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Search results for: Life Cycle
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THE ESSENCE OF THE TRANSFORMATION OF SOCIO-ECONOMIC RELATIONS IN THE NATIONAL ECONOMY: THEORETICAL AND METHODOLOGICAL ASPECT
PublicationThe article is devoted to a thorough study of the theoretical and methodological foundations of the essence of the transformation of socio-economic relations of the national economy. Based on the study of scientific sources, a proper definition of the concept of "transformation of socio-economic relations" was formed. It is proposed to consider transformational processes from the point of view of their direct or indirect impact...
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Utilizing Genome-Wide mRNA Profiling to Identify the Cytotoxic Chemotherapeutic Mechanism of Triazoloacridone C-1305 as Direct Microtubule Stabilization
PublicationRational drug design and in vitro pharmacology profiling constitute the gold standard in drug development pipelines. Problems arise, however, because this process is often dicult due to limited information regarding the complete identification of a molecule’s biological activities. The increasing aordability of genome-wide next-generation technologies now provides an excellent opportunity to understand a compound’s diverse eects...
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Modelling of heat transfer in supercritical pressure recuperators
PublicationIn the paper presented is analysis of convective flow heat transfer at supercritical pressure in channels of heat exchanger working in the thermodynamic cycle. The modelling is based on the division of the flow into three regions, namely the heavy fluid, a two phase flow consisting of the heavy and light fluids and finally the light fluid flow. Modelling is concentrated on the region of simultaneous flow of two fluids divided into...
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New insights on lithium storage in silicon oxycarbide/carbon composites: Impact of microstructure on electrochemical properties
PublicationIn this work, we study the impact of the preceramic precursor vinyltriethoxysilane (VTES) on the electrochemical performance of silicon oxycarbide (SiOC) glass/graphite composites. We apply an innovative approach based on high-power ultrasounds in order to obtain highly homogenous composites with a uniform distribution of small graphitic flakes. This procedure enhances gelation and drying of VTES-based preceramic polymer/graphite...
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Investigation of ecological parameters of a gas turbine combustion chamber with steam injection for the floating production, storage, and offloading vessel
PublicationThe article is dedicated to the investigation of the possibility of using the contact type gas turbine cycle with steam injection into the combustion chamber for the floating production, storage, and offloading vessel in order to increase the specific power and efficiency and reduce emissions of toxic components. A new approach is proposed, associated with the use of the two-stage injection of superheated steam into a gas turbine...
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Planning optimised multi-tasking operations under the capability for parallel machining
PublicationThe advent of advanced multi-tasking machines (MTMs) in the metalworking industry has provided the opportunity for more efficient parallel machining as compared to traditional sequential processing. It entailed the need for developing appropriate reasoning schemes for efficient process planning to take advantage of machining capabilities inherent in these machines. This paper addresses an adequate methodical approach for a non-linear...
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Detection and removal of priority substances and emerging pollutants from stormwater: case study of the Kołobrzeska collector, Gdańsk, Poland
PublicationProgressive urban development affects environmental balance and disrupts the hydrologic cycle, in which rainfall plays a significant role. Since rainwater is considered a valuable resource of the environment, many technical solutions are implemented that enable effective rainwater management. On the other hand, stormwater runoff from urban areas contains numerous (also toxic) substances, and therefore should be properly treated....
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Tetrahydroquinolinone derivatives exert antiproliferative effect on lung cancer cells through apoptosis induction
PublicationThe anticancer properties of quinolones is a topic of interest among researchers in the scientific world. Because these compounds do not cause side effects, unlike the commonly used cytostatics, they are considered a promising source of new anticancer drugs. In this work, we designed a brief synthetic pathway and obtained a series of novel 8-phenyltetrahydroquinolinone derivatives functionalized with benzyl-type moieties at position...
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Numerical analysis of CO2-water separation in a horizontal double T-junction
PublicationCarbon dioxide is considered one of the main factors leading to global warming. Considering the significant impacts of CO2 on climate change, various technologies have been developed in recent decades to control carbon emission, such as for example CO2 capture and storage. The developed cycle of a negative CO2 emission power plant includes some devices, out of which, separator plays an indispensable role. To this end, T-junction...
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An approach to improve the time efficiency of disjoint paths calculation
PublicationFailures of network elements can be appropriately dealt with by utilization of alternate disjoint paths to provide redirection of flows affected by failures of the respective working paths. Known approaches can be broadly divided by decision on backup paths installation into proactive and reactive mechanisms, as well as based on the scope of recovery actions into local and global rerouting. There are several important scenarios...
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CO2 EMISSION TO THE ATMOSPHERE FROM CARBONATE WATERS: THE STUDY CASE OF THE LUBLIN UPLAND AND ROZTOCZE REGIONS
PublicationThe concentration of carbon dioxide dissolved in water (CO2(aq)) was measured in consecutive phases of the hydrological cycle. Its potentially possible degassing from groundwaters to the atmosphere was also assessed. The research was conducted in the area of occurrence of carbonate rocks of the Lublin Upland and Roztocze (SE Poland). The results of the measurements of CO2(aq) concentration varied as follows (min-max/mean): precipitation...
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A simple modification of PCR thermal profile applied to evade persisting contamination
PublicationThe polymerase chain reaction (PCR), one of the most commonly applied methods of diagnostics and molecular biology has a frustrating downside known as the false positive signal or contamination. Several solutions to avoid and to eliminate PCR contaminations have been worked out to date but the implementation of these solutions to laboratory practice may be laborious and time consuming. A simple approach to circumvent the problem...
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Network Graph Transformation Providing Fast Calculation of Paths for Resilient Routing
PublicationProtection of transmission against failures can be appropriately dealt with by alternative paths. However, common schemes (e.g., Bhandaris scheme) are characterized by a remarkable delay while determining the transmission paths. This in turn may have a serious impact on serving dynamic demands (characterized by relatively short duration time). As a remedy to this problem, we introduce an approach to pre-compute the sets of disjoint...
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High-efficiency mini and micro heat exchangers for dispersed power generation
PublicationTaking into account the dispersed systems technologies and their development, the ORC systems seem to be promising technology amongst various micro-CHP domestic units (electrical power production below 10 kWe), however practical realization of the ORC cycle in a micro-scale is technically challenging. The system consists in devices such as the vapour generation unit (boiler), expansion device and heat exchangers. Each of them should...
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High Quality Multi-Zone and 3D CFD Model of Combustion in Marine Diesel Engine Cylinder
PublicationThe paper presents a 3D model of the processes taking place in the cylinder of a large 4-stroke marine engine. The model is based on CFD calculations performed on the moving mesh. The modelling range includes the full duty cycle (720° crankshaft position) and the complete geometry of the cylinder with inlet and exhaust ducts. The input data, boundary conditions and validation data were obtained by direct measurements on the real...
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Bone healing under different lay‐up configuration of carbon fiber‐reinforced PEEK composite plates
PublicationSecondary healing of fractured bones requires an application of an appropriate fixa-tor. In general, steel or titanium devices are used mostly. However, in recent years,composite structures arise as an attractive alternative due to high strength to weightratio and other advantages like, for example, radiolucency. According to Food andDrug Administration (FDA), the only unidirectionally reinforced composite allowed tobe implanted...
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DIGITAL HYDRAULICS CIRCUIT BASED ON PWM FUNCTION FOR CONTROLLING HYDRAULIC ACTUATOR POSITION
PublicationHydraulic systems are used in many different industries, such as multi-source hydrostatic drive systems. In traditional hydraulic systems, a proportional servo valve is used to control the position of hydraulic actuators. The low energy efficiency and high cost of these control valves are two major problems with these systems. Digital hydraulics is one of the most unique ideas on how to solve these problems. Researchers like digital...
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Novel chalcone-derived pyrazoles as potential therapeutic agents for the treatment of non-small cell lung cancer
PublicationLung cancer is considered to account for approximately one-fifth of all malignant tumor-related deaths worldwide and is therefore one of the most lethal malignancies. Pyrazole scaffold possesses a wide range of biological and pharmacological activities, which play important roles in medicinal chemistry. The present study reports the synthesis and in vitro biological characterization of nine pyrazoles derived from chalcones as potential...
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Współpraca pomp ciepła ze źródłem konwencjonalnym. Algorytmy obliczenia bilansu energetycznego i efektywności ekonomicznej
PublicationW wielu przypadkach pompy ciepła w instalacjach ogrzewania współpracują z innymi źródłami ciepła (kotły wodne opalane olejem opałowym, gazem ziemnym, biogazem, bojlery elektryczne, miejska lub osiedlowa sieć ciepłownicza) tworząc hybrydowe źródło ciepła. W każdym wariancie źródła hybrydowego odbiorcę i producenta ciepła interesuje bilans energetyczny całego obiektu oraz efektywność ekonomiczna wytwarzania ciepła w źródle hybrydowym...
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The concept of sewage-sludge management system for an individual household
PublicationThe individual farms at the rural areas often face problems with domestic sewage collection and treatment. In many cases building of sewerage systems and central wastewater treatment plants (WWTPs) brings too high costs, due to high distances from one farm to another and terrain configuration. Treatment wetlands for individual farms can solve this problem. In the article, an overview of individual treatment wetlands in Europe and...
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H2AX phosphorylation, its role in DNA damage response and cancer therapy
PublicationDouble-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired, may have severe consequences for cell survival, as they lead to chromosome aberrations, genomic instability, or cell death. Various physical, chemical, and biological factors are involved in DSB induction. Cells respond to DNA damage by activating the so-called DNA damage response (DDR), a complex molecular mechanism developed to detect...
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A new viscoelastic method of calculation of low-temperature thermal stresses in asphalt layers of pavements
PublicationThe paper presents a new method of calculation of thermal stresses in asphalt layers of pavements induced by cooling or heating. The method, developed by the author, is based on the analytical solution for the linear viscoelastic Burgers model extended numerically for the case of asphalt layers whose rheological parameters are strongly dependent on temperature. The coefficient of thermal expansion and Poisson’s ratio may optionally...
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Shaping the City Responding to Climate Change – Concept of Development of the Right Bank of the Vistula River in Toruń, Poland,
PublicationThe problems of cities of the 21st century are caused by anthropogenic oppression of the environment, through the growth of economic activity and continuous urbanisation, and taking away ecologically important open areas and biologically active areas. Increasingly frequent and sudden rains, strong winds, turbulence and rising world water levels are some of the consequences of climate change that have a direct impact on the functioning...
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Application of Analytic Signal and Smooth Interpolation in Pulse Width Modulation for Conventional Matrix Converters
PublicationThe paper proposes an alternative and novel approach to the PWM duty cycles computation for Conventional Matrix Converters (CMC) fed by balanced, unbalanced or non–sinusoidal AC voltage sources. The presented solution simplifies the prototyping of direct modulation algorithms. PWM duty cycles are calculated faster by the smooth interpolation technique, using only vector coordinates, without trigonometric functions and angles. Both...
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Switched-capacitor DC-DC converters in arbitrary switching mode - topologically derived resistive models based on incremental graph approach.
PublicationIn the preceding paper we reviewed some of modeling approaches aimed at systematic formulation and solution of switched capacitor DC-DC converters. In our review, special attention was paid to computationally efficient and mathematically elegant methods. In so doing we had tried to demonstrate the virtues of unified Incremental Graph (IG) approach. Incremental Graph is, in concept, a tool originally created for analysis and synthesis...
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Design and numerical testing of 5-box gfrp shell footbridge
PublicationThe paper formulates new design conditions for composite footbridges, taking into account the material and structural specificity of these objects, i.e. the strength condition, the serviceability condition and the frequency condition. A GFRP composite footbridge labelled with CFB2 code has been designed, with the original superstructure in the form of an opened-closed 5-box girder. The foot and cycle track bridge is simply supported,...
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Synthesis, molecular structure, and metabolic stability of new series of N' -(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)-1-(5-phenyl-1 H -pyrazol-1-yl)amidine as potential anti-cancer agents
PublicationA series of new N'-(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)-1-(5-phenyl-1H-pyrazol-1-yl)amidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cancer MCF-7. The studied compounds display selective activity mainly against HCT-116 and HeLa cells. Thus, five compounds show selective cytotoxic...
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The new concept of capillary forces aided evaporator for application in domestic organic rankine cycle
PublicationThis paper presents studies on the possibility of applying capillary forces induced in the porous structure to a modern design of evaporator. The potential application of such heat exchanger is for example an evaporator of the domestic micro combined heat and power (CHP) unit. One of the problems in the micro-CHP is excessive demand for pumping power. The proposed design helps in overcoming that issue. In the evaporator outlined...
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Time-dependent relaxation dynamics of remanent strain in textured PMN–PZ–PT and PMN–PIN–PT piezoceramics
PublicationCrystallographically textured lead-based piezoceramics, particularly P (Mg1/3Nb2/3) O3–Pb ZrO3–PbTi O3 (PMN–PZ PT) and Pb(M1/3Nb2/3)O3–Pb(In1/2Nb1/2)O3–PbTiO3 (PMN–PIN–PT), play a pivotal role in electromechanical applications due to their enhanced field-induced strain responses. However, challenges in precision positioning arise from heightened remanent strain (Sr) caused by embedded templates in the textured grains impacting...
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Analysis of "green methanol" production from carbon dioxide acquired from negative emission power plants using CFD approach for catalytic reactor
PublicationThe growing global demand for energy, coupled with the urgent need to reduce carbon dioxide (CO₂) emissions, has led to the development of innovative energy cycles such as the negative CO₂ gas power plant (nCO2PP). Carbon dioxide storage and reuse in current industries is therefore becoming an important issue. The answer to this is the process of synthesizing methanol, commonly used in many industries from captured carbon dioxide...
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Leaf wettability and plant surface water storage for common wetland species of the Biebrza peatlands (northeast Poland)
PublicationWetlands play a crucial role in buffering the effects of climate change. At the same time, they are one of the most endangered ecosystems on the globe. The knowledge of the water cycle and energy exchange is crucial for the practical preservation and exploiting their capabilities. Leaf wettability is an important parameter characterising the plant's ability to retain water on its surface, and is linked to the ecosystems' hydrological...
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Assessing ecotoxicity, synergic and antagonistic actions of commonly used components of polymerization mixture in molecularly imprinted polymers preparation process
PublicationIncreasingly, the challenge is the optimal process of developing a suitable MIP-type sorptive material (taking into account its final form and application area), which is mainly related to the efficiency/effectiveness of the polymerization process. The lack of reaction or its low efficiency generates additional waste and puts it into the environmental cycle. The main aim of the performed research was the estimation of ecotoxicity,...
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Comparison of traditional district heating with low temperature district heating systems featuring organic Rankine cycle and heat pump
PublicationPaper presents a comparison between a traditional district heating system with conventional boilers as a source of heat and electricity purchases from power utilities and a low temperature DH system incorporating the CHP with organic Rankine Cycle providing electricity and local heat pump raising the temperature of the DH fluid to the required temperature in the dwelling, meaning that both heat and electricity are produced within...
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Reducing the Uncertainty of the Moving Object Location Measurement with the Method of Quasi-Multiple Measurement in GNSS Technology in Symmetrical Arrangement
PublicationThe article presents a solution to the problem of limited accuracy of dynamic measurements performed with GNSS receivers. The proposed measurement method is a response to the needs related to the assessment of the measurement uncertainty of the position of the track axis of the rail transport line. However, the problem of reducing the measurement uncertainty is universal for many different situations where high accuracy of positioning...
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Novel fused pyran derivatives induce apoptosis and target cell cycle progression in anticancer efficacy against multiple cell lines.
PublicationNitrogen-based heterocycles such as pyrazole, imidazole, 1,2,4-triazole, benzimidazole, and benzotriazole substituted fused pyran derivatives (6a–e, 8a–e, 10a–e, 12a–e,&14a–e) have been synthesized and tested for their in vitro anticancer efficacies against MCF7, A549, and HCT116 cancer cell lines. Among the compounds, 6e, 14b, and 8c were identified as the most potent against MCF7, A549, and HCT116, with IC50 values of 12.46 2.72...
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Control structures of Doubly-Fed Induction Generator connected to Current Source Converter
PublicationThe control of Doubly-Fed Induction Generator can be achieved through various techniques. At present, many works published in the literature show the application of Voltage Source Converter in conjunction with Doubly-Fed Induction Generator. Recently published articles rarely involve the operational characteristics and technical aspects of the Doubly-Fed Induction Generator...
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ADAPTATION OF ENGINEERING FEA-BASED ALGORITHMS TO LCF FAILURE AND MATERIAL DATA PREDICTION IN OFFSHORE DESIGN
PublicationThere is an ever growing industrial demand for quantitative assessment of fatigue endurance of critical structural details. Although FEA-based calculations have become a standard in engineering design, problems involving the Low-To-Medium cycle range (101-104) remain challenging. This paper presents an attempt to optimally choose material data, meshing density and other algorithm settings in the context of recent design of the...
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Cycling as a Sustainable Transport Alternative in Polish Cittaslow Towns
PublicationIt is well known that growing motor traffic in urban areas causes air pollution and noise which affects the environment and public health. It is hardly surprising then that cycling should be used as an alternative mode of transport, not just in major cities but also in smaller ones including those that are members of the Cittaslow network. Their approach is based on sustainable development, care for the environment and transport...
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Evaluation of the significance of the effect of the active cross-sectional area of the inlet air channel on the specific enthalpy of the exhaust gas of a diesel engine using statistics F of the Fisher-Snedecor distribution
PublicationThis paper presents the application of Fisher-Snedecor distribution F statistics to assess the significance of the influence of changes in the active cross-sectional area of the inlet air channel (Adol) flow in a diesel engine on the observed diagnostic parameter determined on the basis of measurements of the quick changing exhaust gas temperature in the outlet channel, which is the specific enthalpy of the exhaust gas stream within...
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Novel N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives: synthesis and anticancer activity evaluation
PublicationA new series of N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives 4-21 have been synthesized, and evaluated at the National Cancer Institute (USA) for their in vitro activities against a panel of 60 different human cancer cell lines. Among them, compounds 16, 20 and 21 exhibited remarkable cytotoxic activity against numerous human cancer cell lines. We found that sulfonamide derivative 21 appeared to be more selective...
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A New Approach to the PWM Modulation for the Multiphase Matrix Converters Supplying Loads with Open-End Winding.
PublicationThis article presents three variants of the Pulse Width Modulation (PWM) for the Double Square Multiphase type Conventional Matrix Converters (DSM-CMC) supplying loads with the open-end winding. The first variant of PWM offers the ability to obtain zero value of the common-mode voltage at the load's terminals and applies only six switches within the modulation period. The second proposal archives for less Total Harmonic Distortion...
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From tryptophan to novel mitochondria-disruptive agent, synthesis and biological evaluation of 1,2,3,6-tetrasubstituted carbazoles
PublicationMitochondrial targeting plays an important role in anticancer therapy. The Mn(III)-promoted cyclization of 5- (1H-indol-3-yl)-3-oxopentanoic acid allow to obtain novel substituted carbazole derivatives that can act as mitochondria-disruptive agents. The starting materials used for the synthesis of these new aminocarbazoles are oxopentanoate derivatives of tryptophan. The scope and limitation of this method of synthesis are determined...
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Deformable model of a butterfly in motion on the example of Attacus atlas
PublicationInsect wings can undergo significant chordwise (camber) as well as spanwise (twist) deformation during flapping flight but the effect of these deformations is not well understood. The shape and size of butterfly wings leads to particularly large wing deformations, making them an ideal test case for investigation of these effects. High-speed videogrammetry was used to capture the wing kinematics and deformations. The movements of...
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ROAD SAFETY FOR CYCLISTS BASED ON THE CALORIES NEEDED
PublicationCyclists are a vulnerable group of road users, especially when no separate infrastructure for cyclists is provided. Then, road factors such as distance and altitude differences can indirectly affect cyclists' safety. Therefore, the authors proposed a procedure based on the geometric characteristics of the road that can determine riding difficulties for cyclists. The proposed procedure can be used both by the public authorities who...
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Performance Characteristics of a Micro-Turbine
PublicationIn the paper a design of a multi-stage micro-turbine with partial admission of all the stages is described in detail and the results of particular experimental investigations and numerical calculations are shown, followed by conclusions. The co-generative micro-power plant with the HFE7100 as a working medium was designed and built for experimental investigations. The values of the main cycle parameters were as follows:heat output:...
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Performance Characteristics of a Micro-turbine, International
Publication. In the paper a design of a multi-stage micro-turbine with partial admission of all the stages is described in detail and the results of particular experimental investigations and numerical calculations are shown, followed by conclusions. The co-generative micro-power plant with the HFE7100 as a working medium was designed and built for experimental investigations. The values of the main cycle parameters were as follows:- heat...
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Toward Fast Calculation of Communication Paths for Resilient Routing
PublicationUtilization of alternate communication paths is a common technique to provide protection of transmission against failures of network nodes/links. However, a noticeable delay is encountered when calculating the relevant sets of disjoint paths using the available algorithms (e.g., using Bhandari’s approach). This, in turn, may have a serious impact on the ability of a network to serve dynamic demands...
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Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents
PublicationAcridine and acridone analogues were prepared by Ullmann condensation and then cyclization reaction. As a result of nucleophilic substitution reaction 1-nitro-9-phenoxyacridine or 1-chloro-4-nitro-9(10H)-acridone with the corresponding peptides, the planned acridine derivatives (10a-c, 12, 17-a-d, 19) have been obtained. The cytotoxic activity of the newly obtained analogs were evaluated against melanotic (Ma) and amelanotic (Ab)...
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The microbial and sensory quality of mackerel hot smoked in mild conditions
PublicationThe quality indices of Atlantic mackerel, hot smoked at core temperature not exceeding 60°C, containing 14–27 g salt and 580–670 g water per kg meat, was determined just after smoking and during storage. The aerobic plate count after smoking, chilling and packing in cardboard boxes was 0–12 cfu/25 cm2of the skin of the smoked fish and 10–240 cfu/g of flesh. It was 1.9 log cycle lower than that in the frozen raw material. At 2°C,...
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Investigation of use of hydrophilic/hydrophobic NADESs for selective extraction of As(III) and Sb(III) ions in vegetable samples: Air assisted liquid phase microextraction and chemometric optimization
PublicationIn this paper, a green, cost-effective sample preparation method based on air assisted liquid phase microextraction (AA-LPME) was developed for the simultaneous extraction of As(III) and Sb(III) ions from vegetable samples using hydrophilic/hydrophobic natural deep eutectic solvents (NADESs). Central composite design was used for the optimization of extraction factors including NADES volume, extraction cycle, pH, and curcumin concentration....