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wyświetlamy 1000 najlepszych wyników Pomoc
Wyniki wyszukiwania dla: AGF-DERIVED PEPTIDES
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Immunosuppressive properties of amino acid and peptide derivatives of mycophenolic acid
PublikacjaMycophenolic acid (MPA) was coupled with amino acids and biologically active peptides including derivatives of tuftsin to modify its immunosuppressive properties. Both amino acid unit in the case of simple MPA amides and modifications within peptide moiety of MPA - tuftsin conjugates influenced the observed activity. Antiproliferative potential of the obtained conjugates was investigated in vitro and MPA amides with threonine methyl...
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Obrony prac doktorskich na Wydziale Chemicznym
WydarzeniaDn. 12.10.2022 r. o godz. 13.00 w Audytorium 1.4 Wydziału Chemicznego PG (budynek nr 5) odbędzie się w trybie hybrydowym publiczna obrona pracy doktorskiej mgr inż. Patrycji Jakubek.
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Monthly mean concentration of chlorophyll a on the sea surface of the Baltic Sea
Dane BadawczeMonthly mean surface concentration of chlorophyll a in the years 2003-2022 calculated on the basis of data from the SatBaltic System (https://satbaltyk.iopan.gda.pl/). Maps of monthly average values with a resolution of 1 km were derived from daily satellite data from the Moderate Resolution Imaging Spectroradiometer (MODIS). Gaps in satellite images...
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FDTD Method for Electromagnetic Simulations in Media Described by Time-Fractional Constitutive Relations
PublikacjaIn this paper, the finite-difference time-domain (FDTD) method is derived for electromagnetic simulations in media described by the time-fractional (TF) constitutive relations. TF Maxwell’s equations are derived based on these constitutive relations and the Grünwald–Letnikov definition of a fractional derivative. Then the FDTD algorithm, which includes memory effects and energy dissipation of the considered media, is introduced....
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Nowe monomery pochodzenia roślinnego w syntezie termoplastycznych elastomerów poliuretanowych
PublikacjaJak dotychczas w syntezie termoplastycznych elastomerów poliuretanowych (TPU) są powszechnie wykorzystywane surowce pochodzenia petrochemicznego. Sytuacja jednak zmienia się dynamicznie i w wielu gospodarkach świata widoczne są już trendy, polegające na coraz większym wykorzystaniu substancji pochodzenia roślinnego w produkcji surowców, np. glikoli, izocyjanianów czy polioli, jako zamienników analogów syntetycznych. Praca obejmuje...
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Scanning Electrone Microscope images of biochar produced from straw and wood chips
Dane BadawczeThis dataset contains scanning electron microscope images of two types of biochars derived from waste plant biomass: straw and wood chips. Imaging was performed using a scanning electron microscope, FEI Quanta FEG250. with a SE-ETD detector (secondary electron – Everhart-Thornley detector), using 20 kV accelerating voltage.
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Beneficial effects and potential risks of tomato consumption for human health: An overview
PublikacjaTomato and its derived products have a very interesting nutritional value in addition to prominent antioxidant,anti-inflammatory, and anticancer activities. In terms of tomatoes are generally quite safe to eat. However,overall consumption varies from individual to individual. Indeed, either beneficial or harmful effects of plantsor their derived products are closely related to quality, including the presence of biologically active...
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On dynamics of origami-inspired rod
PublikacjaWe discuss the dynamics of a relatively simple origami-inspired structure considering discrete and continuum models. The latter was derived as a certain limit of the discrete model. Here we analyze small in-plane deformations and related equations of infinitesimal motions. For both models, dispersion relations were derived and compared. The comparison of the dispersion relations showed that the continuum model can capture the behavior...
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Carbon Nanomaterials From Metal-Organic Frameworks: A New Material Horizon for CO2 Reduction
PublikacjaThe rise of CO2 in the atmosphere, which results in severe climate change and temperature increase, is known as the major reason for greenhouse effect. Reducing CO2 to value-added products is an attractive solution to this severe problem, along with addressing the energy crisis, to which the catalysts being employed are of vital importance. Due to their high porosity and tunable compositions, Metal-Organic Frameworks (MOFs) show...
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Recent Developments in Data-Assisted Modeling of Flexible Proteins
PublikacjaMany proteins can fold into well-defined conformations. However, intrinsically-disordered proteins (IDPs) do not possess a defined structure. Moreover, folded multi-domain proteins often digress into alternative conformations. Collectively, the conformational dynamics enables these proteins to fulfill specific functions. Thus, most experimental observables are averaged over the conformations that constitute an ensemble. In this...
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Synthetic strategies in construction of organic low molecular-weight carrier-drug conjugates
PublikacjaInefficient transportation of polar metabolic inhibitors through cell membranes of eukaryotic and prokaryotic cells precludes their direct use as drug candidates in chemotherapy. One of the possible solutions to this problem is application of the ‘Trojan horse’ strategy, i.e. conjugation of an active substance with a molecular carrier of organic or inorganic nature, facilitating membrane penetration. In this work, the synthetic...
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The Use of Sustainability Reporting Instruments in the Global Airline Industry in Financial Year 2019
Dane BadawczeThis dataset provides an overview of the GRI topic-specific disclosures global passenger airline companies reported in their 2019 financial year sustainability reports and the specific SDGs they addressed. Additionally, it includes information on the frequency of application of other well-known SR instruments (i.e., SASB, IIRC, CDSB, CDP, UNGC, ISO...
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Problem of proper decomposition and initialization of acoustic and entropy modes in a gas affected by the mass force
PublikacjaThe relations connecting perturbations specific for acoustic and entropy modes in an accelerated fluid or in a fluid affected by constant mass force, are derived. They allow to decompose the total vector of perturbations and the overall energy into acoustic and non-acoustic parts uniquely at any instant. In order to do this, three quantities are required, for example total perturbations in entropy, pressure and velocity. The evaluations...
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Comparative analysis of balancing of V6 engines with common- and split-pin crankshafts
PublikacjaAn analysis of balancing of V6 engines equipped with split-pin crankshafts with any cylinder bank angle based on the mathematical relations derived in the paper was carried out. A comparison of the quality of their balancing with engines equipped with common-pin crankshafts was also carried out. The bank angle ranges beneficial for balancing of moments of inertia forces in reciprocating motion were determined. A mathematical relation...
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The Influence of Substitution of a Phosphorus-Containing Polyol with the Bio-polyol on the Properties of Bio-based PUR/PIR Foams
PublikacjaIn this work, effects of incorporating of a phosphorus-containing polyol into rigid polyurethane/polyisocyanurate foams’ formulations developed with use of two different bio-based polyols, derived from crude glycerol or liquefied cellulose were examined. The bio-polyol derived from crude glycerol was synthesized via two-step process from crude glycerol and castor oil, whereas the bio-polyol derived from liquefied cellulose was...
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Derivatization of single-walled carbon nanotubes with redox mediator biocatalytic oxygen electrodes
PublikacjaSingle-walled carbon nanotubes were covalently modyfied with a redox mediator derived from 2,2'-azino-bis-(3-ethylbenzothiazole)-6-sulfonic acid.
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Solubilization of keratins and functional properties of their isolates and hydrolysates
PublikacjaThe keratinous wastes of the textile industry and poultry slaughterhouses may be used as sources of soluble keratins or hydrolysates. This review presents methods for processing raw keratin-based materials into bioproducts with functional and bioactive properties suitable for biomedical, cosmetic, food, and agricultural applications. Soluble keratin can be obtained by thermal treatment in some organic solvents, reduction, or oxidation...
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Peptide dendrimers as antifungal agents and carriers for potential antifungal agent—N3‐(4‐methoxyfumaroyl)‐(S)‐2,3‐ diaminopropanoic acid—synthesis and antimicrobial activity
PublikacjaA series of peptide dendrimers and their conjugates with antimicrobial agent FMDP (N3‐(4‐methoxyfumaroyl)‐(S)‐2,3‐diamino‐propanoic acid) were synthesized. The obtained compounds were tested for the antibacterial and antifungal activity. All novel dendrimers displayed much better activity against the tested strains than FMDP itself. Moreover, their conjugates with FMDP also exhibited antimicrobial activity. The most promising molecules...
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Production of trehalose in a single step enzymatic reaction
PublikacjaThe aim of this study was isolation and cloning of trehalose synthase gene derived from extremophilic microorganisms Deinoccoci to the expressive E. coli vectors and its biosythesis in different hosts.
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Mirosław Andrusiewicz prof. dr hab. n. med. i n. o zdr.
OsobyPosiadane dyplomy, stopnie naukowe lub artystyczne ̶ stopień doktora habilitowanego nauk medycznych (dyscyplina biologia medyczna) z dnia 4 grudnia 2017 r. Tytuł osiągnięcia naukowego: „Analiza wybranych genów związanych z przebiegiem zmian patologicznych w komórkach wywodzących się z żeńskich wewnętrznych narządów płciowych”; Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski II; recenzenci: Prof....
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Stability of softly switched multiregional dynamic output controllers with a static antiwindup filter: A discrete-time case
PublikacjaThis paper addresses the problem of model-based global stability analysis of discrete-time Takagi–Sugeno multiregional dynamic output controllers with static antiwindup filters. The presented analyses are reduced to the problem of a feasibility study of the Linear Matrix Inequalities (LMIs), derived based on Lyapunov stability theory. Two sets of LMIs are considered candidate derived from the classical common quadratic Lyapunov...
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SWM for porous hierarchical nanocarbons composites
Dane BadawczeRaw Raman spectra and XRD diffractograms (background subtracted) of 13 among which carbon-derived secondary waste and reference materials.
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Torsion of restrained thin-walled bars of open constant bisymmetric cross-section
PublikacjaElastic and geometric stiffness matrices were derived using Castigliano's first theorem, for the case of torsion of restrained thin-walled bars of open constant bisymmetric cross-section. Functions which describe the angles of torsion were adopted from the solutions of thedifferential equation for restrained torsion. The exact solutions were simplified by expanding them in a power series. Numerical examples were taken from Kujawa...
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Antimicrobial molecular nanocarrier–drug conjugates
PublikacjaMany antimicrobial drugs are poorly active against pathogenic microbes causing intracellular infections, such as Mycobacterium tuberculosis or Plasmodium falciparum. On the other hand, several known antimicrobial agents are not effective enough because of their limited cellular penetration. A common feature of both challenges is the inability of an active agent to cross the biological membrane(s). One of the possible approaches...
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Synthesis of amides under microwave irradiation
PublikacjaAmides belong to the most important carboxylic acid derivatives. They are constituents of natural compounds like peptides and proteins. They found applications in many branches of science and industry, especially in pharmaceutical and polymer science. Conventional procedures for amide preparation involve reaction between amine and carboxylic acid or their more active derivatives such as acid chlorides, acid anhydrides or esters....
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Amino Acid and Peptide‐Based Antiviral Agents
PublikacjaA significant number of antiviral agents used in clinical practice are amino acids, short peptides, or peptidomimetics. Among them, several HIV protease inhibitors (e. g. lopinavir, atazanavir), HCV protease inhibitors (e. g. grazoprevir, glecaprevir), and HCV NS5A protein inhibitors have contributed to a significant decrease in mortality from AIDS and hepatitis. However, there is an ongoing need for the discovery of new antiviral...
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Structural changes of a simple peptide—Trpzip-1—in aqueous solutions and the corresponding hydration phenomena under the influence of temperature
PublikacjaTrpzip-1, a simple β-hairpin, is a rare example of peptide with stable secondary structure and can be a convenient model to study temperature-related processes that potential prion or amyloid proteins undergo. Although its sequence is simple, the exact processes which the peptide undergoes in aqueous solutions are quite complex and not well understood. The selection of well-established experimental (DSC, FTIR) and theoretical methods...
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Specific Binding of Cholesterol to the Amyloid Precursor Protein: Structure of the Complex and Driving Forces Characterized in Molecular Detail
PublikacjaC99 is the C-terminal membrane-bound fragment of the amyloid precursor protein that is cleaved by γ-secretase to release Aβ peptides, the hallmark of Alzheimer’s disease (AD). Specific interactions of C99 with cholesterol have been proposed to underlie the recognized role of cholesterol in promoting amyloidogenesis. By using molecular dynamics simulations, we studied cholesterol binding to C99 in a lipid bilayer. We determined...
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Buckling of thin-walled columns accounting for initial geometrical imperfections
PublikacjaThe paper is devoted to the effect of some geometrical imperfections on the critical buckling load of axially compressed thin-walled I-columns. The analytical formulas for the critical torsional and flexural buckling loads accounting for the initial curvature of the column axis or the twist angle respectively are derived. The classical assumptions of theory of thin-walled beams with non-deformable cross-sections are adopted. The...
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Aluminium in glacial meltwater demonstrates an association with nutrient export (Werenskiöldbreen, Svalbard)
PublikacjaThe aluminium (Al) cycle in glacierised basins has not received a great deal of attention in studies of biogeochemical cycles. As Almay be toxic for biota, it is important to investigate the processes leading to its release into the environment. It has not yet been ascertained whether filterable Al (passing through a pore size of 0.45 m) is incorporated into biogeochemical cycles in glacierised basins. Our study aims to determine...
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A solution of non-linear differential problem with application to selected geotechnical problems
PublikacjaA certain non-linear differential equation containing a power of unknown function being the solution is considered with application to selected geotechnical problems. The equation can be derived to a linear differential equation by a proper substitution and properties of the operations G and S.
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Relatively high-Seebeck thermoelectric cells containing ionic liquids supplemented by cobalt redox couple
PublikacjaMeanwhile no general and reliable equation determining the Seebeck coefficient (S e ) and involving electro-chemical reaction effects was derived for solutions. We reported the database of 15,000 ionic liquids supplemented by three different redox couple systems: 0.01 mol/l Co 3+/2+ (bpy) 3 , 0.01 mol/l I 3-/3I- and 0.2 mol/l 3- /3I- , and the corresponding estimated Seebeck coefficients. We also reported methods for estimating...
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Renewable natural resources as green alternative substrates to obtain bio-based non-isocyanate polyurethanes-review
PublikacjaCommercially available polyurethanes are synthesized by the polyaddition of diisocyanates with polyols and low molecular weight chain extenders. A new approach to polyurethanes synthesis is realized via non-isocyanate routes. Negative impacts of petroleum-based chemicals on the environment and human health as well as gradual reduction of fuel-based resources, which leads to an increase in their prices, are an incentive to looking...
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Analytical Expression for the Time-Domain Green's Function of a Discrete Plane Wave Propagating in the 3-D FDTD Grid
PublikacjaIn this paper, a closed-form expression for the time-domain dyadic Green’s function of a discrete plane wave (DPW) propagating in a 3-D finite-difference time-domain (FDTD) grid is derived. In order to verify our findings, the time-domain implementation of the DPW-injection technique is developed with the use of the derived expression for 3-D total-field/scattered-field (TFSF) FDTD simulations. This implementation requires computations...
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A DISCRETE-CONTINUOUS METHOD OF MECHANICAL SYSTEM MODELLING
PublikacjaThe paper describes a discrete-continuous method of dynamic system modelling. The presented approach is hybrid in its nature, as it combines the advantages of spatial discretization methods with those of continuous system modelling methods. In the proposed method, a three-dimensional system is discretised in two directions only, with the third direction remaining continuous. The thus obtained discrete-continuous model is described...
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Anharmonic Infrared Spectroscopy through the Fourier Transform of Time Correlation Function Formalism in ONETEP
PublikacjaDensity functional theory molecular dynamics (DFT-MD) provides an efficient framework for accurately computing several types of spectra. The major benefit of DFTMD approaches lies in the ability to naturally take into account the effects of temperature and anharmonicity, without having to introduce any ad hoc or a posteriori corrections. Consequently, computational spectroscopy based on DFT-MD approaches plays a pivotal role in...
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Relative quantification of pork and beef in meat products using global and species-specific peptide markers for the authentication of meat composition
PublikacjaWe used global and species-specific peptide markers for a relative quantitative determination of pork and beef in raw and processed meat products made of the two meat species. Four groups of products were prepared (i.e., minced raw meats, sausages, raw and fried burgers) in order to represent products with different extents of food processing. In each group, the products varied in the pork/beef proportions. All products were analysed...
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Silica In Silico: A Molecular Dynamics Characterization of the Early Stages of Protein Embedding for Atom Probe Tomography
PublikacjaA novel procedure for the application of atom probe tomography (APT) to the structural analysis of biological systems, has been recently proposed, whereby the specimen is embedded by a silica matrix and ablated by a pulsed laser source. Such a technique, requires that the silica primer be properly inert and bio-compatible, keeping the native structural features of the system at hand, while condensing into an amorphous, glass-like...
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DMSO and TMAO—Differences in Interactions in Aqueous Solutions of the K-Peptide
PublikacjaInteractions between a solvent and their co-solute molecules in solutions of peptides are crucial for their stability and structure. The K-peptide is a synthetic fragment of a larger hen egg white lysozyme protein that is believed to be able to aggregate into amyloid structures. In this study, a complex experimental and theoretical approach is applied to study systems comprising the peptide, water, and two co-solutes: trimethylamide...
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Transformation of polyvinyl chloride (PVC) into a versatile and efficient adsorbent of Cu(II) cations and Cr(VI) anions through hydrothermal treatment and sulfonation
PublikacjaThe reuse of waste polyvinyl chloride (PVC) has drawn much attention as it can reduce plastic waste and associated pollution, and provide valuable raw materials and products. In this study, sulfonated PVC-derived hydrochar (HS-PVC) was synthesized by two-stage hydrothermal treatment (HT) and sulfonation, and shown to be a versatile adsorbent. The reoval of Cu(II) cations and Cr(VI) anions using HS-PVC reached 81.2 ± 1.6% and 60.3...
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Paweł Szymon Dąbrowski dr inż.
OsobyDr inż. Paweł Szymon Dąbrowski w latach 2004-2009 studiował na kierunku geodezja i kartografia na Uniwersytecie Warmińsko-Mazurskim w Olsztynie, gdzie uzyskał tytuł zawodowy magistra inżyniera. W latach 2009-2016 pracował w wykonawstwie geodezyjnym w Iławie i Gdańsku. Doświadczenie zawodowe zdobył on podczas realizacji inwestycji Pomorskiej Kolei Metropolitalnej, co pomogło mu w zdobyciu w 2015 r. geodezyjnych uprawnień zawodowych...
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On unique kinematics for the branching shells
PublikacjaWe construct the unique two-dimensional (2D) kinematics which is work-conjugate to the exact, resultant local equilibrium conditions of the non-linear theory of branching shells. Several types of junctions are described. For each type the explicit form of the principle of virtual work is derived.
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Analiza nieliniowa powłok z materiałów gradientowych w ośrodku mikropolarnym
PublikacjaW pracy zaprezentowano analizę powłok z materiałów gradientowych dla zakresu dużych przemieszczeń. Macierz konstytutywna została wyprowadzona dla elementu powłokowego o 6 stopniach swobody w węźle w teorii ośrodka mikropolarnego. Zaprezentowano wyniki numeryczne dla swobodnie podpartej kwadratowej płyty FGM i porównano je z wynikami z literatury oraz uzyskanymi w programie Abaqus.
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Orthogonality relations for the associated Legendre functions of imaginary order
PublikacjaOrthogonality relations for the associated Legendre functions of imaginary order are derived. They are expressed in terms of the Dirac delta function. The method is based on some known properties of the associated Legendre functions and the Dirac delta distribution. A special case of one of the relations has appeared in some recent applications.
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Supporting compliance with safety standards by trust case templates
PublikacjaStandard Compliance (SC) Framework presented in this paper encompasses methods and tools which provide support for application of standards. The framework is based on trust case methodology. A trust case is a data structure which represents a justification that an object (a system, an infrastructure, an organization) exhibits certain properties. It contains an argument and related evidence which support claimed properties. A trust...
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Lab-in-syringe as a practical technique for automatic microextraction: Evaluation by Blue Applicability Grade Index
PublikacjaLab-in-syringe (LIS) is a powerful automatic technique that is derived from sequential injection analysis. In LIS, a computer-controlled syringe pump is employed, and its syringe barrel serves as a mixing, reaction, and/or extraction chamber. Until now, the LIS concept has been efficiently employed for the automation of solid-phase microextraction and liquid-phase microextraction protocols as a front-end to a plethora of chromatographic...
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Assessment of Therapeutic Progress After Acquired Brain Injury Employing Electroencephalography and Autoencoder Neural Networks
PublikacjaA method developed for parametrization of EEG signals gathered from participants with acquired brain injuries is shown. Signals were recorded during therapeutic session consisting of a series of computer assisted exercises. Data acquisition was performed in a neurorehabilitation center located in Poland. The presented method may be used for comparing the performance of subjects with acquired brain injuries (ABI) who are involved...
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Phage-Directed Synthesis of Photoluminescent Zinc Oxide Nanoparticles under Benign Conditions
PublikacjaBiological systems, especially bacteriophages and peptides, are an attractive green alternative to other known methods of nanoparticle synthesis. In this work, for the first time, bacteriophages were employed to synthesize a specific peptide, capable of producing nanoparticles (NPs). Derivatives of M13 bacteriophage exposing a ZnO-binding peptide (TMGA-LGLKWPV) on either pIII or pVIII phage coat protein were constructed and used...
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Cytocompatibility of stabilized black phosphorus nanosheets tailored by directly conjugated polymeric micelles for human breast cancer therapy
PublikacjaThe novel procedure of few-layer black phosphorus (FLBP) stabilization and functionalisation was here proposed. The cationic polymer PLL and non-ionic PEG have been involved into encapsulation of FLBP to allow sufficient time for further nanofabrication process and overcome environmental degradation. Two different spacer chemistry was designed to bind polymers to tumor-homing peptides. The efficiency of functionalisation was examined...
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The POCOBIO Database for Computed Scattering Cross-Sections for Positron Collisions with Biomolecular Systems
PublikacjaThe design of a database for positron interactions with biomolecular systems is outlined. The database contains only scattering cross sections, which are derived from theory. The data model is defined in a very flexible way, which facilitates the usage of weakly bound clusters of molecules and molecular systems with many tautomeric forms.