainable development. This work attempts to validate the possibility of replacing petrochemical polyols with previously synthesized bio-polyols and their impact on the structure and properties...
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Projektowanie, synteza oraz badanie aktywności biologicznej nowych inhibitorów sulfatazy steroidowej (STS) na bazie amidosiarczanowych pochodnych zawierających wiązania C-F
ProjektyProjekt realizowany w Katedra Chemii Organicznej zgodnie z porozumieniem UMO-2015/19/N/NZ7/00938 z dnia 2016-07-22
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Inhibitory sulfatazy steroidowej na bazie amidosiarczanowych pochodnych 4-(1-fenylo-1H-[1,2,3]triazol-4-ylo)-fenolu jako potencjalne środki przeciwnowotworowe
ProjektyProjekt realizowany w Katedra Chemii Nieorganicznej zgodnie z porozumieniem TANGO-IV-A/0004/2019-00 z dnia 2020-08-28
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Correlation between the Reactivity and Spectroscopic Properties of N-Substituted Secondary Thioamides. New Intramolecular N• •H+• •N Binding Approach and Proton Complexes Based on Thioamide Ligation
PublikacjaFrom a comparison of chem. shifts and wavenumbers of several secondary thioamides and amides having monocationic substituents attached to thiocarbamoyl or carbamoyl groups by a polymethylene chain, new intramol. unconventional N···H+···N H bonding effects were discovered. It is argued that the CH2-N rotation is hindered and two +H···NHMe nonequiv. protons occur in a proton spectrum of hydrochloride RCH2C(S)NH(CH2)3NHMe-HCl...
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Atmospheric deposition in coniferous and deciduous tree stands in Poland
PublikacjaThe objective of this study was to assess the transformation of precipitation in terms of quantity and chemical composition following contact with the crown layer in tree stands with varied species composition, to investigate the effect of four predominant forest-forming species (pine, spruce, beech, and oak) on the amount and composition of precipitation reaching forest soils, and to determine the sources of pollution in atmospheric...
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Sequential treatment of landfill leachate by electrocoagulation/aeration, PMS/ZVI/UV and electro-Fenton: Performance, biodegradability and toxicity studies
PublikacjaThis study presents a systematic study on sequential treatment of highly resistant landfill leachate by electrocoagulation (EC)/aeration, sulfate radical advanced oxidation process (SR-AOP) and electro-Fenton (EF). In case of SR-AOP, peroxymonosulfate (PMS) catalyzed by zero valent iron (ZVI) and ultraviolet irradiation (UV) system was developed. Treatment process was optimized in respect to COD removal. Analysis of results revealed...
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Advanced Oxidation Processes for the Treatment of Contaminants of Emerging Concern
PublikacjaThe application of contaminants of emerging concern (CEC) such as pharmaceuticals and personal care products (PPCPs), pesticides, plasticizers, endocrine disruptors, surfactants, flame retardants and polycyclic aromatic hydrocarbons (PAHs) became an indispensable requirement of the current era. Although the CEC are useful for wide-spectrum purposes, they can also result in undesirable effects on human health and other animals....
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Transport deficiency is the molecular basis of Candida albicans resistance to antifungal oligopeptides
Publikacja(FMDP), an inhibitor of glucosamine-6-phosphate synthase, exhibited growth inhibitory activity against Candida albicans, with minimal inhibitory concentration values in the 0.05–50 mg/L range. Uptake by the peptide permeases was found to be the main factor limiting an anticandidal activity of these compounds. Di- and tripeptide containing FMDP (F2 and F3) were transported by Ptr2p/Ptr22p peptide transporters (PTR) and FMDP-containing...
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Synthesis, characteristics, and photocatalytic activity of zinc oxide nanoparticles stabilized on the stone surface for degradation of metronidazole from aqueous solution
PublikacjaAbstract Background: The presence of antibiotics such as metronidazole in wastewater even at low concentrations requires searching for a suitable process such as advanced oxidation process (AOP) to reduce the level of pollutants to a standard level in water. Methods: In this study, zinc oxide (ZnO) nanoparticles were synthesized by thermal method using zinc sulfate (ZnSO4) as a precursor, then, stabilized on stone and was used...
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Projektowanie, synteza oraz badanie aktywności biologicznej nowych amidosiarczanowych inhibitorów sulfatazy steroidowej zawierających w swojej konstytucji ugrupowania fosforowe lub wiązania C-F
ProjektyProjekt realizowany w Katedra Chemii Organicznej zgodnie z porozumieniem UMO-2017/24/T/NZ7/00271 z dnia 2017-09-18
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Two small RNAs conserved in Enterobacteriaceae provide intrinsic resistance to antibiotics targeting the cell wall biosynthesis enzyme glucosamine-6-phosphate synthase
PublikacjaFormation of glucosamine-6-phosphate GlcN6P) by enzyme GlcN6P synthase (GlmS) represents the first step in bacterial cell envelope synthesis. In Escherichia coli, expression of glmS is controlled by small RNAs (sRNAs) GlmY and GlmZ. GlmZ activates the glmS mRNA by base-pairing. When not required, GlmZ is bound by adapter protein RapZ and recruited to cleavage by RNase E inactivating the sRNA. The homologous sRNA GlmY activates...
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Józef Kur prof. dr hab.
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DETERMINATION OF SURFACTANTS IN ENVIRONMENTAL SAMPLES. PART II. ANIONIC COMPOUNDS
PublikacjaSurfactants (SAA) with negative charge of polar group are named as anionic compounds. They are main constituent of most products containing synthetic surfactants. The linear alkylbenzene sulfonates (LAS), alkyl ethoxysulfates (AES) and alkyl sulfates (AS) are typically applied from this class of compounds. Those surfactants are ingredients of household detergents and cleaners, laundry detergents, cosmetic. Moreover they can be...
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L1 Cell Adhesion Molecule Overexpression Down Regulates Phosphacan and Up Regulates Structural Plasticity-Related Genes Rostral and Caudal to the Complete Spinal Cord Transection
PublikacjaL1 cell adhesion molecule (L1CAM) supports spinal cord cellular milieu after contusion and compression lesions, contributing to neuroprotection, promoting axonal outgrowth, and reducing outgrowth-inhibitory molecules in lesion proximity. We extended investigations into L1CAM molecular targets and explored long-distance effects of L1CAM rostral and caudal to complete spinal cord transection (SCT) in...
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Ab initio and nuclear inelastic scattering studies of Fe3Si/GaAs heterostructures
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Seasonal changes of mercury speciation in the coastal sediments
PublikacjaPurpose Mercury speciation in sediments is linked to environmental conditions and processes. Domination of particular mercury species depends on its source, displays considerable seasonal behavior, and may be further modified due to oxygen levels, icing conditions, or the input of fresh organic matter. The purpose of this study was to examine the coastal area of the Gulf of Gdańsk in terms of mercury contamination and the influence...