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Search results for: CELLULAR ANTIOXIDANT ACTIVITY
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The effect of lyophilization on selected biologically active components (vitamin c, catalase, lysozyme), total antioxidant capacity and lipid oxidation in human milk
PublicationHuman milk is rich in polyunsaturated fatty acids, as well as lysozyme, vitamin C and other bioactive compounds. The effect of lyophilization on the content of antioxidants (vitamin C and catalase CAT), bactericidal compounds (lysozyme), total antioxidant capacity (TAC) and lipid peroxidation in human milk was investigated in this study. Samples of mature human milk were collected from five healthy women who gave birth on the scheduled...
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Solid Phase Synthesis and Biological Activity of Tuftsin Conjugates
PublicationNew tuftsin/retro-tuftsin conjugates were designed and synthesized using a classical fluorenylmethoxycarbonyl (Fmoc) solid phase procedure. All the peptide conjugates were divided into three series: 1,4-dihydroxyanthraquinone (type A), 1-nitroacridine (type B), and 4-carboxyacridone (type C) derivatives. In type A conjugates, the N-terminal group of the peptide chain is directly connected to the anthraquinone ring at C1 (Scheme...
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Tea and Liver Antioxidant Capabilities in Ethanol Toxicity
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Antioxidant properties of black tea in alcohol intoxication
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Inhibition of cancer antioxidant defense by natural compounds
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The antioxidant properties of anthocyanins in different Aronia products
PublicationOgromne znaczenie w patologii wielu chorób, w tym chorób układu krążenia oraz nowotworów, ma stan przewlekłego stresu oksydacyjnego. Podwyższonej produkcji reaktywnych form tlenu mogą zapobiegać naturalne przeciwutleniacze pochodzenia roślinnego. Z tego powodu przedmiotem badań w wielu ośrodkach naukowych na świecie są rośliny, których składniki charakteryzują się wysokim potencjałem przeciwutleniającym. Do takich roślin zalicza...
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The Role of the Natural Antioxidant Mechanism in Sperm Cells
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The effect of high pressure and sub-zero temperature on total antioxidant capacity and the content of vitamin C, fatty acids and secondary products of lipid oxidation in human milk
PublicationThe objective of this study was to compare of the effects of high pressure of 193 MPa at - 20°C and Low Temperature Long Time pasteurization (LTLT or holder pasteurization, 62,5°C; 30 min) on the content and composition of fatty acids (FAs), concentrations of secondary products of lipid oxidation (TBARS), the total antioxidant capacity (TAC), total vitamin C and ascorbic acid (AsA) content in human milk. It was shown that no significant...
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Antifungal Activity and Synergism with Azoles of Polish Propolis
PublicationThe aim of our work was to check if one of the products of natural origin, namely honey 19 bee propolis may be an alternative or supplement to currently used antifungal agents. The activity 20 of 50 ethanolic extracts of propolis (EEPs), harvested in Polish apiaries, was tested on a group of 69 21 clinical isolates of C. albicans. Most of the EEPs showed satisfactory activity, with minimum 22 fungicidal concentrations (MFC) mainly...
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Knowledge representation of motor activity of patients with Parkinson’s disease
PublicationAn approach to the knowledge representation extraction from biomedical signals analysis concerning motor activity of Parkinson disease patients is proposed in this paper. This is done utilizing accelerometers attached to their body as well as exploiting video image of their hand movements. Experiments are carried out employing artificial neural networks and support vector machine to the recognition of characteristic motor activity...
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The extracts from Panax quinquefolium shoots derived from somatic embryos accumulate ginsenosides and have the antioxidant properties
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Pathological brain network activity: memory impairment in epilepsy
PublicationOur thinking, memory and cognition in general, relies upon precisely timed interactions among neurons forming brain networks that support cognitive processes. The surgical evaluation of drug-resistant epilepsy using intracranial electrodes provides a unique opportunity to record directly from human brain and to investigate the coordinated activity of cognitive networks. In this issue of Neurology®, Kleen and colleagues1 implicate...
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Selected organophosphorus compounds with biological activity. Applications in medicine
PublicationThe purpose of this article is to provide an overview of the latest applications of organophosphorus compounds (OPs) that exhibit biological activity. A large family of OPs have become popular in recent years. The practical application of OPs in modern medicine has been attributed to their unique properties. In this article, the methods used to select these compounds will be emphasized. This paper will first outline the findings...
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Awareness of patients suffering from selected chronic diseases of the importance of physical activity in treating their disorders
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Antifungal Activity of Homoaconitate and Homoisocitrate Analogs
PublicationThirteen structural analogs of two initial intermediates of the L-alpha-aminoadipate pathway of L-lysine biosynthesis in fungi have been designed and synthesized, including fluoro- and epoxy-derivatives of homoaconitate and homoisocitrate. Some of the obtainedcompounds exhibited at milimolar range moderate enzyme inhibitory properties against homoaconitase and/or homoisocitrate dehydrogenase of Candida albicans. The structural...
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New conjugates of mycophenolic acid and their antiproliferative activity
PublicationThe new conjugates of mycophenolic acid (MPA) were obtained in the reaction of N6-(ω-aminoalkyl)adenosines with MPA in the presence of EDCI as a coupling reagent. New compounds 4a–h were evaluated on leukemia cell line (Jurkat) and PBMC from healthy donors. Length of the linker influenced observed activity. The compound 4b possessing 1,3-diamine spacer exhibited the most promising results and can be considered to further investigations.
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Synthesis, Antimicrobial and Mutagenic Activity of a New Class of d-Xylopyranosides
PublicationEight N-[2-(2′,3′,4′-tri-O-acetyl-α/β-d-xylopyranosyloxy)ethyl]ammonium bromides, a new class of d-xylopyranosides containing a quaternary ammonium aglycone, were obtained. Their complete structure was confirmed using NMR spectroscopy (1H, 13C, COSY and HSQC) and high-resolution mass spectrometry (HRMS). An antimicrobial activity against fungi (Candida albicans, Candida glabrata) and bacteria (Staphylococcus aureus, Escherichia...
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Cellular senescence induced by DNA damage and its role in carcinogenesis and chemotherapy
PublicationUszkodzenia DNA indukują w komórce różne procesy, w tym starzenie komórkowe, co może uruchamiać proces karcinogenezy jak i być związane z odpowiedzią na leki przecinowotworowe. Biologiczna rola starzenia komórkowego nie jest jednak jasna. Zasugerowano, że proces starzenia komórkowego może hamować proces karcinogenezy poprzez indukcję nieodwracalnego zahamowania wzrostu przez czynniki genotoksyczne. Indukcja starzenia komórkowego...
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Correction of Huntington’s Disease Phenotype by Genistein-Induced Autophagy in the Cellular Model
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Vitamin C enhances substantially formation of 5-hydroxymethyluracil in cellular DNA
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Genes of cellular components of morphogenesis in porcine oocytes before and after IVM
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Study on the Effect of Rotating Magnetic Field on Cellular Response of Mammalian Cells
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Identification of Cellular Automata Based on Incomplete Observations With Bounded Time Gaps
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A statistical approach to the identification of diploid cellular automata based on incomplete observations
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A systematic review on cellular responses of Escherichia coli to nonthermal electromagnetic irradiation
PublicationInvestigation of Escherichia coli under electromagnetic fields is of significance in human studies owing to its short doubling time and human‐like DNA mechanisms. The present review aims to systematically evaluate the literature to conclude causality between 0 and 300 GHz electromagnetic fields and biological effects in E. coli. To that end, the OHAT methodology and risk of bias tool were employed. Exponentially growing cells exposed...
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The Relation Between Art and Physical Activity in the Public Space of the Contemporary City
PublicationArt has always been and still is a mirror in which human activity is reflected. One of the basic human activities is physical activity, thanks to which humans are able to satisfy their needs, improve health and also function in society. Therefore, there are different relationships between physical activity and art. Both of them are present in the public space of cities and this aspect of connection is addressed in the article. The...
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The influence of food phytochemicals on cyclic phosphodiesterase 4 (PDE4) activity
PublicationCyclic phosphodiesterase 4 (PDE4) belongs to family of cyclic phosphodiesterases, which are expressed predominantly in inflammatory cells, airway smooth muscles, cardiovascular tissues and brain. Inhibitors of this family of enzymes found medicinal applications as antidepressants, antiinflamatory drugs (mainly in airway diseases) or antiasthmatics (Ibudilast). PDE4 inhibitors are also being tested for preventing the development...
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Comparison of Acoustic and Visual Voice Activity Detection for Noisy Speech Recognition
PublicationThe problem of accurate differentiating between the speaker utterance and the noise parts in a speech signal is considered. The influence of utilizing a voice activity detection in speech signals on the accuracy of the automatic speech recognition (ASR) system is presented. The examined methods of voice activity detection are based on acoustic and visual modalities. The problem of detecting the voice activity in clean and noisy...
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Detection of person presence and its activity in the bathtub
PublicationA practical application of a bioimpedance technique for a detection of a bathing person is presented in the paper. It addresses the possibility of supervising people in the bathtub without voiding of their intimacy. The measurement system installed in a fiber-glass or a plastic bathtub is able to detect a presence of the bathing person, to estimate its activity and thus to detect potentially dangerous events. In the paper a principle...
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Influence of temperature on the activity of anammox granular biomass.
PublicationThe aim of this study was to determine a short-term and long-term effect of temperature on the anammox rate and determination of temperature coefficients in the Arrhenius and Ratkowsky equations. The short-term effects of temperature on the anammox granular biomass were investigated in batch tests at ten different temperatures in the range of 10–55 °C. The maximum overall nitrogen removal rate of 1.3 gN gVSS−1·d−1 was observed...
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Territorial Aspects of Entrepreneurial Activity in Polish Suburban Zones
PublicationGlobalization has led to an increased correlation and integration of various fields in modern civilization, including those connected with allocation of entrepreneurial functions. Connection, on a global scale, has shown an increased significance of worldwide corporations. Territorial allocation of the entrepreneurial function has become the subject of translocation and revaluation. Translocation can be understood as the change...
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Optimal placement of IMU sensor for the detection of children activity
PublicationIn this paper an investigation to determine the optimal placement of IMU sensors for the purpose of children characteristic activity detection is presented. The article compares four different placement of two IMU sensors on human body. Ten healthy volunteers participated within the study. Data were collected firstly from two wireless 9-axial IMU sensors placed at the left and right wrists, then sensors were placed at lower back...
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Elderly persons professional activity - substantive issues and methodical challenges
PublicationPopulation ageing and mass withdrawal of persons around retirement age from the labour market constitutes a serious threat for European Union economy, especially in the so-called new member states. The coming years are expected to bring a considerable increase in public spending on pensions and health care, as well as changes in the structure and size of consumer demand and an increase in the number of socially excluded individuals....
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Comparison of Morphological, Antidiabetic and Antioxidant Properties of Goji Fruits
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The influence of temperature on the antioxidant potential in different types of honey*
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Antioxidant Properties and Nutritional Composition of Matcha Green Tea
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Photosensitive and pH-dependent activity of pyrazine-functionalized carbazole derivative as promising antifungal and imaging agent
PublicationCarbazole skeleton plays a significant role as a structural scaffold of many pharmacologically active compounds. Pyrazine-functionalized carbazole derivative was constructed by coupling 2-amino-5-bromo-3-methylaminepyrazine (ABMAP) into 3 and 6 positions of the carbazole ring. Multi-experimental methods were used, e.g., potentiometric, spectroscopic (ATR, UV, XRD powder,1H and13C NMR), electrochemical (cyclic voltammetry), and...
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Epigenetic modifications and NF-κB pathway activity in Cu,Zn-SOD-deficient mice
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Cellular Effects of Selected Unsymmetrical Bisacridines on the Multicellular Tumor Spheroids of HCT116 Colon and A549 Lung Cancer Cells in Comparison to Monolayer Cultures
PublicationMulticellular tumor spheroids are a good tool for testing new anticancer drugs, including those that may target cancer stem cells (CSCs), which are responsible for cancer progression, metastasis, and recurrence. Therefore, we applied this model in our studies of highly active antitumor unsymmetrical bisacridines (UAs). We investigated the cellular response induced by UAs in 2D and 3D cultures of HCT116 colon and A549 lung cancer...
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Method for Clustering of Brain Activity Data Derived from EEG Signals
PublicationA method for assessing separability of EEG signals associated with three classes of brain activity is proposed. The EEG signals are acquired from 23 subjects, gathered from a headset consisting of 14 electrodes. Data are processed by applying Discrete Wavelet Transform (DWT) for the signal analysis and an autoencoder neural network for the brain activity separation. Processing involves 74 wavelets from 3 DWT families: Coiflets,...
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Comparison of antimicrobial activity of selected, commercially available wound dressing materials
PublicationOBJECTIVE: The aim of our study was to examine the antimicrobial potential of eight selected, commercially available wound dressings containing different antimicrobial agents: silver, chlorhexidine acetate, povidone-iodine, and manuka honey. METHOD: The materials were tested against four reference strains of bacteria: Staphylococcus aureus (PCM 2051), Staphylococcus epidermidis (PCM 2118), Pseudomonas aeruginosa (ATCC 27853),...
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Pr-doped TiO2: The effect of metal content on photocatalytic activity
PublicationThe Pr-TiO2 nanoparticles were prepared by using the sol-gel method. As-prepared samples were characterized by BET measurements, X-ray powder diffraction analysis (XRD) and UV-Vis spectra. Visible and ultraviolet light photocatalytic activity of the sample was studied by photodegradation of phenol while considering the influence of the dopant concentration. TiO2 doped with 0.25 mol% of praseodymium showed the highest photocatalytic...
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Accelerometer signal pre-processing influence on human activity recognition
PublicationA study of data pre-processing influence on accelerometer-based human activity recognition algorithms is presented. The frequency band used to filter-out the accelerometer signals and the number of accelerometers involved were considered in terms of their influence on the recognition accuracy.
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Modelling and simulation analysis of process alternatives in the cellular manufacturing of axially symmetric parts
PublicationAnalizowano procesy technologiczne (PT) alternatywnego wytwarzania określonego spektrum przedmiotów (PO) w różnych systemach gniazdowych. Rozpatrzono warianty PT z operacjami zintegrowanej obróbki wiórowej kształtującej i obróbki wykańczającej poprzez nagniatanie, oraz wariantów z różnicowaniem operacji, w których obróbka wykańczająca realizowana jest w oddzielnych operacjach szlifowania. Dla potrzeb gniazdowej dekompozycji systemów...
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Does migrative and proliferative capability of epithelial cells reflect cellular developmental competence?
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Cellular localization and putative role of aquaporin-2 Ser-261 in the bovine kidney
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Affine continuous cellular automata solving the fixed-length density classification problem
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Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid
PublicationThe series of 16 novel amino acid and peptide mycophenolic acid (MPA) derivatives was obtained as potential antibacterial agents. Coupling of MPA with respective amines was optimized with condensing reagents such as EDCI/DMAP and T3P/TEA. Amino acid analogs were received both as methyl esters and also with the free carboxylic group. The biological activity of the products was tested on five references bacterial strains: Klebsiella...
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Automatic Clustering of EEG-Based Data Associated with Brain Activity
PublicationThe aim of this paper is to present a system for automatic assigning electroencephalographic (EEG) signals to appropriate classes associated with brain activity. The EEG signals are acquired from a headset consisting of 14 electrodes placed on skull. Data gathered are first processed by the Independent Component Analysis algorithm to obtain estimates of signals generated by primary sources reflecting the activity of the brain....
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Meiothermus ruber cells as β-galactosidase activity biocatalyst
PublicationThe current study allowed to establish the possibility of using whole cells of thermophilic bacteria Meiothermus ruber as a biocatalyst with β-galactosidase activity. β-galactosidases are used for hydrolysis of lactose as well as for oligosaccharides synthesis. The advantages of using whole bacterial cells catalysis is not only elimination of tedious, expensive protein isolation and/or purification but also stabilization of enzymes...