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Wyniki wyszukiwania dla: L-GLUTAMINE: D-FRUCTOSE-6-PHOSPHATE AMIDOTRANSFERASE
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Structural factors affecting affinity of cytotoxic oxathiole-fused chalcones toward tubulin
PublikacjaSynthesis, in vitro cytotoxic activity, and interaction with tubulin of (E)-1-(6-alkoxybenzo[d][1,3]oxathiol- 5-yl)-3-phenylprop-2-en-1-one derivatives (2) are described. Some of the compounds demonstrated cytotoxic activity at submicromolar concentrations, and the activity could be related to interaction with tubulin at the colchicine binding site. Interaction of selected derivatives with tubulinwas evaluated using molecular modeling,...
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Zbadanie struktury i wybranych własności elementów wykonanych z ABS i ABS/PC oraz ustalenie przyczyn występowania wad powierzchniowych na tych elementach
PublikacjaPrzebadano próbki wykonane z ABS oraz PC/ABS. Zakres przeprowadzonych badań i analiz obejmował: (1) Spektroskopię w podczerwieni z transformacją Fouriera (FTIR), (2) Różnicową Kalorymetrię Skaningową (DSC), (3) Analizę Termograwimetryczną (TGA), (4) Masowy i Objętościowy Wskaźnik Szybkości Płynięcia (MFR i MVR), (5) Twardość metodą Shore’a D oraz (6) wizytę w zakładzie produkcyjnym i analizę procesów montażowych.
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Measurement of mass flow of viscous liquid through a Cylindrical Orifice under laminar flow (CylOr)
Dane BadawczeThe data was obtained as part of the project "Measurement of mass flow of viscous liquid through a Cylindrical Orifice under laminar flow (CylOr)", in which flow tests of hydraulic oil through a cylindrical orifice with a thickness of l = 25 mm and a throat b = 0.5 (diameter pipes D = 50 mm, orifice diameter d = 25 mm) on the test stand at the Department...
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Understanding the Electronic Structure and Optical Properties of Vacancy-Ordered Double Perovskite A2BX6 for Optoelectronic Applications
PublikacjaOver the past few years, metal halide perovskite solar cells have made significant advances. Currently, the single-junction perovskite solar cells reach a conversion efficiency of 25.7%. Perovskite solar cells with a wide band gap can also be used as top absorber layers in multi-junction tandem solar cells. We examined the dynamical and thermal stability, electronic structure, and optical features of In2PtX 6 (X = Cl, Br, and I)...
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Evidence of mutations conferring resistance to clarithromycin in wastewater and activated sludge
PublikacjaThe occurrence of clarithromycin in wastewater samples and of the activated sludge bacteria possibly resistant to this pharmaceutical was the object of the study. Samples of wastewater or activated sludge were taken from a municipal wastewater treatment plant in summer and winter and characterised regarding their clarithromycin concentrations and the presence of nucleic acid fragments (Cla-sequences) known to be responsible for...
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Synthesis, crystal structure, and high-resolution NMR spectroscopy of methyl 3-azido-2,3-dideoxy-4,6-di-O-p-tolylsulfonyl-α-D-xylo-hexopyranoside
PublikacjaOpisano syntezę 3-azydo-2,3-dideoksy-4,6-di-O-p-toluenosulfonylo- i 6-O-p-toluenosulfonylo-alfa-D-ksylo-heksopiranozydów. Dla obu związków i ich prekursorów wykonano wysokorozdzielczą spektroskopię 1H i 13C NMR. Strukturę tytułowego związku określono metodą rentgenowskiej analizy strukturalnej. W pracy dyskutuje się wpływ grup ochronnych przy atomach tlenu na przesunięcia chemiczne sąsiadujących atomów w węglowej i protonowej spektroskopii...
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Natural deep eutectic solvent based ultrasound assisted liquid-liquid micro-extraction method for methyl violet dye determination in contaminated river water
PublikacjaSimple and green natural deep eutectic solvent (NADES) based ultrasound assisted liquid-liquid micro-extraction (UA-LLME) method was developed for extraction and determination of methyl violet dye in contaminated river water samples using UV/Vis spectrophotometry. Choline chloride - decanoic acid based natural deep eutectic solvent was used for extraction. Important analytical parameters like pH, deep eutectic solvent volume/phase...
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2-D constitutive equations for orthotropic Cosserat type laminated shells in finite element analysis
PublikacjaWe propose 2-D Cosserat type orthotropic constitutive equations for laminated shells for the purpose of initial failure estimation in a laminate layer. We use nonlinear 6-parameter shell theory with asymmetric membrane strain measures and Cosserat kinematics as the framework. This theory is specially dedicated to the analysis of irregular shells, inter alia, with orthogonal intersections, since it takes into account the drilling...
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Electrical Interface Parameters of PEDOT: PSS: Effect of Electrodeposition Charge Evaluated Under Body Conditions for Neural Electrode Applications
PublikacjaThis study explores the influence of the deposition charge of poly(3,4-ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) on its electrical interface parameters. For this purpose, PEDOT:PSS was fabricated by electrodeposition on commercial platinum electrodes with the time limited by different charges (1, 3, 6, 9 mC). Further, the electrodes were characterized regarding their electrical interface such as interfacial...
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Characterization of two aminotransferases from Candida albicans
PublikacjaAminoadipate aminotransferase (AmAA) is an enzyme of α-aminoadipate pathway (AAP) for l-lysine biosynthesis. AmAA may also participated in biosynthesis or degradation of aromatic amino acids and in d-tryptophan based pigment production. The AAP is unique for fungal microorganisms. Enzymes involved in this pathway have specific structures and properties. These features can be used as potential molecular markers. Enzymes catalyzing...
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Numerical analysis of elastic wave propagation in unbounded structures
PublikacjaThe main objective of this paper is to show the effectiveness and usefulness of the concept of an absorbing layer with increasing damping (ALID) in numerical investigations of elastic wave propagation in unbounded engineering structures. This has been achieved by the authors by a careful investigation of three different types of structures characterised by gradually increasing geometrical and mathematical description complexities....
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Computational model for simulation of lifeboat motions during its launching from ship in rough seas
PublikacjaW artykule przedstawiono model obliczeniowy 3 D, opisujący ruch obiektu w 6 stopniach swobody (6DoF), do symulacji ruchu jedno- lub dwuzawiesiowej łodzi ratunkowej lub ratowniczej podczas opuszczania ze statku na wzburzonej wodzie. Jest to złożony model uwzględniający warunki morskie oraz elastyczność i własności tłumiące elementów i mechanizmów żurawika, liny oraz kadłuba łodzi. Ponadto przedstawiono przykładowe wyniki obliczeń...
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Rendezvous of Distance-Aware Mobile Agents in Unknown Graphs
PublikacjaWe study the problem of rendezvous of two mobile agents starting at distinct locations in an unknown graph. The agents have distinct labels and walk in synchronous steps. However the graph is unlabelled and the agents have no means of marking the nodes of the graph and cannot communicate with or see each other until they meet at a node. When the graph is very large we want the time to rendezvous to be independent of the graph size...
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Long-term performance and microbial characteristics of the anammox-enriched granular sludge cultivated in a bench-scale sequencing batch reactor
PublikacjaThe anammox-enriched granular sludge was successfully formed during the long-term biogranulation experiment lasting over 330 days. The cultivation was conducted at 30 ◦C in a 10-L sequencing batch reactor (SBR) fed with synthetic medium containing ammonia, nitrite and trace elements. The properties of the developed granules were investigated in terms of the biomass activity (including the growth rate of anammox bacteria), size...
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Cylindrical orifice testing in laminar flow with the orifice diameter ratio β = 0.5
PublikacjaThe paper presents the results of an experimental study of a cylindrical orifice with the orifice diameter ratio β = 0.5 and the flow opening length‑to‑diameter ratio L/d = 1, with hydraulic oil flowing in the DN50 measuring channel. The measurements of the values characterising the oil flow were made in the laminar flow regime, for the Reynolds numbers ranging between Re = 100 to 950. Based on the experimental tests, standard...
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Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid
PublikacjaBackground: Although Mycophenolic Acid (MPA) is applied as prodrugs in clinic as an immunosuppressant, it also possesses anticancer activity. MPA acts as Inosine-5’-Monophosphate Dehydrogenase (IMPDH) inhibitor, where the carboxylic group at the end of the side chain interacts with Ser 276 of the enzyme via hydrogen bonds. Therefore, MPA derivatives with other polar groups indicated high inhibition too. On the other hand, potent...
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Geometrically Nonlinear Analysis of Functionally Graded Shells Based on 2-D Cosserat Constitutive Model
PublikacjaIn this paper geometrically nonlinear analysis of functionally graded shells in 6-parameter shell theory is presented. It is assumed that the shell consists of two constituents: ceramic and metal. The mechanical properties are graded through the thickness and are described by power law distribution. Formulation based on 2-D Cosserat constitutive model is used to derive constitutive relation for functionally graded shells. Numerical...
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Birthweight and the risk of childhood-onset type 1 diabetes: a meta-analysis of observational studies using individual patient data
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Stark effect of atomic helium singlet lines
PublikacjaWe present experimental and theoretical investigations of the He spectral series 2S1−nQ1 (n=3÷9, Q=S,P,D,…,n−1) and 2P1−nQ1 (n=3÷9, Q=S,P,D,…,n−1) in electric fields up to 1635 kV/cm. Apart from the allowed transitions with |ΔL|=1, the transitions with |ΔL|=0,2,3,…-without field strictly forbidden-were observed. Several He patterns become similar to hydrogen patterns, which means they are nearly symmetric and show in higher fields...
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Degradation of xylose using a microbial fuel cell
PublikacjaIt is generally known, that many kind of microorganisms are capable of using carbohydrates as a source of carbon and energy in an environment. The biodegradation process of monosaccharides from pentoses (in this case- racemic mixture of D - and L – xylose) is an immense opportunity for an entire reduction of biological contamination to neutral compounds through MFC. The process is occurred in a single-chamber MFC, which is contained...
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A standardised static in vitro digestion method suitable for food – an international consensus
PublikacjaSimulated gastro-intestinal digestion is widely employed in many fields of food and nutritional sciences, as conducting human trials are often costly, resource intensive, and ethically disputable. As a consequence, in vitro alternatives that determine endpoints such as the bioaccessibility of nutrients and non-nutrients or the digestibility of macronutrients (e.g. lipids, proteins and carbohydrates) are used for screening and building...
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Glutathione conjugation of the antitumor-active 1-nitroacridine derivatives compounds C-857 and C-1748 – the major role of glutathione S-transferase M1-1
Dane BadawczeObjectives: C-857 and C-1748 are antitumor-active agents, monomers of unsymmetrical bisacridine derivatives. The aim of this study was to analyze their glutathione (GSH) conjugation in vitro in the presence of glutathione S-transferase (GST) M1-1.
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High temperature proton conduction in LaSbO4
PublikacjaLanthanum orthoantimonate was synthesized using a solid‐state synthesis method. To enhance the possible protonic conductivity, samples with the addition of 1 mol% Ca in La‐site, were also prepared. The structure was studied by the means of X‐ray diffraction, which showed that both specimens were single phase. The materials crystallized in the space group P2 1 /n. Dilatometry revealed that material expands non‐linearly with the...
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Phenotypic consequences of the LYS4 gene disruption in Candida albicans
PublikacjaThe main scientific purpose of our studies was to verify the hypothesis that homoaconitase (HA) from Candida albicans, an enzyme catalyzing a second step of the α-aminoadipate pathway (AAP) of L-Lys biosynthesis may become a new target for antifungal chemotherapy. Previous studies indicated that the A. fumigatus mutant lacking the functional lysF gene, encoding HA, exhibited attenuated virulence in a low-dose mouse infection model...
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Efficient production of Staphylococcus simulans lysostaphin in a benchtop bioreactor by recombinant Escherichia coli.
PublikacjaLysostaphin is an enzyme with bactericidal activity against Staphylococcus aureus and other staphylococcal species. In spite of many advantages and promising results of preliminary research, the enzyme is still not widely used in medicine, veterinary or as a food preservative. One of the most important factors limiting application of the enzyme in clinical or technological practice is the high costs of its production. In the present...
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l-ascorbic acid modified poly(ester urethane)s as a suitable candidates for soft tissue engineering applications
PublikacjaIn this paper we created novel poly(ester urethane)s (PESUs) designed specifically for tissue engineering. The PESUs were derived from oligomeric α,ω-dihydroxy(ethylene-butylene adipate) (dHEBA), 1,4-butanediol (BDO) and aliphatic 1,6-hexamethylene diisocyanate (HDI) and modified with l-ascorbic acid to improve their biocompatibility. In addition, we determined their mechanical properties (such as tensile strength, elongation at...
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Susceptibility to Degradation in Soil of Branched Polyesterurethane Blends with Polylactide and Starch
PublikacjaA very important method of reducing the amount of polymer waste in the environment is the introduction to the market of polymers susceptible to degradation under the influence of environmental factors. This paper presents the results of testing the susceptibility to degradation in soil of branched polyesterurethane (PUR) based on poly([R,S]-3-hydroxybutyrate) (R,S-PHB), modified with poly([D,L]-lactide) (PLA) and starch (St). Weight...
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Analysis of the structure of the atomized fuel spray with marine diesel engine injector in the early stage of injection
PublikacjaThis paper presents the results of the experimental research of the atomized fuel spray with the marine diesel engine injector in the constant volume chamber. The specificity of the phenomena occurring in the marine engine cylinder was the reason to use the optical visualisation method in the studies – the Mie scattering technique. This work presents an analysis of the influence of different geometry of outlet orifice and opening...
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Determination of tributyltin in marine sediment.
PublikacjaPrzedstawiono wyniki badań międzynarodowego porównawczego, międzylaboratoryjnego oznaczania zawartości tributylocyny w osadzie morskim. Badania były organizowane przez Comite Consultatif pour la Quantite de Matiere (CCQM) pilot study P-18 international intercomparison i była to ich pierwsza część - badania pilotażowe. W badaniach uczestniczyło 11 laboratoriów. Uzyskano zadowalająco zgodne wyniki oznaczeń tributylocyny.
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RAPORT - EKSPERTYZA Z POMIARÓW DRGAŃ LINII WAŁÓW NA JEDNOSTCE ORP „DĄBIE”
PublikacjaEkspertyza diagnostyczna dotycząca stanu technicznego dwóch linii transmisji mocy (linii wałów) opracowana na podstawie przeprowadzonych pomiarów drgań w 26 punktach pomiarowych, przy jednoczesnej pracy silników napędowych L i PB (wspólnej pracy linii wałów obu burt), w II zakresach ustalonego obciążenia „pół-naprzód” i „cała-naprzód”. Pomiary prędkości i przyspieszeń drgań generowanych przez węzły konstrukcyjne okrętowego układu...
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Chapter 13. Immunological determination of the pharmaceutical diclofenac in environmental and biological samples
PublikacjaOpracowano wysoce specyficzną i czułą metodę immunologiczną oznaczania przeciwzapalnego leku diklofenaku. Jest to jeden z najczęściej wykrywanych farmaceutyków w środowisku. Granicę wykrywalności oraz wartość IC50 określono na poziomie 6 ng/L oraz 60 ng/L dla wody wodociągowej, odpowiednio. W badaniu porównawczym, stosując test ELISA oraz GC-MS określono poziomy stężeń diklofenaku w wodach ściekowych z 21 oczyszczalni ścieków i...
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Analysis of efficiency of phosphates sorption by different granulation of selected reactive material
PublikacjaIn the light of the need to find an effective way to remove phosphorus from wastewater, studies on the suitability of sorption materials in this process should be conducted. The aim of the study was to examine the potential benefits of using selected adsorbents to reduce orthophosphates from the model solution under steady conditions. The study was conducted on a laboratory scale using synthetic wastewater with concentration of...
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Global 30-day outcomes after bariatric surgery during the COVID-19 pandemic (GENEVA): an international cohort study
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Modelling a 6-dof manipulator using Matlab software
PublikacjaThis paper presents an alternative approach to modelling a revolute robot. The manipulator in question is Kuka KR 16-2. The main problem in robot modelling is a kinematic analysis. The revolute robot consist of six rotary joints (6-DOF) with base, shoulder, elbow and wirst. The kinematics problem is defined as a transformation from the cartesian space to the joint space. The Denavit- Hartenberg (D-H) model of representation was...
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Common variants of DNA repair genes and malignant melanoma
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Wiktoria Wojnicz dr hab. inż.
OsobyDSc in Mechanics (in the field of Biomechanics) - Lodz Univeristy of Technology, 2019 PhD in Mechanics (in the field of Biomechanics) - Lodz Univeristy of Technology, 2009 (with distinction) Publikacje z listy MNiSW (2009 - ) Wojnicz W., Wittbrodt E., Analysis of muscles' behaviour. Part I. The computational model of muscle. Acta of Bioengineering and Biomechanics, Vol. 11, No.4, 2009, p. 15-21 Wojnicz W., Wittbrodt E.,...
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Existence of Two Periodic Solutions to General Anisotropic Euler-Lagrange Equations
PublikacjaAbstract. This paper is concerned with the following Euler-Lagrange system d/dtLv(t,u(t), ̇u(t)) =Lx(t,u(t), ̇u(t)) for a.e.t∈[−T,T], u(−T) =u(T), Lv(−T,u(−T), ̇u(−T)) =Lv(T,u(T), ̇u(T)), where Lagrangian is given by L=F(t,x,v) +V(t,x) +〈f(t),x〉, growth conditions aredetermined by an anisotropic G-function and some geometric conditions at infinity.We consider two cases: with and without forcing termf. Using a general version...
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Analysis of the macrostructure of the fuel spray atomized with marine engine injector
PublikacjaOne of the main problem influencing the combustion process in the cylinder of the marine engine is an fuel spray phenomena. The parameters describing the shape of the fuel spray are named macro parameters. This article presents the research results of the macrostructure parameters of the fuel spray atomized with the marine engine injector. The research were carried out by optical visualization measurement method of Mie scattering....
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Phenotypic consequences of LYS4 gene disruption in Candida albicans
PublikacjaA BLAST search of the Candida Genome Database with the Saccharomyces cerevisiae LYS4 sequence known to encode homoaconitase (HA) revealed ORFs 19.3846 and 19.11327. Both alleles of the LYS4 gene were sequentially disrupted in Candida albicans BWP17 cells using PCR-based methodology. The null lys4Δ mutant exhibited lysine auxotrophy in minimal medium but was able to grow in the presence of L-Lys and α-aminoadipate, an intermediate...
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40th EASD Annual Meeting of the European Association for the Study of Diabetes
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Salicylaldimine-based receptor as a material for iron(III) selective optical sensing
Publikacjaα,α-Bis(salicylimino)-m-xylene (L) was prepared using both conventional and microwave-assisted procedure. The compound exhibits ability to colorimetric recognition of iron(III) ions in aqueous environment, what is shown by significant color change from yellow to purple. In DMSO : water (9:1 v/v) solvent system receptor creates with iron(III) cations complexes of 2:1 stoichiometry (L:Fe3+) with stability constant (log K) 7.54±0.21....
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Influence of the particle size of carbonate-siliceous rock on the efficiency of phosphorous removal from domestic wastewater
PublikacjatThe aim of the study was to determine the influence of the particle size of carbonate–silica rock (opoka)used in rock filters on the efficiency of phosphorus removal from domestic wastewater. The investigationswere carried out in a laboratory using a model consisting of three vertical flow filters with carbonate–silicarock of different particle sizes (G1= 1–2 mm; G2= 2–5 mm; G3= 5–10 mm). The tested rock was subjectedto decarbonising...
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The electrochemical studies of thin boron-doped diamond films deposited at conductive poly(lactic acid) 3D prints
Dane BadawczeThe dataset contains the electrochemical characteristics of the electrodes composed of thin boron-doped diamond films coated on commercially available graphene-doped polylactide acid. The boron doping level expressed as the [B]/[C] ratio in the gas phase for these studies was 500 and 10,000 ppm.
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Incremental dynamic analysis and fragility assessment of buildings founded on different soil types experiencing structural pounding during earthquakes
PublikacjaThe effect of the soil type on buildings experiencing pounding during earthquakes is investigated in this study using the incremental dynamic analysis and fragility assessment methods. Three 3-D structures with different number of storeys (4, 6 and 8) were considered in this study. Three pounding scenarios between these three buildings were taken into account, i.e. pounding between 4-storey and 6-storey buildings, between 4-storey...
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Operation of a free-electron laser from the extreme ultraviolet to the water window
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Ryszard Staniszewski PhD, DSc
OsobyAbsolwent Technikum Energetycznego w Poznaniu (1988 r.) oraz Wydziału Melioracji i Inżynierii Środowiska AR Poznań (1994 r.). Przebieg pracy zawodowej: 2019; Katedra Ekologii i Ochrony Środowiska, UP w Poznaniu; profesor UPP 2015; Katedra Ekologii i Ochrony Środowiska, UP w Poznaniu; adiunkt z habilitacją 2002; Katedra Ekologii i Ochrony Środowiska, UP w Poznaniu; adiunkt 1996; Katedra Ekologii i Ochrony Środowiska Rolniczego,...
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The enantiomeric determination of chloro-precursors of methamphetamine
PublikacjaImpurity profiling and classification of seized methamphetamine may supply valuable information with respect to the conditions and the chemicals used in the illicit methamphetamine manufacture and may provide information on the original source of the sample. Determination of the stereochemical makeup of forensic samples is important as well for the same reasons. Laboratories in many places are engaged in clandestine manufacture...
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Wyznaczanie współczynnika dyspersji metodą kondultometryczną
PublikacjaW artykule przedstawiono konduktometryczną metodę wyznaczania współczynnika dyspersji w przypadku jednowymiarowym statystyczną metodą Fischera. Obliczenia wykonano na podstawie pomiarów przewodności nierozkładalnego trasera w postaci roztworu solanki (NaCl). Do tego celu wykonane zostało stanowisko pomiarowe złożone z prostego odcinka rurociągu wykonanego z polipropylenu o średnicy D=15 mm i długości L=44,05 m. Na wlocie i wylocie...
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New coordination polymers based on a V-shaped ligand and lanthanides: Structural description and symmetry-luminescence correlation using europium as a probe
PublikacjaWe have synthesized new luminescent coordination polymers using 4,4'-sulfonyldibenzoic acid (H2SDA) and several lanthanide ions by open crystallization in DMF. Three different 1-D structures were obtained, as determined by single-crystal X-ray diffraction: [La(η2-NO3)(μ-SDA)(DMF)3]n (1), [Sm(η2-NO3)(μ-SDA)(DMF)2 2DMF]n (3), [Ln(η2-NO3)(μ-SDA)(DMF)2 DMF]n (Ln ¼ Eu (4), Dy (5), Ho (6), Er (7), Tm (8) and Lu(9)). A 2-D structure,...
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Advanced Scalar-valued Intensity Measures for Residual Drift Prediction of SMRFs with Fluid Viscous Dampers
PublikacjaMaximum Residual Inter-story Drift Ratio (RIDRmax) plays an important role to specify the state of a structure after severe earthquake and the possibility of repairing the structure. Therefore, it is necessary to predict the RIDRmax of Steel Moment-Resisting Frames (SMRFs) with high reliability by employing powerful Intensity Measures (IMs). This study investigates the efficiency and sufficiency of scalar-valued IMs for predicting...