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Design, synthesis and high antitumor potential of new unsymmetrical bisacridine derivatives towards human solid tumors, specifically pancreatic cancers and their unique ability to stabilize DNA G-quadruplexes
PublikacjaNew promising unsymmetrical bisacridine derivatives (UAs), have been developed. Three groupsincluding 36 compounds were synthesized by the condensation of 4-nitro or 4-methylacridinone, imi-dazoacridinone and triazoloacridinone derivatives with 1-nitroacridine compounds linked with anaminoalkyl chain. Cytotoxicity screening revealed the high potency of these compounds against severaltumor cell lines. Particularly, imidazoacridinone-1-nitroacridine...
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Improving depth maps of plants by using a set of five cameras
PublikacjaObtaining high-quality depth maps and disparity maps with the use of a stereo camera is a challenging task for some kinds of objects. The quality of these maps can be improved by taking advantage of a larger number of cameras. The research on the usage of a set of five cameras to obtain disparity maps is presented. The set consists of a central camera and four side cameras. An algorithm for making disparity maps called multiple...
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Synthesis and molecular structure of novel 2-(alkylthio)-4-chloro-N-(4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-5-methylbenzenesulfonamideswith potential anticancer activity
PublikacjaOtrzymano 15 nowych związków: 2-(alkilotio)-4-chloro-N-(4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-5-metylobenzenosulfonamidów, dla których opracowano nową metodę syntezy. Dla jednej pochodnej wyznaczono strukturę rentgenowską. Związek nr 36 wykazuje wysoką aktywność przeciwnowotworową w stosunku do 13 linii komórek nowotworowych o poziomie GI_50 w zakresie stężeń 1,9-3,0 μM.
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C-1311 (Symadex), a potential anti-cancer drug, intercalates into DNA between A and G moieties. NMR-derived and MD-refined stereostructure of the d(GAGGCCTC) 2 :C-1311 complex
PublikacjaImidazoacridinone C-1311 (Symadex®) is an antitumor agent which has been recommended for Phase II clinical trials a few years ago. Previously, it was shown experimentally that during the initial stage of its action C-1311 forms stable intercalation complexes with DNA duplexes. Herein, a NMR-derived stereostructure of d(GAGGCCTC)2:C-1311 complex was reported. The ligand was found locating itself between A and G moieties, forming...
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Solubility of carbon dioxide in water: Some useful results for hydrate nucleation
PublikacjaIn this paper, the solubility of carbon dioxide (CO2) in water along the isobar of 400 bar is determined by computer simulations using the well-known TIP4P/Ice force field for water and the TraPPE model for CO2. In particular, the solubility of CO2 in water when in contact with the CO2 liquid phase and the solubility of CO2 in water when in contact with the hydrate have been determined. The solubility of CO2 in a liquid–liquid...
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Carnivorous plants used for green synthesis of silver nanoparticles with broad-spectrum antimicrobial activity
PublikacjaIn this study, we exploit the anti-oxidative potential of four carnivorous plants to produce uniform and biologically active silver nanoparticles. The use of polyvinylpyrrolidone promoted syn-thesis of quasi-spherical nanoparticles characterized by stability and high uniformity. Their activity was tested against three human pathogens and three species of plant pathogenic bacteria. The study demonstrates the influence of synthesis...
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Oscylacje różnicy potencjału elektrochemicznego między fazami oscylatora z membraną ciekłą zawierającego bromek heksadecylotrimetyloamoniowy.Oscyllations of electrochemical potential difference between phases of liquid membrane oscillator containing heksadecyltrimethylammonium bromide.
PublikacjaBadano zmiany różnicy potencjału elektrochemicznego między fazami wodnymi oscylatora z membraną ciekłą zawierającego bromek heksadecylotrimetyloamoniowy przy zastosowaniu mikroelektrod Ag/AgCl/Cl. Stwierdzono, iż główny udział do różnicy potencjału elektrochemicznego między fazami wodnymi, wnoszą różnice potencjału między odpowiednią faza wodną i membraną ciekłą. Wartości obliczone z poszczególnych składowych są w bardzo dobrej...
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Exsolution of Ni nanoparticles on the surface of cerium and nickel co-doped lanthanum strontium titanate as a new anodic layer for DIR-SOFC. Anti-coking potential and H2S poisoning resistance of the prepared material
PublikacjaThe aim of this study was to evaluate a new catalytic material for biogas fueled DIR-SOFC. This material was a perovskite-type SrTiO3 doped with La, Ce and Ni of a general formula La0.27Sr0.54Ce0.09Ni0.1Ti0.9O3-σ (LSCNT). Additional preparation steps were undertaken to promote a nickel exsolution process. Heat post-treatment of powders in a humidified H2 resulted in an intensive growth of nickel nanoparticles (NPs) while the temperature...
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Determination of pseudocapacitance chan ges of nickel oxide NiO electrode with use of dynamic electrochemical impedancje spectroscopy
PublikacjaThe electrochemical capacitors (ECs) are attractive energy storage devices which can be applied in many electronic products (e.g., cameras, laptops, cell phones) or hybrid electric vehicles (HEV). The energy storage in ECs is based on capacitive (the electrical double layer charging/discharging) and pseudocapacitive (additional charge provided by faradic reaction) phenomena. Considering the electrodes exhibiting pseudocapacitance,...
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Mechanical Properties of Twisted Carbon Nanotube Bundles with Carbon Linkers from Molecular Dynamics Simulations
PublikacjaThe manufacturing of high-modulus, high-strength fibers is of paramount importance for real-world, high-end applications. In this respect, carbon nanotubes represent the ideal candidates for realizing such fibers. However, their remarkable mechanical performance is difficult to bring up to the macroscale, due to the low load transfer within the fiber. A strategy to increase such load transfer is the introduction of chemical linkers...
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Chromatographic analysis of extracts isolated from different poplar species as potential inhibitors of enzymatic hydrolysis Analiza chromatograficzna substancji ekstrakcyjnych pozyskanych z różnych odmian topoli jako potencjalnych inhibitorów hydrolizy enzymatycznej
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Synthesis, molecular structure, and metabolic stability of new series of N' -(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)-1-(5-phenyl-1 H -pyrazol-1-yl)amidine as potential anti-cancer agents
PublikacjaA series of new N'-(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)-1-(5-phenyl-1H-pyrazol-1-yl)amidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cancer MCF-7. The studied compounds display selective activity mainly against HCT-116 and HeLa cells. Thus, five compounds show selective cytotoxic...
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Internationalization and Quality Assurance in Higher Education
PublikacjaInternationalization is an inevitable phenomenon among all contemporary higher education institutions (HEIs) in a globalizing world. It is the driving force for development and progress. In course of the last 30 years, it became an inevitable element of HE management. However, it carries along a number of risks, pitfalls, and organizational challenges. To hedge those, quality assurance (QA) is called to the stage. HEIs therefore...
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Time series analysis and impact assessment of the temperature changes on the vegetation and the water availability: A case study of Bakun-Murum Catchment Region in Malaysia
PublikacjaThe Bakun-Murum (BM) catchment region of the Rajang River Basin (RRB), Sarawak, Malaysia, has been under severe threat for the last few years due to urbanization, global warming, and climate change. The present study aimed to evaluate the time series analysis and impact assessment of the temperature changes on the vegetation/agricultural lands and the water availability within the BM region. For this purpose, the Landsat data for...
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Serum bisphenol A concentrations correlate with serum testosterone levels in women with polycystic ovary syndrome
PublikacjaThe aim of this study was to determine serum bisphenol A (BPA) concentrations using high performance liquid chromatography with tandem mass spectrometry (HPLC–MS/MS) in women with polycystic ovary syndrome (PCOS) (n=106, age range 18–40 yrs) and to evaluate its potential impact on their hormonal and metabolic profile. The control group consisted of age- and BMI-matched 80 eumenorrheic women with no clinical or biochemical hyperandrogenism....
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3D scanning system for railway current collector contact strips
PublikacjaUndisturbed collection of current from a contact wire of the catenary constitutes one of the basic elements in reliable operation of electrified rail transport, particularly when vehicles move at high speed. Quality of current collection is influenced by the construction of catenary and current collectors, as well as by the technical condition and regulation of these two elements. Total contact force of a current collector head...
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Integrated spatial and energy planning – importance of a problem for contemporary architects and urban planners with focus on environmental factors
PublikacjaAlong with respecting basic sustainable development goals, planners will also be obliged to meet more stringent provisions related to energy efficiency in the coming years. In Poland, a crucial year will be 2021, when the EU directive on the energy efficiency of buildings comes into force. In this matter, not only the characteristics of individual objects are of great importance, but their whole complexes and the overall approach...
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A. Computational analysis by molecular docking of thirty alkaloid compounds from medicinal plants as potent inhibitors of SARS-CoV-2 main protease(2020). Focused on analysis of the Medicinal plants that have potential therapeutic ability against COVID-19.
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Significance of Dermoscopy in Association with Clinical Features in Differentiation of Basal Cell Carcinoma and Benign Trichoblastic Tumours
PublikacjaBackground: Although basal cell carcinoma (BCC) can, in the majority of cases, be diagnosed based on clinical and dermoscopic assessment, a potential overlap with benign adnexal skin tumours seems to exist, including trichoblastic tumours (TT). Methods: Retrospective analysis of clinical and dermoscopic features of benign TT and BCC cases was performed to develop a diagnostic algorithm with a potential utility in clinical practice....
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A Bayesian regularization-backpropagation neural network model for peeling computations
PublikacjaA Bayesian regularization-backpropagation neural network (BRBPNN) model is employed to predict some aspects of the gecko spatula peeling, viz. the variation of the maximum normal and tangential pull-off forces and the resultant force angle at detachment with the peeling angle. K-fold cross validation is used to improve the effectiveness of the model. The input data is taken from finite element (FE) peeling results. The neural network...
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Solubility of Methane in Water: Some Useful Results for Hydrate Nucleation
PublikacjaIn this paper, the solubility of methane in water along the 400 bar isobar is determined by computer simulations using the TIP4P/Ice force field for water and a simple LJ model for methane. In particular, the solubility of methane in water when in contact with the gas phase and the solubility of methane in water when in contact with the hydrate has been determined. The solubility of methane in a gas–liquid system decreases as temperature...
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The Physicochemical and Antibacterial Properties of Chitosan-Based Materials Modified with Phenolic Acids Irradiated by UVC Light
PublikacjaThis paper concerns the physicochemical properties of chitosan/phenolic acid thin films irradiated by ultraviolet radiation with wavelengths between 200 and 290 nm (UVC) light. We investigated the preparation and characterization of thin films based on chitosan (CTS) with tannic (TA), caffeic (CA) and ferulic acid (FA) addition as potential food‐packaging materials. Such materials were then exposed to the UVC light (254 nm) for...
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Assessing the Significance of Displacements Using Local Coefficients of Variance as an Alternative to the Classical Approach
PublikacjaThe safety of use of civil engineering structures remains an important issue that is approached by various sciences. Due to this fact, geodetic control measurements are conducted with the purpose of identifying threats connected with the potential displacement of structural elements. In this context, the authors discuss issues connected with determining the displacements of controlled points located in the studied object in a three-dimensional...
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An Empirical System Loss Model for Body Area Networks in a Passenger Ferry Environment
PublikacjaThis paper presents a general empirical system loss model for estimating propagation loss in Body Area Networks in off-body communications at 2.45 GHz in a passenger ferry environment. The model is based on measurements, which were carried out in dynamic scenarios in the discotheque passenger ferry environment. The model consists of three components: mean system loss, attenuation resulting from the variable antenna position on...
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An Empirical System Loss Model for Body Area Networks in a Passenger Ferry Environment
PublikacjaThis paper presents a general empirical system loss model for estimating propagation loss in Body Area Networks in off-body communications at 2.45 GHz in a passenger ferry environment. The model is based on measurements, which were carried out in dynamic scenarios in the discotheque passenger ferry environment. The model consists of three components: mean system loss, attenuation resulting from the variable antenna position on...
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Manufacturing and Recycling Impact on Environmental Life Cycle Assessment of Innovative Wind Power Plant Part 1/2
PublikacjaWind power plants are considered as ecologically-clean source of energy. However, manufacturing processes cannot be treated that way. Manufacturing processes consume huge amount of electrical and thermal energy and significant amount of materials, e.g. steel, polymers, oils and lubricants. All of the above could be potentially harmful for environment. There are not many works and publications regarding life-cycle analysis of wind...
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Combined numerical and experimental approach to determine numerical model of abdominal scaffold
PublikacjaA proper junction of the prosthesis and the abdominal wall is important in successful hernia repair. The number of tacks should be balanced to assure appropriate mesh fixation and not to induce post-operative pain. Numerical simulations help to find this balance. The study is aimed at creating a proper numerical model of a knitted surgical mesh subjected to boundary conditions and load occurring in the abdominal cavity. Continuous,...
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Low-strain sensor based on the flexible boron-doped diamond-polymer structures
PublikacjaA free-standing high boron-doped diamond nanosheet (BDDNS) has been fabricated for the development of a flexible BDDNS strain senor. High boron-doped diamond was initially grown on a tantalum substrate in a microwave plasma-assisted chemical vapor deposition method, and was then transferred to a Kapton polymer substrate to fabricate the flexible BDDNS/Kapton device. Before performing the transfer process, the thin BDDNS’s morphology...
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POTENTIAL APPLICATIONS OF ELECTRONIC NOSE BASED ON ULTRA FAST GAS CHROMATOGRAPHY TO DISTINGUISH ALCOHOLIC BEVERAGES MADE OF GRAIN = POTENCJALNE MOŻLIWOŚCI ZASTOSOWANIA ELEKTRONICZNEGO NOSA OPARTEGO NA ULTRA SZYBKIEJ CHROMATOGRAFII GAZOWEJ DO ODRÓŻNIANIA NAPOJÓW SPIRYTUSOWYCH POCHODZENIA ZBOŻOWEGO
PublikacjaStan środowiska a zwłaszcza powietrza ma wpływ na wiele aspektów życia, m in. na jakość produktów spożywczych. Z tego względu niezwykle ważne jest monitorowanie stanu środowiska, które odbywa się za pomocą wielu technik analitycznych. Jedną z nich jest elektroniczny nos. Pierwotnie elektroniczny nos był wykorzystywany tylko do badania uciążliwości zapachowej powietrza. Obecnie technika ta wykorzystywana jest również do monitorowania...
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Tetracycline and ampicillin resistance of Escherichia coli strains of surface water origin: the potential for horizontal transfer of resistance genes = Oporność na tetracyklinę i ampicylinę szczepów Escherichia Coli wyizolowanych z wody powierzchniowej : możliwość horyzontalnego przenoszenia genów oporności
PublikacjaThe aim of this preliminary study was to assess the occurrence and molecular diversity of tetracycline and ampicillin resistance genes carried by Escherichia coli present in surface water. Bacterial strains were isolated from two watercourses (the Reda River and the Oliwski Stream) that influence the quality of coastal waters in the Gdańsk Bay (Northern Poland) by direct discharge. The bacterial drug susceptibility, tested against...
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Highly linear self-assembled porphyrin wires
PublikacjaAn efficient noncovalent assembly process involving high geometrical control was applied to a linear bis(imidazolyl zinc porphyrin) 7Zn, bearing C18 substitutents, to generate linear multiporphyrin wires. The association process is based on imidazole recognition within the cavity of the phenanthroline-strapped zinc porphyrin. In chlorinated solvents, discrete soluble oligomers were obtained after (7Zn)n was end-capped with a terminal...
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State-of-the-art ideas for engineering laboratory classes – virtual reality framework
PublikacjaNowadays challenges in science and technology are a driving force in the development of contemporary solutions in education. Virtual reality brings to an edge human imagination. In this paper, authors propose a framework for civil engineering laboratory classes which brings a new quality in this area. The framework shows how to provide learners with an environment where they can realize the health and safety hazards of construction...
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REVIEW OF CURRENT RESEARCH ON CHITOSAN AS A RAW MATERIAL IN THREE-DIMENSIONAL PRINTING TECHNOLOGY IN BIOMEDICAL APPLICATIONS
PublikacjaThree-dimensional (3D) biomaterial manufacturing strategies show an extraordinary driving force for the development of innovative solutions in the biomedical sector, including drug delivery systems, disease modelling and tissue and organ engineering. Due to its remarkable and promising biological and structural properties, chitosan has been widely studied for decades in several potential applications in the biomedical field. However,...
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The elasto-plastic numerical study of crack initiation in notched PMMA specimens under uniaxial loading conditions – Tension and torsion
PublikacjaThis paper presents the results of FEM numerical calculations aimed at describing the plastic strain and stress fields under critical loading conditions: tensile force or torsional moment. The calculations were carried out with reference to the results of experimental tensile and torsional tests of flat PMMA specimens weakened with V-notches of different root radii: 0.5, 2 and 10 mm. The procedure for conducting nonlinear numerical...
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Call Control Evaluation in ASON/GMPLS Architecture
PublikacjaThe Automatically Switched Optical Network (ASON) utilizing Generalized Multi–Protocol Label Switching (GMPLS) protocols named as ASON/GMPLS is one of the propositions of Next Generation Network. The basic assumption of ASON control plane is a separation of call control from connection control. The control plane is divided into call control and connection control components. Presented work regards the problem of call control evaluation...
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Spontaneous electron emission vs dissociation in internally hot silver dimer anions
PublikacjaReferring to a recent experiment, we theoretically study the process of a two-channel decay of the diatomic silver anion (Ag2-), namely the spontaneous electron ejection giving Ag2 + e- and the dissociation leading to Ag- + Ag. The ground state potential energy curves of the silver molecules of diatomic neutral and negative ion were calculated using proper pseudo-potentials and atomic basis sets. We also estimated the non-adiabatic...
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Extended duration running and impulse loading characteristics of an acoustic bearing with enhanced geometry
PublikacjaThis paper presents performance during prolonged running of the acoustic bearing when PZTs are switched off and when they are switched on. The effect of active PZT on shaft’s displacements in X and Y directions is clearly demonstrated. Performance of the acoustic bearing was also assessed when an impulse force was applied to the running shaft at speed. Once again the benefits of having PZTs active are beyond doubt. The instability...
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Spatial distribution of pharmaceuticals in conventional wastewater treatment plant with Sludge Treatment Reed Beds technology
PublikacjaPharmaceutical residues are an emerging environmental problem. It is strongly confirmed that pharmaceuticals are present in soils and environmental waters (surface, marine and even groundwater), and that wastewater treatment plant (WWTP) effluents are the main source of pharmaceuticals in the watershed. The aim of this studywas to recognize the spatial distribution and seasonal changes of selected pharmaceuticals in conventional WWTP...
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Wpływ strat mechanicznych w siłowniku teleskopowym zespołu zagęszczającego w pojeździe do usuwania odpadów z pojemników na skuteczność prasowania odpadów
PublikacjaHydraulic telescopic cylinders are used to power the moving wall of rear loader garbage trucks equipped with the traditional "sweep and slide" system. As the garbage compression force is directly dependent on the resistance force of the moving wall, losses in the hydraulic telescopic cylinder influence the compaction process. Taking them into account in the control system may improve the operation of the compaction...
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Comparison of Average Energy Slope Estimation Formulas for One-dimensional Steady Gradually Varied Flow
PublikacjaTo find the steady flow water surface profile, it is possible to use Bernoulli’s equation, which is a discrete form of the differential energy equation. Such an approach requires the average energy slope between cross-sections to be estimated. In the literature, many methods are proposed for estimating the average energy slope in this case, such as the arithmetic mean, resulting in the standard step method, the harmonic mean and...
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Call Processing Performance in a Multidomain IMS/NGN with Asymmetric Traffic
PublikacjaIn this paper we continue our research using the previously proposed analytical traffic model of a multidomain Next Generation Network (NGN), which is standardized for delivering multimedia services based on the IP Multimedia Subsystem (IMS). The aim of the model is to assess mean Call Set-up Delay (CSD) and mean Call Disengagement Delay (CDD), which are standardized call processing performance parameters. The output variables...
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Rola nowego tramwaju wodnego w Gdańsku
PublikacjaStreszczenie Tramwaj wodny – środek miejskiej komunikacji zbiorowej czy jednostka przewozów turystyczny? Identyfikacja, zestawienie i analiza czynników transportu nowopowstałej usługi przewozowej z komunikacją miejską i przewozem turystycznym tj. :cennik biletów, sposobu dystrybucji biletów, czasu przejazdu dostępności, przebieg trasy i częstotliwości kursowania. Wskazanie funkcji przewozowej tramwaju wodnego w Gdańsku.
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The significance of the properties of water for the working cycle of the kinesin molecular motor
PublikacjaExplicit solvent molecular dynamics simulations were performed in this study to investigate and discuss several aspects of the influence of the properties of water on the working cycle of a molecular motor from the kinesin superfamily. The main objects of attention were: the binding of the neck linker and the association of the kinesin and the tubulin. The docking of the neck linker is considered a crucial event during the working...
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Self-assessment of competencies of students and graduates participating in didactic projects – Case study
PublikacjaAim/purpose: the aim of this article is to examine the opinions of students and graduates of the faculty of economics of a technical university as regards their selfassessment of their preparation for entering the modern labour market. All the respondents participated during their studies in didactic projects aimed at improving their competencies taking into account the expectations of potential employers. Design/methodology/approach:...
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Computational Complexity and Its Influence on Predictive Capabilities of Machine Learning Models for Concrete Mix Design
PublikacjaThe design of concrete mixtures is crucial in concrete technology, aiming to produce concrete that meets specific quality and performance criteria. Modern standards require not only strength but also eco-friendliness and production efficiency. Based on the Three Equation Method, conventional mix design methods involve analytical and laboratory procedures but are insufficient for contemporary concrete technology, leading to overengineering...
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Path Loss Measurements in Wideband Radio Link Designed for Maritime Environment
PublikacjaIn the article, the research and analysis of path loss in designed and evaluated digital radio link for high-speed data transmission in maritime environment is presented. Collected samples of received signal were used to determine the mean path loss and its standard deviation. Measuring campaign was carried out in a real maritime conditions. The mean value of path loss reached 126 dB on a distance of 11.16 km.
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Practical Eco-Driving Strategy for Suburban Electric Multiple Unit
PublikacjaIn this paper, a practical approach to velocity profile optimization for electric multiple unit was presented. The study focuses on a case of fast urban railway, which is a popular mean of transport across Tricity, Poland. Based on observations and measurements, a potential for improvement of energy efficiency by modifying the speed profile was recognized. In order to conduct necessary calculations, simulation model of railway...
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Exergy and Energy Analyses of Microwave Dryer for Cantaloupe Slice and Prediction of Thermodynamic Parameters Using ANN and ANFIS Algorithms
PublikacjaThe study targeted towards drying of cantaloupe slices with various thicknesses in a microwave dryer. The experiments were carried out at three microwave powers of 180, 360, and 540 W and three thicknesses of 2, 4, and 6 mm for cantaloupe drying, and the weight variations were determined. Artificial neural networks (ANN) and adaptive neuro-fuzzy inference systems (ANFIS) were exploited to investigate energy and exergy indices of...
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Stability of truss with side - supports. The case of linear and rotational elastic supports
PublikacjaThe research is devoted to study lateral buckling of truss with linear and rotational elastic side-supports. Geometrically nonlinear analysis of example truss with linear and rotational elastic sidesupports is carried out. The limit normal force in compressed chord of the truss due to stiffness of side supports is calculated. The elastic support reaction in relation to force in compressed chordand coefficient of buckling length...
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ANALIZA PORÓWNAWCZA DROGI HAMOWANIA MOTOCYKLA Z WŁĄCZONYM I WYŁĄCZONYM UKŁADEM ABS
PublikacjaW artykule przedstawiono wyniki pomiaru drogi hamowania motocykla przy użyciu hamulca koła przedniego, koła tylnego oraz kombinacji obu tych hamulców. Próby intensywnego hamowania motocykla przeprowadzono na suchej nawierzchni asfaltowej z włączonym i wyłączonym układem ABS. Na podstawie zmierzonej drogi hamowania dokonano obliczenia średniego opóźnienia hamowania.