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Wyniki wyszukiwania dla: IN VIVO MOUSE MODELS

Wyniki wyszukiwania dla: IN VIVO MOUSE MODELS

  • Use of Data from Satellite Navigation System in Operational and Strategic Management of Transport in Cities

    The article presents the possibilities of using data from the Global Positioning System for the development of traffic models and examples of use this data in the transport management. Traffic models are useful tools in planning and evaluation of transport solutions, but also can be used for current, operational transport management.

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  • Zdolności dynamiczne do budowania chmury wartości w modelach biznesów

    Publikacja

    - Rok 2018

    Obserwacja współczesnych metod tworzenia wartości daje podstawy do wyłonienia nowej logiki ich generowania. Analiza modeli wytwarzania wartości przez przedsiębiorstwa np. sieciowe wykazała, że formułują one chmury wartości. Struktury tych chmur są różnorodne, niejednolite, kłębiaste. Przeprowadzone prace pozwoliły na sformułowanie obrazów wartości generowanych przez twarde komponenty modeli biznesów. Osiągnięcie tych wyników pozwoliło...

  • Multiscalar Model Based Control Systems for AC Machines

    Publikacja

    - Rok 2011

    Contents of the Chapter: Nonlinear transformations and feedback linearization. Models of the squirrel cage induction machine: Vector model of the squirrel cage induction machine. Multiscalar models of the squirrel cage induction machine.Feedback linearization of multiscalar models of the induction motor.Models of the double fed induction machine: Vector model of the double fed induction machine. Multiscalar model of the...

  • Applying Fuzzy Logic of Expert Knowledge for Accurate Predictive Algorithms of Customer Traffic Flows in Theme Parks

    This study analyzes two forecasting models based on the application of fuzzy logic and evaluates their effectiveness in predicting visitor expenditure and length of stay at a popular theme park. The forecasting models are based on a set of more than 600 decision rules constructed in the form of a complex series of IF-THEN statements. These algorithms store expert knowledge. A descriptive instrument that records the individual visitor's...

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  • Modelling fatalities on regional road networks

    Publikacja

    During the last decade Poland’s road fatalities went down by 44%. The trend differs from region to region. Effective road safetymanagement in regions requires tools for forecasting road safety measures and identifying factors influencing road fatality numbers. Mathematical models can provide such tools. They take into account local characteristics such as: demography, economy, infrastructure and motorization. Such models could...

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  • Retention modeling of some saccharides separated on an amino column.

    Using an amino column (Supelcosil LC-NH2) and different mixtures of acetonitrile-water, quantitative structure-retention relationship models are discussed. These models are based on computed molecular descriptors representing numerically structured features of some saccharides. The obtained results are underlining the lipophilicity/hydrophilicity balance, and how this is controlling the separation of the saccharides. The resulting...

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  • THE PHASE SHIFTERS INFLUENCE ON THE POWER SYSTEM STABILITY

    Publikacja

    The paper presents the effect of phase shifters as FACTS devices on the possibility of improving the angle stability. Presented results obtained by the dynamic simulation performed on the mathematical model of the three machine system cooperating with the 400 kV network. The generative blocks models include turbine models with their controllers and models of synchronous generators with their excitation systems and voltage regulation....

  • Stability of roof trusses stiffened by trapezoidal sheeting and purlins

    In the article linear buckling analysis of a set of steel trusses braced by purlins and trapezoidal sheeting are conducted. The buckling load factor due to the height of a corrugated sheeting profile is investigated in parametric studies. The minimal height of trapezoidal sheeting required for preventing the sheeting and chords of the trusses against the buckling is obtained. Two groups of models are considered: “axial” model as...

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  • CAD. 3D modelling (2023/24)

    Kursy Online
    • D. Cyparski

    Conducting unit: Faculty of ArchitectureField of the study: ArchitectureAcademic year: 2023/2024 Summer TermDuration:  15 weeks (30 hours laboratory per term) Subject objectives: The course aim is to demonstrate the application of Computer Aided Design in preparation of architectural 3D models and project presentations. No previous CAD experience is necessary. Using hands-on exercises, students explore how to create project presentations...

  • Correction of far-field measurements obtained in non-anechoic test site

    Dane Badawcze

    The dataset contains raw and processed measurements of radiation pattern characteristics performed in non-anechoic regime for two geometrically small antenna structures: a spline-parameterized Vivaldi structure and a compact spline-based monopole. The responses have been obtained at the selected frequencies of interest as a function of mentioned structures...

  • Optical Sensor Based Gestures Inference Using Recurrent Neural Network in Mobile Conditions

    In this paper the implementation of recurrent neural network models for hand gesture recognition on edge devices was performed. The models were trained with 27 hand gestures recorded with the use of a linear optical sensor consisting of 8 photodiodes and 4 LEDs. Different models, trained off-line, were tested in terms of different network topologies (different number of neurons and layers) and different effective sampling frequency...

  • Two examples of Quantum Dynamical Semigroups

    The Hamiltonians of the considered bi-partite systems are of the form $$ H_{S,R} = H_S /times 1_R + Q_{S} /times M_R + 1_S /times H_R $$ Subindex $S$ corresponds to the observed system and $R$ to the reservoir (the enviroment of $S$). Two classes of systems are distinguished: the discrete-continuous...

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  • Determining and verifying the safety integrity level of the controland protection systems under uncertainty

    Publikacja

    The probabilistic models of the electrical, electronic and programmable electronic (E/E/PE)systems, which are proposed in the IEC 61508 and IEC 61511 standards, do not cover the uncertainty aspectsof results obtained from these models. The proposed method takes into consideration the sensitivity analysisof probabilistic models of E/E/PE systems as well as the uncertainty of probabilistic results. It uses differentialfactors, which...

  • On Symmetry of Uniform and Preferential Attachment Graphs

    Publikacja

    - ELECTRONIC JOURNAL OF COMBINATORICS - Rok 2014

    Motivated by the problem of graph structure compression under realistic source models, we study the symmetry behavior of preferential and uniform attachment graphs. These are two dynamic models of network growth in which new nodes attach to a constant number m of existing ones according to some attachment scheme. We prove symmetry results for m=1 and 2 , and we conjecture that for m≥3 , both models yield asymmetry with high...

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  • A Multi-Fidelity Surrogate-Model-Assisted Evolutionary Algorithm for Computationally Expensive Optimization Problems

    Publikacja

    - Journal of Computational Science - Rok 2016

    Integrating data-driven surrogate models and simulation models of different accuracies (or fideli-ties) in a single algorithm to address computationally expensive global optimization problems has recently attracted considerable attention. However, handling discrepancies between simulation models with multiple fidelities in global optimization is a major challenge. To address it, the two major contributions of this paper include:...

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  • Surrogate Modeling and Optimization Using Shape-Preserving Response Prediction: A Review

    Publikacja

    - ENGINEERING OPTIMIZATION - Rok 2016

    Computer simulation models are ubiquitous in modern engineering design. In many cases, they are the only way to evaluate a given design with sufficient fidelity. Unfortunately, an added computa-tional expense is associated with higher fidelity models. Moreover, the systems being considered are often highly nonlinear and may feature a large number of designable parameters. Therefore, it may be impractical to solve the design problem...

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  • Frequency and time domain characteristics of digital control of electric vehicle in-wheel drives

    In-wheel electric drives are promising as actuators in active safety systems of electric and hybrid vehicles. This new function requires dedicated control algorithms, making it essential to deliver models that reflect better the wheel-torque control dynamics of electric drives. The timing of digital control events, whose importance is stressed in current research, still lacks an analytical description allowing for modeling its...

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  • Disruption of homocitrate synthase genes in Candida albicans affects growth but not virulence

    Publikacja

    - Rok 2010

    Dwa geny, LYS21 i LYS22, kodujące izoformy syntazy homocytrynianowej, enzymu katalizującego pierwszy wyjątkowy etap w szlaku biosyntezy lizyny, zostały rozbite z komórkach Candida albicans z wykorzystaniem strategii ''SAT flipper''. Podwójny mutant lys21delta/lys22delta nie wykazywał aktywności syntazy homocytrynianowej, natomiast charakteryzował się auksotrofią wzrostową wobec lizyny w podłożach minimalnych, co można było odwrócić...

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  • Health-Promoting Effects of Ethylene-Treated Kiwifruit ‘Hayward’ from Conventional and Organic Crops in Rats Fed an Atherogenic Diet

    Publikacja
    • M. Leontowicz
    • I. Jesion
    • H. Leontowicz
    • Y. Park
    • J. Namieśnik
    • M. Weisz
    • S. Gorinstein

    - JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY - Rok 2013

    Kiwifruit is a subtropical fruit that is very popular among consumers. Kiwifruit ‘Hayward’ (Actinidia deliciosa C.F. Liang et A.R. Ferguson) is an important source of bioactive compounds and possesses high antioxidant capacity, but its value can be changed during ripening. The aim of this study was to compare the levels of total polyphenols (TP), ascorbic acid (AA), and total antioxidant capacities (TACs) of ethylene-treated and...

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  • Michał Bernard Pietrzak dr hab.

           Michał Bernard Pietrzak jest kierownikiem Katedry Statystyki i Ekonometrii na Wydziale Ekonomii i Zarządzania Politechniki Gdańskiej oraz zastępcą redaktora naczelnego ds. oceny pod względem poprawności statystycznej czasopism: Oeconomia Copernicana i Equilibrium. Quarterly Journal of Economics and Economic Policy. Do października 2021 pracował na stanowisku profesora nadzwyczajnego na Wydziale Nauk Ekonomicznych i Zarządzania,...

  • Nonlinear strain gradient and micromorphic one-dimensional elastic continua: Comparison through strong ellipticity conditions

    Publikacja

    We discuss the strong ellipticity (SE) conditions for strain gradient and micromorphic continua considering them as an enhancement of a simple nonlinearly elastic material called in the following primary material. Recently both models are widely used for description of material behavior of beam-lattice metamaterials which may possess various types of material instabilities. We analyze how a possible loss of SE results in the behavior...

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  • An Attempt to Create Speech Synthesis Model That Retains Lombard Effect Characteristics

    Publikacja

    - Rok 2019

    The speech with the Lombard effect has been extensively studied in the context of speech recognition or speech enhancement. However, few studies have investigated the Lombard effect in the context of speech synthesis. The aim of this paper is to create a mathematical model that allows for retaining the Lombard effect. These models could be used as a basis of a formant speech synthesizer. The proposed models are based on dividing...

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  • Toward Robust Pedestrian Detection With Data Augmentation

    Publikacja

    In this article, the problem of creating a safe pedestrian detection model that can operate in the real world is tackled. While recent advances have led to significantly improved detection accuracy on various benchmarks, existing deep learning models are vulnerable to invisible to the human eye changes in the input image which raises concerns about its safety. A popular and simple technique for improving robustness is using data...

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  • Fundamentals of Physics-Based Surrogate Modeling

    Publikacja

    Chapter 1 was focused on data-driven (or approximation-based) modeling methods. The second major class of surrogates are physics-based models outlined in this chapter. Although they are not as popular, their importance is growing because of the challenges related to construction and handling of approximation surrogates for many real-world problems. The high cost of evaluating computational models, nonlinearity of system responses,...

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  • Doskonalenie logistycznego łańcucha dostaw w usługach w ujęciu relacyjnym

    Publikacja

    - Rok 2023

    W literaturze zagadnienia związane z modelami doskonałości zarządzania łańcuchem dostaw, modelami zarządzania relacjami, modelami doskonałości EFQM oraz obszarami logistycznymi funkcjonują rozłącznie. Opracowany model w postaci MAPY RELACJI pozwala na pokazanie jak wyglądają korelacje między obszarami logistycznymi, obszarami działalności w odniesieniu do modeli doskonałości EFQM, modelami doskonałości zarządzania łańcuchem dostaw...

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  • Model biznesu przedsiębiorstwa wodociągowego

    W artykule przedstawiono badania nad wartościami modelu biznesu przedsiębiorstw wodociągowych w Polsce oraz przeprowadzono dyskusję nad ich postrzeganiem przez same przedsiębiorstwa. Wartości te w wielu aspektach postrzegane są w zbliżony sposób przez klientów. O ile jednak przedsiębiorstwa, jako istotne wartości postrzegały elementy związa-ne ze sprawnością i ciągłością procesu o tyle klienci kładli nacisk na sferę społeczną doty-czącą...

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  • Application of different building representation techniques in HEC-RAS 2-D for urban flood modeling using the Toce River experimental case

    Publikacja

    This paper presents the impact of the choice of building representation techniques and hydrodynamic models on urban flood simulations using HEC-RAS 2-D for the Toce River physical model. To this end, eight numerical models based on previous laboratory experiments were prepared to simulate unsteady urban flooding on each side of building units. Two simplified building layouts (aligned and staggered) were examined, where models were...

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  • An integrated framework for security protocol analysis

    Publikacja

    - Rok 2008

    Assurance of security protocols needs particular attention. Flaws in a protocol can devastate security of the applications that rely on it. Analysis of the protocols is difficult and it is recommended that formal methods are employed to provide for higher levels of assurance. However, the formal methods can cover only a part of the scope of the problem. It is important that the formal models are valid representations of the protocol...

  • Estimation of the steam condensation flow via CFD methods

    Publikacja

    The results of numerical simulations to predict the performance of different steam models have been presented. All of the considered models of steam condensation have been validated on the base of benchmark experiment employing expansion in nozzle and next on the low pressure part of the steam turbine stage. For numerical analysis three models have been finally used – the ideal steam model without condensation, an equilibrium steam...

  • Numerical analysis and in situ tests of the Grot Rowecki Bridge in Warsaw

    The paper presents the FEM analysis of the reconstructed the Grot-Rowecki Bridge over Vistula river in Warsaw. The bridge has seven spans and consists of two independent structures with the longest spans of 120 m. After reconstruction the bridge is over 10 m wider. The numerical, nonlinear analysis has been con-ducted on a global and local FEM models. These models are defined so as they strictly comply with global structural bridge...

  • Traffic Modeling in IMS-based NGN Networks

    In the modern world the need for accurate and quickly delivered information is becoming more and more essential. In order to fulfill these requirements, next generation telecommunication networks should be fast introduced and correctly dimensioned. For this reason proper traffic models must be identified, which is the subject of this paper. In the paper standardization of IMS (IP Multimedia Subsystem) concept and IMS-based NGN...

  • Robustness Analysis of a Distributed MPC Control System of a Turbo-Generator Set of a Nuclear Plant – Disturbance Issues

    Publikacja

    - Advances in Intelligent Systems and Computing - Rok 2021

    Typically, there are two main control loops with PI controllers operating at each turbo-generator set. In this paper, a distributed model predictive controller with local quadratic model predictive controllers for the turbine generator is proposed instead of a set of classical PI controllers. The local quadratic predictive controllers utilize step-response models for the controlled system components. The parameters of these models...

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  • The distributed model predictive controller for the nuclear power plant turbo-generator set

    Typically there are two main control loops with PI controllers operating at each turbo-generator set. In this paper a distributed model predictive controller DMPC, with local QDMC controllers for the turbine generator, is proposed instead of a typical PI controllers. The local QDMC controllers utilize step-response models for the controlled system components. These models parameters are determined based on the proposed black-box...

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  • Electrochemical simulation of enzymatic transformations studied for the selected antitumor acridine derivatives

    The elucidation of the metabolic pathways and the biotransformation mechanisms of potential drugs is a crucial point in drug development. It allows to know the activation routes of the new biologically active compounds, especially in respect to their possible toxicity. Generally, in vivo or in vitro experiments with liver microsomes or hepatocytes are performed. However, these testing schemes are tedious, time consuming and of...

  • Rapana venosa consumption improves the lipid profiles and antioxidant capacities in serum of rats fed an atherogenic diet

    Publikacja
    • M. Leontowicz
    • H. Leontowicz
    • J. Namieśnik
    • R. Apak
    • D. Barasch
    • A. Nemirovski
    • S. Moncheva
    • I. Goshev
    • S. Trakhtenberg
    • S. Gorinstein

    - NUTRITION RESEARCH - Rok 2015

    In the recent years, the consumption of seafood has increased. There are no results on the studies of Rapana venosa (Rv) as a supplementation to the diets. We hypothesized that Rv would increase antioxidant capacity and reduce blood lipids, based on the composition of bioactive compounds and fatty acids. Therefore, the aim of this investigation was to evaluate in vitro and in vivo actions of Rv from contaminated (C) and non-C (NC)...

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  • A Note on Reduced Strain Gradient Elasticity

    Publikacja

    - Rok 2018

    We discuss the particular class of strain-gradient elastic material models which we called the reduced or degenerated strain-gradient elasticity. For this class the strain energy density depends on functions which have different differential properties in different spatial directions. As an example of such media we consider the continual models of pantographic beam lattices and smectic and columnar liquid crystals.

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  • Modele budowy wartości dla klienta - charakterystyka i rozwinięcie

    Publikacja

    Rozwój form realizacji biznesu umożliwił zbadanie nowych obiektów związanych z generowaniem wartości dla klienta i przedsiębiorstwa. W pracy scharakteryzowano logiki tworzenia wartości będące podstawą modeli łańcucha wartości, sklepu wartości, sieci wartości oraz chmury wartości. Zaproponowano także wprowadzenie nowego składnika do struktury tych modeli w postaci węzła wartości.

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  • On Reduced-Cost Design-Oriented Constrained Surrogate Modeling of Antenna Structures

    Design of contemporary antenna structures heavily relies on full-wave electromagnetic (EM) simulation models. Such models are essential to ensure reliability of evaluating antenna characteristics, yet, they are computationally expensive and therefore unsuitable for handling tasks that require multiple analyses, e.g., parametric optimization. The cost issue can be alleviated by using fast surrogate models. Conventional data-driven...

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  • How to model ROC curves - a credit scoring perspective

    Publikacja

    - Rok 2018

    ROC curves, which derive from signal detection theory, are widely used to assess binary classifiers in various domains. The AUROC (area under the ROC curve) ratio or its transformations (the Gini coefficient) belong to the most widely used synthetic measures of the separation power of classification models, such as medical diagnostic tests or credit scoring. Frequently a need arises to model an ROC curve. In the biostatistical...

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  • Modelling of Asphalt Mixes under Long Time Creep at Low Temperatures

    Proper description of asphalt mixtures behavior under long time load is one of the most important factors in analyses of strain and stress relations at low temperatures both from traffic and environmental loads. For example different models of thermal stress accumulation require different approaches of description of asphalt concrete. But in all cases it is required to describe its behavior under long time loading, which in some...

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  • Determination of flow properties of a pneumatic hose from changes in air pressure in a tank being emptied or filled by a differently configured pneumatic line

    Dane Badawcze
    open access

    The aim of the study was to determine the flow properties of various pneumatic hoses. The experiments were to measure the pressure changes in a being filled or emptied tank for a differently configured pneumatic line, including pneumatic hoses of different length and diameter. Three test configurations were used: (1) pressure source -> pneumatic...

  • Radiation pattern measurements of geometrically small antennas performed in non-anechoic environments

    Dane Badawcze

    The dataset contains unprocessed measurements of radiation pattern characteristics performed in non-anechoic regime for three geometrically small antenna structures: a spline-parameterized Vivaldi structure, a compact spline-based monopole, and a quasi-Yagi geometry with enhanced bandwidth. The responses have been obtained over broad frequency ranges...

  • Measurements of electrically small antenna radiation patterns in non-anechoic environments using TGM

    Dane Badawcze
    open access

    The dataset contains raw and processed measurements of radiation pattern characteristics performed in non-anechoic regime for four antenna structures: a spline-parameterized Vivaldi structure, a compact spline-based monopole, super-ultrawideband antenna, and a quasi-Yagi component. The responses have been obtained at the selected frequencies of interest...

  • Markov Model of Disease Development and Recovery

    Publikacja

    - Rok 2016

    Markov models are commonly used to simulate diseases and allow modeling of multiple health states and outcomes. Starting with the well known Le Bras multistate model (cascading failure model) with time-independent transitions we will see how simple Markov mortality models may be pressed into the service of survival and event history analysis. We will focus on more complex models which will be able to take into account remission,...

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  • The effect of Ag, Au, Pt, and Pd on the surface properties, photocatalytic activity and toxicity of multicomponent TiO2-based nanomaterials

    Publikacja
    • A. Malankowska
    • A. Mikołajczyk
    • J. Mędrzycka
    • I. Frąckiewicz
    • G. Nowaczyk
    • M. Jarek
    • T. Puzyn
    • E. Mulkiewicz

    - Environmental Science-Nano - Rok 2020

    Multicomponent TiO2-based nanomaterials (MC-NMs) show better physicochemical properties than their individual components or bulk materials. However, the same unique properties that offer innovative applications might also pose unknown risks to human health and the environment. In this context, TiO2- based nanomaterials with a mixture of noble metal precursors (Ag, Au, Pt, and Pd) for large-scale technological applications in air...

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  • Phenotypic consequences of the LYS4 gene disruption in Candida albicans

    Publikacja

    - MYCOSES - Rok 2012

    The main scientific purpose of our studies was to verify the hypothesis that homoaconitase (HA) from Candida albicans, an enzyme catalyzing a second step of the α-aminoadipate pathway (AAP) of L-Lys biosynthesis may become a new target for antifungal chemotherapy. Previous studies indicated that the A. fumigatus mutant lacking the functional lysF gene, encoding HA, exhibited attenuated virulence in a low-dose mouse infection model...

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  • Microporous Polyurethane Thin Layer as a Promising Scaffold for Tissue Engineering

    The literature describes that the most efficient cell penetration takes place at 200–500 µm depth of the scaffold. Many different scaffold fabrication techniques were described to reach these guidelines. One such technique is solvent casting particulate leaching (SC/PL). The main advantage of this technique is its simplicity and cost efficiency, while its main disadvantage is the scaffold thickness, which is usually not less than...

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  • Evaluation of adhesion strength, corrosion, and biological properties of the MWCNT/TiO2 coating intended for medical applications

    Publikacja

    - RSC Advances - Rok 2023

    Multi-wall carbon nanotube (MWCNT) coatings are gaining increasing interest because of their special properties used in many science fields. The titania coatings are known for their improvement of osteoblast adhesion, thus changing the surface architecture. Bi-layer coatings comprising 0.25 wt% of the MWCNTs and 0.30 wt% of titania (anatase structure) were synthesized in a two-stage procedure using the electrophoretic deposition...

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  • Analogues of muramyl dipeptide (MDP) and tuftsin limit infection and inflammation in murine model of sepsis

    Publikacja

    - VACCINE - Rok 2009

    Badano koniugaty MDP z tuftsyną oraz pochodną tuftsyny w leczeniu ciężkich infekcji bakteryjnych takich jak posocznica. Oceniano aktywność żerną komórek układu fagocytów jednojądrzastych, wpływ na klirens bakteryjny kluczowych organów wewnętrznych oraz ekspresję genów dla cytokin pro- i antyzapalnych charakterystycznych dla odpowiedzi immunologicznej w posocznicy i indukowanych działaniem analizowanych zwiazków. W badaniach in...

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  • Low-coherence method of hematocrit measurement

    Publikacja

    During the last thirty years low-coherence measurement methods have gained popularity because of their unique advantages. Low-coherence interferometry, low-coherence reflectometry and low-coherence optical tomography offer resolution and dynamic range of measurement at the range of classical optical techniques. Moreover, they enable measurements of the absolute value of the optical path differences, which is still an unsolved problem...

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