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Wyniki wyszukiwania dla: classical capacity
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Application of GC-MS/MS technique for the determination of benzodiazepines in blood samples
PublikacjaAbstract Benzodiazepines (BZD) are widely used as pharmaceuticals in medicine. However, due to psychostimulatory effect of BZD, in the last decade, they are more and more often used as drugs of abuse. These compounds produce similar effects to classical illicit drugs and are sold as “legal” alternatives to them as new psychoactive substances (NPS). Currently new BZD, named designer benzodiazepines (DBZD), are synthesized each year...
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GreedyMAX-type Algorithms for the Maximum Independent Set Problem
PublikacjaA maximum independent set problem for a simple graph G = (V,E) is to find the largest subset of pairwise nonadjacent vertices. The problem is known to be NP-hard and it is also hard to approximate. Within this article we introduce a non-negative integer valued functionp defined on the vertex set V(G) and called a potential function of agraph G, while P(G) = max{vinV(G)| p(v)} is called a potential of G. For any graph P(G) <= D(G),...
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Bridging challenges of clinical decision support systems with a semantic approach. A case study on breast cancer
PublikacjaThe integration of Clinical Decision Support Systems (CDSS) in nowadays clinical environments has not been fully achieved yet. Although numerous approaches and technologies have been proposed since 1960, there are still open gaps that need to be bridged. In this work we present advances from the established state of the art, overcoming some of the most notorious reported difficulties in: (i) automating CDSS, (ii) clinical workflow...
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Lagrangian model of an isolated dc-dc converter with a 3-phase medium frequency transformer accounting magnetic cross saturation
PublikacjaThis article presents a nonlinear equivalent circuit model of an isolated dc-dc converter with a 3-phase medium frequency transformer. The model takes into account the magnetic cross saturation of the 3-phase core-type magnetic circuit. The model is suitable in detailed electromagnetic transient simulations of power systems involving isolated dc-dc converters. The model is developed using the Lagrange energy method. It involves...
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How acidic amino acid residues facilitate DNA target site selection
PublikacjaDespite the negative charge of the DNA backbone, acidic residues (Asp/Glu) commonly participate in the base readout, with a strong preference for cytosine. In fact, in the solved DNA/protein structures, cytosine is recognized almost exclusively by Asp/Glu through a direct hydrogen bond, while at the same time, adenine, regardless of its amino group, shows no propensity for Asp/Glu. Here, we analyzed the contribution of Asp/Glu...
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Arithmetic Loophole in Bell's Theorem: Overlooked Threat to Entangled-State Quantum Cryptography
PublikacjaBell’s theorem is supposed to exclude all local hidden-variable models of quantum correlations. However,an explicit counterexample shows that a new class of local realistic models, based on generalized arith-metic and calculus, can exactly reconstruct rotationally symmetric quantum probabilities typical oftwo-electron singlet states. Observable probabilities are consistent with the usual arithmetic employedby macroscopic observers...
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Market Structure and Market Power in Selected Sectors of The Polish Economy Based on COICOP Classification
PublikacjaThis paper present new and simple measures of market structure and market power. Based on the classical models of market structures, where a given structure is determined by the number of enterprises, indexes of degree of monopoly have been estimated, representing an average number of entities per branch. Additionally, market power indexes have been determined as an average revenue per an enterprise in a given branch. This approach...
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An energetic analysis of a gas turbine with regenerative heating using turbine extraction at intermediate pressure - Brayton cycle advanced according to Szewalski's idea
PublikacjaIn this paper, a modification of a simple gas turbine into the Brayton cycle with regenerative heating, using turbine extraction at intermediate pressure, is presented. The main concept of the retrofitting is based on the transfer of heat from the turbine exhaust gases to the air entering the combustion chamber. The extracted gas transfers heat to air via the divided regenerative heat exchanger and after that is compressed and...
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On the deformation and frequency analyses of SARS-CoV-2 at nanoscale
PublikacjaThe SARS-CoV-2 virus, which has emerged as a Covid-19 pandemic, has had the most significant impact on people's health, economy, and lifestyle around the world today. In the present study, the SARS-CoV-2 virus is mechanically simulated to obtain its deformation and natural frequencies. The virus under analysis is modeled on a viscoelastic spherical structure. The theory of shell structures in mechanics is used to derive the governing...
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Active Control of Highly Autocorrelated Machinery Noise in Multivariate Nonminimum Phase Systems
PublikacjaIn this paper, a novel multivariate active noise control scheme, designed to attenuate disturbances with high autocorrelation characteristics and preserve background signals, is proposed. The algorithm belongs to the class of feedback controllers and, unlike the popular feedforward FX-LMS approach, does not require availability of a reference signal. The proposed approach draws its inspiration from the iterative learning control...
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Deep Eutectic Solvents as Agents for Improving the Solubility of Edaravone: Experimental and Theoretical Considerations
PublikacjaIn this study, both practical and theoretical aspects of the solubility of edaravone (EDA) in Deep Eutectic Solvents (DESs) were considered. The solubility of edaravone in some media, including water, can be limited, which creates the need for new efficient and environmentally safe solvents. The solubility of EDA was measured spectrophotometrically and the complex intermolecular interactions within the systems were studied with...
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Deep Eutectic Solvents as Agents for Improving the Solubility of Edaravone: Experimental and Theoretical Considerations
PublikacjaIn this study, both practical and theoretical aspects of the solubility of edaravone (EDA) in Deep Eutectic Solvents (DESs) were considered. The solubility of edaravone in some media, including water, can be limited, which creates the need for new efficient and environmentally safe solvents. The solubility of EDA was measured spectrophotometrically and the complex intermolecular interactions within the systems were studied with...
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Discrete and continuous fractional persistence problems – the positivity property and applications
PublikacjaIn this article, we study the continuous and discrete fractional persistence problem which looks for the persistence of properties of a given classical (α=1) differential equation in the fractional case (here using fractional Caputo’s derivatives) and the numerical scheme which are associated (here with discrete Grünwald–Letnikov derivatives). Our main concerns are positivity, order preserving ,equilibrium points and stability...
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Revisiting The Determination Of Cutting Power While Sawing Of Wood With Circular Saw Blades By Means Of Fracture Mechanics
PublikacjaIn the classical approach, energetic effects (cutting forces and cutting power) of wood sawing process are generally calculated on the basis of the specific cutting resistance, which is in the case of wood cutting the function of more or less important factors. On the other hand, cutting forces (power) could be considered from a point of view of modern fracture mechanics. Cutting forces may be employed to determine not only toughness...
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Diagnostic system of wheeled tractors detecting four defect's categories
PublikacjaIn a classical approach to damage diagnosis, the technical condition of an analyzed machine is identified based on the measured symptoms, such as performance, thermal state or vibration parameters. In wheeled tractor the fundamental importance has monitoring and diagnostics during exploitation concerning technical inspection and fault element localizations. The main functions of a diagnostic system are: monitoring tractor components...
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Quantum structure in competing lizard communities
PublikacjaAlmost two decades of research on applications of the mathematical formalism of quantum theory as a modeling tool in domains different from the micro-world has given rise to many successful applications in situations related to human behavior and thought, more specifically in cognitive processes of decision-making and the ways concepts are combined into sentences. In this article, we extend this approach to animal behavior, showing...
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Localization of impulsive disturbances in audio signals using template matching
PublikacjaIn this paper, a new solution to the problem of elimination of impulsive disturbances from audio signals, based on the matched filtering technique, is proposed. The new approach stems from the observation that a large proportion of noise pulses corrupting audio recordings have highly repetitive shapes that match several typical “patterns”. In many cases a representative set of exemplary pulse waveforms can be extracted from the...
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Influence of the notch rounding radius on estimating the elastic notch stress concentration factor in a laser welded tee joint
PublikacjaIn recent years an increased interest of industry in sandwich-type metal structures can be observed. These structures consist of thin plates of 2.5 mm in thickness separated by stiffeners of different shapes and forms. Welds joining the plates and stiffeners are made on the outer side of the plates using laser welding technique. A locally focused source of heat causes the plate to melt creating a very narrow and elongated joint....
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3D seafloor reconstruction using data from side scan and synthetic aperture sonar
PublikacjaSide scan and synthetic aperture sonars are widely used imaging systems in the underwater environment. They are relatively cheap and easy to deploy, in comparison with more powerful sensors, like multibeam echosounders. Although side scan and synthetic aperture sonars does not provide seafloor bathymetry directly, their records are finally related to seafloor images. Moreover, the analysis of such images performed by human eye...
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Wild oscillations in a nonlinear neuron model with resets: (II) Mixed-mode oscillations
PublikacjaThis work continues the analysis of complex dynamics in a class of bidimensional nonlinear hybrid dynamical systems with resets modeling neuronal voltage dynamics with adaptation and spike emission. We show that these models can generically display a form of mixed-mode oscillations (MMOs), which are trajectories featuring an alternation of small oscillations with spikes or bursts (multiple consecutive spikes). The mechanism by...
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Theoretical calculation of the physico-chemical properties of 1-butyl-4-methylpyridinium based ionic liquids
PublikacjaACCEPTED MAIonic liquids (ILs) have attracted much attention for their unique physicochemical properties, which can be designed as needed by altering the ion combinations. Besides experimental work, numerous computational studies have been concerned with prediction of physical properties of ILs. The results of molecular dynamics simulations of ILs depend strongly on the proper force field parameterization. Classical force fields...
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Increased Certification of Semi-device Independent Random Numbers using Many Inputs and More Postprocessing
PublikacjaQuantum communication with systems of dimension larger than two provides advantages in information processing tasks. Examples include higher rates of key distribution and random number generation. The main disadvantage of using such multi-dimensional quantum systems is the increased complexity of the experimental setup. Here, we analyze a not-so-obvious problem: the relation between randomness certification and computational requirements...
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An Ultra-Low-Energy Analog Comparator for A/D Converters in CMOS Image Sensors
PublikacjaThis paper proposes a new solution of an ultra-low-energy analog comparator, dedicated to slope analog-to-digital converters (ADC), particularly suited for CMOS image sensors (CISs) featuring a large number of ADCs. For massively parallel imaging arrays, this number may be as high as tens-hundreds of thousands ADCs. As each ADC includes an analog comparator, the number of these comparators in CIS is always high. Detailed analysis...
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On possible applications of media described by fractional-order models in electromagnetic cloaking
PublikacjaThe purpose of this paper is to open a scientific discussion on possible applications of media described by fractional-order (FO) models (FOMs) in electromagnetic cloaking. A 2-D cloak based on active sources and the surface equivalence theorem is simulated. It employs a medium described by FOM in communication with sources cancelling the scattered field. A perfect electromagnetic active cloak is thereby demonstrated with the use...
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Interaction Design in Agile IT Projects
PublikacjaIn recent years, interactive systems, such as various types of software, online services or mobile applications, have become an integral part of everyday life. Interactive systems and digital services should be easy to use and provide a positive User Experience (UX). For this reason, interaction design has recently emerged as a distinct professional area of information technology (IT). Easy interaction and user experience (UX)...
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Condition-Based Monitoring of DC Motors Performed with Autoencoders
PublikacjaThis paper describes a condition-based monitoring system estimating DC motor degradation with the use of an autoencoder. Two methods of training the autoencoder are evaluated, namely backpropagation and extreme learning machines. The root mean square (RMS) error in the reconstruction of successive fragments of the measured DC motor angular-frequency signal, which is fed to the input of autoencoder, is used to determine the health...
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DESIGN LOGICAL LINGUISTIC MODELS TO CALCULATE NECESSITY IN TRUCKS DURING AGRICULTURAL CARGOES LOGISTICS USING FUZZY LOGIC
Publikacja: The study is aimed to develop the logic-linguistic models to design a number of rules for the correct calculation of the vehicles needed, taking into account the technical, technological, and weather and climate conditions of the harvesting and transport complex. The article has shown that the construction of the design of logic-linguistic models was not performed earlier to solve the problem of the agro-industrial production...
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Detection and time/frequency analysis of electric fields in the ground
PublikacjaThis paper sets out to detect and characterize electric fields in the ground (such as stray current fields) using a tandem time/frequency method of signal analysis. Results were obtained from investigations performed in the presence of a generated electric field with controlled variable characteristics, and in the presence of an electric field generated by a tramline. The analysis of measurement registers was performed using Short‐Time...
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Polygons vs. clumps of discs: A numerical study of the influence of grain shape on the mechanical behaviour of granular materials
PublikacjaWe performed a series of numerical vertical compression tests on assemblies 01 20 granular material using a Discrete Element code and studied the results with regard to the grain shape. The samples consist of 5000 grains made from either 3 overlapping discs (clumps - grains with concavities) or six-edged polygons (convex grains). These two grain type have similar external envelope, which is a fund ion of a geometrical parameter...
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Transport of dangerous goods by rail, and threats to the subsoil of the railway surface in the event of a disaster
PublikacjaIn Poland, in 2020, the mass of dangerous goods (loads) transported by rail was 26 151.06 thousand tone. This translated into the performance of 8 899 691.89 thousand tone - km of transport performance. In 2020, these figures accounted for 11.72% of the weight of goods transported by rail. The situation is similar in other countries around the world. With such a large volume of transport of dangerous...
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Graph Neural Networks and Structural Information on Ionic Liquids: A Cheminformatics Study on Molecular Physicochemical Property Prediction
PublikacjaIonic liquids (ILs) provide a promising solution in many industrial applications, such as solvents, absorbents, electrolytes, catalysts, lubricants, and many others. However, due to the enormous variety of their structures, uncovering or designing those with optimal attributes requires expensive and exhaustive simulations and experiments. For these reasons, searching for an efficient theoretical tool for finding the relationship...
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Deterministic versus stochastic modelling of unsaturated flow in a sandy field soil based on dual tracer breakthrough data
PublikacjaThe 216 km2 Neuenhagen Millcreeck catchment can be characterized as a drought sensitive landscape in NE Germany. It is therefore a fundamental human interest to understand how water that fell as precipitation moves through the unsaturated soils and recharges groundwater. Additionally, a better knowledge of nutrient transport from soil to groundwater is important also, especially in landscapes with light sandy soils. For a better...
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Discrete identification of continuous non-linear and non-stationary dynamical systems that is insensitive to noise correlation and measurement outliers
PublikacjaThe paper uses specific parameter estimation methods to identify the coefficients of continuous-time models represented by linear and non-linear ordinary differential equations. The necessary approximation of such systems in discrete time in the form of utility models is achieved by the use of properly tuned `integrating filters' of the FIR type. The resulting discrete-time descriptions retain the original continuous parameterization...
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Identyfikacja i izolacja genu kodującego zaadaptowaną do zimna β-galaktozydazę Paracoccus sp. = Identification and izolation of the gene encoding cold-active β-galactosidase from paracoccus sp.
PublikacjaZaprezentowane badania były prowadzone u eehi wyizolowania ze środo¬wiska organizmu psychrofilnego, zdolnego do hydrolizy laktozy w niskiej tempe¬raturze, oraz zidentyfikowania genu kodującego (i-galaktozydazę zaadaptowaną do zimna.Poszukiwan gen został w izolowany z psychrofilnego szczepu autarkicz¬nego Paracoccus sp. 321). Na podstawie sekwencji nukleotydowej genu kodują¬cego fS-galaktozdaze ustalono skład aminokwasów),...
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Efficient production of Staphylococcus simulans lysostaphin in a benchtop bioreactor by recombinant Escherichia coli.
PublikacjaLysostaphin is an enzyme with bactericidal activity against Staphylococcus aureus and other staphylococcal species. In spite of many advantages and promising results of preliminary research, the enzyme is still not widely used in medicine, veterinary or as a food preservative. One of the most important factors limiting application of the enzyme in clinical or technological practice is the high costs of its production. In the present...
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Cooperative control in production and logistics
PublikacjaClassical applications of control engineering and information and communication technology (ICT) in production and logistics are often done in a rigid, centralized and hierarchical way. These inflexible approaches are typically not able to cope with the complexities of the manufacturing environment, such as the instabilities, uncertainties and abrupt changes caused by internal and external disturbances, or a large number and variety...
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Novel approach to modeling spectral-domain optical coherence tomography with Monte Carlo method
PublikacjaNumerical modeling Optical Coherence Tomography (OCT) systems is needed for optical setup optimization, development of new signal processing methods and assessment of impact of different physical phenomena inside the sample on OCT signal. The Monte Carlo method has been often used for modeling Optical Coherence Tomography, as it is a well established tool for simulating light propagation in scattering media. However, in this method...
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Novel application of terminal restriction fragments length polymorphism method (t-RFLP) for identification of six clinically important Candida sp.
PublikacjaTerminal restriction fragments length polymorphism method (t-RFLP) is a modified classical RFLP method. The main difference is based on carrying out PCR using a fluorescently labeled primer or primers. The result of such modification is that after digestion of amplicons only terminal fragments of PCR product (containing fluorescent dye) are visualized. T-RFLP method has found application in environmental microbiology and epidemiology....
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Challenges in determination of pesticides from various chemical groups in fruits and vegetables applying QuEChERS method
PublikacjaPesticides are a large group of compounds with different physical and chemical properties, which place some of them among the most toxic, environmentally stable, and mobile substances. Nevertheless, their number, use, and application are continuously expanding. A consequence of their use is the possible presence of residues in treated food products. To protect consumers from exposure to unacceptable levels of pesticides Maximum...
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TMSCl Promoted Acylation of Amines with 5-(α-amino- α'-hydroxy)methylene Meldrum's Acids - Elucidation of Mechanism.
PublikacjaRecently we have observed accelerating influence of trimethyl silyl chloride addition on the rate of the reactions of 5-(α-amino- α'-hydroxy)methylene Meldrum's Acids with amines, particularly in the case of highly basic amines. However the nature of the aforementioned process remain unexplained. In proposed communication we wish to report insightful elucidation of this mechanism. The reaction under investigation involves simply...
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Distributed graph searching with a sense of direction
PublikacjaIn this work we consider the edge searching problem for vertex-weighted graphs with arbitrarily fast and invisible fugitive. The weight function w provides for each vertex v the minimum number of searchers required to guard v, i.e., the fugitive may not pass through v without being detected only if at least w(v) searchers are present at v. This problem is a generalization of the classical edge searching problem, in which one has...
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Dominant Pathways of Adenosyl Radical-Induced DNA Damage Revealed by QM/MM Metadynamics
PublikacjaBrominated nucleobases sensitize double stranded DNA to hydrated electrons, one of the dominant genotoxic species produced in hypoxic cancer cells during radiotherapy. Such radiosensitizers can therefore be administered locally to enhance treatment efficiency within the solid tumor while protecting the neighboring tissue. When a solvated electron attaches to 8-bromoadenosine, a potential sensitizer, the dissociation of bromide...
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Phase I and phase II metabolism simulation of antitumor-active 2-hydroxyacridinone with electrochemistry coupled on-line with mass spectrometry.
PublikacjaHere, we report the metabolic profile and the results of associated metabolic studies of 2-hydroxyacridinone (2-OH-AC), the reference compound for antitumor-active imidazo- and triazoloacridinones. Electrochemistry coupled with mass spectrometry was applied to simulate the general oxidative metabolism of 2-OH-AC for the first time. The reactivity of 2-OH-AC products to biomolecules was also examined. The usefulness of the electrochemistry...
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Manganese(III) Promoted Cyclization of N-alkenyl-N-(2-hydroxyethyl) amides to Iso-Oxacepham Potent β-Lactamase Inhibitors
PublikacjaBackground: β-Lactams are still a subject of interest of organic chemists. The main reason for this interest is due to their application as a chemotherapeutic. β-Lactam antibiotics are still the most commonly used drugs in bacterial infections. Method: Methods using 4-exo-trig radical cyclization leading to β-lactams are an alternative to classical Staudinger`s β-Lactams formation. We prepared N-alkenyl-N-(2-hydroxyethyl)amides...
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Compensation Topologies in IPT Systems: Standards, Requirements, Classification, Analysis, Comparison and Application
PublikacjaWireless power transfer devices are becoming more relevant and widespread. Therefore, an article is devoted to a review, analysis and comparison of compensation topologies for an inductive power transfer. A new classification of topologies is developed. A lot of attention is paid to the problems of the physical fundamentals of compensation work, standards, safety, and five main topology requirements. It is determined, that topologies...
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Catalytic Mechanism of Non-Target DNA Cleavage in CRISPR-Cas9 Revealed by Ab Initio Molecular Dynamics
PublikacjaCRISPR-Cas9 is a cutting-edge genome editing technology, which uses the endonuclease Cas9 to introduce mutations at desired sites of the genome. This revolutionary tool is promising to treat a myriad of human genetic diseases. Nevertheless, the molecular basis of DNA cleavage, which is a fundamental step for genome editing, has not been established. Here, quantum–classical molecular dynamics (MD) and free energy methods are used...
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Experience based knowledge representation for Internet of Things and Cyber Physical Systems with case studies
PublikacjaCyber Physical Systems and Internet of Things have grown significant attention from industry and academia during the past decade. The main reason behind this interest is the capabilities of such technologies to revolutionize human life since they appear as seamlessly integrating classical networks, networked objects and people to create more efficient environments. However, enhancing these technologies with intelligent skills becomes...
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Multi-layered mineral glass units used as viewport elements of underwater ship structures
PublikacjaIn the paper, Authors deals with viewport elements of underwater marine constructions. If a single-plate viewport constructions are considered, big thicknesses of the glass plate are required to resist the pressure. To build the viewports from the commercially accessible glass panes, multi-layered glass units are proposed in the paper. Numerical calculations are presented, summarized and compared with experimental tests. Focusing...
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Selected Aspects of 3D Printing for Emergency Replacement of Structural Elements
PublikacjaThe paper presents a synthetic characterization of modern methods of manufacturing or regenerating machine elements. Considered methods are machining and additive methods, in particular 3D printing in the FDM/FFF technique. For the study, the authors made samples of the holder bracket using selected methods. Samples made by machining operations, 3D printing with various filling were tested. The paper contains a technical and economic...
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A Single-Carrier-Based Pulse-Width Modulation Template for Cascaded H-Bridge Multilevel Inverters
PublikacjaMultiplicity of the triangular carrier signals is a criterion for the extension of sinusoidal pulsewidth modulation, SPWM, to a number of output voltage levels per phase-leg in cascaded H-bridge (CHB) multilevel inverter (MLI). Considering medium and high voltage applications where appreciable number of output voltage levels from CHB MLI is needed, commensurate high number of carrier signals in either classical level- or phase-shifted...