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Wyniki wyszukiwania dla: drug screening platform
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MOST Wiedzy jako narzędzie promocji potencjału naukowo-badawczego uczelni wyższej
PublikacjaRozwój Internetu wpłynął na wiele aspektów naszego życia. Pośród wielu z nich zrewolucjonizował sposób komunikacji. Pochodną tego jest zmiana sposobu przekazywania wszelkiego rodzaju wiedzy. Ogromne znaczenie mają przeszukiwane źródła wiedzy, ich jakość i dostępność. W związku z tym, w obecnych czasach, o potencjale naukowym uczelni wyższej stanowią, obok pracowników w nich zatrudnionych, przede wszystkim zgromadzone bazy wiedzy...
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Transport of paracetamol in swellable and relaxing polyurethane nanocomposite hydrogels
PublikacjaPolyurethane hydrogels are potentially attractive materials for biomedical applications. They are able to absorb large amount of water, biological fluids or active substances, and thus, they have potential to be used as absorbents or wound-healing dressings. They are also used for the controlled release of therapeutics because of their capacity to embed biologically active agents in their water-swollen network. The presence of...
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Development of potential candidate reference materials for drugs in bottom sediment, cod and herring tissues
PublikacjaRegular use of a reference material and participation in a proficiency testing program can improve the reliability of analytical data. This paper presents the preparation of candidate reference materials for the drugs metoprolol, propranolol, carbamazepine, naproxen, and acenocoumarol in freshwater bottom sediment and cod and herring tissues. These reference materials are not available commercially. Drugs (between 7 ng/g and 32...
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Effect of chemical structure on complexation efficiency of aromatic drugs with cyclodextrins: The example of dibenzazepine derivatives
PublikacjaIt is widely believed that the hydrophobic effect governs the binding of guest molecules to cyclodextrins (CDs). However, it is also known that high hydrophobicity of guest molecules does not always translate to the formation of stable inclusion complexes with CDs. Indeed, a plethora of other factors can play a role in the efficiency of guest–CD interactions, rendering structure-based prediction of the complexation efficiency with...
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Activation of peroxymonosulfate using carbon black nano-spheres/calcium alginate hydrogel matrix for degradation of acetaminophen: Fe3O4 co-immobilization and microbial community response
PublikacjaHerein, we focused on the degradation of acetaminophen (ACT) drug in liquid phase by peroxymonosulfate (PMS) activated by carbon black nano-spheres (CBNS). The nanostructured activator was immobilized into calcium alginate hydrogel matrix (CAHM) to avoid the washout of the fine nanostructures. The Langmuir modeling showed an insignificant contribution to the adsorption process in the removal of ACT. The basic pH conditions favored...
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A novel hierarchically-porous diamondized polyacrylonitrile sponge-like electrodes for acetaminophen electrochemical detection
PublikacjaA novel composite electrode material consisting of tangled fibrous polyacrylonitrile-based hierarchically-struc- tured nanocomposites has been produced by wet-spinning, carbonized and decorated with a carbon nano- architecture by microwave plasma-enhanced chemical vapor deposition and investigated as a metal-free electrode for the enhanced electrochemical detection of acetaminophen. Surprisingly, the hierarchical fiber ar- chitecture...
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Design, synthesis, and biological evaluation of tetrahydroquinolinones and tetrahydroquinolines with anticancer activity
PublikacjaColorectal cancer (CRC) is the most commonly diagnosed cancer in Europe and the United States and the second leading cause of cancer related mortality. A therapeutic strategy used for the treatment of CRC involves targeting the intracellular levels of reactive oxygen species (ROS). In this study, we synthesized a series of novel tetrahydroquinolinones and assessed their ability to inhibit CRC growth and proliferation by evoking...
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Targeting DNA Topoisomerase II in Antifungal Chemotherapy.
PublikacjaTopoisomerase inhibitors have been in use clinically for the treatment of several diseases for decades. Although those enzymes are significant molecular targets in antibacterial and anticancer chemotherapy very little is known about the possibilities to target fungal topoisomerase II (topo II). Raising concern for the fungal infections, lack of effective drugs and a phenomenon of multidrug resistance underlie a strong need to expand...
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In vitro and in silico assessment of anti-inflammatory activity of cocoa powders
PublikacjaPlants are considered the major sources of biologically active compounds, which provide unlimited opportunities for their use either as medical treatments or as novel drug formulations. Cocoa powder is frequently used in nutrition and is known to have many benefits thanks to its wide range of biological activities. The presented study was focused on th evaluation of the anti-inflammatory potential of extracts obtained from cocoa...
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Techniczne aspekty implementacji nowoczesnej platformy e-learningowej
PublikacjaZaprezentowano aspekty techniczne implementacji nowoczesnej platformy nauczania zdalnego. Omówiono obszary funkcjonalne takie jak: system zarządzania nauczaniem, serwis informacyjny, dodatkowe oprogramowanie dydaktyczne oraz kolekcja zasobów multimedialnych. Przybliżono zagadnienia związane z bezpieczeństwem takiej platformy. Na końcu przedstawiono parametry techniczne wdrożonej na Politechnice Gdańskiej platformy eNauczanie.
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Parametry mechaniczne platformy roboczej na podstawie badań DMT
PublikacjaNośność platformy roboczej określana jest w sposób analogiczny do nośności podłoża uwarstwionego, w którym warstwa wierzchnia zbudowana z gruntu niespoistego spoczywa na słabonośnym podłożu z gruntu spoistego. Badanie DMT wykorzystano do wyznaczenia parametrów wytrzymałościowych podłoża (kąta tarcia wewnętrznego warstwy górnej i wytrzymałości na ścinanie bez odpływu podłoża słabonośnego) oraz do wyznaczenia modułu odkształcenia...
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CENTRUM w systemie STRADAR – funkcje, architektura i realizacja
PublikacjaSystem STRADAR jest rozwiązaniem umożliwiającym utworzenie infrastruktury komunikacyjno-teleinformatycznej przeznaczonej dla Morskiego Oddziału Straży Granicznej. Artykuł ten jest kolejną z cyklu publikacji opisujących architekturę i rozwiązanie systemu i dotyczy jego centralnego elementu, jakim jest CENTRUM. Przedstawiono i opisano funkcje, architekturę i realizację oprogramowania CENTRUM, które może być zainstalowane na dowolnym...
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Real-Time Gastrointestinal Tract Video Analysis on a Cluster Supercomputer
PublikacjaThe article presents a novel approach to medical video data analysis and recognition. Emphasis has been put on adapting existing algorithms detecting le- sions and bleedings for real time usage in a medical doctor's office during an en- doscopic examination. A system for diagnosis recommendation and disease detec- tion has been designed taking into account the limited mobility of the endoscope and the doctor's requirements. The...
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A Parallel Genetic Algorithm for Creating Virtual Portraits of Historical Figures
PublikacjaIn this paper we present a genetic algorithm (GA) for creating hypothetical virtual portraits of historical figures and other individuals whose facial appearance is unknown. Our algorithm uses existing portraits of random people from specific historical period and social background to evolve a set of face images potentially resembling the person whose image is to be found. We then use portraits of the person's relatives to judge...
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Rapid development of custom web application with ruby on rails framework on the example of group project system
PublikacjaTechnology industry labor market requires engineers with a good preparation for work with project's tasks and team cooperation skills. One of the way for achieve that abilities during technical university education are students group projects. Running of group projects at university brings new challenges, from recruitment of students with required skills for par-ticular project, to lack of industrial procedures and ready to use...
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Quality measure of VoIP services in carrier grade systems
PublikacjaThis paper describes passive measurement method of VoIP services quality in carrier grade systems, engaging slight system resources. Measurement is based on analyzing quality information in sender and receiver reports in RTCP packets sent by the end points of RTP session. Data is analyzed and stored by Session Boarder Controllers SBC. Objective evaluation of VoIP calls is based on quality information of IP connection and voice...
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A Model-Driven Solution for Development of Multimedia Stream Processing Applications
PublikacjaThis paper presents results of action research related to model-driven solutions in the area of multimedia stream processing. The practical problem to be solved was the need to support application developers who make their multimedia stream processing applications in a supercomputer environment. The solution consists of a domain-specific visual language for composing complex services from simple services called Multimedia Stream...
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GPU-Accelerated Finite-Element Matrix Generation for Lossless, Lossy, and Tensor Media [EM Programmer's Notebook]
PublikacjaThis paper presents an optimization approach for limiting memory requirements and enhancing the performance of GPU-accelerated finite-element matrix generation applied in the implementation of the higher-order finite-element method (FEM). It emphasizes the details of the implementation of the matrix-generation algorithm for the simulation of electromagnetic wave propagation in lossless, lossy, and tensor media. Moreover, the impact...
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Au–Si plasmonic platforms: synthesis, structure and FDTD simulations
PublikacjaPlasmonic platforms based on Au nanostructures have been successfully synthesized by directional solidification of a eutectic from Au and the substrate. In order to determine homogeneous shape and space distribution, the influence of annealing conditions and the initial thickness of the Au film on the nanostructures was analyzed. For the surface morphology studies, SEM and AFM measurements were performed. The structure of platforms...
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Modeling the Effects of Slowly Biodegradable Substrate at Large WWTP in Northern Poland
PublikacjaThe essential study was divided into two parts: experimental investigation and mathematical modeling using special platform to computer simulations. In the first part of research an innovative measurement procedure for an indirect determination of the effect of biodegradable particulate and colloidal Xs substrate was developed and implemented. The results of laboratory tests were used futher to verify the mechanism of the hydrolysis...
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NbIr 2 B 2 and TaIr 2 B 2 – New Low Symmetry Noncentrosymmetric Superconductors with Strong Spin–Orbit Coupling
PublikacjaSuperconductivity was first observed more than a century ago, but the search for new superconducting materials remains a challenge. The Cooper pairs in superconductors are ideal embodiments of quantum entanglement. Thus, novel superconductors can be critical for both learning about electronic systems in condensed matter and for possible application in future quantum technologies. Here two previously unreported materials, NbIr2B2...
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Real-Time Bleeding Detection in Gastrointestinal Tract Endoscopic Examinations Video
PublikacjaThe article presents a novel approach to medical video data analysis and recognition of bleedings. Emphasis has been put on adapting pre-existing algorithms dedicated to the detection of bleedings for real-time usage in a medical doctor’s office during an endoscopic examination. A real-time system for analyzing endoscopic videos has been designed according to the most significant requirements of medical doctors. The main goal of...
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Communication as a Factor Limiting University-Business Cooperation
PublikacjaObjective - Despite the broad extent of the scientific activity dealing with university-business cooperation, Poland has yet to develop a satisfactory cooperation strategy that takes business needs into account. This issue is still relevant due to the need for continuous improvement and resulting benefits aimed at improving enterprise competitiveness. Methodology/Technique - Authors of this article attempt to select an overriding...
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Salinity enhances high optically active L-lactate production from co-fermentation of food waste and waste activated sludge: Unveiling the response of microbial community shift and functional profiling
PublikacjaLactic acid (LA), a versatile platform molecule, can be fermented from organic wastes, such as food waste and waste activated sludge. In this study, an efficient approach using salt, a component of food waste as an additive, was proposed to increase LA production. The LA productivity was increased at 10 g NaCl/L and optical pure L-lactate was obtained at 30 g NaCl/L. The enhancement of LA was in accordance with the increased solubilization...
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The Touristification of Italian Historic City Centres: The Lesson for Central Europe about the Airbnb Eruption
PublikacjaThe unparalleled scale of the recent growth in tourism – the rise of the number of temporary visitors – could not have emerged without the impact on other socio‑economic aspects, namely, a change on the part of the destinations. Especially historic city centres are vulnerable to such an impact that could be manifested through diverse transformations of public space usage, housing market economics, availability of services, employment...
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Application of Least Squares with Conditional Equations Method for Railway Track Inventory Using GNSS Observations
PublikacjaSatellite geodetic networks are commonly used in surveying tasks, but they can also be used in mobile surveys. Mobile satellite surveys can be used for trackage inventory, diagnostics and design. The combination of modern technological solutions with the adaptation of research methods known in other fields of science offers an opportunity to acquire highly accurate solutions for railway track inventory. This article presents the...
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Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2
PublikacjaWe combine molecular dynamics, statistical mechanics, and hybrid quantum mechanics/molecular mechanics simulations to describe mechanistically the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp). Our study analyzes the binding mode of both natural triphosphate substrates as well as remdesivir triphosphate (the active form of drug), which is bound preferentially over ATP by RdRp while...
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First report on echinocandin resistant Polish Candida isolates
PublikacjaPurpose: Candida spp. are ranked as one of the four major causative agents of fungal infections. The number of infections caused by Candida species resistant to fluconazole, which is applied as the first line drug in candidiasis treatment, increases every year. In such cases the application of echinocandin is necessary. Echinocandin susceptibility testing has become a routine laboratory practice in many countries due to the increasing...
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Effect of choline chloride based natural deep eutectic solvents on aqueous solubility and thermodynamic properties of acetaminophen
PublikacjaIn this work, natural deep eutectic solvents (NADESs) containing choline chloride as hydrogen bond acceptor and 1,2-propanediol, malic acid and tartaric acid as hydrogen bond donors have been synthesized and applied to enhance the aqueous solubility of model sparingly water-soluble drug – acetaminophen. The results indicate that the greatest impact on the solubility of acetaminophen have deep eutectic solvents based on 1,2-propanediol...
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TiO2-based magnetic nanocomposites with core-shell structure
PublikacjaThe main aim of the doctoral dissertation was preparation and characterization of photocatalysts, with particular emphasis on modified titanium (IV) oxide photocatalysts, which can be applied for the degradation of organic pollutants not susceptible to biodegradation. A particularly important aspect of the work was the development of preparation method of nanocomposites with the magnetic core-shell and photocatalyst shell (TiO2)...
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Phage Therapy—Challenges, Opportunities and Future Prospects
PublikacjaThe increasing drug resistance of bacteria to commonly used antibiotics creates the need to search for and develop alternative forms of treatment. Phage therapy fits this trend perfectly. Phages that selectively infect and kill bacteria are often the only life-saving therapeutic option. Full legalization of this treatment method could help solve the problem of multidrug-resistant infectious diseases on a global scale. The aim of...
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Implementacja w FPGA algorytmu detekcji krawędzi obrazu w czasie rzeczywistym
PublikacjaW artykule przedstawiono projekt architektury oraz implementację układową toru przetwarzania wstępnego obrazu z modułem detekcji krawędzi. Układ został zaimplementowany w FPGA Intel Cyclone. Zrealizowany moduł wykorzystuje pięć wybranych algorytmów wykrywania krawędzi, w tym Robertsa, Sobela i Prewitt.
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Study on a polish peat bog “Rucianka” as a source of yeast strains capable of effective phenol biodegradation
PublikacjaPhenol is one of the most widely distributed environmental pollutants which can be found in wastewaters and industrial effluents. Due to its toxicity and resistance to self-degradation, it could become even lethal for humans and animals. The treatment of this toxic compound is focused on psychical–chemical methods, although biological treatment of phenol is preferable for economic aspects related to relatively...
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New Carvone-Based Deep Eutectic Solvents for Siloxanes Capture from Biogas
PublikacjaDuring biogas combustion, siloxanes form deposits of SiO2 on engine components, thus shortening the lifespan of the installation. Therefore, the development of new methods for the purification of biogas is receiving increasing attention. One of the most effective methods is physical absorption with the use of appropriate solvents. According to the principles of green engineering, solvents should be biodegradable, non-toxic, and...
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Interpretable deep learning approach for classification of breast cancer - a comparative analysis of multiple instance learning models
PublikacjaBreast cancer is the most frequent female cancer. Its early diagnosis increases the chances of a complete cure for the patient. Suitably designed deep learning algorithms can be an excellent tool for quick screening analysis and support radiologists and oncologists in diagnosing breast cancer.The design of a deep learning-based system for automated breast cancer diagnosis is not easy due to the lack of annotated data, especially...
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Evaluation of polycaprolactone as a new sorbent coating for determination of polar organic compounds in water samples using membrane–SPME
PublikacjaCommercially available solid-phase microextraction fibers used for isolation of polar analytes are based on the adsorption phenomenon. In consequence, typical limitations bonded with analytes displacement and matrix effects are very frequent. In the present study, alternative solution is described. Polycaprolactone (PCL) was used for the first time as sorbent to isolate polar organic compounds from water samples using the membrane–solid-phase...
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Subarachnoid Space: New Tricks by an Old Dog
PublikacjaPurpose: The purpose of the study was to: (1) evaluate the subarachnoid space (SAS) width and pial artery pulsation in both hemispheres, and (2) directly compare magnetic resonance imaging (MRI) to near-infrared transillumination/backscattering sounding (NIR-T/BSS) measurements of SAS width changes in healthy volunteers.Methods: The study was performed on three separate groups of volunteers, consisting in total of 62 subjects (33...
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The New Test Procedure for Group-Type Composition of Base Oils of Lubricating Oils, Especially Emitted into the Environment
PublikacjaMineral base oil, a product of multistep fine refining of the relevant fractions from vacuum distillation of crude oil, is a main component of so-called mineral lubricating oils containing aliphatic and alicyclic substituted aromatic hydrocarbons, i.e., derivatives of benzene and biphenyl. Mineral lubricating oil is composed mostly of mineral base oil and a low amount of enriching additives, most often products of advanced organic...
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Olfactory receptor-based biosensors as potential future tools in medical diagnosis
PublikacjaThe detection of biomarkers is the future of non-invasive medical diagnosis and screening. Discovery and identification of reliable disease specific volatile organic compounds is dependent on repeatable, accurate analysis of trace level gaseous analytes mainly in breath samples. Natural variety of the olfactory systems and the compounds capable of gas molecules binding creates wide possibilities of acquisition and implementation...
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Determination of Odor Air Quality Index (OAQII) Using Gas Sensor Matrix
PublikacjaThis article presents a new way to determine odor nuisance based on the proposed odor air quality index (OAQII), using an instrumental method. This indicator relates the most important odor features, such as intensity, hedonic tone and odor concentration. The research was conducted at the compost screening yard of the municipal treatment plant in Central Poland, on which a self-constructed gas sensor array was placed. It consisted...
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How thermal stability of ionic liquids leads to more efficient TiO2-based nanophotocatalysts: Theoretical and experimental studies
PublikacjaIonic liquids (ILs) containing distinct nitrogen-bearing organic cations (pyridinium, pyrrolidinium, imidazolium, ammonium, morpholinium) were first used for the preparation of 23 IL-TiO2 types of composites by ionic liquid assisted solvothermal synthesis. These 23 optimal ILs structures (i.e. compounds exhibiting an optimal combination of specific properties, functionality, and safety) for synthesis and experimental validation...
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Embedded gas sensing setup for air samples analysis
PublikacjaThis paper describes a measurement setup (eNose) designed to analyze air samples containing various volatile organic compounds (VOCs). The setup utilizes a set of resistive gas sensors of divergent gas selectivity and sensitivity. Some of the applied sensors are commercially available and were proposed recently to reduce their consumed energy. The sensors detect various VOCs at sensitivities determined by metal oxide sensors’ technology...
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Attention-Based Deep Learning System for Classification of Breast Lesions—Multimodal, Weakly Supervised Approach
PublikacjaBreast cancer is the most frequent female cancer, with a considerable disease burden and high mortality. Early diagnosis with screening mammography might be facilitated by automated systems supported by deep learning artificial intelligence. We propose a model based on a weakly supervised Clustering-constrained Attention Multiple Instance Learning (CLAM) classifier able to train under data scarcity effectively. We used a private...
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Magnetic deep eutectic solvents as efficient media for extraction of furfural and 5-hydroxymethylfurfural from aqueous samples
PublikacjaThe extraction of furfural (FF) and 5-hydroxymethylfurfural (HMF) from hydrolysates is currently one of the main challenges in bio-refinery. In this work, the separation of FF and HMF from the aqueous phase was carried out using a new type of green solvents – Magnetic Deep Eutectic Solvents (MDES). A conductor-like screening model for realistic solvents (COSMO-RS) was used for the preselection of 400 MDES. MDES which exhibit the...
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E-learning course "International comparative studies on SMEs"
PublikacjaProjekt Leonardo da Vinci "International comparative studies and course development on SMEs" został zainspirowany poprzednim projektem LdV "A European Diploma in SME Management". Bazując na poprzednich doświadczeniach projektowych zaproponowano opracowanie struktur dla opisania narodowych systemów małych i średnich przedsiębiorstw (ang. SME Small Media Enterprises) przy wykorzystaniu dostępnych krajowych danych. Udowodniono, że...
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MobileNet family tailored for Raspberry Pi
PublikacjaWith the advances in systems-on-a-chip technologies, there is a growing demand to deploy intelligent vision systems on low-cost microcomputers. To address this challenge, much of the recent research has focused on reducing the model size and computational complexity of contemporary convolutional neural networks (CNNs). The state-of-the-art lightweight CNN is MobileNetV3. However, it was designed to achieve a good trade-off between...
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Metodyka szacowania maksymalnej generacji rozproszonej ulokowanej w elektrowniach wiatrowych
PublikacjaPraca przedstawia metodykę szacowania maksymalnej mocy zainstalowanej tzw. generacji rozproszonej. Metodyka ta umożliwia określenie wartości maksymalnej mocy, możliwej do przyłączenia w danym miejscu (miejscach) systemu elektroenergetycznego w źródłach generacji rozproszonej, a w tym pozwala na ocenę wariantów przyłączenia. W metodyce wykorzystuje się funkcję celu, która uwzględnia wymagania stawiane źródłom energii elektrycznej...
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Diagnostics of the tram track shape with the use of the global positioning satellite systems (GPS/Glonass) measurements with a 20 Hz frequency sampling
PublikacjaSatellite geodetic measurements used in the diagnosis of railway tracks require professional receivers and a very high frequency rate of data processing. It stems from a significant speed (10 km/h) kinematic measurements carried out during the passage of a measuring platform. The survey results (positions) of deformed railroad track have waveforms nature requiring additional processing methods and approximations. Due to the announcement...
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Szacowanie maksymalnej mocy generacji rozproszonej w systemie elektroenergetycznym
PublikacjaW monografii przedstawiono metodykę szacowania maksymalnej mocy zainstalowanej, tzw. generacji rozproszonej. Metodyka ta umożliwia określenie wartości maksymalnej mocy możliwej do przyłączenia w danym miejscu (miejscach) systemu elektroenergetycznego w źródłach generacji rozproszonej, a ponadto pozwala na ocenę wariantów przyłączenia. W metodyce wykorzystuje się funkcję celu, która uwzględnia wymagania wobec źródeł energii elektrycznej...
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The development of an underwater telephone for digital communication purposes
PublikacjaThe underwater telephone HTL-10 has been designed to provide voice and data communication between helicopter and submarines using acoustic waves. It works in a half-duplex mode and uses analogue power-efficient modulation in the form of a single side-band, suppressed carrier, in a wide range of frequencies. It generates the transmitted signal, and processes the received signals. It is implemented with the use of digital signal...