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Search results for: active pharmaceutical ingredients
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Sensorless Rotor Position Estimation of Doubly-Fed Induction Generator Based on Backstepping Technique
PublicationThis paper proposes a speed observer algorithm for the sensorless control of a doubly-fed induction generator based on classical adaptive backstepping technique. The sensorless control is shown using classic stator field oriented control which is used to active and reactive power control. Performance of the proposed algorithm of a speed observer is validated by simulation and experimental results obtained using a small-rating generator...
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A new approach to the stereoselective synthesis of trans-3-carbamoyl-b-lactam moieties†
PublicationOne-pot synthesis of optically active 1,4-disubstituted-3-carbamoyl-azetidinones from 5-[(N-arylamino)- (hydroxyl)methylene]-2,2-dimethyl-1,3-dioxa-4,6-diones and chiral aldimines is achieved via thermal generation of carbamoyl ketenes and subsequent [2+2] cycloaddition. Three possible chiral induction approaches were tested and (R)-(+)-1-phenylethylamine was confirmed as the best chiral auxiliary. Among the four possible diastereoisomers,...
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Assessment of cytotoxic and endocrine potential of selected xenobiotics commonly present in food products
PublicationMore and more increased intensity of anthropopressure processes can be observed, among other things, in the release of great quantities of synthetic substances into the environment, including the Endocrine Disrupting Compounds (EDC). A vast number of chemical substances is considered to belong to the this group, including substances which occur naturally in the environment, such as mycotoxins and phytoestrogens, and substances...
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Enzyme Conjugation - A Promising Tool for Bio-catalytic and Biotransformation Applications – A Review
PublicationEnzymes have revolutionized conventional industrial catalysts as more efficient, eco-friendly, and sustainable substitutes that can be used in different biotechnological processes, food, and pharmaceutical industries. Yet, the enzymes from nature are engineered to make them adapt and enhance their durability in the industrial environment. One promising approach involves the combined use of multiple enzymes that catalyze highly...
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Mercury content in beetroot and beetroot-based dietary supplements
PublicationTotal mercury (THg) concentrations in fifty-four beetroot-based DSs and seven lots of conventional and organic beetroots (divided into unpeeled, peeled, and skins) were determined by direct thermal decomposition-gold amalgamation cold vapour atomic absorption spectrometry. The analytical procedure was optimised and validated. The recovery (%) for Hg was 101.9 and 92.73 in BCR-463 and DOLT 4, respectively. The intermediate precision...
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A rapid and sensitive method for the quantitative analysis of ibuprofen and its metabolites in equine urine samples by gas chromatography-tandem mass spectrometry
PublicationIbuprofen is widely used in human and veterinary medicine for the treatment of chronic pain as well as rheumatic and musculoskeletal disorders. However, t he anal- gesic and anti-inflammatory properties of Ibuprofen have contributed to frequent drug abuse in equestr ian s ports. A sensitive and rapid gas chromatography with tandem mass spectrometry based method with a simple liquid-liquid extraction and deriva- tization requiring...
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Simultaneous opto-electrochemical monitoring of carbamazepine and its electro-oxidation by-products in wastewater
PublicationThe growing human impact on aquatic environments, due to the extensive use of pharmaceuticals and the release of persistent pollutants, makes it necessary to implement new widespread methods for the characterisation and quantification of such contaminants and relative degradation products. Carbamazepine, 5H-dibenzo[b,f]azepine-5-carboxamide, (CBZ) is a widely used anti-epileptic drug, characterised by its limited removal by conventional...
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Deep eutectic solvents microbial toxicity: Current state of art and critical evaluation of testing methods
PublicationDeep eutectic solvents (DESs) were described at the beginning of 21st century and they consist of a mixture of two or more solid components, which gives rise to a lower melting point compared to the starting materials. Over the years, DESs have proved to be a promising alternative to traditional organic solvents and ionic liquids (ILs) due to their low volatility, low inflammability, easy preparation, and usually low cost of compounds...
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Industry-level analysis of COVID-19’s impact in emerging markets – evidence from Pakistan
PublicationPurpose – The main purpose of this study is to evaluate COVID-19’s impact on the emerging stock markets. Design/methodology/approach – To evaluate the influence of COVID-19, this study uses a novel method of event study methodology to measure the impact of COVID-19 on emerging stock markets. The research’s sample includes a total of 79 firms from 26 industries that are included in the KSE-100 Index from the Pakistan Stock Exchange....
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Potential degradation of norfloxacin using UV-C/Fe2+/peroxides-based oxidative pathways
PublicationThe removal of norfloxacin (NOR), a widely used pharmaceutical and emerging water pollutant, was studied using UV-C and Fe2+ catalyzed peroxides-based oxidative processes (e.g., UV-C/Fe2+/H2O2, UV-C/Fe2+/S2O82− and UV-C/Fe2+/HSO5−) and compared with UV-C and UV-C/Fe2+. The UV-C and UV-C/Fe2+ degraded NOR to 38 and 55 %. However, use of peroxides, i.e., H2O2, S2O82−, HSO5− with UV-C and UV-C/Fe2+ promoted NOR %degradation to 75,...
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Nanofiltration-Assisted Concentration Processes of Phenolic Fractions and Carotenoids from Natural Food Matrices
PublicationIn new food formulations, carotenoids and phenolic compounds are likely to be the most sought after food ingredients according to their bioactivity, nutraceutical, nutritional value, and compatibility properties once incorporated into food formulations. Such solutes are naturally present in many plant-based sources, and some portions are directly consumed when enriching food products and formulations; however, some portions, which...
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Machine-learning methods for estimating compressive strength of high-performance alkali-activated concrete
PublicationHigh-performance alkali-activated concrete (HP-AAC) is acknowledged as a cementless and environmentally friendly material. It has recently received a substantial amount of interest not only due to the potential it has for being used instead of ordinary concrete but also owing to the concerns associated with climate change, sustainability, reduction of CO2 emissions, and energy consumption. The characteristics and amounts of the...
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Supramolecular deep eutectic solvents and their applications
PublicationIn recent years, the growing awareness of the harmfulness of chemicals to the environment has resulted in the development of green and sustainable technologies. The compromise between economy and environmental requirements is based on the development of new efficient and green solutions. Supramolecular deep eutectic solvents (SUPRADESs), a new deep eutectic solvent (DES) subclass characterized by inclusion properties, are a fresh...
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The role of time perspectives and impulsivity dimensions in coping styles
PublicationBoth time perspectives and impulsivity dimensions are groups of traits that are connected to self-control abilities and might be important for coping styles. However, to date, no study has systematically investigated their utility in predicting coping styles with regard to their multidimensional nature. The current study was correlational and exploratory, aiming to discover what amount of variance in each of the three coping...
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GNSS INVENTORY OF HISTORIC NARROW-GAUGE RAILWAY LINE IN KOSZALIN UNDER EXTREMELY UNFAVORABLE MEASUREMENTS CONDITIONS FROM THE POINT OF VIEW OF SATELLITE SIGNALS AVAILABILITY
PublicationA team of academic researchers from the Gdańsk University of Technology, Gdynia Maritime University and the Polish Naval Academy have been working since 2009 on the methodology of using active GNSS geodetic networks for geodetic inventory of railways and on adapting this measurement technique for designing geometric layouts of railway and tram lines. Over the years, the team tested a variety of configurations of receivers and settings...
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Mechanism of antifreeze protein functioning and the “anchored clathrate water” concept
PublicationIn liquid water, there is a natural tendency to form aggregates that consist of water molecules linked by hydrogen bonds. Such spontaneously formed aggregates are surrounded by a "sea" of disordered water molecules, with both forms remaining in equilibrium. The process of creating water aggregates also takes place in the solvation water of proteins, but in this case the interactions of water molecules with the protein surface shift...
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Extracting functional groups of ALLINI to design derivatives of FDA‐approved drugs: Inhibition of HIV‐1 integrase
PublicationHIV‐1 integrase (IN) is crucial for integration of viral DNA into the host genome and a promising target in development of antiretroviral inhibitors. In this work, six new compounds were designed by linking the structures of two different class of HIV‐1 IN inhibitors (active site binders and allosteric IN inhibitors (ALLINIs)). Among newly designed compounds, INRAT10b was found most potent HIV‐1 IN inhibitor considering different...
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Personalized nutrition in ageing society: redox control of major-age related diseases through the NutRedOx Network (COST Action CA16112)
PublicationA healthy ageing process is important when it is considered that one-third of the population of Europe is already over 50 years old, although there are regional variations. This proportion is likely to increase in the future, and maintenance of vitality at an older age is not only an important measure of the quality of life but also key to participation and productivity. So, the binomial “nutrition and ageing” has different aspects...
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Investigating lubricants behaviour in microgravity for vibration damping purposes
PublicationVibration is one of the harshest environments an object is exposed to during and after launch into space on a launch vehicle. Such vibrations should be damped to avoid destruction of the spacecraft or its elements. Currently, active and material damping is used. A possibility of using lubrication as the damping factor is suggested by some research. MoS2 is a typical solid lubricant used in space applications. Its properties vary...
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c-Myc Protein Level Affected by Unsymmetrical Bisacridines Influences Apoptosis and Senescence Induced in HCT116 Colorectal and H460 Lung Cancer Cells
PublicationUnsymmetrical bisacridines (UAs) are highly active antitumor compounds. They contain in their structure the drugs previously synthesized in our Department: C-1311 and C-1748. UAs exhibit different properties than their monomer components. They do not intercalate to dsDNA but stabilize the G-quadruplex structures, particularly those of the MYC and KRAS genes. Since MYC and KRAS are often mutated and constitutively expressed in cancer...
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The evidence for the impact of policy on physical activity outcomes within the school setting: A systematic review
PublicationPurpose Despite the well-established health benefits of physical activity (PA) for young people (aged 4–19 years), most do not meet PA guidelines. Policies that support PA in schools may be promising, but their impact on PA behavior is poorly understood. The aim of this systematic review is to ascertain the level and type of evidence reported in the international scientific literature for policies within the school setting that...
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Electrophoretic Deposition of Chitosan/Eudragit E 100/AgNPs Coatings for Controlled Release of Antibacterial Substance
PublicationThe development of bacterial infection of the tissues surrounding an implant is one of the leading causes of implant surgery failure. In order to prevent the deposition of bacteria on the implant surface and the formation of biofilm, coatings that exhibit antibacterial properties are manufactured. However, the problem is the controlled release of the therapeutic substance from the coating over the extended life of the implant [1],...
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Systemy krążenia wód podziemnych w rejonie Zalewu Kamieńskiego, Pomorze Zachodnie
PublicationSystemy krążenia wód podziemnych w rejonie Zalewu Kamieńskiego zależą od budowy geologicznej, ukształtownia terenu a także ascenzji solanek i ingresji wód morskich.Do obliczenia czasu przepływu wody w rozpatrywanych warunkach w ośrodku o znanej porowatości aktywnej posłuzono sie programem TFS opracowanym przez K. Burzyńskiego.Model przepływu wód podziemnych opracowano dla przekroju hydrogeologicznego wzdłuż linii Miedzywodzie -...
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SUBIEKTYWNE POSTRZEGANIE RÓŻNORODNOŚCI ZESPOŁU – PERSPEKTYWA MENADŻERA
PublicationZarządzanie zespołami zróżnicowanymi powinno przejawiać się aktywnym i świadomym działaniem prowadzącym do pełnego wykorzystania potencjału zespołu. To, czy potencjał ten zostanie wykorzystany, zależy od wielu czynników. Wydaje się, że jednym z najważniejszych jest nie tyle rzeczywiste,obiektywne zróżnicowanie członków zespołu, ile to, w jaki sposób różnorodność ta jest subiektywnie postrzegana. Artykuł przedstawia wyniki badań...
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Predykcyjne sterowanie równoległym filtrem aktywnym ze sprzężeniem od prądu zasilającego
PublicationArtykuł przedstawia nowatorską strategię predykcyjnego sterowania równoległym energetycznym filtrem aktywnym (EFA). Proponowane sterowanie zawiera sprzężenie zwrotne od prądu zasilającego i wiąże zalety sterowania w układzie otwartym oraz zamkniętym – szybkość reakcji na zmianę prądu odbioru i bardzo wysoką skuteczność kompensacji. Wysoka jakość prądu kompensacyjnego wynika również z zastosowania w sterowaniu algorytmów predykcyjnych,...
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Audiovisual speech recognition for training hearing impaired patients
PublicationPraca przedstawia system rozpoznawania izolowanych głosek mowy wykorzystujący dane wizualne i akustyczne. Modele Active Shape Models zostały wykorzystane do wyznaczania parametrów wizualnych na podstawie analizy kształtu i ruchu ust w nagraniach wideo. Parametry akustyczne bazują na współczynnikach melcepstralnych. Sieć neuronowa została użyta do rozpoznawania wymawianych głosek na podstawie wektora cech zawierającego oba typy...
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Vibrational Properties of LaNb0.8M0.2O4-δ (M=As, Sb, V, and Ta)
PublicationLaNb0.8M0.2O4-δ (where M=As, Sb, V, and Ta) oxides with pentavalent elements of different ionic sizes were synthesized by a solid-state reaction method. The vibrational properties of these oxides have been investigated. These studies revealed that the substituent element influences both Debye temperature value as well as the Raman active vibrational modes. Additionally, the low-temperature vibrational properties of LaNb0.8Sb0.2O4-δ...
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Cytotoxic and Antioxidant Activities of Benzohydroxamic Acid Analogues
Publication20 benzohydroxamic acid analogues were synthesized and evaluated for their in vitro cytotoxicities against mouse mammary tumor cells as well as antioxidant activities against DPPH radical and superoxide anion. It was found that benzothiohydroxamic acids exhibit greater cytotoxicities than benzohydroxamic acids and N-isopropyl derivatives are more active than N-methyl ones. On the other hand, benzothiohydroxamic acids show more...
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STEADY STATE VISUALLY EVOKED POTENTIALS FOR BRAIN COMPUTER INTERFACE
PublicationAn experiment conducted to validate a possibility of use a single active electrode EEG device for detecting Steady State Visually Evoked Potentials (SSVEP) is shown. A LED stimulator was applied to stimulate patients with two different frequencies - 13 Hz and 17 Hz. First, EEG signals were recorded and pre-processed using MATLAB software. In the next step recordings were analysed and classified employing the WEKA software. As indicated...
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Remarkable visible-light induced hydrogen generation with ZnIn2S4 microspheres/CuInS2 quantum dots photocatalytic system
PublicationA new and active material in the form of ZnIn2S4 microspheres decorated by CuInS2 quantum dots have been obtained by hydrothermal method for the first time. The optimum amount of CuInS2 quantum dots (1.13 wt.%) introduced into rection medium during ZnIn2S4 microspheres synthesis increased the photocatalytic H2 generation rate by 2.5 times than that of bare ZnIn2S4 photocatalysis under visible light irradiation. This sample exhibited...
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Non-Adaptive Speed and Position Observer of Doubly-Fed Induction Generator
PublicationThe non-adaptive speed and position estimation of a doubly-fed induction generator (DFIG) is presented in this paper. The speed observer is based on the mathematical model of DFIG and to stabilize the structure the Lyapunov method is used. The classic stator field-oriented control to active and reactive power control is used in the sensorless control system. The performance of the proposed algorithm of a speed observer is validated...
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Feedback Control of Doubly-Fed Generator Connected to Current Source Converter
PublicationDoubly-fed induction generator (DFIG) system supplied by current source converter (CSC) is considered in this article. The DFIG can work in two independent modes: AC grid connection and stand-alone mode. The DFIG is connected to the ac grid directly through its stator and the CSC links the rotor side. In this mode, the active and reactive powers of the DFIG must be controlled. This article proposes two control system structures...
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CERTIFICATION SYSTEM AS A TOOL FOR IMPROVING THE SAFETY AND SUSTAINABILITY OF SCHOOL-RELATED TRAVELS
PublicationDespite the well-established physical, social, emotional, cognitive, and spatial benefits of active and autonomous school commuting of children and adolescents', many are driven by car. Pilot surveys and field research held in 2019 in 10 Gdansk primary schools confirmed this trend. The article presents a certification system for schools, commissioned by the City of Gdańsk, which is an element of a systemic solution shaping patterns...
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MEDIA ARCHITECTURE AND INTERACTIVE ART INSTALLATIONS STIMULATING HUMAN INVOLVEMENT AND ACTIVITIES IN PUBLIC SPACES
PublicationThis paper examines the potential for media architecture and interactive art installations to stimulate human involvement and activities in public spaces. On the basis of theoretical approaches, case studies and interdisciplinary surveys, the paper provides insight into how screens projecting media and interactive installations in city spaces can inspire people to become active on many levels. The research is focused, both on temporary...
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Ground lemon and stevia leaves as renewable functional fillers with antioxidant activity for high-density polyethylene composites
PublicationThe development of new sustainable material solutions in the processing of thermoplastic polymers concerns both the application of biopolymers and the use of valorized plant derivatives as fillers and modifiers of petrochemical polymers. Herein, the possibility of using unprocessed raw parts of two commonly used in the food industry leaves, i.e., lemon (LL) and stevia (ST), as active and functional fillers for high-density polyethylene...
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Nickel-based catalysts for electrolytic decomposition of ammonia towards hydrogen production
PublicationNickel is an attractive metal for electrochemical applications because it is abundant, cheap, chemically resilient, and catalytically active towards many reactions. Nickel-based materials (metallic nickel, its alloys, oxides, hydroxides, and composites) have been also considered as promising electrocatalysts for ammonia oxidation. The electrolysis of ammonia aqueous solution results in evolution of gaseous hydrogen and nitrogen....
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Deciphering the Molecular Mechanism of Substrate-Induced Assembly of Gold Nanocube Arrays toward an Accelerated Electrocatalytic Effect Employing Heterogeneous Diffusion Field Confinement
PublicationThe complex electrocatalytic performance of gold nanocubes (AuNCs) is the focus of this work. The faceted shapes of AuNCs and the individual assembly processes at the electrode surfaces define the heterogeneous conditions for the purpose of electrocatalytic processes. Topographic and electron imaging demonstrated slightly rounded AuNC (average of 38 nm) assemblies with sizes of ≤1 μm, where the dominating patterns are (111) and...
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Optimum number of actuators to minimize the cross-sectional area of prestressable cable and truss structures
PublicationThis paper describes a new computational method for determining the optimum number of actuators to design the optimal and economic cross-sectional area of pin-jointed assemblies based on the conventional force method. The most active members are selected to be prestressed to redistribute stress in the whole structure, resulting in regulating the internal force of bars that face high stress. Reducing stress in critical members allows...
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Fabrication and photoactivity of ionic liquid–TiO2 structures for efficient visible-light-induced photocatalytic decomposition of organic pollutants in aqueous phase
PublicationTo investigate the effect of the ionic liquid (IL) chain length on the surface properties and photoactivity of TiO2, a series of TiO2 microspheres have been synthesized via a solvothermal method assisted by 1-methyl-3-octadecylimidazolium chloride ([ODMIM][Cl]) and 1-methyl-3-tetradecylimidazolium chloride ([TDMIM][Cl]). All as-prepared samples were characterized by X-ray powder diffraction (XRD), X-ray photoelectron spectroscopy...
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pH-dependent composite coatings for controlled drug delivery system - Review
PublicationNowadays in case of long-term implants, the most common postoperative complications are bacterial infections, which in consequence may provoke loos- ening of the implants in the primary phase of stabilization. Bacterial infections are currently the most frequent cause of revision surgery of the implants such as hip joint endoprosthesis, knee joint endoprosthesis and dental implants. In order to provide the local and long-term antibacterial...
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Structure and the space vector modulation for a medium-voltage power-electronic-transformer based on two seven-level cascade H-bridge inverters
PublicationThis study presents the structure and the space vector pulse-width modulation (SVPWM) for power electronic transformer (PET) based on two seven-level cascade H-bridge (CHB) inverters. The DC links of CHB inverters are coupled with nine dual-active bridge (DAB) converters with medium-frequency transformers. The DC-link voltages are equalised with two methods – through the control of DAB voltages...
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Size-Controlled Synthesis of Pt Particles on TiO2 Surface: Physicochemical Characteristic and Photocatalytic Activity
PublicationDifferent TiO2 photocatalysts, i.e., commercial samples (ST‐01 and P25 with minority of rutile phase), nanotubes, well‐crystallized faceted particles of decahedral shape and mesoporous spheres, were used as supports for deposition of Pt nanoparticles (NPs). Size‐controlled Pt NPs embedded in TiO2 were successfully prepared by microemulsion and wet‐impregnation methods. Obtained photocatalysts were characterized using XRD, TEM,...
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Combining visual and acoustic modalities to ease speech recognition by hearing impaired people
PublicationArtykuł prezentuje system, którego celem działania jest ułatwienie procesu treningu poprawnej wymowy dla osób z poważnymi wadami słuchu. W analizie mowy wykorzystane zostały parametry akutyczne i wizualne. Do wyznaczenia parametrów wizualnych na podstawie kształtu i ruchu ust zostały wykorzystane modele Active Shape Models. Parametry akustyczne bazują na współczynnikach melcepstralnych. Do klasyfikacji wypowiadanych głosek została...
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Biopolymers in designing modern antimicrobial medical materials. Part I. Biopolymer medical materials - collagen, chitosan
PublicationThe article is a review of the literature concerning the possible use of biopolymers for the preparation of dressings with antimicrobial activity. Authors show the potential of biopolymers: collagen and chitosan - which have the ability to immobilize and control the release of various active compounds - for providing the appropriate antibacterial, bacteriostatic and wound healing properties. Types of threats, for which the dressing...
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Titania nanotubes infiltrated with conducting polymer PEDOT modified by Prussian Blue – a novel type of organic-inorganic heterojunction characterised with enhanced photoactivity.
PublicationA highly ordered p–n heterojunction was formed based on titania nanotubes containing a conducting polymer with Prussian blue matrix. The study demonstrates, for the first time, cases when a composite based on titania array scaffolding and Prussian blue embedded in PEDOT exhibits reversible FeII/FeIII redox activity. Highly enhanced photoactivity and capacitance of the obtained material are depicted in comparison to pristine titania....
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A modified method of vibration surveillance by using the optimal control at energy performance index
PublicationA method of vibration surveillance by using the optimal control at energy performance index has been creatively modified. The suggested original modification depends on consideration of direct relationship between the measured acceleration signal and the optimal control command. The paper presents the results of experiments and Hardware- in-the-loop simulations of a new active vibration reduction algorithm based on the energy...
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Synergic Effect of Naphthylated Carbon Nanotubes and Gold Nanoparticles on Catalytic Performance of Hybrid Films Containing Bilirubin Oxidase for the Dioxygen Reduction
PublicationTo improve the direct electron transfer from a multicopper oxidase MvBOd to the glassy carbon electrode surface the naphthylated multiwall carbon nanotubes (Napht-MWCNTs) are ombined with gold nanoparticles (AuNPs) to form a conductive network at the electrode and to increase its working surface. Such approach allowed to eliminate the necessity of employing mediators to reach elevated current values. The enzyme stability was improved...
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Lower rim substituted p-tert-butyl-calix[4]arene. Part 17. synthesis, extractive and ionophoric properties of p-tert-butylcalix[4]arene appended with hydroxamix acid moieties
PublicationThe synthesis and characterization of four p-tert-butylcalix[4]arene-hydroxamic acidc are reported. The dependence of the metal ion binding, assessed by liquid extraction of the metal nitrates from water into dichloromethane in individual and competitive experiments, on the ligand structure, is presented. The results showed that those ligands could be successfully used in separation process of trnasition and heavy metals often...
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Face Recognition: Shape versus Texture
PublicationThis paper describes experiments related to the application of well-known techniques of the texture feature extraction (Local Binary Patterns and Gabor filtering) to the problem of automatic face verification. Results of the tests show that simple image normalization strategy based on the eye center detection and a regular grid of fiducial points outperforms the more complicated approach, employing active models that are able to...
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Performance analysis of an rfid-based 3d indoor positioning system combining scene analysis and neural network methods
PublicationThe main purpose of this research is to improve localization accuracy of an active Radio Frequency Identification, RFID tag, in 3D indoor space. The paper presents a new RFID based 3D Indoor Positioning System which shows performance improvement. The proposed positioning system combines two methods: the Scene Analysis technique and Artificial Neural Network. The results of both simulation using Log-Distance Path Loss Model and...