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Positron-electron correlation-polarization potentials for the calculation of positron collisions with atoms and molecules
PublikacjaWe present correlation-polarization potentials for the calculation of scattering cross sections of positrons with atoms and molecules. The potentials are constructed from a short-range correlation term and a long-range polarization term. For the short-range correlation term we present four different potentials that are derived from multi-component density functionals. For the long-range polarization term we employ a multi-term...
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Targeting shelterin proteins for cancer therapy.
PublikacjaAs a global health challenge, cancer prompts continuous exploration for innovative therapies that are also based on new targets. One promising avenue is targeting the shelterin protein complex, a safeguard for telomeres crucial in preventing DNA damage. The role of shelterin in modulating ataxia- telangiectasia mutated (ATM) and ataxia-telangiectasia and Rad3-related (ATR) kinases, key players in the DNA damage response (DDR),...
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Application of Maximum Lenght Sequence in Silent Sonar
PublikacjaSilent sonars are designed to reduce the distance over which their sounding pulses can be detected by intercept sonars. In order to meet this objective, we can use periodical sounding signals that have low power, a very long duration and wide spectrum. If used in the silent sonar's receiver, matched filtration ensures very good detection of motionless or slow moving targets. However, it is more difficult to detect echo signals...
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Developing a cycling subsystem as part of a sustainable mobility strategy: the case of Gdansk
PublikacjaModal share is an important component in developing sustainable transport within a city. In recent years, many cities have set modal share targets for balanced and sustainable transport modes: 30% of public transport and 30% of non-motorized (cycling and walking) modes. Gdansk strategic documents have set similar goals with some actions already taken towards those goals. The cycle network is increasing popular. Gdansk’s cycling...
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Fast clutter cancellation for noise radars via waveform design
PublikacjaCanceling clutter is an important, but very expensive part of signal processing in noise radars. It is shown that considerable improvements can be made to a simple least squares canceler if minor constraints are imposed onto noise waveform. Using a combination of FPGA and CPU, the proposed scheme is capable of canceling both stationary clutter and moving targets in real-time, even for high sampling rates.
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A method of determining and visualizing safe motion parameters of a ship navigating in restricted waters
PublikacjaThe paper presents a method of displaying ship collision avoidance information which is based on an unconventional Collision Threat Parameters Area (CTPA) technique. The solution presented here extends CTPA's functionality from past works by supporting navigation in restricted waters and handling ship domains analytically instead of numerically. It visualizes potential navigational threats as well as possible collision avoidance...
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Efektywna metoda wyznaczania trasy statków żaglowych
PublikacjaZaproponowano metodę wyznaczania suboptymalnej trasy statków żaglowych poruszających się w ograniczonym akwenie morskim. Uwzględniono przy tym dynamikę tego środowiska w tym warunki pogodowe oraz charakterystyki prędkościowe statków żaglowych. Jako kryterium optymalizacji przyjęto czas żeglugi T oraz liczbę wykonanych manewrów ω. Zaprojektowano heurystyczny algorytm oraz odpowiednią aplikację wyznaczania trasy dla ustalonych punktów...
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Effect Of Resveratrol And Quercetin On Telomerase Regulation In Cancer Cells And Their Anti-Cancer Potential
PublikacjaTelomeres and telomerase are nowadays one on targets for anticancer therapy. Telomerase is expressed in ~90% of human cancer cell lines and tumor specimens, whereas its enzymatic activity is not detectable in most human somatic cells. Was found that some dietary compounds can modulate telomerase activity in cancer cells. This review summarizes the current knowledge about the effects of resveratrol and quercetin on telomerase regulation...
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Cheap Cancellation of Strong Echoes for Digital Passive and Noise Radars
PublikacjaThe problem of cancellation of strong, potentially nonstationary,echoes in noise radars and passive radars utilizing digitaltransmissions is considered. The proposed solution is a multi-stage procedure.Initial clutter estimates, obtained using the least mean squares(LMS) algorithm, are refined using specially designed filters, "matched"to spectral densities of targets and clutter. When the postprocessing filtersare noncausal, the...
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Small rov to detection and identification of dangerous underwater objects
PublikacjaA small unmanned underwater vehicle (UUV) to inspection of an undersea space is presented in the paper. Its behavior is controlled by a trained pilot. Correct detection and identification of targets depends on vehicle'sprecise displacement along a predefined route. Nowadays, the UUVs are equipped with an automatic control system to execute some basic maneuvers without constant human interventions. Hence, in the paper, an autopilot...
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Etyka marketingu - czy marketing jest etyczny?
PublikacjaOd jakiegoś czasu pojawiają się krytyczne głosy wobec marketingu, jako działań nieetycznych, wycelowanych przeciwko klientom i społeczeństwu jako całości. Można stwierdzić, że wizerunek marketingu jest w tym kontekście negatywny. Celem artykułu jest próba odpowiedzi na pytanie czy marketing jest etyczny. Stwierdzono, że istotą marketingu jest dbanie o dobro interesariuszy przedsiębiorstw oraz łączenie interesu firmy, klientów...
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METHOD OF ROUTING SHIPS SAILING IN DEDICATED ENVIRONMENT
PublikacjaThe method for determining the suboptimal route of sailing vessels operating in a restricted area of the sea are proposed in the paper. The dynamics of the environment including weather conditions and speed characteristics of ships sailing are considered. As optimiza-tion criterion, measure sailing time T, and the number of maneuvers performed ω, are taken into account. An heuristic algorithm, and the appropriate application routing...
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Koncepcja systemu wspomagania decyzji nawigatora statku opartego na ewolucyjnym planowaniu manewrów antykolizyjnych
PublikacjaArtykuł przedstawia koncepcję systemu wspomagania decyzji nawigatora statku opartego na wątkach badań prowadzonych wcześniej przez autora. System będzie rozszerzał funkcjonalność systemów dotychczasowych o możliwość szczegółowego planowania bezpiecznej trajektorii statku na wodach zamkniętych, z dużą liczbą statków obcych i ograniczeniami toru wodnego. Artykuł zawiera dyskusję możliwych podejść do planowania manewrów, optymalizacji...
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Modified DNA polymerases for PCR troubleshooting
PublikacjaPCR has become an essential tool in biological science. However, researchers often encounter problems with difficult targets, inhibitors accompanying the samples, or PCR trouble related to DNA polymerase. Therefore, PCR optimization is necessary to obtain better results. One solution is using modified DNA polymerases with desirable properties for the experiments. In this article, PCR troubleshooting, depending on the DNA polymerase...
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The accuracy of a new approach to order determination for the Modified Prony method in swath mapping application
PublikacjaThis article presents the performance of a new approach to determine the model order for the modified Prony method applied to swath acoustic mapping. Key requirements for any mapping application are depth determination accuracy and angular resolution. Depth determination accuracy is strictly related to angular accuracy and geometrical relations between receiver and sources of the backscattered signal. Angular resolution determines...
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Distance measurement errors in silent FM-CW sonar with matched filtering
PublikacjaThe secretiveness of sonar operation can be achieved by using continuous frequency-modulated sounding signalswith reduced power and significantly prolonged repeat time. The application of matched filtration in the sonarreceiver provides optimal conditions for detection against the background of white noise and reverberation, and avery good resolution of distance measurements of motionless targets. The article shows that target...
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In silico approaches for better understanding cysteine cathepsin-glycosaminoglycan interactions
PublikacjaCysteine cathepsins constitute the largest cathepsin family, with 11 proteases in human that are present primarily within acidic endosomal and lysosomal compartments. They are involved in the turnover of intracellular and extracellular proteins. They are synthesized as inactive procathepsins that are converted to mature active forms. Cathepsins play important roles in physiological and pathological processes and, therefore, receive...
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Polarisation effects in low-energy positron–molecule scattering
PublikacjaThe UK molecular R-matrix method has been adapted to treat positron collisions from polyatomic targets. A simple empirical enhancement factor which corrects for the underestimation of electron–positron polarisation and correlation effects in the calculations performed with the static-plus-polarization model at low scattering energies is presented. Application of this model to positron scattering from carbon dioxide at energies...
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Low-energy positron scattering from gas-phase uracil
PublikacjaQuantum scattering calculations are presented for the interaction of low energy positrons with the uracil molecule, an important component of biological systems. The rotational elastic and inelastic cross sections and vibrational inelastic cross sections are reported and compared with existing experiments, indicating a general trend of the cross sections different from the experimental findings and in line with what should be expected...
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Impact of AlphaFold on structure prediction of protein complexes: The CASP15‐CAPRI experiment
PublikacjaWe present the results for CAPRI Round 54, the 5th joint CASP-CAPRI protein assembly prediction challenge. The Round offered 37 targets, including 14 homodimers, 3 homo-trimers, 13 heterodimers including 3 antibody–antigen complexes, and 7 large assemblies. On average 70 CASP and CAPRI predictor groups, including more than 20 automatics servers, submitted models for each target. A total of 21 941 models submitted by these groups...
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Rethinking Sustainable Cities at Night: Paradigm Shifts in Urban Design and City Lighting
PublikacjaSince the establishment of the 17 Sustainable Development Goals (SDGs) by the United Nations General Assembly in 2015, various perspectives on sustainable cities have been developed and adopted in order to achieve a better and more sustainable future. However, background research has revealed that these goals and targets are limited because they do not take into account the growing body of lighting-related research in diverse fields...
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A concept of software extension of 3D low-PRF radar systems to 4D semi-medium-PRF radar systems
PublikacjaWe present a concept of software modification of three-dimensional (3D) radar systems, designed to work in the low pulse repetition frequency mode, that equips them with the ability to estimate the radial velocity and to properly measure the range of targets that are detected outside the radar’s instrumented range. Despite the fact that the proposed modifications are designed so as to require only minor changes in software, they...
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Diver Observations by Means of Acoustic Methods
PublikacjaSearching for objects, especially small ones, moving under water near its the free surface, is always not an easy task. Designing tools for the detection of such targets is a real challenge when the possibility of a terrorist attack is a real threat. This paper presents some aspects of diver detection by means of acoustics methods, both active (side scan sonar) and passive ones (linear receiving antenna). This approach is quite...
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Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
PublikacjaSkin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose...
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Phase transition of a dimorphic fungus Penicillium marneffei
PublikacjaPenicillium marneffei is a pathogenic fungus that afflicts immunocompromised individuals who live or travel in Southeast Asia. This species is unique, because it is the only dimorphic member of the genus Penicillium. Dimorphism results from a process, termed phase transition, which is regulated by temperature of incubation. At room temperature, the fungus grows filamentously (mould phase), but at body temperature (37°C), a uninucleate...
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Positron collisions with molecular hydrogen: cross sections and annihilation parameters calculated using theR-matrix with pseudo-states method
PublikacjaThe molecular R-matrix with pseudo-states (MRMPS) method is employed to study positron collisions with H2. The calculations employ pseudo-continuum orbital sets containing up to h (l = 5) functions. Use of these high l functions is found to give converged eigenphase sums. Below the positronium formation threshold, the calculated cross sections agree with other high-accuracy theories and generally with the measurements. Calculation...
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Approximate Cramér–Rao bound on Doppler error in correlation-processing relatively narrowband noise radar
PublikacjaThe paper studies limitations on accuracy of Doppler estimation in continuous-wave noise radar with correlation processing. Second order properties of output of the correlation receiver are evaluated and an approximate Cram´er-Rao bound on errors of Doppler measurement is derived. The accuracy of Doppler measurements is found to be affected by the following factors: power spectral density of noise signal, frequency response of the...
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Recent total cross section measurements in electron scattering from molecules
PublikacjaThe grand-total cross sections (TCSs) for electron scattering from a range of molecules, measured over the period 2009-2019 in various laboratories, with the use of different electron transmission systems, are reviewed. Where necessary, the presented TCS data are also compared to earlier results. Collection of investigated molecular targets (biomolecules, biofuels, molecules of technological application,hydrocarbons) reflects their...
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Comparative molecular modelling of biologically active sterols
PublikacjaMembrane sterols are targets for a clinically important antifungal agent – amphotericin B. The relatively specific antifungal action of the drug is based on a stronger interaction of amphotericin B with fungal ergosterol than with mammalian cholesterol. Conformational space occupied by six sterols has been defined using the molecular dynamics method to establish if the conformational features correspond to the preferential interaction...
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Road safety information system in Poland - supporting tools and their development
PublikacjaAs a signatory to the UN Declaration on road safety and member of the EU, Poland has an obligation to comply with relevant EU policies and in particular to halve the overall number of road deaths by 2020. To monitor the progress in reaching the targets, the road safety situation must be evaluated and its processes understood. For this purpose regional and national road safety observatories were launched in Poland, which triggered...
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The Empirical Application of Automotive 3D Radar Sensor for Target Detection for an Autonomous Surface Vehicle’s Navigation
PublikacjaAvoiding collisions with other objects is one of the most basic safety tasks undertaken in the operation of floating vehicles. Addressing this challenge is essential, especially during unmanned vehicle navigation processes in autonomous missions. This paper provides an empirical analysis of the surface target detection possibilities in a water environment, which can be used for the future development of tracking and anti-collision...
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Optimizing of target detection and tracking processes realized on consoles of passive sonar with linear towed antenna
PublikacjaThe long-range passive towed sonar was first modernised a few years ago. Building on operator experience over that period, a concept was developed of optimising the tasks performed by sonar operators, and improving forms of imaging to inform about object detection and support object tracking. The concept was implemented and successfully tested during ships’ manoeuvres. The optimisation of operator tasks was designed to keep listening...
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Conversion of Biomass and Municipal Wastes into Syngas and Hydrogen using Highly Preheated Agent (HTAG)
PublikacjaGasification is considered to be one of the most promising energy recovery technologies for the widespread utilization of biomass and wastes. During this process raw feedstock is converted into a combustible gas, which can then be burnt to produce thermal energy, or to run engines for mechanical or electrical power. The studies of biomass gasification demonstrate it as a friendly alternative to fossil fuels as one of renewable...
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Plasmon-enhanced photoluminescence from TiO2 and TeO2 thin films doped by Eu3+ for optoelectronic applications
PublikacjaIn this work we study the luminescence properties of europium-doped titanium dioxide and tellurium oxide thin films enhanced by gold plasmonic nanostructures. We propose a new type of plasmon structure with an ultrathin dielectric film between plasmonic platform and luminescent material. Plasmonic platforms were manufactured through thermal annealing of the gold thin film. Thermal dewetting of gold film results in spherical gold...
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Inhibitors of amino acids biosynthesis as antifungal agents
PublikacjaFungal microorganisms, including the human pathogenic yeast and filamentous fungi, are able to synthesize all proteinogenic amino acids, including nine that are essential for humans. A number of enzymes catalyzing particular steps of human-essential amino acid biosynthesis are fungi specific. Numerous studies have shown that auxotrophic mutants of human pathogenic fungi impaired in biosynthesis of particular amino acids exhibit...
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Nutrient loss from three small-size watersheds in the southern Baltic Sea in relation to agricultural practices and policy
PublikacjaAgriculture is the major contributor of waterborne nutrient fluxes into the Baltic Sea, one of the world’s most eutrophication-sensitive areas. Poland, as a large, densely populated state ohf the Baltic Region, with dominating agricultural land use, largely contributes to riverborne loads of N and P. The aim of our study was to examine the input of nutrients from three small first-order agricultural watersheds (Bladzikowski Stream,...
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Evaluating experimental molecular physics studies of radiation damage in DNA*
PublikacjaThe field of Atomic and Molecular Physics (AMP) is a mature field exploring the spectroscopy, excitation, ionisation of atoms and molecules in all three phases. Understanding of the spectroscopy and collisional dynamics of AMP has been fundamental to the development and application of quantum mechanics and is applied across a broad range of disparate disciplines including atmospheric sciences, astrochemistry, combustion and environmental...
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On Some Aspects of Fish Target Strength Estimation in Shallow Waters
PublikacjaThe theory of acoustic surveys for determining fish abundance are well established in fishery acoustics. The origins of the estimation are related to overcoming the problem of unknown position of target in the beam using statistical inversion. Although recently researchers use more sophisticated echosounders that provides more informative data allowing for direct solution it is known that the results are biased due to not ideally...
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Influence of Natural Conditions on the Imaging of the Bottom of the Gdańsk Bay by Means of the Side Scan Sonar
PublikacjaThe interest in underwater resources is the reason for the development of modern hydroacoustic systems, including side sonars, which find numerous applications such as: research of seabed morphology and sediment characteristics, preparation of sea sediment maps, and even in special cases of biocenoses such as sea grass meadows, detection of specific targets at the bottom such as shipwrecks, mines, identification of suitable sites...
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Volunteerism in the last year as a moderator between empathy and altruistic social value orientation: An exploratory study
PublikacjaVolunteerism is a sustained prosocial activity, and young adults are one of the most important targets for organizations recruiting volunteers. Empathy and altruistic social value orientation measured by a decomposed game are dispositional traits that might foster engagement in volunteerism. Using a self-report online-based questionnaire study on two groups of young adults (aged 18-35, N = 224 non-volunteers and N = 178 volunteers...
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HDAC Inhibitors: Innovative Strategies for Their Design and Applications
PublikacjaHistone deacetylases (HDACs) are a large family of epigenetic metalloenzymes that are involved in gene transcription and regulation, cell proliferation, differentiation, migration, and death, as well as angiogenesis. Particularly, disorders of the HDACs expression are linked to the development of many types of cancer and neurodegenerative diseases, making them interesting molecular targets for the design of new efficient drugs...
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Experimental Study of Silent Sonar
PublikacjaStealth is a frequent requirement in military applications and involves the use of devices whose signals are difficult to intercept or identify by the enemy. The silent sonar concept was studied and developed at the Department of Marine Electronic Systems of the Gdansk University of Technology. The work included a detailed theoretical analysis, computer simulations and some experimental research. The results of the theoretical...
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Targeting DNA Topoisomerase II in Antifungal Chemotherapy.
PublikacjaTopoisomerase inhibitors have been in use clinically for the treatment of several diseases for decades. Although those enzymes are significant molecular targets in antibacterial and anticancer chemotherapy very little is known about the possibilities to target fungal topoisomerase II (topo II). Raising concern for the fungal infections, lack of effective drugs and a phenomenon of multidrug resistance underlie a strong need to expand...
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Shape and force control of cable structures with minimal actuators and actuation
PublikacjaShape adjustment and stress control can be considered as one of the effective parameters in prestressed cable structures since such structures are widely constructed nowadays due to their characteristics. The assembly errors and applied loads hugely affect the cables’ nodal positions and stress due to their delicacy. The former could disturb the shape, which affects the appearance and the function of the structure. In contrast,...
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Organic semiconductor rubrene thin films deposited by pulsed laser evaporation of solidified solutions
PublikacjaOrganic semiconductor rubrene (C42H28) belongs to most preferred spintronic materials because of the high charge carrier mobility up to 40 cm2(V·s)-1. However, the fabrication of a defect-free, polycrystalline rubrene for spintronic applications represents a difficult task. We report preparation and properties of rubrene thin films deposited by pulsed laser evaporation of solidified solutions. Samples of rubrene dissolved in aromatic...
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A universal method for the identification of genes encoding amatoxins and phallotoxins in poisonous mushrooms
PublikacjaABSTRACT Background. As the currently known diagnostic DNA targets amplified in the PCR assays for detection of poisonous mushrooms have their counterparts in edible species, there is a need to design PCR primers specific to the genes encoding amanitins and phallotoxins, which occur only in poisonous mushrooms. Objective. The aim of the study was testing of PCR-based method for detection of all genes encoding hepatotoxic cyclic...
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Metal nanoparticles-assisted early diagnosis of diseases
PublikacjaEarly diagnosis is essential for the effective illness treatment, but traditional diagnostic approaches inevitably have major downsides. Recent advancements in nanoparticle-based biosensors have created new opportunities for accelerating diagnosis. High surface area, exceptional sensitivity, high specificity, and optical characteristics of metal and metal oxide nanoparticles have made it possible to detect a variety of health conditions...
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Multivariate Assessment of Procedures for Molecularly Imprinted Polymer Synthesis for Pesticides Determination in Environmental and Agricultural Samples
PublikacjaIn the case of quantitative and qualitative analysis of pesticides in environmental and food samples, it is required to perform a sample pre-treatment process. It allows to minimalize the impact of interferences on the final results, as well as increase the recovery rate. Nowadays, apart from routinely employed sample preparation techniques such as solid-phase extraction (SPE) or solid-phase microextraction (SPME), the application...
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Modified Peptide Molecules As Potential Modulators of Shelterin Protein Functions; TRF1
PublikacjaIn this work, we present studies on relatively new and still not well-explored potential anticancer targets which are shelterin proteins, in particular the TRF1 protein can be blocked by in silico designed "peptidomimetic" molecules. TRF1 interacts directly with the TIN2 protein, and this protein-protein interaction is crucial for the proper functioning of telomere, which could be blocked by our novel modified peptide molecules....
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Energy policy and the role of bioenergy in Poland
PublikacjaPrzedstawiono sytuacje energetyczną kraju. Omówiono poszczególne sektory wytwarzania energii oraz zapotrzebowania na energię i paliwa. Omówiono przekształcenia sektorów energetycznych w Polsce na przestrzeni lat 1990-2002. Na tym tle przedstawiono techniczne, ekonomiczne, społeczne i prawne aspekty rozwoju energetyki źródeł odnawialnych a w szczególności opartych o bioenergię. Przedstawiono wnioski dla Polski płynące z dotychczasowych...