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Search results for: CELLULAR ANTIOXIDANT ACTIVITY
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Coastal cellular distress system
PublicationPrzedstawiono koncepcję systemu bezpieczeństwa w morskiej strefie A1, opartego o istniejące sieci komórkowe GSM. System ten został opracowany dla potrzeb małych jednostek pływających (nieinstytucjonalnych), które mają ograniczony dostęp do zasobów systemu GMDSS. Zostały przeprowadzone również badania symulacyjne efektywności lokalizowania terminala ruchomego w warunkach morskich. Otrzymane rezultaty w wybranych warunkach spełniają...
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Transcriptional activity of epigenetic remodeling genes declines in keratinocytes after in vitro expansion
PublicationPURPOSE: In vitro expansion is an invaluable method to obtain keratinocytes in amounts necessary for effective transplantation therapies. In vitro cell culturing provokes questions concerning potential epigenetic alterations occurring in expanded cells in the context of usefulness for transplantation and safety. The purpose of this study was to investigate as to whether keratinocyte expansion is associated with changes in the activity...
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Phenolic composition and antioxidant properties of polish blue-berried honeysuckle genotypes by HPLC-DAD-MS, HPLC postcolumn derivatization with ABTS or FC, and TLC with DPPH visualization
PublicationIn this study, different Polish cultivars of blue-berried honeysuckles (Lonicera caerulea L.), wild and bog bilberry, were analyzed for bioactive compounds. The chemical properties verified included composition of anthocyanins and other polyphenols, antioxidant activity, and profiles of antioxidants by HPLC postcolumn derivatization or TLC. The antioxidant activities of different blue-berried honeysuckle cultivars were similar...
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Cellular and molecular basis of thyroid autoimmunity
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Rapana venosa consumption improves the lipid profiles and antioxidant capacities in serum of rats fed an atherogenic diet
PublicationIn the recent years, the consumption of seafood has increased. There are no results on the studies of Rapana venosa (Rv) as a supplementation to the diets. We hypothesized that Rv would increase antioxidant capacity and reduce blood lipids, based on the composition of bioactive compounds and fatty acids. Therefore, the aim of this investigation was to evaluate in vitro and in vivo actions of Rv from contaminated (C) and non-C (NC)...
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Design of a Cellular Dual-Band Sticker Antenna for Thickness-Independent 3D-Printed Substrates
PublicationAdditive manufacturing technology provides high flexibility in designing custom enclosures for prototype devices such as nodes of distributed sensor networks. Although integration of components is desired from the perspective of sensor mobility, it might negatively affect the performance of radio-connectivity due to couplings between the antenna and system peripherals, as well as other unaccounted effects of the 3D printed enclosure....
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Regulated Assembly of LPS, Its Structural Alterations and Cellular Response to LPS Defects
PublicationDistinguishing feature of the outer membrane (OM) of Gram-negative bacteria is its asymmetry due to the presence of lipopolysaccharide (LPS) in the outer leaflet of the OM and phospholipids in the inner leaflet. Recent studies have revealed the existence of regulatory controls that ensure a balanced biosynthesis of LPS and phospholipids, both of which are essential for bacterial viability. LPS provides the essential permeability...
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Quantum Dots as a Good Carriers of Unsymmetrical Bisacridines for Modulating Cellular Uptake and the Biological Response in Lung and Colon Cancer Cells
PublicationNanotechnology-based drug delivery provides a promising area for improving the efficacy of cancer treatments. Therefore, we investigate the potential of using quantum dots (QDs) as drug carriers for antitumor unsymmetrical bisacridine derivatives (UAs) to cancer cells. We examine the influence of QD–UA hybrids on the cellular uptake, internalization (Confocal Laser Scanning Microscope), and the biological response (flow cytometry...
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Chemical composition, antioxidant and anticancer effects of the seeds and leaves and indigo (polygonum tinctorium Ait.) Plant
PublicationSeeds and leaves of indigo (Polygonum tinctorium Ait.) plant were investigated and compared with another medicinal plant named prolipid for their properties such as chemical composition, antioxidant, and anticancer effects by Fourier transform infrared, three-dimensional fluorescence spectroscopy, and electrospray ionization-MS in negative mode. It was found that polyphenols, flavonoids, and flavanols were significantly higher...
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The antioxidant properties of alcoholic extracts from Sambucus nigra L. (antioxidant properties of extracts)
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In Vitro Studies on the Relationship Between the Antioxidant Activities of Some Berry Extracts and Their Binding Properties to Serum Albumin
PublicationThe aim of this study was to investigate the possibility to use the bioactive components from cape gooseberry (Physalis peruviana), blueberry (Vaccinium corymbosum), and cranberry (Vaccinium macrocarpon) extracts as a novel source against oxidation in food supplementation. The quantitative analysis of bioactive compounds (polyphenols, flavonoids, flavanols, carotenoids, and chlorophyll) was based on radical scavenging spectrophometric assays...
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New Chalcones Derivatives With Potent Antitumor Activity And Their Metabolism In Vitro
PublicationChalcone derivatives exhibit a broad range of biological activities, with antioxidant and cytotoxic properties among the most studied. Despite numerous reports on chalcones as cytotoxic, and potentially anticancer agents, very little is know on their actual mechanism of activity. Generally, chalcones are considered as antimitotic agents, which interfere with tubulin assembly.We have recently developed a new class of chalcones with...
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Non invasive optical cellular imaging in humans.
PublicationOne of the most appealing and still unsolved problems in biological and medical imaging is the possibility of noninvasive visualization of tissue in vivo with an accuracy of microscopic examination. A major difficulty to solve in biomedical imaging is a degradation of image quality caused by the presence of optical inhomogeneity of tissue. Is there any chance to develop a microscopic method that allows non-invasive observation...
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Cellular Interactions in the Intestinal Stem Cell Niche
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Applying artificial intelligence for cellular networks optimization
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A Statistical Approach to the Identification of Diploid Cellular Automata
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Planning cellular machining systems for lean production.
PublicationRozważano zagadnienie projektowania struktur systemów obróbki o zdeterminowanych możliwościach technologicznych, odpowiadających wymaganiom oszczędnej produkcji. Przedstawiono model matematyczny wyznaczania struktur systemów grupowego wytwarzania, wykorzystujący zasady formalizmu relacji i grafów rozmytych. Zawarto wyniki badań symulacyjnych efektywności procesów wytwarzania określonego spektrum przedmiotowego, przebiegających...
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Application of a cellular automata model to granular flow
PublicationPrzedstawiono wyniki modelowania przepływów granulowanych przy zastosowaniu automatu komórkowego. Obliczenia wykonano dla silosów ze wstawkami i ścianką szczelną. Przyjęto różne schematy propagacji ziaren.
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Application of an improved cellular automaton for granular flow.
PublicationW artykule omówiono wyniki numeryczne z zastosowaniem ulepszonego aparatu komórkowego do przepływów silosowych materiałów granulowanych. W modelu uwzgledniono zderzenia cząstek i dysypację energii. Wyniki porównano z wynikami badań modelowych.
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Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.
PublicationThe acridinone derivates C-1305 and C-1311 are promising antitumor agents with high activity against several experimental cellular and tumor models and which are under evaluation in pre-clinical and early phase clinical trials. Recent evidence from our laboratories has indicated that both compounds were conjugated by several UGT isoforms with the most active being extrahepatic UGT1A10. The present studies were designed to test...
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Organic and conventional kiwifruit, myths versus reality: antioxidant, antiproliferative and helth effects
PublicationComparison between organic and conventional kiwifruit cultivars 'Hayward' and 'Bidan', which was done by four radical scavenging assays, ESI-MS, and DSC measurements, showed significant differences between the cultivars. Such results were not estimated in kiwifruit growing under organic and conventional conditions. The extraction of bioactive compounds was done by two different methods: sequential extraction with ethyl acetate...
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Antifungal Activity of Capridine β as a Consequence of Its Biotransformation into Metabolite Affecting Yeast Topoisomerase II Activity
PublicationIn the last few years,increasing importance is attached to problems caused by fungal pathogens. Current methods of preventing fungal infections remain unsatisfactory. There are several antifungal compounds whichare highly effective in some cases, however, they have limitations in usage: Nephrotoxicity and other adverse effects. In addition, the frequent use of available fungistatic drugs promotes drug resistance....
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Innovative activity of SMEs In Poland
PublicationInnovative activity of enterprises is determined by many factors. On one hand, these are external factors creating a sort of innovative climate in the economy, on the other hand - there are many internal factors stimulating or reducing the intensity of innovative activities. What influences the innovativeness of enterprises is the effectiveness of the system supporting innovations, which was stated by for example Pyciński and Żołnierski...
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Design, synthesis, and biological evaluation of tetrahydroquinolinones and tetrahydroquinolines with anticancer activity
PublicationColorectal cancer (CRC) is the most commonly diagnosed cancer in Europe and the United States and the second leading cause of cancer related mortality. A therapeutic strategy used for the treatment of CRC involves targeting the intracellular levels of reactive oxygen species (ROS). In this study, we synthesized a series of novel tetrahydroquinolinones and assessed their ability to inhibit CRC growth and proliferation by evoking...
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Chemical Aspects of Biological Activity of Isothiocyanates and Indoles, the Products of Glucosinolate Decomposition
PublicationThere is growing evidence that cancer chemoprevention employing natural, bioactive compounds may halt or at least slow down the different stages of carcinogenesis. A particularly advantageous effect is attributed to derivatives of sulfur-organic phytochemicals, such as glucosinolates (GLs) synthesized mainly in Brassicaceae plant family. GLs are hydrolysed enzymatically to bioactive isothiocyanates (ITC) and indoles, which exhibit strong...
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Antimicrobial Activity of Honey
PublicationHoney has had a valued place in traditional medicine for centuries. It was used to overcome liver, cardiovascular and gastrointestinal problems and for treatment of some types of infectious disease. Particularly, good results were achieved in the case of application of this product for therapy of infected, difficult to heal wounds. The high health-promoting properties of honey have been recently confirmed in many research investigations....
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Metabolomic and antioxidant properties of different varieties and origins of Dragon fruit
PublicationDragon fruit has appealed much concern from consumers as a novelty fruit with potent nutritional and medicinal benefits. Dragon fruit quality warrants comprehensive evaluation, based on the contents of pigments and health- promoting natural compounds in different varieties. This study was aimed to evaluate the differences among dragon fruit varieties extracted with methanol–water (CD3OD-D2O) and methanol (CD3OD) by proton nuclear magnetic...
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CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells
PublicationHigh CYP3A4 expression sensitizes tumor cells to certain antitumor agents while for others it can lower their therapeutic ef fi cacy. We have elucidated the in fl uence of CYP3A4 overexpression on the cellular response induced by antitumor acridine derivatives, C-1305 and C-1748, in two hepatocellular carcinoma (HepG2) cell lines, Hep3A4 stably transfected with CYP3A4 isoenzyme, and HepC34 expressing empty vector. The compounds...
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Cellular uptake of biotransformed graphene oxide into lung cells
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Cellular neural network application to moire pattern filtering
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Accuracy analysis of a mobile station location in the cellular networks
PublicationJakość usług lokalizacyjnych oferowanych w sieciach komórkowych zależy od efektywności estymacji położenia terminala ruchomego. Dokładność obecnie stosowanych metod lokalizacyjnych jest niewystarczająca, szczególnie w odniesieniu do wywołań w niebezpieczeństwie. Modyfikacja istniejących algorytmów może istotnie wpłynąć na zwiększenie dokładności lokalizowania terminala ruchomego przy jednocześnie niewielkich nakładach finansowych....
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The Density Classification Problem in the Context of Continuous Cellular Automata
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Analysis of non-linear properties of cardiomyocyte cellular membranes.
PublicationNieliniowe właściwości błon komórkowych kardiomiocytów są dotychczas słabo poznane. W pracy zamodelowano błonę komórkową przy pomocy modelu Beelera-Reutera w modyfikacji Drouharda-Roberge. Przeprowadzono symulacje z użyciem pobudzenia napięciowego o częstotliwości 1 lub 100 kHz i wartości skutecznej 1 lub 10 mV. Prądy płynące przez błonę rozpatrywano jako odpowiedź. Stwierdzono odpowiedź na częstotliwości podstawowej oraz jej drugiej...
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Planning and simulation studies of cellular-type manufacturing processes
PublicationZaproponowano metodę i algorytmy projektowania struktur organizacyjnych systemów wytwarzania typu gniazdowego, z wykorzystaniem zdefiniowanych modeli zapisu wiedzy technologicznej i zasad grupowej obróbki przedmiotów. Wyznaczono wskaźniki efektywności procesu grupowego przebiegającego w systemach gniazdowych z rozmieszczeniem komórkowym oraz funkcjonalnym stanowisk wg przyjętych formuł analitycznych. Zawarto wyniki zrealizowanych...
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Analysis of activity of people using motion sensors
PublicationThe article presents the designed and implemented system for activity monitoring of people using passive motion sensors and methods for activity maps generation. In the paper he method is presented and results obtained for simulated data and for data from observations with the participation of people.
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The correlation between nutritional and health potential and antioxidant properties of raw edible oils from cultivated and wild plants
PublicationThe nutritional properties and health potential of oils from 15 various cultivated and wild plants were investigated on the basis of the fatty acids profiles, total carotenoids and tocopherols content, antioxidant properties and health potential indexes such as atherogenicity index (AI). The oil contents of the plants varied between 0.9 g/100 g for lychee seeds and 29.7 g/100 g for borage seeds. The tocopherol content in oils ranged...
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Extracellular proteolytic activity of Deinococcus geothermalis
PublicationProduction of extracellular protease by extremophilic bacteria Deinococcus geothermalis cultivated in liquid media containing 0.1% (w/v) of peptone K, 0.1% yeast extract and 0.2% marine salt reached a maximum in 14 h of the cell growth at 45°C and pH 8.0. The enzyme was purified by a two-step procedure using fractionation by a graded ammonium sulphate precipitation technique and gel filtration on Sephadex G-100 column. Protease...
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Assessment of Lipophilicity Indices Derived from Retention Behavior of Antioxidant Compounds in RP-HPLC
PublicationReverse phase high pressure liquid chromatography was employed in order to evaluate the lipophilicity of antioxidant compounds from different classes, such as phenolic acids, flavanones, flavanols, flavones, anthocyanins, stilbenes, xantonoids, and proanthocyanidins. The retention time of each compound was measured using five different HPLC columns: RP18 (LiChroCART, Purosphere RP-18e), C8 (Zorbax, Eclipse XDBC8), C16-Amide (Discovery...
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Distinct cellular uptake patterns of two anticancer unsymmetrical bisacridines and their metabolic transformation in tumor cells.
PublicationUnsymmetrical bisacridines (UAs) represent a novel class of anticancer agents. Their high cytotoxicity towards multiple human cancer cell lines and inhibition of human tumor xenograft growth in nude mice signal their potential for cancer treatment. Therefore, the mechanism of their strong biological activity is broadly investigated. Here, we explore the efflux and metabolism of UAs, as both strongly contribute to the development...
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Enhanced susceptibility of SARS-CoV-2 spike RBD protein assay targeted by cellular receptors ACE2 and CD147: Multivariate data analysis of multisine impedimetric response
PublicationSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the cells through the binding of spike protein to the host cell surface-expressing angiotensin-converting enzyme 2 (ACE2) or by endocytosis mediated by extracellular matrix metalloproteinase inducer (CD147). We present extended statistical studies of the multisine dynamic electrochemical impedance spectroscopy (DEIS) revealing interactions between Spike RBD and...
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Beta-galactosidase activity of Meiothermus ruber cells
PublicationFreeze-dried cells of Meiothermus ruber catalyses cleavage of o-nitrophenyl-b-D-galactopiranoside (oNPb-gal) and conversion of lactose into glucose and galactose. The permeabilization with 2%toluene,20%ethanol and 20%acetone increased enzymatic activity from 74.87 U/g of lyophilized cells up to 129.44,114.38 and 90.19 U/g,respectively. Ethanol was an effective permeabilizing agent and its efficiency was dependent on the concentration,...
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Influence of S-Oxidation on Cytotoxic Activity of Oxathiole-Fused Chalcones
PublicationSynthesis, in vitro cytotoxic activity, and interaction with tubulin of oxidized, isomeric 1-(5-alkoxybenzo[d] [1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-ones and 1-(6- alkoxybenzo[d][1,3]oxathiol-5-yl)-3-phenylprop-2-en-1- ones are described. Most of the compounds demonstrated cytotoxic activity at submicromolar concentrations. It was found that oxidation of sulfur atom of the oxathiole-fused chalcones strongly influenced activity...
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Efficient methods for radio location service in cellular communication networks
PublicationW artykule przedstawiono dwie oryginalne metody lokalizowania terminala ruchomego w sieciach komórkowych trzeciej generacji. Metody te podczas estymacji położenia terminala nie wymagają znajomości różnicy czasów w synchronizacji poszczególnych stacji bazowych, przez co są tanie w implementacji. Przedstawiono wyniki badań symulacyjnych zaproponowanych metod.
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Cellular Nuclei Differentiation Evaluated by Automated Analysis of CLSM Images
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Two-dimensional rotation-symmetric number-conserving cellular automata
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Mesoporous silica nanoflakes – Biocompatibility, cellular uptake and drug transport
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An evolutionary approach to the identification of Cellular Automata based on partial observations
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Design framework and simulation investigation of cellular parts manufacturing applications
PublicationPrzedstawiono koncepcję projektowania przebiegów grupowego wytwarzania asortymentu przedmiotów w systemach typu przepływowego, z wykorzystaniem algorytmu analizy podobieństwa ciągów znakowych, reprezentujących marszruty procesów, i jego oceny wg kryterium odległości Levenshteina, zgodnie z paradygmatem oszczędnej produkcji. Efektywność proponowanej metodyki weryfikowano symulacyjnie wg określonych scenariuszy, opisujących wariantowe...
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Simulations of flow patterns in silos with a cellular automaton - part 2
PublicationW artykule przedstawiono wyniki symulacji przepływów silosowych przy zastosowaniu zaawansowanego aparatu komórkowego, w którym uwzględniono kolizje cząstek i dysypację energii. Obliczenia wykonano dla przepływu masowego i kominowego.
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The Physical Activity Environment Policy Index for monitoring government policies and actions to improve physical activity
PublicationBackground A multifaceted response, including government action, is essential to improve population levels of physical activity (PA). This article describes the development process of the ‘Physical Activity Environment Policy Index’ (PA-EPI) monitoring framework, a tool to assess government policies and actions for creating a healthy PA environment. Methods An iterative process was undertaken. This involved a review of policy...