Wyniki wyszukiwania dla: REGULATORY - MOST Wiedzy

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Wyniki wyszukiwania dla: REGULATORY

Wyniki wyszukiwania dla: REGULATORY

  • I, Robot: between angel and evil

    Publikacja

    - Rok 2020

    The boosting of most digital innovations within recent technology progress by artificial intelligence (AI) constitutes a growing topic of interest. Besides its technical aspects, increasing research activity may be observed in the domain of security challenges, and therefore of responsibility related to the controlled or hypothetically uncontrolled or autonomous emergence of AI solutions. Consequently, responsibility and ethics...

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  • Biofilm formation and its regulation in Staphylococcus aureus

    Publikacja

    - Rok 2013

    Infections caused by the major human and animal pathogen, Staphylococcus aureus are becoming an important problem due to its emerging resistance mechanisms and variety of virulence factors. Biofilm formation is considered to be one of the most important factor attributed to high pathogenicity of S. aureus. Described in the literature methods used in identification of biofilm forming abilities of bacteria consist of phenotypic and...

  • Integration and Dependency in Software Lifecycle Based on Jazz Platform

    Publikacja
    • B. Chrabski

    - Rok 2011

    Software delivery organizations are being asked to meet goals that seem mutually exclusive. Teams are asked to increase product quality, accelerate time to market, and meet increasing mandates from regulatory bodies. As software solutions and software development environments become rapidly more complex. Many business drivers compound these challlenges.

  • Optymalizacja nastaw regulatorów PID do sterowania suwnicą 3D

    Suwnica stanowi ciekawy, a zarazem skomplikowany obiekt sterowania, który znajduje zastosowanie w różnych gałęziach przemysłu. W artykule przedstawiono obiekt sterowania wraz jego układami sterowania wykorzystującymi regulatory PID. Następnie dobrano parametry regulatorów wybranymi metodami inżynierskimi i optymalizacyjnymi. Przeprowadzono szczegółową analizę porównawczą zaproponowanych rozwiązań.

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  • Uniwersytet organizacją służącą otoczeniu

    Publikacja

    - Rok 2008

    W opracowaniu przedstawiono warunki, jakie muszą być spełnione, aby uniwersytet przekształcił się w organizację służącą otoczeniu. Wykorzystując koncepcję Wawrzyniaka, zidentyfikowano oczekiwania interesariuszy uczelni, czynniki (regulatory) wpływające na ewolucję uczelni oraz niezbedne zmiany w organizacji uczelni, polegające na ewolucji uczelni w kierunku organizacji opartej na wiedzy.

  • Improving the regulation of the derivatives market as an objective prerequisite for sustainable development of the global financial system

    Publikacja

    - E3S Web of Conferences - Rok 2021

    The development of financial markets is characterized by the emergence of new financial instruments, in particular derivatives, the risk level analysis of which is complicated. Counterparties are not always fully aware of and do not adequately assess the potential risks of derivatives, which may lead to large financial losses and sometimes bankruptcies. The purpose of the study is to generalize approaches to regulating derivative...

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  • Evolution of chemotaxis in single-cell artificial organisms

    Publikacja

    The model of a liquid two-dimensional environment, which is based on physics of diffusion, allows us to simulate the diffusion of morphogenes. Artificial organisms move using a chemotaxis reacting to concentration difference. Organisms are controlled by a gene regulatory network coded in a linear genome and reproduce by division. We made a lot of experiments presenting organisms’ behaviour in various environment conditions. We...

  • Method of selecting programming practices for the safety-critical software development projects

    Publikacja

    - Rok 2019

    In recent years a plan-driven approach traditionally used in safety-critical software development has been put to a test by rapidly changing technologies, more diverse group of clients and volatile market requirements. The need to deliver good quality systems, faster and at lower cost in comparison to competitors encouraged companies to look for more efficient solutions. Agile methodologies are known to successfully address these...

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  • Introduction to smart solutions for wastewater: Road-mapping the transition to circular economy

    Publikacja
    • G. Mannina
    • D. Presti
    • A. Pandey
    • H. Helness
    • R. Sirohi
    • J. Mąkinia

    - Rok 2022

    Today there is an urgent need to move from a linear to a circular economy approach with special focus to water and environment. Despite the paramount importance, this transition is hampered by barriers which concern not only technological but embrace also organizational, regulatory, social, and economic aspects. In order to overcome such barriers, innovative water-smart solutions are needed and a robust roadmap for the transition...

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  • Sterowanie silnikiem indukcyjnym w zakresie osłabiania pola

    Publikacja

    Prezentowany w referacie układ regulacji silnika indukcyjnego oparty na modelu multiskalarnym zapewnia zachowanie odsprzężonego sterowania w szerokim zakresie zmian strumienia w szczelinie powietrznej. Układ regulacji zawiera regulatory trzech zmiennych multiskalarnych, co oznacza, że strumień jest sterowany w sposób bezpośredni. Proponowany układ zrealizowano jako bezczujnikowy, przy czym prędkość kątowa wału jest odtwarzana w...

  • Introducing agile practices into development processes of safety critical software

    Publikacja

    In this paper we present AgileSafe - a method which supports introduction of agile practices into safety-critical software development processes. To represent safety assurance constraints resulting from the regulatory context, AgileSafe uses assurance case patterns. The knowledge base of AgileSafe helps the user to select the agile practices relevant for the considered software development project. The corresponding assurance case...

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  • Calculations of notch stress factor of a thin-walled spreader bracket fillet weld with the use of a local stress approach

    Publikacja

    Presence of geometric notches in welded joints causes concentration of strains and stresses, therefore reducing fatigue strength of such joints. This article presents an analysis of stress concentrations in a fillet weld of a spreader mounting bracket on a small sailing yacht. The aim of this article is to direct the attention of designers, manufacturers and regulatory bodies to issues of fatigue cracks that form in brackets fastening...

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  • Evolution of Animats Following a Moving Target in an Artificial Ecosystem

    Publikacja

    - Rok 2014

    Many biological animals, even microscopically small, are able to track moving sources of food. In this paper, we investigate the emergence of such behavior in artificial animals (animats) in a 2-dimensional simulated liquid environment. These "predators" are controlled by evolving artificial gene regulatory networks encoded in linear genomes. The fate of the predators is determined only by their ability to gather food and reproduce—no...

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  • Regulacja transformatorów zasilajacych sieci 110kV w Polsce.

    Publikacja

    - Rok 2003

    Do regulacji transformatorów zasilających sieci 110kV w polskim systemie elektroenergetycznym coraz powszechniejsze są tzw. regulatory grupowe ARST. Nie ma różnic w ocenie struktury, wykonania, ani sposobu powiązania ze sterowanym obiektem. Jest spór o algorytm. Przedstawiona w referacie koncepcja algorytmu regulacji ma, zdaniem autora, przewagę nad algorytmami stosowanymi obecnie. Wymiana algorytmów sterowania w istniejących,...

  • Quality Assurance and Quality Control in the Analytical Chemical Laboratory. A practical approach : Second edition

    Publikacja

    The second edition defines the tools used in QA/QC, especially the application of statistical tools during analytical data treatment. Clearly written and logically organized, it takes a generic approach applicable to any field of analysis. The authors begin with the theory behind quality control systems, then detail validation parameter measurements, the use of statistical tests, counting the margin of error, uncertainty estimation,...

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  • The networking of the justice system as part of public court networks

    Publikacja

    - Rok 2015

    The goal of this paper is to look at the organizational structure of the justice system and provide the answer to the basic question of the possible network relations, their force, and imapct. As part od the paper, I have defined public inetrorganisational court network, dividing them into regulatory inter-organisational networks nad voluntary inetrorganisational networks. Emphasis has also been placed on the benefits and threats...

  • Modelling, Simulation and Optimization of the Wavemaker in a Towing Tank

    The paper analyses the problem of experimental identification (frequency response), modelling and optimization of the towing tank wavemaker in the Scilab/Xcos environment. The experimental identification of the objects (the towing tank wavemaker placed in the hydrodynamic laboratory of the CTO S.A. Ship Design and Research Centre (CTO)) and the implementation of the models in the simulation environment, enable to perform: 1. tuning...

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  • Ship course control system taking into account the steering gear dynamic properties

    W artykule zostały przedstawione różne konfiguracje regulatorów nieliniowych do sterowania kursem statku. Zaprojektowane regulatory oparto na metodzie backstepping, regulatorze PD oraz sterowaniu ślizgowym. Algorytmy uwzględniają na etapie projektowania liniowe własności dynamiczne urządzenia wykonawczo - sterującego maszyny sterowej. Dokonano analizy porównawczej jakości pracy rozpatrywanych struktur sterowania podczas badań symulacyjnych...

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  • Reakcja maszyny dwustronnie zasilanej sterowanej nieliniowo na symetryczny zapad napięcia sieci

    Publikacja

    Maszyna dwustronnie zasilana ma szerokie zastosowanie w układach generatorowych elektrowni wiatrowych. Pomimo licznych zalet tych układów, rozwiązania generatorowe tego typu mają zasadniczą wadę, dużą czułość na zakłócenia napięcia po stronie sieci elektroenergetycznej. W artykule zaprezentowano i porównano wyniki badań reakcji maszyny dwustronnie zasilanej na zapad napięcia sieci. Do sterowania mocą maszyn wykorzystano metodę...

  • Structure and evolution of the 4-helix bundle domain of Zuotin, a J-domain protein co-chaperone of Hsp70

    Publikacja
    • O. Shrestha
    • R. Sharma
    • B. Tomiczek
    • W. Lee
    • M. Tonelli
    • G. Cornilescu
    • M. Stolarska
    • Ł. Nierzwicki
    • J. Czub
    • J. Markley... i 3 innych

    - PLOS ONE - Rok 2019

    The J-domain protein Zuotin is a multi-domain eukaryotic Hsp70 co-chaperone. Though it is primarily ribosome-associated, positioned at the exit of the 60S subunit tunnel where it promotes folding of nascent polypeptide chains, Zuotin also has off-ribosome functions. Domains of Zuotin needed for 60S association and interaction with Hsp70 are conserved in eukaryotes. However, whether the 4-helix bundle (4HB) domain is conserved remains...

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  • Evolution of artificial single-cell organisms foraging for resources in a 3-dimensional environment

    Publikacja

    Foraging for resources is a simple cognitive task that even one-celled biological organisms can ac- complish. We present an Artificial Life system in which artificial unicellular organisms (animats) forage for food in a 3-dimensional simulated liquid environment. The movement of animats is controlled by evolving artificial gene regulatory networks encoded in linear genomes. When an animat consumes enough food, it produces offspring...

  • An analytical approach to determine the health benefits and health risks of consuming berry juices

    Publikacja

    - FOOD CHEMISTRY - Rok 2024

    Food products composition analysis is a prerequisite for verification of product quality, fulfillment of regulatory enforcements, checking compliance with national and international food standards, contracting specifications, and nutrient labeling requirements and providing quality assurance for use of the product for the supplemen- tation of other foods. These aspects also apply to the berry fruit and berry juice. It also must...

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  • Deregulation of the labour markets in the countries of Central and Eastern Europe — selected issues

    The countries of Central and Eastern Europe in the 1990s pursued the transformation processes which were to result in introducing systemic changes and building market economies. It was a process requiring adjustment of the regulatory and system framework to the requirements of the EU. One of the areas covered by the changes was the labour market. The reforms related to the functioning of national labour markets necessitated taking...

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  • Delivery of Ancillary Services in Distribution Power Systems

    One of the technical and organizational challenges the power system faces in deregulated market conditions is to organize an ancillary services market. The growing share of distributed generation of variable (intermittent) energy sources and a change in the market position of consumers, causes the demand for distributed delivery of ancillary services. For this purpose, it is sought to use the ability of the regulatory measures:...

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  • Is Digitalization Improving Governance Quality? Correlating Analog and Digital Benchmarks

    Publikacja

    The digitalization of public governance and the resulting concept of electronic governance is a characteristic feature of contemporary information society. Both can be defined as the process and outcome of digital transformation: transformation of the “analog” version of governance into “digital” governance. Measuring both versions of governance against typical performance measures of efficiency, effectiveness, equity, openness...

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  • Analytical procedures for quality control of pharmaceuticals in terms of residual solvents content: Challenges and recent developments

    Publikacja

    Residual solvents play an important role in the synthesis of drugs and in product formulations. In addition, they pose a serious problem, that is toxicity, as many of them exhibit toxic or environmentally hazardous properties. Therefore, constant monitoring of quality control is needed. In this study, we present an overview of regulatory and general methods described by various pharmacopoeias. Then, the most commonly used methodologies...

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  • Wieloobszarowa regulacja systemu turbogeneratora elektrowni jądrowej =Multiregional control of nuclear power plant turbogenerator system

    W artykule przedstawiono propozycję zaawansowanej struktury sterowania układem turbogeneratora w szerokim zakresie zmian zapotrzebowania na moc czynną. Dla potrzeb syntezy tej struktury wykorzystano nieliniowe, dynamiczne modele turbiny parowej i generatora synchronicznego współpracującego z systemem elektroenergetycznym. Zaproponowane algorytmy sterowania oparte są odpowiednio o wieloobszarowe regulatory rozmyte, z lokalnymi regulatorami...

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  • Lessons learned in a decade: Medical‐toxicological view of tattooing

    Publikacja
    • M. Giulbudagian
    • B. Battisini
    • W. Bäumler
    • A. M. Rico Blass
    • B. Bocca
    • C. Brungs
    • M. Famele
    • M. Foerster
    • B. Gutsche
    • V. Houben... i 12 innych

    - JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY - Rok 2024

    Tattooing has been part of the human culture for thousands of years, yet only in the past decades has it entered the mainstream of the society. With the rise in popularity, tattoos also gained attention among researchers, with the aim to better understand the health risks posed by their application. 'A medical-toxicological view of tattooing'-a work published in The Lancet almost a decade ago, resulted from the international collaboration...

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  • Interaction of the conserved region 4.2 of sigma(E) with the RseA anti-sigma factor

    Publikacja
    • C. Tam
    • B. Collinet
    • G. Lau
    • S. Raina
    • D. Missiakas

    - JOURNAL OF BIOLOGICAL CHEMISTRY - Rok 2002

    Eo-E RNA polymerase transcribes a regulon of folding factors for the bacterial envelope and is induced by physical and chemical stresses. The RseA anti-sigma factor inhibits the activity of Esigma(E) RNA, polymerase. It is shown here that the N-terminal portion of sigma(E), residues 1-153, binds core RNA polymerase. RseA interacts with residues 154-191 of sigma(E), a site that is homologous to region 4, the sigma factor binding...

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  • Regulator rozmyty o właściwościach regulatora trójpołożeniowego

    Regulatory trójpołożeniowe są najprostszymi i najbardziej popularnymi regulatorami w układach automatyki, w których jako element wykonawczy zwykle stosuje się silnik elektryczny pracujący w sposób nawrotny. W takich układach jakość regulacji określa się m.in. poprzez analizę amplitudy i częstotliwości występujących oscylacji, przy zmianach wartości zadanej i wprowadzanych zakłóceniach. Referat jest próbą porównania otrzymywanej...

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  • MODELLING OF TOXIC COMPOUNDS EMISSION IN MARINE DIESEL ENGINE DURING TRANSIENT STATES AT VARIABLE PRESSURE OF FUEL INJECTION

    Publikacja

    - Journal of Polish CIMEEAC - Rok 2014

    Transient states are an important part of the spectrum of engine loads, especially the traction engines. In the case of marine diesel engines, transient states are of particular importance in reducing the analysis of motion units for special areas and maneuvering in port, the participation of transient states in the load spectrum significantly increases, also, the emission of toxic compounds from this period increases proportionally....

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  • The new SDMT-family of servo-drives for CNC systems with AC permanent magnet synchronous motors

    Publikacja

    - Rok 2006

    W artykule przedstawiono strategię sterowania podstawowe parametry oraz wyniki badań nowej rodziny serwonapędów typu SDMT. Układ sterowania serwonapędu zbudowano na procesorze sygnałowym TMS320F2812 firmy Texas Instruments. W serwonapędzie zastosowano metodę sterowania tupu FOC (ang. Field Oriented Control). Regulatory położenia, prędkości i momentu zreali-zowano na bazie klasycznego regulatora PID z układem ograniczenie sygnału...

  • Path dependence, modularity and the offshoring of (some) physician services

    Publikacja

    - Rok 2010

    This paper integrates ideas from modularity and path dependency to explain the potential for and limitations of the offshoring of high value added physician services. While not all medical services are amenable to offshoring, a growing number of physician activities can be viewed as modular components which, at least technically, could be performed remotely. As a result, the presumption that concerns for efficiency dictate how...

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  • Aplikacje informacyjne w kontroli finansowej w przedsiębiorstwie.

    Publikacja

    - Rok 2004

    Celem rozprawy jest prezentacja możliwości komputerowego wspomagania kontroli finansowej w przedsiębiorstwie. Temu celowi podporządkowano jej zakres, w ramach którego dokonano: prezentacji historii i definicji pojęć związanych z kontrolą i systemem, omówiono rolę aplikacji informacyjnych w kontroli finansowej, podsumowano stan wiedzy odnośnie przedmiotu badania. Wykonano analizę metodologiczną modelowania opisowego i sformułowano...

  • Representing Process Characteristics to Increase Confidence in Assurance Case Arguments

    Publikacja

    An assurance case is a structured, evidence-based argument demonstrating that a safety or other quality objective of a high integrity system is assured. Assurance cases are required or recommended in many industry domains as a means to convince the regulatory bodies to allow commissioning of such system. To be convincing, an argument should address all potential doubts and thus cover numerous additional issues, including the processes...

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  • Light-Modulated Sunscreen Mechanism in the Retina of the Human Eye

    Publikacja

    - JOURNAL OF PHYSICAL CHEMISTRY B - Rok 2021

    The functioning of the human eye in the extreme range of light intensity requires a combination of the high sensitivity of photoreceptors with their photostability. Here, we identify a regulatory mechanism based on dynamic modulation of light absorption by xanthophylls in the retina, realized by reorientation of pigment molecules induced by trans–cis photoisomerization. We explore this photochemically switchable system using chromatographic...

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  • The transformation of the Chinese stock market between 1990 and 2012

    The main purpose of this paper is to examine the transformation of the stock market in the People’s Republic of China (i.e. concentrated on stock exchanges in Shanghai and Shenzhen; the stock exchange in Hong Kong was omitted) from its beginnings in the early 1990s, through rapid development over the next two decades, up to the financial crisis of 2008 (the period examined is 1990–2012). The paper presents a short history of the...

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  • Engineering education for smart grid systems in the quasi-industrial environment of the LINTE^2 laboratory

    Smart grid systems are revolutionising the electric power sector, integrating advanced technologies to enhance efficiency, reliability and sustainability. It is important for higher education to equip the prospective smart grid professional with the competencies enabling them to navigate through the related complexities and drive innovation. To achieve this, interdisciplinary education programmes are necessary, addressing inter...

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  • Spatial and Regional Planning Studies

    Kursy Online
    • I. Haxhiaj
    • Ł. Pancewicz

    The course objective is to teach the basic, practical skills of planning for the architects. Three aspects of planning will be taught during the course: building control, regulatory planning and operational planning. The students will explore the role of planning in granting the building permissions, how to prepare the planning (zoning) regulations and finally what are urban design tools, which can be used to coordinate the development...

  • The influence of pre- and postharvest treatments on selected biological and epigenetic activities of Brassica sprouts

    Introduction The Brassica vegetables are rich in glucosinolates (GLs), which are enzymatically hydrolysed to bioactive isothiocynates (ITC) and indoles, regarded as the most promising chemopreventing agents. However, in the majority of brassica sprouts the GL conversion into these beneficial derivatives occurs at the level of about 1 %, while in cabbage leaves exceeds 70%. Since sprouts represent plant material, which is frequently...

  • Future opportunities for products derived from black soldier fly (BSF) treatment as animal feed and fertilizer - A systematic review

    Publikacja
    • S. A. Siddiqui
    • A. S. Gadge
    • M. Hasan
    • T. Rahayu
    • S. N. Povetkin
    • I. Fernando
    • R. Castro Munoz

    - ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY - Rok 2024

    The pursuit of novel food products with good nutritional value for both direct and indirect human consumption is crucial. Given the nutritional benefits of insects and the sustainability of this sort of farming, using them as food for farmed animals is a promising alternative. In this regard, the black soldier fly (Hermetia illucens) is most capable of efficiently converting a wide variety of organic materials, from food waste...

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  • Data governance: Organizing data for trustworthy Artificial Intelligence

    Publikacja
    • M. Janssen
    • P. Brous
    • E. Estevez
    • L. S. Barbosa
    • T. Janowski

    - GOVERNMENT INFORMATION QUARTERLY - Rok 2020

    The rise of Big, Open and Linked Data (BOLD) enables Big Data Algorithmic Systems (BDAS) which are often based on machine learning, neural networks and other forms of Artificial Intelligence (AI). As such systems are increasingly requested to make decisions that are consequential to individuals, communities and society at large, their failures cannot be tolerated, and they are subject to stringent regulatory and ethical requirements....

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  • Composition of fatty acids in selected sorts of biscuits, offered for children

    Publikacja

    - Acta Alimentaria - Rok 2012

    The fatty acid (FA) composition, especially total trans-fatty acids (TFA) content in 12 assortments of biscuits offered for children, produced by four different companies, were determined by gas chromatography. Total fat content of the biscuit samples ranged from 2.2 to 22.8 g/100 g of product. The major FAs were palmitic C16:0, oleic C18:1, and linoleic C18:2 acids. Depending on the biscuit type, the total saturated fatty acids...

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  • The impact of institutions on innovation networks: empirical evidence from Poland

    Publikacja

    - Technological and Economic Development of Economy - Rok 2022

    Innovation networks may accelerate and improve the innovation process, while institutional pathologies may hamper it. This study employs the Kruskal-Wallis H test and regression analysis to determine if the relationship between institutions and innovation networks does exist among the investigated variables. The purpose of the study was to find out whether cooperation with special local institutions influences the innovative behaviour...

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  • State of the Art in Open Platforms for Collaborative Urban Design and Sharing of Resources in Districts and Cities

    Publikacja

    - Sustainability - Rok 2021

    This work discusses recent developments in sharing economy concepts and collaborative co-design technology platforms applied in districts and cities. These developments are being driven both by new technological advances and by increased environmental awareness. The paper begins by outlining the state of the art in smart technology platforms for collaborative urban design, highlighting a number of recent examples. The case of peer-to-peer...

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  • Digital Innovations and Smart Solutions for Society And Economy: Pros and Cons

    Publikacja

    Recent developments in artificial intelligence (AI) may involve significant potential threats to personal data privacy, national security, and social and economic stability. AI-based solutions are often promoted as “intelligent” or “smart” because they are autonomous in optimizing various processes. Be-cause they can modify their behavior without human supervision by analyzing data from the environ-ment, AI-based systems may be...

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  • DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis

    Publikacja
    • L. Kular
    • Y. Liu
    • S. Ruhrmann
    • G. Zheleznyakova
    • F. Marabita
    • D. Gomez-Cabrero
    • T. James
    • E. Ewing
    • M. Lindén
    • B. Górnikiewicz... i 38 innych

    - Nature Communications - Rok 2018

    The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that DRB1*15:01 is hypomethylated and predominantly expressed in monocytes among carriers of DRB1*15:01. A differentially methylated region (DMR) encompassing HLA-DRB1 exon 2 is particularly affected and displays methylation-sensitive regulatory properties in vitro. Causal inference and Mendelian randomization...

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  • Spatial and Regional Studies 2022/2023

    Kursy Online
    • Ł. Pancewicz
    • M. Arczyńska

    The objective of the course Spatial Planning is to teach the architects the key concepts of town planning as well as about its relationship with the architectural practice. The exercises are designed to familiarize the participants with the main concepts that directly impacts on the work of architects, regardless of their respective national context:planning control, role of the technical regulations and the planning permissions; zoning...

  • Podstawy automatyki, W/ĆW, Energetyka, sem.05, zimowy 22/23 (PG_00042061)

    Kursy Online
    • M. H. Ghaemi

    Kurs dla studentek/ów studiów międzywydziałowego kierunku energetyka I stopnia, semestr 5. Skrót tematyki kursu: podstawy automatyki, pojecia podstawowe w automatyce, klasyfikacja układów automatyki, podstawowe elementy ukladów automatyki, rodzaje modeli matematycznych, funkcje przejścia, sposoby analizy układów sterowania w tym metoda częstotliwościowa, stabilność układów sterowania, regulatory, uchyb regulacyjny, kryteria jakości...

  • Regulated Assembly of LPS, Its Structural Alterations and Cellular Response to LPS Defects

    Distinguishing feature of the outer membrane (OM) of Gram-negative bacteria is its asymmetry due to the presence of lipopolysaccharide (LPS) in the outer leaflet of the OM and phospholipids in the inner leaflet. Recent studies have revealed the existence of regulatory controls that ensure a balanced biosynthesis of LPS and phospholipids, both of which are essential for bacterial viability. LPS provides the essential permeability...

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