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Preliminary antifungal activity assay of selected chlorine-containing derivatives of xanthone and phenoxyethyl amines
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Simplified, serine‐rich theta‐defensin analogues as antitumour peptides
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Synthesis and biological evaluation of N-acylated tyramine sulfamates containing C-F bonds as steroid sulfatase inhibitors
PublikacjaSteroid sulfatase (STS) is responsible for the hydrolysis of biologically inactive sulfated steroids into their active un-sulfated forms and promotes the growth of various hormone-dependent cancers (e.g., breast cancer). Therefore, the STS enzyme is a promising therapeutic target for the treatment of steroid-sensitive cancers. Herein, we report the synthesis and biological evaluation of sulfamate analogs as potential STS inhibitors...
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Structure–activity relationships study on biological activity of peptides as dipeptidyl peptidase IV inhibitors by chemometric modeling
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Design and characteristics of gellan gum beads for modified release of meloxicam
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Aryl- and heteroaryl-substituted phenylalanines as AMPA receptor ligands
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Short Term Monitor of Photodegradation Processes in Ranitidine Hydrochloride Observed by FTIR and ATR FTIR
PublikacjaThe effects of degradation of ranitidine hydrochloride exposed to UVB radiation (l = 310 nm) and oxygen in a weathering chamber were studied by Fourier Transform Infrared spectroscopy (FTIR) and Attenuated Total Reflectance Fourier Transform Infrared spectroscopy (ATR-FTIR). ATR-FTIR profile indicated that the degradation was spatially heterogeneous. Significant amounts of photoproducts were detected only in a directly...
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CDK9: Therapeutic Perspective in HCC Therapy
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Current Challenges in Targeting Tumor Desmoplasia to Improve the Efficacy of Immunotherapy
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Investigating the disease‐modifying properties of sclerotiorin in Alzheimer's therapy using acetylcholinesterase inhibition
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Current state of a dual behaviour of antimicrobial peptides-Therapeutic agents and promising delivery vectors
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Structural Factors Affecting Cytotoxic Activity of (E)-1-(Benzo[d ][1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-one Derivatives
PublikacjaDerivatives of (E)-1-(5-alkoxybenzo[d][1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-one (1) demonstrated exceptionally high in vitro cytotoxic activity, with IC50 values of the most active derivatives in the nanomolar range. To identify structural fragments necessary for the activity, several analogs deprived of selected fragments were prepared, and their cytotoxic activity was tested. It was found that the activity depends on combined effects...
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Synthesis and biological evaluation of fluorinated 3-phenylcoumarin-7-O-sulfamate derivatives as steroid sulfatase inhibitors
PublikacjaIn the present work, we report the initial results of our study on a series of 3-phenylcoumarin sulfamate-based compounds containing C-F bonds as a novel inhibitors of steroid sulfatase (STS). The new compounds are potent STS inhibitors, possessing more than 10 times higher inhibitory potency than coumarin-7-O-sulfamate. In the course of our investigation, compounds 2b and 2c demonstrated the highest inhibitory effect in the enzymatic...
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Novel anticancer strategy aimed at targeting shelterin complexes by the induction of structural changes in telomeric DNA: hitting two birds with one stone.
PublikacjaThe ends of chromosomes in mammals are composed of telomeric DNA containing TTAGGG repeats, which bind specific proteins called shelterins. This telomeric DNA together with shelterins form a cap that protects the ends of chromosomes from being recognized as sites of DNA damage and from chromosomal fusions. Many very successful antitumor drugs used in the treatment of cancer patients bind to DNA, some of them with a prominent sequence...
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Effects of an immunosuppressive treatment on the rat prostate
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Influence of S-Oxidation on Cytotoxic Activity of Oxathiole-Fused Chalcones
PublikacjaSynthesis, in vitro cytotoxic activity, and interaction with tubulin of oxidized, isomeric 1-(5-alkoxybenzo[d] [1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-ones and 1-(6- alkoxybenzo[d][1,3]oxathiol-5-yl)-3-phenylprop-2-en-1- ones are described. Most of the compounds demonstrated cytotoxic activity at submicromolar concentrations. It was found that oxidation of sulfur atom of the oxathiole-fused chalcones strongly influenced activity...
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Magdalena Brzozowska-Woś dr hab. inż.
OsobyMagdalena Brzozowska-Woś jest absolwentką Wydziału Zarządzania i Ekonomii Politechniki Gdańskiej (specjalność: systemy zarządzania). Jest również absolwentką Podyplomowego Studium Reklamy (Wydział Zarządzania i Ekonomii PG) oraz Podyplomowego Studium Public Relations (SWPS Uniwersytet Humanistycznospołeczny). W latach 2000-2003 współpracowała z Panoramą Internetu sp. z o. o. jako specjalista ds. marketingu. Pełniła również obowiązki...
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Synthesis and biological activity of ester derivatives of mycophenolic acid and acridines/acridones as potential immunosuppressive agents
PublikacjaImproved derivatives of mycophenolic acid (MPA) are necessary to reduce the frequency of adverse effects, this drug exerts in treated patients. In this study, MPA was coupled with N-(x-hydroxyalkyl)-9-acridone-4-carboxamides or N-(x-hydroxyalkyl)acridine-4-carboxamides to give respective ester conjugates upon Yamaguchi protocol. This esterification required protection of phenol group in MPA. Designed conjugates revealed higher...
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Protokoły łączności do transmisji strumieni multimedialnych na platformie KASKADA
PublikacjaPlatforma KASKADA rozumiana jako system przetwarzania strumieni multimedialnych dostarcza szeregu usług wspomagających zapewnienie bezpieczeństwa publicznego oraz ocenę badań medycznych. Wydajność platformy KASKADA w znaczącym stopniu uzależniona jest od efektywności metod komunikacji, w tym wymiany danych multimedialnych, które stanowią podstawę przetwarzania. Celem prowadzonych prac było zaprojektowanie podsystemu komunikacji...
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Dietary intervention with beetroot juice during doxorubicin cancer chemotherapy in vivo reduces markers of oxidative stress
PublikacjaCancer chemotherapy with doxorubicin, despite high antitumor activity and broad spectrum of this drug, is on decline due to toxic side effects. The clinical efficacy of anthracyclines have continuously prompted the search for new adjuvants to alleviate undesirable side toxicity incurred by this group of cytostatics. The recent approaches involve the application of synthetic or purified natural antioxidants in combination with doxorubicin...
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Peptydy penetrujące – rodzaje i mechanizmy przenikania przez błony komórkowe
PublikacjaPeptydy penetrujące z pewnością są wyjątkową i ciekawą grupą związków peptydowych. Zostały odkryte ponad dwadzieścia lat temu, ale wiedza na ich temat wciąż jest rozbudowywana. Liczne badania nad mechanizmami ich przenikania do wnętrza komórek pozwalają zrozumieć jakie cechy strukturalne warunkują ich zdolność do penetracji komórek. Wiedza ta pozwala na projektowanie nowych, bardziej efektywnych peptydów penetrujących., które mogą...
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Multi-objective Tabu-based Differential Evolution for Teleportation of Smart Virtual Machines in Private Computing Clouds
PublikacjaWe propose a multi-objective approach for using differential evolution algorithm with tabu search algorithm as an additional mutation for live migration (teleportation) of virtual machines. This issue is crucial in private computing clouds. Teleportation of virtual machines is supposed to be planned to determine Pareto-optimal solutions for several criteria such as workload of the bottleneck host, communication capacity of the...
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FEM ANALYSIS AND EXPERIMENTAL TESTS OF RIGID RISER HANGING SYSTEM
PublikacjaThe article presents the analysis, project, and experimental examination of an original rigid riser for Coil Tubing Pipes. The principle of riser operation is based on the use of friction forces. The research included the FEM analysis of the designed riser, calculations of the required bolt tensions, and checking the effect of the clamping force on stress distribution in the pipeline. The results of computer simulation were verified...
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REALIZACJA NADAJNIKA I ODBIORNIKA OFDM W TECHNOLOGII RADIA PROGRAMOWALNEGO
PublikacjaMetoda wielodostępu OFDM, jest stosowana obecnie w wielu nowoczesnych cywilnych i wojskowych standardach łączności radiowej. Technologia radia programowalnego (ang. Software Defined Radio) umożliwia realizacje urządzeń pracujących z tą metodą wielodostępu. W referacie zaprezentowano przykłady dwóch środowisk oprogramowania służących do realizacji oprogramowania w technologii SDR. Przedstawiono również przykłady platform sprzętowych...
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ANALYSIS OF THE PUNCHING FAILURE MECHANISM IN WORKING PLATFORMS
PublikacjaPaper presents an analysis of the shear failure mechanism which occurs from the punching of a working platform layer in relation to its thickness, grain size arrangement and mechanical properties, taking into consideration the interaction with soft subgrade. The study is based on the observations of performance of natural scale structures (Streefkerk) and the results of model investigations numerically represented with the use...
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Adaptive filtering approach to dynamic weighing: a checkweigher case study
PublikacjaDynamic weighing, i.e., weighing of objects in motion, with out stopping them on the weighing platform, allows one to increase the rate of operation of automatic weighing systems used in industrial production processes without compromising their accuracy. The paper extends and compares two approaches to dynamic weighing, based on system identification and variable-bandwidth filtering, respectively. Experiments, carried on a conveyor...
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Eye tracking within near-to-eye display
PublikacjaIn this paper we investigate the effectiveness of the gaze interaction within near-to-eye display. The practical aspect of the paper is about combining an eye tracker with smart glasses. Presented research is related with the eGlasses project, which is focused on the development of an open platform in the form of multisensory electronic glasses and related interaction methods. One of the implemented interaction methods is the one...
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Application of smart glasses for fast and automatic color correction in health care
PublikacjaIn recent years different applications of smart glasses in health care have been proposed. In this paper we present the experiments related to automatic color correction using smart glasses platform developed within the eGlasses project. The color pattern is proposed and tested enabling the automatic detection of the pattern and automatic correction of colors. Additionally, the method for encoding and decoding of patient ID in...
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Report of the ISMIS 2011 Contest : Music Information Retrieval
PublikacjaThis report presents an overview of the data mining contestorganized in conjunction with the 19th International Symposiumon Methodologies for Intelligent Systems (ISMIS 2011), in days betweenJan 10 and Mar 21, 2011, on TunedIT competition platform. The contestconsisted of two independent tasks, both related to music information retrieval:recognition of music genres and recognition of instruments, for agiven music sample represented...
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Game with a Purpose for Mappings Verification
PublikacjaMappings verification is a laborious task. The paper presents a Game with a Purpose based system for verification of automatically generated mappings. General description of idea standing behind the games with the purpose is given. Description of TGame system, a 2D platform mobile game with verification process included in the gameplay, is provided. Additional mechanisms for anti-cheating, increasing player’s motivation and gathering...
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Supporting Assurance by Evidence-based Argument Services
PublikacjaStructured arguments based on evidence are used in many domains, including systems engineering, quality assurance and standards conformance. Development, maintenance and assessment of such arguments is addressed by TRUST-IT methodology outlined in this paper. The effective usage of TRUST-IT requires an adequate tool support. We present a platform of software services, called NOR-STA, available in the Internet, supporting key activities...
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Intermolecular Interactions as a Measure of Dapsone Solubility in Neat Solvents and Binary Solvent Mixtures
PublikacjaDapsone is an effective antibacterial drug used to treat a variety of conditions. However, the aqueous solubility of this drug is limited, as is its permeability. This study expands the available solubility data pool for dapsone by measuring its solubility in several pure organic solvents: N-methyl-2-pyrrolidone (CAS: 872-50-4), dimethyl sulfoxide (CAS: 67-68-5), 4-formylmorpholine (CAS: 4394-85-8), tetraethylene pentamine (CAS:...
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Sustainable polymers targeted at the surgical and otolaryngological applications: Circularity and future
PublikacjaThe ongoing climate changes, high air and noise pollution have significant impact on humans’ health. This influence is especially visible in otolaryngology, which focuses on respiratory and hearing systems disfunctions. However, even though surgeries are done in response to diseases related to climate changes, they also have a negative impact on the environment, mostly connected with the inherence of single-use fossil fuel derived...
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Docking simulations, Molecular properties and ADMET studies of novel Chromane6,7diol analogues as potential inhibitors of Mushroom tyrosinase
PublikacjaResearch on inhibition of tyrosinase enzyme has attained significant value, because tyrosinase inhibitors have potential applications in medicine, cosmetics (as whitening agents) and in agriculture (as bioinsecticides). Determination and elucidation of new tyrosinase inhibitors are not only beneficial for medical purposes, but their promising applications in improving food quality and nutritional...
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Activation Energy and Inclination Magnetic Dipole Influences on Carreau Nanofluid Flowing via Cylindrical Channel with an Infinite Shearing Rate
PublikacjaThe infinite shear viscosity model of Carreau fluid characterizes the attitude of fluid flow at a very high/very low shear rate. This model has the capacity for interpretation of fluid at both extreme levels, and an inclined magnetic dipole in fluid mechanics has its valuable applications such as magnetic drug engineering, cold treatments to destroy tumors, drug targeting, bio preservation, cryosurgery, astrophysics, reaction kinetics,...
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Termin zgłaszania wystapień do eTEE 2022
Wydarzenia8. ogólnopolska konferencja "e-Technologie w Kształceniu Inżynierów". Zgłaszanie propozycji wystapień w zakładce "Zgłaszanie abstraktów" na stronie konferencji eTEE: www.pg.edu.pl/etee.
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Etyka zawodu architekta, III semestr, rok akademicki 2021/2022
Kursy OnlineWelcome to e-learning course of Architect's Proffesional Ethics. Classes will be conducted via TEAMS platform. Link to clasess below: https://teams.microsoft.com/l/meetup-join/19%3ameeting_NGYyZjU0OTItMjgwZC00N2MxLTg5ZjItZDliZDY2YTNiNGUw%40thread.v2/0?context=%7b%22Tid%22%3a%2286760356-0022-486f-b793-a2d470bba5a5%22%2c%22Oid%22%3a%22744d498a-011e-4d0b-8a3d-08b49c9156ff%22%7d
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Meconium analysis as a promising diagnostic tool for monitoring fetal exposure to toxic substances: Recent trends and perspectives
PublikacjaPrenatal exposure to toxic substances is an important public health problem. Many biological specimens obtained from the fetus or mother are used for biomonitoring. Each material reflects exposure in a specific time period and has different advantages and disadvantages in terms of accuracy, time window of detection and cost/benefit ratio. Recently, meconium has become the matrix of choice in toxicology screening for detecting exposure...
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Evaluation of Three Peptide Immobilization Techniques on a QCM Surface Related to Acetaldehyde Responses in the Gas Phase
PublikacjaThe quartz-crystal microbalance is a sensitive and universal tool for measuring concentrations of various gases in the air. Biochemical functionalization of the QCM electrode allows a label-free detection of specific molecular interactions with high sensitivity and specificity. In addition, it enables a real-time determination of its kinetic rates and affinity constants. This makes QCM a versatile bioanalytical screening tool for...
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Low-Cost Behavioral Modeling of Antennas by Dimensionality Reduction and Domain Confinement
PublikacjaBehavioral modeling has been rising in importance in modern antenna design. It is primarily employed to diminish the computational cost of procedures involving massive full-wave electromagnetic (EM) simulations. Cheaper alternative offer surrogate models, yet, setting up data-driven surrogates is impeded by, among others, the curse of dimensionality. This article introduces a novel approach to reduced-cost surrogate modeling of...
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Estimation of respiration rate using an accelerometer and thermal camera in eGlasses
PublikacjaRespiration rate is a very important vital sign. Different methods of respiration rate measurement or estimation have been developed. However, especially interesting are those that enable remote and unobtrusive monitoring. In this study, we investigated the use of smart glasses for the estimation of respiration rate especially useful for indoors applications. Two methods were analyzed. The first one is based on measurements of...
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Topological Model of an Electromagnetic Environment Inside a Ship for Electromagnetic Compatibility (EMC) Analysis
PublikacjaThe mutual electromagnetic (EM) interactions between electrical and electronic devices in a segmented space, such as a ship's environment, ared described. Firstly, the topological structure of a ship's segmented internal environment, which consists of many electrical screening walls (shielding planes), is presented. Then, taking into account the ship's topological structure, a general description of the EM disturbance distribution,...
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Chemometric Evaluation of WWTPs’ Wastewaters and Receiving Surface Waters in Bulgaria
PublikacjaWastewater treatment plant (WWTP) installations are designed and operated to reduce the quantity of pollutants emitted to surface waters receiving treated wastewaters. In this work, we used classical instrumental studies (to determine chemicals and parameters under obligations put with Directive 91/271/EEC), ecotoxicological tools (Sinapis alba root growth inhibition (SA-RG) and Heterocypris incongruens mortality (MORT) and growth...
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Platforma edX - nowe podejście do kursów online
PublikacjaWspółczesne metody nauczania na odległość zmieniają się dynamicznie. Powstają światowe konsorcja podejmujące starania zapewnienia dostępu do edukacji na najwyższym poziomie z wykorzystaniem Internetu. Jedną z takich prób jest platforma edX. Jej rozwój zapoczątkowały niemal 2 lata temu MIT i Harvard. Obecnie zespół liczy już 30 uczelni z całego świata. Renoma ośrodków naukowych biorących udział w projekcie przyciągnęła już ponad...
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Light4Health eLearning Course: health research for interior lighting design. Re-thinking design approaches based on science
PublikacjaThis paper presents the results of 'Light4Health' (L4H), a three-year EU Erasmus+ Strategic Partnership grant project (2019-2021), which investigated, systematized and taught health-related research on the impact of natural and artificial light on human health and well-being relevant to indoor lighting design. The objective was to re-think evidence-based lighting design approaches for residential, working/educational, and healthcare...
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Misje i misjonarska retoryka w zarządzaniu platformami mediów
PublikacjaTrudno o bardziej znane i poruszające zbiorową wyobraźnię przekazy cyfrowych platforma, niż zapisy ich misji. Nie tylko łatwo wyjaśniają one rolę organizacji, ale zapewniają racjonalizację tego, kto lub czym jest coś lub jak działa. Dla Facebooka, Google i wielu innych organizacji pragnących „zmienić świat na lepszy” są elementem samonapędzającego się mechanizmu utwierdzającego w słuszności obranej drogi. W przypadku cyfrowych...
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SPECTRAL RESPONSE OF STATIONARY JACK-UP PLATFORMS LOADED BY SEA WAVES AND WIND USING PERTURBATION METHOD
PublikacjaThe paper addresses non-linear vibrations of offshore jack-up drilling platforms loaded by sea waves and wind in their stationary condition using the perturbation method. Non-linearity of dynamic equations of motion for fixed offshore platforms yields from two factors. The first is load excitation generating non-linear velocity coupling in a dynamic system. This coupling is inherent in the modified Morison equation, involving the...
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Physical and Mechanical Evaluation of Silicone-Based Double-Layer Adhesive Patch Intended for Keloids and Scar Treatment Therapy
PublikacjaGrowing interest in silicone elastomers for pharmaceutical purposes is due to both theirbeneficial material effect for scar treatment and their potential as drug carriers. Regarding their morphological structure, silicone polymers possess unique properties, which enable a wide range of applicability possibilities. The present study focused on developing a double-layer adhesive silicone film (DLASil) by evaluating its physical...
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Analytical procedures for determination of cocaine and its metabolites in biological samples
PublikacjaThe dangerous effects and increased usage of illicit drugs have inspired the development of analytical methodologies. We based our review of analytical procedures for determination of cocaine (COC) and its metabolites on literature from the past two decades. Our main aim was to compare the capabilities of different analytical techniques. The diversity of matrices from which COC is determined (e.g., blood, hair, saliva, plasma,...
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A Stand for Measurement and Prediction of Scattering Properties of Diffusers
PublikacjaIn this paper we present a set of solutions which may be used for prototyping and simulation of acoustic scattering devices. A system proposed is capable of measuring sound field. Also a way to use an open source solution for simulation of scattering phenomena occurring in proximity of acoustic diffusers is shown. The result of our work are measurement procedure and a prototype of the simulation script based on FEniCS - an open source...