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Search results for: HUME DAVID
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Physicochemical profile of Os (III) complexes with pyrazine derivatives: From solution behavior to DNA binding studies and biological assay
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Development of Technical Creativity Featuring Modified TRIZ-AM Inventive Principle to Support Design for Additive Manufacturing
Publicationhe design for additive manufacturing (DFAM) processing was introduced to fully utilise the design freedom provided by additive manufacturing (AM). Consequently, appropriate design methodologies have become essential for this technology. Recently, many studies have identified the importance of DFAM method utilisation to produce AM parts, and TRIZ is a strategy used to formalise design methodologies....
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Initial Field Validation of Poroelastic Pavement Made with Crumb Rubber, Mineral Aggregate and Highly Polymer-Modified Bitumen
PublicationTire/road noise in most driving conditions dominates other sources of traffic noise. One of the most efficient ways of reducing tire/road noise is to use the so-called “low noise pavement”. According to numerous studies, at present, poroelastic road pavement that is composed of rubber and mineral aggregate and polyurethane or bituminous binder gives the best noise reduction up to 12 dB. Unfortunately, there are many problems with...
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Seawater intrusion due to pumping mitigated by natural freshwater flux: a case study in Władysławowo, northern Poland
PublicationThe paper presents a case study of seawater intrusion into a coastal aquifer, caused by a groundwater intake located close to the seashore in Władysławowo, northern Poland. Evolution of the basic hydrogeochemical parameters for the 50-year period from 1964 to 2014 indicates progressing encroachment of saline seawater into the aquifer. However, the spatial pattern of salinity was influenced by the variability of hydraulic gradient...
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Plant Extracts Containing Saponins Affects the Stability and Biological Activity of Hempseed Oil Emulsion System
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Role for chitin and chitooligomers in the capsular architecture of Cryptococcus neoformans
PublicationW pracy opisano wyniki badań nad rolą struktur zawierających N-acetylo-D-glukozaminę (GlcNAc) w tworzeniu kapsuły otaczającej komórki patogennych dla człowieka grzybów Cryptococcus neoformans. Ekspresja w warunkach in vivo chitooligomerów łączących polisacharydy kapsuły ze ścianą komórkową jest różna, w zależności od rodzaju zainfekowanej tkanki, co określono poprzez wykazanie różnej reaktywności komórek form drożdżowych C. neoformans...
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Enhancing Availability for Critical Services
PublicationTraditional approaches to provide classes of resilient service take the physical network availability as an input and then deploy redundancy and restoration techniques at various layers, often without full knowledge of mappings between layers. This makes it hard (and often inefficient) to ensure the high availability required by critical services which are typically a small fraction of the total traffic. Here, the innovative technique...
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Cytocompatibility of stabilized black phosphorus nanosheets tailored by directly conjugated polymeric micelles for human breast cancer therapy
PublicationThe novel procedure of few-layer black phosphorus (FLBP) stabilization and functionalisation was here proposed. The cationic polymer PLL and non-ionic PEG have been involved into encapsulation of FLBP to allow sufficient time for further nanofabrication process and overcome environmental degradation. Two different spacer chemistry was designed to bind polymers to tumor-homing peptides. The efficiency of functionalisation was examined...
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Looking for New Ideas of Public Space – Public Space Projects in Gdansk Reinforced by Art Activities
PublicationRevitalization of public open spaces is a complex enterprise in Poland in terms of the art, cultural andinformation aspects of this process. Simultaneously the public space should play an important role whenbuilding the quality of revitalization programs and the quality of city development. The new art and culturalactivities are the revitalization tools, which are also the good examples of bottom up ideas helping to start aprocess...
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The work-family interface: Job demands, work engagement and turnover intentions of Polish nurses
PublicationA conflict between one's professional life and one's family life may lead to lower well-being both at work and home. Most nurses are women who have traditionally reconciled their professional life with family life. One aim of this study was to examine the relationships between the work-family conflict (WFC),the family-work conflict (FWC), and the perception of job demands (quantitative workload and interpersonal conflicts at work)....
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‘Personas for lighting’. Three methods to develop personas for the indoor lighting environment
PublicationThe objective of this research is to describe and compare three different methods of generating ‘persona for lighting’ to envision users’ behaviour within the lighting environment. ‘Personas’ are used to represent typical users, highlighting their needs, perspectives, and expectations to aid user-centric design approaches. The researchers looked for the most useful method of shaping ‘personas for lighting’ to learn about users’...
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OOA-modified Bi-LSTM network: An effective intrusion detection framework for IoT systems
PublicationCurrently, the Internet of Things (IoT) generates a huge amount of traffic data in communication and information technology. The diversification and integration of IoT applications and terminals make IoT vulnerable to intrusion attacks. Therefore, it is necessary to develop an efficient Intrusion Detection System (IDS) that guarantees the reliability, integrity, and security of IoT systems. The detection of intrusion is considered...
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User Authentication by Eye Movement Features Employing SVM and XGBoost Classifiers
PublicationDevices capable of tracking the user’s gaze have become significantly more affordable over the past few years, thus broadening their application, including in-home and office computers and various customer service equipment. Although such devices have comparatively low operating frequencies and limited resolution, they are sufficient to supplement or replace classic input interfaces, such as the keyboard and mouse. The biometric...
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Can bottom sediments be a prospective fertilizing material? A chemical composition analysis for potential reuse in agriculture.
PublicationEvery year huge amounts of bottom sediments are extracted worldwide, which need to be dis-posed. The recycling of bottom sediments for soil fertilization is in line with the long-promoted circular economy policy and enables the use of micro and macronutrients accumulated in sedi-ments for soil fertilization. When considering potential agricultural reuse of the dredge sediments, the first necessary step should be to analyze whether...
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Designing digital displays and interactive media in today’s cities by night. Do we know enough about attracting attention to do so?
PublicationWith the huge transformation in the development of digital screen technology and its consistently decreasing cost, digital billboards are progressively replacing traditional static, two-dimensional poster advertisements in our cities1. Previously, due to the substantial expenditure involved, they were only available to major international brands with vast promotional resources to build their brand fame. Today, however, they are...
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Simultaneous voltammetric determination of Cd2+, Pb2+, and Cu2+ ions captured by Fe3O4@SiO2 core-shell nanostructures of various outer amino chain length
PublicationIn the present study, we examined a novel functionalised magnetic nanoparticles Fe3O4@SiO2-Nn as a nano adsorbent for binding of Cd2+, Pb2+, Cu2+ ions in an aqueous solution. First, we obtained the nanoparticles functionalised with various carbon chains containing different number of amino groups: (3-amino)propyltriethoxysilane (Fe3O4@SiO2-N1), N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (Fe3O4@SiO2-N2) and N1-(3-trimethoxysilylpropyl)diethylenetriamine...
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Differential and Overlapping Effects of 20,23(OH)2D3 and 1,25(OH)2D3 on Gene Expression in Human Epidermal Keratinocytes: Identification of AhR as an Alternative Receptor for 20,23(OH)2D3
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Novel Lytic Enzyme of Prophage Origin from Clostridium botulinum E3 Strain Alaska E43 with Bactericidal Activity against Clostridial Cells
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Tunable broadband integrated circuits for adaptive optical interconnects
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Novel Nystatin A1 derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis
PublicationOpportunistic oral infections caused by Candida albicans are frequent problems in immunocompromised patients. Management of such infections is limited due to the low number of antifungal drugs available, their relatively high toxicity and the emergence of antifungal resistance. Given these issues, our investigations have focused on novel derivatives of the antifungal antibiotic Nystatin A1, generated by modifications at the amino...
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Inhibition of Human and Yeast 20S Proteasome by Analogues of Trypsin Inhibitor SFTI-1
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Conversion of Potato Industry Waste into Fodder Yeast Biomass
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Synthesis and photochemical characteristics of novel tribenzoporphyrazines possessing peripherally annulated tetrahydrodiazepine and diazepine rings
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Experimental and first-principles studies of high-pressure effects on the structural, electronic, and optical properties of semiconductors and lanthanide doped solids
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Paraffin-Embedded Tissue as a Novel Matrix in Metabolomics Study: Optimization of Metabolite Extraction Method
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Photoluminescence enhancement study in a Bi-doped Cs2AgInCl6 double perovskite by pressure and temperature-dependent self-trapped exciton emission
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Inhibitors of Matriptase‐2 Based on the Trypsin Inhibitor SFTI‐1
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Effect of pine essential oil and rotating magnetic field on antimicrobial performance
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Evaluation of differences in expression pattern of three isoforms of the transforming growth factor beta in patients with lumbosacral stenosis
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Implication of the disulfide bridge in trypsin inhibitor SFTI-1 in its interaction with serine proteinases
PublicationFourteen monocyclic analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds were synthesized by the solid-phase method. The purpose of this work was to establish the role of a disulfide bridge present in inhibitor's side chains of Cys3 and Cys11 in association with serine proteinases. This cyclic fragment was replaced by the disulfide bridges formed by L-pencillamine (Pen), homo-L-cysteine (Hcy), N-sulfanylethylglycine...
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Analogues of trypsin inhibitor SFTI-1 modified in the conserved P1′ position by synthetic or non-proteinogenic amino acids retain their inhibitory activity
PublicationA series of linear and monocyclic (with a disulfide bridge only) analogues of trypsin inhibitor SFTI-1 modified in the P-1 and/or P-1' positions were synthesized by the solid-phase method. In the substrate specificity P-1 position, Phe or N-benzylglycine (Nphe) were introduced, whereas the conserved Ser6 in Bownam-Birk (BBI) inhibitors was replaced by Hse (L-homoserine), Nhse [N-(2-hydroxyethyl)glycine], Sar, and Ala. Kinetic studies...
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Nowy polski katalog typowych konstrukcji nawierzchni podatnych i półsztywnych
PublicationPrzyczyny opracowania i nowowprowadzone elementy katalogu. Uporządkowanie terminologii. Obliczenia ruchu projektowego i nowe współczynniki przeliczeniowe. Nowe materiały i technologie oraz klasyfikacja warunków gruntowo-wodnych. Projektowanie warstw wzmacniających podłoże gruntowe i górnych warstw nawierzchni.
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Opracowanie nowego "Katalogu typowych konstrukcji nawierzchni podatnych i półsztywnych"
PublicationReferat zawiera opis prac badawczych i projektowych przeprowadzonych na Politechnice Gdańskiej w celu opracowania nowego katalogu. Prace te obejmowały normalizację terminologii, studia istniejących katalogów i metod projektowych w innych krajach, analizy kryteriów zmęczeniowych do projektowania konstrukcji nawierzchni, analizy ruchu projektowego na podstawie danych ze stacji ważenia w ruchu, metody wzmacniania podłoża gruntowego,...
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New polish catalogue of typical flexible and semi-rigid pavements
PublicationThe paper covers the following topics important for the development of the new Polish Catalogue of typical flexible and semi-rigid pavements: reasons for preparing the new issue of the Catalogue of typical flexible and semi-rigid pavements, items introduced in the new issue, organise the terminology related to pavements, design traffic calculations and new equivalent axle load factors,...
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Symulacje numeryczne stalowej bariery ochronnej na łuku drogi
PublicationW pracy wymieniono pewne czynniki związane z bezpieczeństwem ruchu drogowego, wskazując łuki poziome dróg jako miejsca, gdzie występuje istotna liczba groźnych w skutkach wypadków. W części pracy obejmującej symulacje numeryczne, zrealizowano serię badań spełniających warunki testu zderzeniowego TB11 ze zmiennym promieniem bariery. Oszacowano wpływ zróżnicowania geometrii na parametry bezpieczeństwa.
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Remediation of soils on municipal rendering plant territories using Miscanthus × giganteus
PublicationPhytoremediation, as a cost-effective, highly efficient, environmentally friendly, and green approach, gained attention to the removal of metals, including heavy metals, from contaminated soils. The toxic nature of heavy metals can have an adverse effect on human health and the ecosystem, and their removal remains a worldwide problem. Therefore, in this study, a field experiment was carried out to evaluate the potential of Miscanthus × giganteus...
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In vitro enzyme kinetics and NMR-based product elucidation for glutathione S-conjugation of the anticancer unsymmetrical bisacridine C-2028 in liver microsomes and cytosol: major role of glutathione S-transferase M1-1 isoenzyme
PublicationThis work is the next step in studying the interplay between C-2028 (anticancer-active unsymmetrical bisacridine developed in our group) and the glutathione S-transferase/glutathione (GST/GSH) system. Here, we analyzed the concentration- and pH-dependent GSH conjugation of C-2028 in rat liver microsomes and cytosol. We also applied three recombinant human GST isoenzymes, which altered expression was found in various tumors. The...
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Impact of rotor geometry optimization on the off-design ORC turbine performance
PublicationThe paper describes the method of CFD based Nelder-Mead optimization of a 10 kW single-stage axial turbine operating in an ORC system working on R7100. The total-to-static isentropic efficiency is defined as an objective function. Multi-point linear regression is carried out to determine the significance of the objective function arguments and to pick up the set of particular variables and characteristic quantities (e.g. flow angles)...
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Are Pair Trading Strategies Profitable During COVID-19 Period?
PublicationPair trading strategy is a well-known profitable strategy in stock, forex, and commodity markets. As most of the world stock markets declined during COVID-19 period, therefore this study is going to observe whether this strategy is still profitable after COVID-19 pandemic. One of the powerful algorithms of DBSCAN under the umbrella of unsupervised machine learning is applied and three clusters were formed by using market and accounting...
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Katalog typowych konstrukcji nawierzchni podatnych i półsztywnych
PublicationKatalog zawiera metodę projektowania konstrukcji nawierzchni podatnych i półsztywnych obowiązującą w Polsce.
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Assessing groundwater vulnerability to sea water intrusion in the coastline of the inner Puck Bay using GALDIT method
PublicationIn this research, GALDIT method was used to assess seawater intrusion in the coastal aquifer of the inner Puck Bay (Southern Baltic Sea). The impact of potential sea-level rise on groundwater vulnerability for years 2081-2100 was also considered. The study area was categorized into three classes of vulnerability: low, moderate and high. The most vulnerable area is the Hel Peninsula with northern part of the Kashubian Coastland....
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The effect of multiaxial geocomposite reinforcement on fatigue performance and crack propagation delay in double-layered asphalt beams
PublicationThe presented study investigates the effect of a recently developed multiaxial geocomposite made of polypropylene geogrid and non-woven fabric on the delay of crack propagation, based on four-point bending tests of large asphalt concrete beams – both for reinforced and non-reinforced specimens. Several approaches are described in this study, including analysis of stiffness modulus decrease and analysis of crack propagation using...
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Numerical Analysis of TB32 Crash Tests for 4-cable Guardrail Barrier System Installed on the Horizontal Convex Curves of Road
PublicationHorizontal curves are one of the elements of road infrastructure where statistically a relatively high number of accidents have been reported. In the last ten years in Poland approx. 10% of all road accidents happened on horizontal curves of roads and was responsible for approx. 14% of all fatalities on Polish roads. Thus, this issue is important and requires extensive research and proper road safety treatments. One possible measure...
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Estimation of Conservative Contaminant Travel Time through Vadose Zone Based on Transient and Steady Flow Approaches
PublicationEstimation of contaminant travel time through the vadose zone is needed for assessing groundwater vulnerability to pollution, planning monitoring and remediation activities or predicting the effect of land use change or climate change on groundwater quality. The travel time can be obtained from numerical simulations of transient flow and transport in the unsaturated soil profile, which typically require a large amount of data and...
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Assessing groundwater vulnerability to sea water intrusion in the coastline of the inner Puck Bay using GALDIT method
PublicationIn this research, GALDIT method was used to assess seawater intrusion in the coastal aquifer of the inner Puck Bay (Southern Baltic Sea). The impact of potential sea-level rise on groundwater vulnerability for years 2081-2100 was also considered. The study area was categorized into three classes of vulnerability: low, moderate and high. The most vulnerable area is the Hel Peninsula with northern part of the Kashubian Coastland....
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Studying road restraint systems to develop new guidelines
PublicationThe paper will present a proposed approach to such work along with preliminary results of numerical studies for selected problems using road safety devices such as safety barriers on horizontal curves, the effect of kerbs on bridges or the location of obstacles within the barrier’s working width. The paper will discuss assumptions to a methodology of numerical models, calculations and automated processing of data to help with assessing...
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Evaluation of the Influence of Farming Practices and Land Use on Groundwater Resources in a Coastal Multi-Aquifer System in Puck Region (Northern Poland)
PublicationThis study focuses on the modeling of groundwater flow and nitrate transport in a multi-aquifer hydrosystem in northern Poland, adjacent to Puck Bay (Baltic sea). The main goal was to investigate how changes in land use and farming practices may affect groundwater recharge and submarine groundwater discharge (SGD) to the sea and the associated N-NO3 fluxes. An integrated modelling approach has been developed, which couples the...
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Effect of applied standard wood machining fluid on colour and chemical composition of the machined wood surface
PublicationAppropriate monitoring of wood machining processes is a key issue to ensure the expected quality of the processed wood, expected efficiency and minimize energy consumption of production processes. A new trend is the design of environmentally friendly machining fluids. In this paper, as a preliminary study in this field, the effect of applied standard wood machining fluid on changes in the colour and chemical composition of the...
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Incorporation of engineered nanoparticles of biochar and fly ash against bacterial leaf spot of pepper
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Early Detection of Malignant Transformation in Resected WHO II Low-Grade Glioma Using Diffusion Tensor-Derived Quantitative Measures
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