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Search results for: CURRENT-CARRYING CAPACITY
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Biomarkers of alcohol consumption in body fluids - possibilities and limitations of application in toxicological analysis
PublicationEthyl alcohol is the most popular legal drug, but its excessive consumption causes social problems. Despite many public campaigns against alcohol use, car accidents, instances of aggressive behaviour, sexual assaults and deterioration in labor productivity caused by inebriated people is still commonplace. Fast and easy diagnosis of alcohol consumption is required in order to introduce proper and effective therapy, and is crucial...
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Volatile Organohalogen Compounds Determination with Dispersive Liquid-Liquid Microextraction Applying Solvent Lighter than Water
PublicationBackground: Volatile organohalogen compounds (VOX) are a group of environmental pollutants that risk the quality of drinking water. These compounds are characterized by certain acute and chronic toxicities, possessing mutagenic properties. Because of these potential risks factors that these compounds cause, the maximum allowable concentrations (MACs) have been established by respective organizations. The abundance of VOX, their...
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Developments in the synthesis and biological activity of Glycyl-L-Histydyl-L-Lysine derivatives
PublicationWe emphasize on the methods of the synthesis described in the literature and present the aspects of Gly-His-Lys structure modifications that played a key role in scientific research.
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The Chemistry of Mycophenolic Acid-Synthesis and Modifictions Towards Desired Biological Activity
PublicationDokonano przeglądu literatury chemicznej na temat metod syntezy kwasu mykofenolowego oraz jego pochodnych, a także zależności pomiędzy ich strukturą i aktywnością biologiczną.
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Application of Immunological Techniques (from Vaccination to FinalMeasurements) in Determination of Pharmaceutical Residues in Environmental Samples
PublicationWiele biologicznie aktywnych związków wytwarzanych przez człowieka trafia ostatecznie do środowiska. Ich los środowiskowy pozostaje nadal wyzwaniem dla analityków środowiskowych i osób odpowiedzialnych za szacowanie ryzyka. Artykuł przedstawia przegląd jednej z najszerszych i bezpośrednich metod analiz środowiskowych - immunoanalitykę - ze szczególnych uwzględnieniem jej zastosowania do oznaczania jakościowego i ilościowego pozostałości...
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Depression as is Seen by Molecular Spectroscopy. Phospholipid- Protein Balance in Affective Disorders and Dementia
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Essentials and Perspectives of Computational Modelling Assistance for CNS-oriented Nanoparticle-based Drug Delivery Systems
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Pincer Complexes Based on Phosphinoaminopyridines: Synthesis, Structural Characterization and Catalytic Applications
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Rhodotorulic Acid and its Derivatives: Synthesis, Properties, and Applications
PublicationSiderophores are low molecular weight compounds produced by microorganisms to scavenge iron in iron-deficient environments. Rhodotorulic acid (RA), a natural hydroxamate siderophore, plays a vital role in iron acquisition for fungi and bacteria. As the simplest natural hydroxamate siderophore, RA exhibits a high affinity for ferric ions, enabling it to form stable complexes that facilitate iron uptake and transport within microorganisms....
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Bioavailability of Tannins and Other Oligomeric Polyphenols: a Still to Be Studied Phenomenon
PublicationPurpose of Review Polyphenols are a group of plant secondary metabolites characterized with the presence ofmultiples of phenol structural units. Tannins are plant originated phenolic substances, which play an important role in plant defense system as well as have found applications in medicine, industry, and other fields of human activity. Despite these, the mechanisms of bioavailability of these substances are poorly studied and...
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Opioid Growth Factor and its Derivatives as Potential Non-toxic Multifunctional Anticancer and Analgesic Compounds
PublicationIn this paper, we review the structure-activity relationship of OGF and its analogues. We highlight also OGF derivatives with analgesic, immunomodulatory activity and the ability to penetrate the blood-brain barrier and may be used as safe agents enhancing chemotherapy efficacy and improving quality of life in cancer patients. The reviewed papers indicate that Met-enkephalin and its analogues are interesting candidates for the...
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Prophylaxis of Non-communicable Diseases: Why Fruits and Vegetables may be Better Chemopreventive Agents than Dietary Supplements Based on Isolated Phytochemicals?
PublicationThe World Health Organization (WHO) report from 2014 documented that non-communicable socalled civilization diseases such as cardiovascular disease, chronic respiratory diseases, cancer or type 2 diabetes are responsible for over 50% of all premature deaths in the world. Research carried out over the past 20 years has provided data suggesting that diet is an essential factor influencing the risk of development of these diseases....
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Culturable bacteria from pesticides contaminated soils in Poland
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Complexation of Bioelements and Toxic Metals by Polyphenolic Compounds - Implications for Health
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Effect of Glycemic Disorders and Habits on the Concentration of Selected Neurotrophic Factors in Patients with Lumbosacral Intervertebral Disc Degeneration
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Protective Effect of Aronia Melanocarpa Polyphenols on Cadmium Accumulation in the Body: A Study in a Rat Model of Human Exposure to this Metal
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QSRR Evaluation of the New Anticancer Sulfonamides in View of the cis-trans Isomerism
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Biological Activity of Compounds Exhibiting Local Anesthetics's Properties Evaluated by QSAR Approach
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Aqueous Extracts of Selected Potentilla Species Modulate Biological Activity of Human Normal Colon Cells
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New Insights into Dietary Supplements Used in Sport: Active Substances, Pharmacological and Side Effects
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Antioxidants as a Potential Preventive and Therapeutic Strategy for Cadmium
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Rhodotorulic Acid and its Derivatives: Synthesis, Properties, and Applications
PublicationSiderophores are low molecular weight compounds produced by microorganisms to scavenge iron in iron-deficient environments. Rhodotorulic acid, a natural hydroxamate siderophore, plays a vital role in iron acquisition for fungi and bacteria. As the simplest natural hydroxamate siderophore, it exhibits a high affinity for ferric ions, enabling it to form stable complexes that facilitate iron uptake and transport within microorganisms....
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Consumer Trust in Online Advertising - How Negative Perception Impacts its Effectiveness
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Fate of Ionic Liquids in Soils and Sediments
PublicationZrozumienie losu cieczy jonowych w glebach i osadach dennych jest istotnym elementem ich implementacji z zachowaniem idei zrównoważonego rozwoju. Niniejsza publikacja zawiera analizę i podsumowanie danych dotyczących oddziaływań cieczy jonowych w roztworach wodnych oraz agregacji na powierzchniach stałych. Zaobserwowano, że silnie lipofilowe ciecze jonowe zawierające długi łańcuch węglowodorowy lub duży organiczny anion wykazują...
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Recent developments in the synthesis and biological activity of muramylpeptides
PublicationZaprezentowano przegląd literaturowy obejmujący syntezę i aktywność biologiczną nowych analogów muramylopeptydów (MDP) oraz ich potencjalne zastosowanie w terapii nowotworowej i chorób infekcyjnych.
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Novel approaches in the synthesis of batracylin and its analogs: rebirth of an old player?
PublicationW pracy opisano batracylinę (BAT), jej syntezę i aktywność biologiczną oraz otrzymane analogi. BAT została wyselekcjonowana przez NCI (Bethesda, USA) w programie poszukiwań nowych potencjalnych leków przeciwnowotworowych. Związek ten w badaniach in vivo na myszach okazał się bardzo aktywny przeciw nowotworowi okrężnicy 38 (Colon 38), trudnemu do wyleczenia przez dotychczas znane leki przeciwnowotworowe. Jest ona skuteczna również...
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Transcriptomic Effects of Estrogen Starvation and Induction in the MCF7 Cells. The Meta-analysis of Microarray Results
PublicationEstrogen is one of the most important signaling molecules which targets a number of genes. Estrogen levels regulate cell proliferation and a plethora of metabolic processes, which may interfere with a range of medical conditions and drug metabolism. The MCF7 breast cancer cell line, expressing the estrogen receptor α, is a well-studied model of cellular answer to estrogen. The aim of this study was to characterize transcriptomic...
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New Trends in Sample Preparation Techniques for the Analysis of the Residues of Pharmaceuticals in Environmental Samples
PublicationPharmaceutical residues in the environment is a field of special interest due to the adverse effects to either human health or aquatic and soil environment. Pharmaceuticals have been already detected in underground, surface and wastewaters, soils, manure and sediments. The growing awareness of environmental pollution arising from human activity forces the need for their comprehensive determination. Environmental samples are complex...
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Inhibitors of angiogenesis in cancer therapy – synthesis and biological activity
PublicationAngiogenesis is the process of formation of new capillaries from preexisting blood vessels. Angiogenesis is involved in normal physiological processes, and plays an important role in tumor invasion and development of metastases. Vascular endothelial growth factor (VEGF) plays a key role in angiogenesis. VEGF is a mitogen for vascular endothelial cells and stimulates their proliferation. By inhibiting the biological activity of...
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Botanical and geographical origin characterization of polish honeys by headspace SPME-GCxGC-TOFMS
PublicationVolatile organic compounds (VOCs) composition of Polish honeys obtained from various geographical regions was studied. Headspace solid phase microextraction (HS-SPME) using Divinylbenzene/Carboxen/Polydimethylsiloxane-coated fibers was used in combination with comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GC× GC-TOFMS) because of the complexity of the samples. Acacia, linden, rapeseed, buckwheat...
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Structural and electrochemical heterogeneities of boron-doped diamond surfaces
PublicationThis brief review is focussed on the recent progress in studies of the heterogeneous electrochemical behaviour of various boron-doped materials extending from zero-dimensional particles through polycrystalline or nanostructured three-dimensional surfaces. A boron-doped diamond reveals large heterogeneities induced by numerous factors, inter alia multi-faceted crystallinity, inhomogeneous boron concentration, sp2/sp3-carbon ratio,...
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Prediction of Bioactive Peptides From Chicken Feather and Pig Hair Keratins Using In Silico Analysis Based on Fragmentomic Approach
PublicationBackground: Keratin is among the most abundant structural proteins of animal origin, however it remains broadly underutilized. Objective: Bioinformatic investigation was performed to evaluate selected keratins originating from mass-produced waste products, i.e., chicken feathers and pig hair, as potential sources of bioactive peptides. Methods: Pepsin, trypsin, chymotrypsin, papain, and subtilisin were used for in silico keratinolysis...
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Microfluidic devices for photo-and spectroelectrochemical applications
PublicationThe review presents recent developments in electrochemical devices for photo- and spectroelectrochemical investigations, with the emphasis on miniaturization (i.e., nanointerdigitated complementary metal-oxide-semiconductor devices, micro- and nano-porous silicon membranes or microoptoelectromechanical systems), silica glass/microreactors (i.e., plasmonic, Raman spectroscopy or optical microcavities) or polymer-based devices (i.e.,...
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Interictal high-frequency oscillations in focal human epilepsy
PublicationPURPOSE OF REVIEW: Localization of focal epileptic brain is critical for successful epilepsy surgery and focal brain stimulation. Despite significant progress, roughly half of all patients undergoing focal surgical resection, and most patients receiving focal electrical stimulation, are not seizure free. There is intense interest in high-frequency oscillations (HFOs) recorded with intracranial electroencephalography as potential...
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Evaluation of Green Sample Preparation Techniques for Organic Compounds
PublicationNowadays, Green Analytical Chemistry (GAC) idea is of high importance, with impact on the rapid growth in the sample preparation area with special emphasis on sample preparation simplification, miniaturization and automation. Due to the fact that GAC is of high importance today, this study is focused on the evaluation of green sample preparation techniques for organic compounds. It is well known that sample preparation is considered...
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Tuftsin-Properties and Analogs
PublicationImmunomodulation is one of the significant therapeutic strategies. It includes both stimulation or suppression of the immune system by a variety of substances called immunomodulators, designed to regulate the immune response of the organism to infections of varying etiology. An example of such a substance is tuftsin (TKPA) 3 (Fig. (1)). Tuftsin is an endogenous immunomodulator of a wide spectrum of biological activity. Tetrapeptide...
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Polish Experience of Implementing Vision Zero
PublicationPurpose of Review The aim of this study is to present an outline and the principles of Poland’s road safety strategic programming as it has developed over the last 25 years since the first Integrated Road Safety System with a strong focus on Sweden’s “Vision Zero”. Recent Findings Countries that have successfully improved road safety have done so by following strategies centred around the idea that people are not infallible and...
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The Role of FLT3 Kinase as an AML Therapy Target
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Modifications of total synthesis of mycophenolic acid
PublicationThe total synthesis of mycophenolic acid (MPA), a potent immunosuppressant, was modified. The obtained mycophenolic acid was suitable for further preparation of new prospective immunosuppressants with improved therapeutic properties.
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Electrifying the bus network with trolleybus: Analyzing the in motion charging technology
PublicationCurrently, electric buses are becoming more and more popular, and their number in operation is increasing. The range of electric buses is also increasing and solutions that seem to be working almost without fixed infrastructure are being promised. However, this requires the use of high-capacity batteries, which increases the weight and price of the vehicle and causes high costs of battery replacement during operation. Moreover,...
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Analysis of electricity generation variability in 2019 with special consideration of electrical energy generation from wind sources.
PublicationThis article presents issues related to the broadly understood development of wind energy. The state of the art of wind energy in the world has been discussed. This paper also shows issues related to factors affecting the development of renewable energy sources and their impact on the natural environment on the basis of available research. The focus is, however, on the critical analysis of phenomena in the data of the Transmission...
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Modal Analysis of Planar Elliptical Resonator Deposited on Unshielded Dielectric Slab
PublicationModal analysis of isolated open planar elliptical patch placed on dielectric slab is presented in the paper. It applies concept of Illuminating Modes which is formulated for the case of two-side opened structure. The current on patch is expanded in basis functions in form of Mathieu radial and angular functions. The spectrum of excited modes for exemplary planar resonators is presented and discussed using the concept of power of...
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Hydrogen sulphide electrocatalytic gas sensor
PublicationIn this article measurement results of the electrocatalytic gas sensor in different concentrations of hydrogen sulphide are presented. Working principle of such sensor is based on electric current acquisition, while voltage ramp is applied to the sensor. During voltage sweep oxidation and reduction reactions occurs on the sensor electrodes. Obtained current-voltage plot has unique shape connected...
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Predictive current controller with simplified load model operating for allfrequencies. Vestnik Nacionalnogo tehniceskogo universiteta ''Harkovskij po- litehniceskij institut'' Problemy avtomatizirowannogo elektroprivoda. Teo- ri i praktika.**2002 vyp. 12 t. 2 s. 355-357, 6 rys. bibliogr. 4 poz. Seri ''Elektrotehnika, elektronika i elektroprivod''. Predykcyjny regulator prądu z uproszczonym modelem obciążenia pracujący wszerokim zakresie częstotliwości.
PublicationZaprezentowano nowy rodzaj regulatora predykcyjnego prądu, umożliwiającydziałanie w szerokim zakresie częstotliwości. Rozpatrzono aspekty praktycznepraktyczne realizacji algorytmu sterowania.
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Ground anchors diagnostic process based on elastic wave propagation method
PublicationThe paper is focused on analysis of elastic wave propagation in the context of diagnostics of ground anchors. Numerical simulations were performed to assess the possibility of evaluation of the anchorage quality. It was assumed that the quality and the load capacity of the anchor system directly depend on the length, on which mortar and steel cooperate.
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Technical and Economic Analysis of an Intermediate Size Photovoltaic Power Plant. Case Study
PublicationThe article presents an analysis of the construction of a photovoltaic power plant with an installed capacity of about 30 kW. The principles of selecting the basic elements of the plant are shown. The impact of a high constant price on the profitability of the project is highlighted. The article also describes the existing mechanisms for subsidizing the investment.
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Influence of geometrical imperfections on stresses in cylindrical shells
PublicationResults of the numerical analysis of the shells of storage tanks of 50 000 m3 capacity with geometrical imperfections are presented in the paper. Results were verified by tensometric tests performed on the real tank. It was recognized that real geometrical imperfections cause increase of stresses in the tank construction by 30%.
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Analysis of The Behavior of Foundations of Historical Buildings
PublicationThe article is devoted to the analysis of the behavior of the foundations of historic buildings. Some basic aspects of foundation engineering are discussed, with an emphasis placed on its development, applied techniques, and materials. Several different approaches and methods for the analysis of foundations of historical buildings are presented. A particular analysis has been focused on an example of a typical stone foundation...
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Shear Cap Size Selection Method Based on Parametric Analysis of ACI-318 Code and Eurocode 2 Standard
PublicationThe scope of the paper is to propose a method for determining the size of shear caps in a slab–column-connections-reinforced concrete structure. Usually, shear heads are used to enhance slab–column connection, especially when the transverse reinforcement does not give the required punching shear load capacity. The dimensions of the shear head should provide the punching shear resistance of the connection inside and outside the...
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Measurement methods for assessing insulation condition of underground pipelines
PublicationThe paper discusses the most frequently applied measurement methods for assessing the quality of external insulation along pipelines and detecting defect locations in the protective coating. The quality of coating along a given pipeline section under investigation is assessed by determining unitary resistance of the coating, which is calculated on the basis of measurement results obtained along a pipeline subjected to cathodic...