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Search results for: LYMPHATIC VESSEL TUMORS
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Inhibition of T-type calcium channel disrupts Akt signaling and promotes apoptosis in glioblastoma cells.
PublicationGlioblastoma multiforme (GBM) are brain tumors that are exceptionally resitant to both radio- and chemotherapy regimens and novel approaches to treatment are needed. T-type calcium channels are one type of low voltage-gated channel (LVCC) involved in embryonic cell proliferation and differentiation; however they are often over-expressed in tumors, including GBM. In this study, we found that inhibition of T-type Ca channels in GBM...
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Future of medicine: personalized oncology
PublicationUnderstanding genetic and epigenetic mechanisms of tumorigenesis allows identifying many vital mutations affected the formation of various malignancies. This led to the discovery of a new therapeutic approach, based on molecular mechanisms in the world of medicine, which is called personalized medicine (PM). This review aims to outline the state of the art of the personalized medicine in treatment, taking into account anti-cancer...
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PROJEKTOWANIE WIELOWYMIAROWEGO REGULATORA BACKSTEPPING W UKŁADZIE DYNAMICZNEGO POZYCJONOWANIA STATKU
PublicationW komercyjnych systemach dynamicznego pozycjonowania statku, pomimo znacznego wzrostu poziomu automatyzacji, wykorzystywane jest nadal sterowanie typu PID. Poprawę jakości procesu pozycjonowania może umożliwić wykorzystanie bardziej efektywnych algorytmów, oferujących zaawansowane nieliniowe techniki sterowania. W artykule przedstawiono zagadnienie projektowania regulatora pozycji i kursu dla układu dynamicznego pozycjonowania...
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Control design for slow speed positioning
PublicationThe problem under study is a synthesis of position and heading control system for low frequency model of surface vessel described by 3 DOF mathematical model. The recursive vectorial backstepping control design was used to keep fixed position and heading in presence of wave disturbances. The controller has been simulated on computer model of scaled supply vessel. It has been assumed that the actuators produce generalized forces...
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Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma
PublicationPURPOSE: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO2)-Pro-Lys-Thr-OCH3]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocytes, neurons) of neuroectodermal origin, and both are tumors with high heterogeneity and unsatisfactory susceptibility to chemotherapies....
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A decision-making system supporting selection of commanded outputs for a ship's propulsion system with a controllable pitch propeller
PublicationThe ship's operators have to make decisions regarding the values of commanded outputs (commanded engine speed and pitch ratio) which ensure maximum vessel speed and minimum fuel consumption. Obviously, the presented decision problems are opposed. Therefore, there is a need for a compromise solution that enables more flexible vessel voyage planning. This paper deals with development of a computer-aided system supporting selection...
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Weather Hazard Avoidance in Modeling Safety of Motor-Driven Ship for Multicriteria Weather Routing
PublicationWeather routing methods find the most suitable ocean?s route for a vessel, taking into account changeable weather conditions and navigational constraints. In the multicriteria approach based on the evolutionary SPEA algorithm one is able to consider a few constrained criteria simultaneously. The approach applied for a ship with hybrid propulsions has already been presented by one of the authors on previous TransNav?2009. This time...
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USING ARTIFICIAL NEURAL NETWORKS FOR PREDICTING SHIP FUEL CONSUMPTION
PublicationIn marine vessel operations, fuel costs are major operating costs which affect the overall profitability of the maritime transport industry. The effective enhancement of using ship fuel will increase ship operation efficiency. Since ship fuel consumption depends on different factors, such as weather, cruising condition, cargo load, and engine condition, it is difficult to assess the fuel consumption pattern for various types...
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Nanodiamonds Doped with Manganese for Applications in Magnetic Resonance Imaging
PublicationNanodiamonds (NDs) are emerging with great potential in biomedical applications like biomarking through fluorescence and magnetic resonance imaging (MRI), targeted drug delivery, and cancer therapy. The magnetic and optical properties of NDs could be tuned by selective doping. Therefore, we report multifunctional manganese-incorporated NDs (Mn-NDs) fabricated by Mn ion implantation. The fluorescent properties of Mn-NDs were tuned...
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Conditions for Multiple Acquisition of Echoes from Stationary Targets in Successive Transmissions of Active Sonars
PublicationIn echolocation, the highest possible number of contacts with a detected target is clearly decisive on the possibilities of echo processing to optimise the estimation of distinctive characteristics of the observed target. In hydrolocation, the slow propagation of acoustic waves in water reduces the number of contacts of echosounders and sonars with detected targets. The article considers model conditions for acquiring multiple...
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Hydrographic Multisensory Unmanned Watercraft
PublicationThis article describes the design of the unmanned surface vessel (USV) and the algorithms for planning the trajectories to be followed on measurement missions. The algorithms take account of the dynamically varying impacts of external forces (wind and surface current) on the vessel's motion. Feedback loops enable the counteraction of external factors that cause disturbance to the desired trajectory. The sensors installed on the...
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The Impact of Sloshing Liquids on Ship Stability for Various Dimensions of Partly Filled Tanks
PublicationLiquid sloshing phenomenon taking place in partly filled ships' tanks directly affects the stability of a vessel. However, only static calculations are carried out onboard ships nowadays and static transfer of liquid weight is taken into account in the course of routine stability calculation. The paper is focused on a dynamic heeling moment due to liquid sloshing in tanks onboard ships. A number of numerical simulations of liquid...
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A Method of Assessment of the Liquid Sloshing Impact on Ship Transverse Stability
PublicationLiquid sloshing phenomenon taking place in partly filled ships? tanks directly affects the stability of a vessel. However, only static calculations are carried out onboard ships nowadays and static transfer of liquid weight is taken into account in the course of routine stability calculation. The paper is focused on a dynamic heeling moment due to liquid sloshing in tanks onboard ships. The set of numerical simulations of liquid...
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Wyznaczenie obciążeń na poszycie okrętu wywołanych uderzeniem fal i uderzeniem w lód i ich wpływ na bezpieczeństwo okrętu
PublicationThe main problem is the vessels rather accurate determination of the hydrodynamic loads so-called hydroelasticity outside . This can be done by theoretical analysis , computer simulation or by experiment. This gives the hydrodynamic pressure distribution on the walls of the ship's hull and also on the walls of marine vessels .The most dangerous are the impact of extreme storm waves , the impact of the wharf and the impact zone...
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Selection of Electrode Material for Inconel 617/P92 Steel SMAW Dissimilar Welds
PublicationThe present work aimed to investigate the microstructure and mechanical properties of the dissimilar shielded metal arc welded (SMAW) joint of Alloy 617 and P92 steel for advanced ultrasupercritical boilers. The SMAW joint was produced using three different types of electrodes, namely, ENiCrFe-3, ENiCrMo-3, and ENiCrCoMo-1. During microstructural observation of the welded joints, no possible cracking was detected in the weldments....
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Prototype of an opto-capacitive probe for non-invasive sensing cerebrospinal fluid circulation
PublicationIn brain studies, the function of the cerebrospinal fluid (CSF) awakes growing interest, particularly related to studies of the glymphatic system in the brain, which is connected with the complex system of lymphatic vessels responsible for cleaning the tissues. The CSF is a clear, colourless liquid including water (H2O) approximately with a concentration of 99 %. In addition, it contains electrolytes, amino acids, glucose, and...
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DETERMINATION OF ADDITIONAL TENSION IN TOWED STREAMER CABLE TRIGGERED BY COLLISION WITH UNDERWATER MOVING OBJECT
PublicationThe paper deals with issues connected with the behaviour of a streamer cable towed by a survey seismic vessel when the cable undergoes a strike triggered by collision with an underwater moving object. The consequences of such collisions may be both threat to the life of marine animals or damage to underwater units and large economic losses suffered by vessel owners. The risk of such collisions has increased over the last years...
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Development of a Response Assessment Tool for a Floating Dock System
PublicationDocking operations of ships require a response assessment to ensure structural and personnel safety. Environmental loads and improper ballast adjustments are the main threats to the docking operations. They can cause severe structural damages and stability loss to a floating dock system which includes a floating dock and a docked vessel, even if the velocities of the dock and the vessel are very low during the docking process....
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Control System Design for Dynamic Positioning using Vectorial Backstepping
PublicationThe problem of synthesis a dynamic positioning system for low frequency model of surface vessel was considered in this paper. The recursive vectorial backstepping control design was used to keep a fixed position and heading in presence of wave disturbances. The passive observer was introduced to smooth the measurements and to estimate the velocities needed for the control algorithm. The computer simulation results were given to...
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Modelling of Ship’s Heeling and Rolling for the Purpose of Gantry Control Improvement in the Course of Cargo Handling Operations in Sea Ports
PublicationThe paper presents two proposals of models of interaction between a ship and cargo being loaded or discharged by a gantry in port, in terms of heeling and rolling of the vessel. The main purpose of such modelling is the need for improvement of gantry control with regard to faster operations thanks to more accurate estimation of level and moment of cargo release from a gantry hook or spreader. The study may be the contribution to...
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Electrochemical simulation of metabolic reduction and conjugation reactions of unsymmetrical bisacridine antitumor agents, C-2028 and C-2053
PublicationElectrochemistry (EC) coupled with analysis techniques such as liquid chromatography (LC) and mass spectrometry (MS) has been developed as a powerful tool for drug metabolism simulation. The application of EC in metabolic studies is particularly favourable due to the low matrix contribution compared to in vitro or in vivo biological models. In this paper, the EC(/LC)/MS system was applied to simulate phase I metabolism of the representative...
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A simplified method to assess the impact of ship-to-ship collision on the risk of tanker ship hull girder breaking accounting for the effect of ageing
PublicationOne of the most critical structural failures is the exceedance of the ship hull girder’s ultimate strength, which may result in hull breaking, and subsequent severe consequences, including loss of life and property as well as environmental damage in case of an oil spill. A cause for such loss of structural continuity can be triggered by a collision with another vessel. In addition, the ageing mechanisms of the hull structure could...
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Wireless Link Selection Methods for Maritime Communication Access Networks—A Deep Learning Approach
PublicationIn recent years, we have been witnessing a growing interest in the subject of communication at sea. One of the promising solutions to enable widespread access to data transmission capabilities in coastal waters is the possibility of employing an on-shore wireless access infrastructure. However, such an infrastructure is a heterogeneous one, managed by many independent operators and utilizing a number of different communication...
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Selection of an artificial pre-training neural network for the classification of inland vessels based on their images
PublicationArtificial neural networks (ANN) are the most commonly used algorithms for image classification problems. An image classifier takes an image or video as input and classifies it into one of the possible categories that it was trained to identify. They are applied in various areas such as security, defense, healthcare, biology, forensics, communication, etc. There is no need to create one’s own ANN because there are several pre-trained...
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Endometrial nitric oxide production and nitric oxide synthases in the equine endometrium: Relationship with microvascular density during the estrus cycle
PublicationNitric oxide (NO) plays an important role in angiogenesis and in the regulation of the blood flow. This study was carried out to investigate (i) the effects of endogenous estrogens and progestins and exogenous progesterone (P(4)) (5 ng/ml or 1 microg/ml) or estradiol 17beta (E(2)beta) (50 pg/ml or 1 microg/ml) on in vitro endometrial NO synthesis; (ii) the presence of different isoforms of NO synthase;...
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MAPSERVER – INFORMATION FLOW MANAGEMENT SOFTWARE FOR THE BORDER GUARD DISTRIBUTED DATA EXCHANGE SYSTEM
PublicationIn this paper the architecture of the software designed for management of position and identification data of floating and flying objects in Maritime areas controlled by Polish Border Guard is presented. The software was designed for managing information stored in a distributed system with two variants of the software, one for a mobile device installed on a vessel, an airplane or a car and second for a central server. The details...
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A multiparameter simulation-driven analysis of ship response when turning concerning a required number of irregular wave realizations
PublicationThe growing implementation of Decision Support Systems on modern ships, digital-twin technology, and the introduction of autonomous vessels cause the marine industry to seek accurate modeling of vessel response. Despite the contemporary 6DOF models can be used to predict ship motions in irregular waves, the impact of their stochastic realization is usually neglected and remains under-investigated. Especially in the case of turning, differences...
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Factory Acceptance Test – Strain Gauge Measurement, Report no: WOiO /II/123/2014
PublicationTested object was 40 meters long jib and its foundation, placed in Gdansk Shiprepair Yard, manufactured by KMK. The contruction was dedicated to the passenger cruise vessel "Quantum of the Seas" The Strain Gauge measurement in different location and load situation was done in order to validate calculation finite element models used during strength analysis for project. The expertise contains: methodology of the measurements, description...
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Factory Acceptance Test – Strain Gauge Measurement - Report no: WOiO /II/88/2014
PublicationTested object was 40 meters long jib and its foundation, placed in Gdansk Shiprepair Yard, manufactured by KMK. The contruction was dedicated to the passenger cruise vessel "North Star" The Strain Gauge measurement in different location and load situation was done in order to validate calculation finite element models used during strength analysis for project. The expertise contains: methodology of the measurements, description...
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NEW CONCEPT OF HYBRID PROPULSION WITH HYDROSTATIC GEAR FOR INLAND WATER TRANSPORT
PublicationThe article presents the development of author’s concept of a diesel/hydraulic propulsion system for inland watercraft. Due to specific nature of vessel navigation on rivers, classical propulsion systems with shaft lines can be effectively replaced by systems with hydraulic power transmission. A solution is also presented of a hybrid design with extra electric port having the form of a pumping system driven from a battery of accumulators....
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LINEAR CHARACTERISTICS OF THE SLOSHING PHENOMENON FOR THE PURPOSE OF ON-BOARD SHIP'S STABILITY ASSESSMENT
PublicationThe paper presents results of experimental research and numerical simulations of the sloshing phenomenon. The research was focused on computation of the heeling moment affecting stability of a vessel. The proposed linearisation enables application of the results to the assessment of the ship's stability. The dependence of the heeling moment upon localisation of a tank in the ship's hull is analysed. The heeling moment obtained...
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The protocol for using elastic wall model in modeling blood flow within human artery
PublicationMedical diagnostic tools will play a major role in the future for an effective patient treatment and reduction their mortality, related to the cardiovascular system diseases (CVDs). There is an urgent need for developing diagnostic procedure to be robust, reliable, accurate and efficient, in the framework of a paradigm shift. Application of numerical techniques is seen as a perspective tool for such purpose. Nevertheless, existing...
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Chloroacridine derivatives as potential anticancer agents which may act as tricarboxylic acid cycle enzyme inhibitors
PublicationThe chloroacridines affect biological forms of melanoma in different ways. Amelanotic (Ab) melanoma (with inhibited melanogenesis and higher malignancy) was particularly sensitive to the action of the chloroacridines. The Ab melanoma cells died through apoptosis and through death without caspase activation. Diminished activity of TAC enzymes was noticed among Ab melanoma cells together with ATP/NAD depletion, especially in the...
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Ship Evolutionary Trajectory Planning Method with Application of Polynomial Interpolation
PublicationPaper presents the application of evolutionary algorithms and polynomial interpolation in ship evolutionary trajectory planning method. Evolutionary algorithms allows to find a coIlision free trajectory in real time, while polynomial interpolation allows to model smooth trajectory which keeps continuity of velocity and acceleration values along path. Combination of this two methods allows to find trajectory, which under some assumptions,...
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Full scale measurements of pressure field induced on the quay wall by bow thrusters – indirect method for seabed velocities monitoring
PublicationThe paper presents the results of full-scale experimental investigation of loads generated on the quay wall by bow thrusters during unberthing of a self-manoeuvring vessel. The presented research allowed for the comparison of the measurements results with generally accepted empirical prediction methods and confirmed the utility of the developed measuring setup for the on-line monitoring of jet induced loads. The conclusions from the...
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SAILING ROUTE PLANNING METHOD CONSIDERING VARIOUS USER CATEGORIES
PublicationThe article describes the methodology related to determining the multi-criteria routes for sailing ships. Details of sea area discretisation and discretisation of the description of the sailing vessel properties and manoeuvring principles are shown. User requirements were specified (for five different categories of users) and on this basis the criteria for selecting the most suitable shipping route were formulated. The presented...
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Variations of Ship’s Deck Elevation Due to Stochastic Process of Containers Loading
PublicationThe stochastic process of container loading is described in the paper with special emphasis to ship motion when she is lying at a quay. The 3 DOF system was applied to describe rolling, pitching and heaving of a vessel which may cause a significant variations of momentary deck elevation. The realistic range of such variations are assessed for a variety of cargo locations on-board and a phase shift between two independent gantries...
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Dynamic Positioning System with Vectorial Backstepping Controller
PublicationThe problem of synthesis a dynamic positioning system for low frequency model of surface vessel was considered in this paper. The recursive vectorial backstepping control design was used to keep a fixed position and heading in presence of wave disturbances. The passive observer was introduced to smooth the measurements and to estimate the velocities needed for the control algorithm. Some parameters of observer were optimized off-line...
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Adaptive dynamic control allocation for over-actuated dynamic positioning system based on backstepping method in case of thruster faults
PublicationThe objective of the research considered in this paper is dynamic positioning of a nonlinear over-actuated marine vessel in the presence of limited information about thruster forces. First, the adaptive backstepping method is used to estimate the input matrix which will compensate partial loss of actuator effectiveness in the presence of actuator dynamics. Then, the adaptive commanded virtual forces and moment are allocated into...
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Designing a ship course controller by applying the adaptivebackstepping method
PublicationThe article discusses the problem of designing a proper and efficient adaptive course-keeping control system for a seagoingship based on the adaptive backstepping method. The proposed controller in the design stage takes into account thedynamic properties of the steering gear and the full nonlinear static maneuvering characteristic. The adjustable parametersof the achieved nonlinear control structure were tuned up by using the...
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Simulation studies into quayside transport and storage yard operations in container terminals
PublicationThe focus of the paper is on quayside transport and storage yard operations in the sea container terminals. Developed algorithms for solving the issues of load handling and storage space allocation have been applied in the frame of adopted simulation model. The criteria chosen for decision making involved the total makespan of vessel unloading and the utilisation levels of the transportation trucks. Recommendations for unloading...
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Phosphoroorganic Metal Complexes in Therapeutics
PublicationThe present mini-review highlights recent developments on antitumor activity of metal-based therapeutics which have been a subject of researches for the last few decades. In 1965, Rosenberg found that during an electrolysis on platinum electrodes a complex of Pt is generated which inhibited to a great extent a binary fission in Escherichia coli bacteria. This discovery started a new chapter in medicinal chemistry and the interesting...
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Automatic Identification System (AIS) Dynamic Data Integrity Monitoring and Trajectory Tracking Based on the Simultaneous Localization and Mapping (SLAM) Process Model
PublicationTo enhance the safety of marine navigation, one needs to consider the involvement of the automatic identification system (AIS), an existing system designed for ship-to-ship and shipto- shore communication. Previous research on the quality of AIS parameters revealed problems that the system experiences with sensor data exchange. In coastal areas, littoral AIS does not meet the expectations of operational continuity and system availability,...
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Review of Selected Methods for Prediction of Added Resistance in Following Waves
PublicationThe added resistance in waves is a mean value of non-linear, second order reaction of a ship to incoming waves. In the beginning of the 20th century, the experimental methods for investigation of ship hydrodynamics at model scale were developed. They allowed the evaluation of added resistance by measurements in irregular waves (directly) or by measurements in regular waves (in-direct method). The main goal was to find more precise...
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New method to monitor changes in the subarachnoid width and pial artery pulsation for physiological and clinical research
PublicationThere are several medical conditions associated with brain oedema such as traumatic brain injury, intoxication or tumors. Brain edema and related brain parenchyma expansion may lead to compression and subsequent injury of several brain structures. So far, the only method enabling detection and monitoring of the progress a cerebral oedema in a patient, has been monitoring of intracranial pressure (ICP) with a pressure probe inserted...
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Data fusion of GPS sensors using Particle Kalman Filter for ship dynamic positioning system
PublicationDepending on standards and class, dynamically positioned ships make use of different numbers of redundant sensors to determine current ship position. The paper presents a multi-sensor data fusion algorithm for the dynamic positioning system which allows it to record the proper signal from a number of sensors (GPS receivers). In the research, the Particle Kalman Filter with data fusion was used to estimate the position of the vessel....
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Shipping Safety Management on Polish Inland Waterways
PublicationOver the past years, the role of inland waterway transport has increased compared to other modes of transport. The increasing intensity of the inland vessel traffic significantly affects the safety of navigation. The article analyses the main causes of accidents and incidents that occurred on the Odra Waterway and Lower Vistula. The authors have classified those accidents and suggested possible directions for the development of...
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Trim Optimisation - Theory and Practice
PublicationForce Technology has been working intensively with trim optimisation tests for almost last 10 years. Focus has primarily been put on the possible power savings and exhaust gases reduction. This paper describes the trim optimisation process for a large cargo vessel. The physics behind changed propulsive power is described and the analyses in order to elaborate the optimum trimmed conditions are presented. Different methods for prediction...
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Antitumor DNA-Damaging C-1748 is a New Inhibitor of Autophagy that Triggers Apoptosis in Human Pancreatic Cancer Cell Lines
PublicationDespite the enormous progress that has been made over the past decades in diagnosis, treatment and prevention of many types of tumors, survival rates in pancreatic cancer still remain poor. Pancreatic cancer is one of the most malignant and chemoresistant tumors and the profound mechanism supporting these phenomena is the constitutively activated prosurvival autophagy. The antitumor 1-nitroacridine derivative C-1748 belongs to...
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Can we rely on the pulse transit time - pressure relationship - models comparison
PublicationAn unobtrusive, noninvasive and continuous pressure measurement is invaluable however, still being under research and development. There are many attempts proposing an appropriate relationship between pulse pressure velocity and pressure. Fifteen different formulas, both theoretical and experimental, describing relation between blood pressure and crosssectional area of the vessel were examined. Using these formulas the relation...