Filtry
wszystkich: 4842
wybranych: 1885
-
Katalog
- Publikacje 1885 wyników po odfiltrowaniu
- Czasopisma 129 wyników po odfiltrowaniu
- Konferencje 1 wyników po odfiltrowaniu
- Wydawnictwa 2 wyników po odfiltrowaniu
- Osoby 74 wyników po odfiltrowaniu
- Wynalazki 38 wyników po odfiltrowaniu
- Projekty 5 wyników po odfiltrowaniu
- Laboratoria 1 wyników po odfiltrowaniu
- Aparatura Badawcza 1 wyników po odfiltrowaniu
- Kursy Online 192 wyników po odfiltrowaniu
- Wydarzenia 16 wyników po odfiltrowaniu
- Dane Badawcze 2498 wyników po odfiltrowaniu
Filtry wybranego katalogu
wyświetlamy 1000 najlepszych wyników Pomoc
Wyniki wyszukiwania dla: AMFOTERYCYNA B
-
The Effect of Sterols on Amphotericin B Self-Aggregation in a Lipid Bilayer as Revealed by Free Energy Simulations
PublikacjaAmphotericin B (AmB) is an effective but toxic antifungal drug, known to increase the permeability of the cell membrane, presumably by assembling into transmembrane pores in a sterol-dependent manner. The aggregation of AmB molecules in a phospholipid bilayer is, thus, crucial for the drug’s activity. To provide an insight into the molecular nature of this process, here, we report an atomistic molecular dynamics simulation study...
-
Synthesis of 3-Carbamoyl b-Lactams via Manganese(III)-Promoted Cyclization of N-Alkenylmalonamides
PublikacjaManganese(III)-promoted cyclization of N-alkenylmalonamides (¼N-alkenylpropanediamides) gave 3-(aryl/(alkylamino)carbonyl) b-lactams as well as 3-(aryl/(alkylamino)thiocarbonyl) b-lactams. The relative configuration of the obtained products was unambiguously determined by X-ray crystallography. The proposed method is very useful for the one-pot synthesis of a number of 3-(aryl/ (alkylamino)carbonyl) b-lactams, especially those...
-
Central nervous system prophylaxis with intrathecal liposomal cytarabine in diffuse large B‑cell lymphomas
Publikacja -
Testbed analysis of video and VoIP transsmission performance in IEEE 802.11 b/g/n networks
PublikacjaThe aim of the work is to analyze capabilities and limitations of different implementations of IEEE 802.11 technologies (IEEE 802.11 b/g/n), utilized for both video streaming and VoIP calls directed to mobile devices. Our preliminary research showed that results obtained with currently popular simulation tools can be drastically different than these possible in real-world environment, so, in order to correctly evaluate performance...
-
Krytyczny stosunek ciśnień b w rozumieniu norm ISO 6358 i ISO 6953
PublikacjaJednym z parametrów służących do opisu właściwości przepływowych elementu pneumatycznego jest krytyczny stosunek ciśnień b, zdefiniowany i wykorzystywany w ISO 6358 oraz ISO 6953. Jednak w myśl metod jego wyznaczania opisanych w ISO 6358 i ISO/DIS 6358 definicja ta wydaje się być inna. W pracy omówiono warunki jakie musi spełniać element pneumatyczny, aby wartość b wyznaczona tymi metodami była zbliżona do wartości definicyjnej....
-
Charge-based deep level transient spectroscopy of B-doped and undoped polycrystalline diamond films
PublikacjaThe undoped and B-doped polycrystalline diamond thin film was synthesized by hot filament chemical vapor deposition and microwave plasma, respectively. The structural characterization was performed by scanning electron microscopy, X-ray diffraction and Raman spectroscopy. The electrical properties of synthesized diamond layer were characterized by dc-conductivity method and charge deep level transient spectroscopy. The B-doped...
-
Performance Analysis of Multicast Video Streaming in IEEE 802.11 b/g/n Testbed Environment
PublikacjaThe aim of the work is to analyse capabilities and limitations of different IEEE 802.11 technologies (IEEE 802.11 b/g/n), utilized for both multicast and unicast video streaming transmissions directed to mobile devices. Our preliminary research showed that results obtained with currently popular simulation tools can be drastically different than these possible in real-world environment, so, in order to correctly evaluate performance...
-
Numerical simulation of the influence of the selected factors on the performance of a concrete road barrier H2/W5/B
PublikacjaThis paper discuss the influence of selected factors on the performance of a concrete road barrier H2/W5/B. Modelling techniques of a concrete road safety system were briefly discussed. Comparison to the full scale crash test results has been shown. The concrete road safety barrier has been investigated for evaluation of the overall damage after collision under various initial conditions. The failure assessment criterion has been...
-
Internacjonalizacja działalności badawczo-rozwojowej (B+R) przedsiębiorstw high-tech. Wyniki badań empirycznych
PublikacjaGłownym celem artykułu jest przedstawienie roli badań i rozwoaju (B+R) w procesie internacjonalizacji przedsiębiorstw high-tech. Artykuł obejmuje przegląd literatury oraz wyniki badań 263 przedsiębiorstw high-tech przeprowadzonych na terytorium Polski. Artykuł powstał w ramach projektu badawczego OPUS 6 pt. Wzorce internacjonalizacji małych i średnich przedsiębiorstw działających w branżach high-tech finansowanego przez Narodowe...
-
Investigation of interaction between xanthene dye rhodamine B and metagenomic-derivated methylthioadenosine phosphorylase RSFP
PublikacjaIn the previous study we found that the expression of the metagenomic - derived methylthioadenosine phosphorylase gene (rsfp) in E. coli cells and the presence of rhodamine B in the growth medium were crucial for the pink fluorescence of one E. coli colony from Antarctic soil metagenomic library (Cieśliński et al., 2009). In this study, rsfp gene expression was induced by an arabinose promoter in an LMG194 E. coli strain and the...
-
Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?
PublikacjaThe structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was revealed as a flexible and structurally polymorphic molecule. Conformational changes that lead to local and global changes in the helix geometry are mediated by a complex choreography of base and backbone rearrangements affecting the ability of the B-DNA...
-
Photocatalytic decolourization of Rhodamine-B dye by visible light active ZIF-8/BiFeO3 composite
PublikacjaIn this work, preparation of ZIF-8 supported BiFeO3 photocatalyst by ultrasound cavitation technique was reported. The synthesized materials were characterized using solid UV absorption spectroscopy, Raman Spectroscopy, and SEM. The catalytic function of synthesized photocatalyst under ultraviolet and visible light was examined for the decolourization of Rhodamine-B (Rh-B) dye. To understand the action of the photocatalyst on Rh-B...
-
MEMORY EFFECT ANALYSIS USING PIECEWISE CUBIC B-SPLINE OF TIME FRACTIONAL DIFFUSION EQUATION
PublikacjaThe purpose of this work is to study the memory effect analysis of Caputo–Fabrizio time fractional diffusion equation by means of cubic B-spline functions. The Caputo–Fabrizio interpretation of fractional derivative involves a non-singular kernel that permits to describe some class of material heterogeneities and the effect of memory more effectively. The proposed numerical technique relies on finite difference approach and cubic...
-
Antibiotic-sterol interactions provide insight into the selectivity of natural aromatic analogues of amphotericin B and their photoisomers
PublikacjaAromatic heptaene macrolides (AHMs) belong to the group of polyene macrolide antifungal antibiotics. Members of this group were the first to be used in the treatment of systemic fungal infections. Amphotericin B (AmB), a non-aromatic representative of heptaene macrolides, is of significant clinical importance in the treatment of internal mycoses. It includes the all-trans heptaene chromophore, whereas the native AHMs contain two...
-
Self-assembly, stability and conductance of amphotericin B channels: bridging the gap between structure and function
PublikacjaAmphotericin B (AmB), one of the most powerful but also toxic drugs used to treat systemic mycoses, is believed to selectively permeabilize fungal cell membranes to ions in a sterol-dependent manner. Unfortunately, the structure of the biologically active AmB channels has long eluded researchers, obstructing the design of safer alternatives. Here, we investigate the structural and thermodynamic aspects of channel formation, stability,...
-
The extracellular loop of Man-PTS subunit IID is responsible for the sensitivity of Lactococcus garvieae to garvicins A, B and C
Publikacja -
Parameter of nonlinearity B/A of three-component systems with separate volumes of liquid, its vapor and a neutral gas
PublikacjaOtrzymane zostało wyrażenie dla zaburzenia entropii substancji o trzech komponentach jako funkcja zaburzeń jej ciśnienia i gęstości. Na podstawie wzoru prędkość i parametru nieliniowosci fali akustycznej zostały wyliczone jako funkcje i ciśnienia i koncentracji pary i powietrza. Rezultaty są przedstawione w postaci wykresów.
-
Analiza redystrybucji środków finansowych przeznaczonych na działalność B+R (na przykładzie wybranej uczelni)
PublikacjaAutor zwraca uwagę na wyjątkowo niskie finansowanie działalności B+R w Polsce na tle innych krajów nowo przyjętych do UE. Przeprowadza analizę redystrybucji tych skromnych środków w skali Polski oraz na przykładzie konkretnej uczelni. Dostrzega dwa charakterystyczne zjawiska, określona jako asymetrie. Pierwsze-dotyczące podziału tych środków między szkoły wyższe, jednostki badawczo-rozwojowe i placówki PAN. Drugie - dotyczące struktury...
-
Nowa metoda wymiarowania żelbetowych słupów uzwojonych w ujęciu nowelizowanej normy PN-B-03264.
PublikacjaW artykule przedstawiono nową metodę wymiarowania słupów uzwojonych w ujęciu nowelizowanej normy PN-B-03264. Podano przyczyny wprowadzenia opisywanych w artykule zmian i przedstawiono wcześniejsze próby modyfikacji sposobu obliczania nośności słupów uzwojonych w ujęciu normowym. Przeprowadzono dyskusję wyników obliczeń uzyskiwanych za pomocą nowej metody na tle wyników uzyskiwanych za pomocą dotychczasowej metody normowej, oraz...
-
Hepatitis D, B and C virus (HDV/HBV/HCV) coinfection as a diagnostic problem and therapeutic challenge
Publikacja -
Liver Cirrhosis in Chronic Hepatitis B Patients Is Associated with Genetic Variations in DNA Repair Pathway Genes
Publikacja -
Zastosowanie algorytmów genetycznych do projektowania ram stalowych zgodnie z PN-90/B-03200.
PublikacjaW artykule przedstawiono optymalizacje ramy przy wykorzystaniu w obliczeniach zapasu nosnosci wynikajacego z dopuszczenia pracy scianek skladajacych sie na profil w stanie nadkrytycznym ograniczonym.Optymalizacje przeprowadzono wykorzystujac metode oparta na algorytmach genetycznych.Wyniki optymalizacji dla stanu krytycznego i nadkrytycznego ograniczonego zestawiono ze soba i porownano.
-
Tailoring Defects in B, N-Codoped Carbon Nanowalls for Direct Electrochemical Oxidation of Glyphosate and its Metabolites
PublikacjaTailoring the defects in graphene and its related carbon allotropes has great potential to exploit their enhanced electrochemical properties for energy applications, environmental remediation, and sensing. Vertical graphene, also known as carbon nanowalls (CNWs), exhibits a large surface area, enhanced charge transfer capability, and high defect density, making it suitable for a wide range of emerging applications. However, precise...
-
Improved mechanical properties of W-Zr-B coatings deposited by hybrid RF magnetron – PLD method
Publikacja -
Base-Catalyzed, Solvent-Free Synthesis of Rigid V-Shaped Epoxydibenzo[b,f][1,5]diazocines
Publikacja -
A study on the interaction of rhodamine B with methylthioadenosine phosphorylase protein sourced from an Antarctic soil metagenomic library.
PublikacjaThe presented study examines the phenomenon of the fluorescence under UV light excitation (312 nm) of E. coli cells expressing a novel metagenomic-derived putative methylthioadenosine phosphorylase gene, called rsfp, grown on LB agar supplemented with a fluorescent dye rhodamine B. For this purpose, an rsfp gene was cloned and expressed in an LMG194 E. coli strain using an arabinose promoter. The resulting RSFP protein was purified...
-
Primary mediastinal B-cell lymphoma – metabolic and anatomical features in 18FDG-PET/CT and response to therapy
Publikacja -
Measurements of OF QoS/QoE parameters for media streaming in a PMIPv6 TESTBED WITH 802.11 b/g/n WLANs
PublikacjaA growing number of mobile devices and the increasing popularity of multimedia services result in a new challenge of providing mobility in access networks. The paper describes experimental research on media (audio and video) streaming in a mobile IEEE 802.11 b/g/n environment realizing network-based mobility. It is an approach to mobility that requires little or no modification of the mobile terminal. Assessment of relevant parameters...
-
Self-Association of Amphotericin B: Spontaneous Formation of Molecular Structures Responsible for the Toxic Side Effects of the Antibiotic
PublikacjaAmphotericin B (AmB) is a lifesaving antibiotic used to treat deep-seated mycotic infections. Both the pharmaceutical activity and highly toxic side effects of the drug rely on its interaction with biomembranes, which is governed by the molecular organization of AmB. In the present work we present detailed analysis of self-assembly of AmB molecules in different environments, interesting from the physiological standpoint, based...
-
Membrane Sterols Modulate the Binding Mode of Amphotericin B without Affecting Its Affinity for a Lipid Bilayer
PublikacjaMembrane-active antibiotics are known to selectively target certain pathogens based on cell membrane properties, such as fluidity, lipid ordering, and phase behavior. These are in turn modulated by the composition of a lipid bilayer and in particular by the presence and type of membrane sterols. Amphotericin B (AmB), the golden standard of antifungal treatment, exhibits higher activity toward ergosterol-rich fungal membranes, which...
-
Modeling, simulation, and validation of a TB41 crash test of the H2/W5/B concrete vehicle restraint system
PublikacjaThe paper addresses numerical simulations of a concrete vehicle restraint system. The model is described in detail. The advanced material law of the continuous surface cap model was used to analyze the damage locations in concrete barrier segments. The results were validated against the TB41 full-scale crash test. The test was conducted in compliance with European standard EN 1317, and the validation was performed in accordance...
-
Le reti della terza Italia.Imprese, calcio, sponsirzzazioni e territorio in Serie B 81982-2006)
PublikacjaIl capitolo si occupa dei rapporti tra imprese e sponsirzzazioni dei club calcistici italiani della serie B tra il 1982 e il 2006
-
Thermodynamic Cycle Concepts for High-Efficiency Power Plants. Part B: Prosumer and Distributed Power Industry
PublikacjaAn analysis was carried out for different thermodynamic cycles of power plants with air turbines. A new modification of a gas turbine cycle with the combustion chamber at the turbine outlet has been described in the paper. A special air by-pass system of the combustor was applied, and in this way, the efficiency of the turbine cycle was increased by a few points. The proposed cycle equipped with an effective heat exchanger could...
-
Influence of B/N co-doping on electrical and photoluminescence properties of CVD grown homoepitaxial diamond films
PublikacjaBoron doped diamond (BDD) has great potential in electrical, and electrochemical sensing applications. The growth parameters, substrates, and synthesis method play a vital role in the preparation of semiconducting BDD to metallic BDD. Doping of other elements along with boron (B) into diamond demonstrated improved efficacy of B doping and exceptional properties. In the present study, B and nitrogen (N) co-doped diamond has been...
-
Immune escape of B-cell lymphoblastic leukemic cells through a lineage switch to acute myeloid leukemia
PublikacjaAcute leukemia (AL) with a lineage switch (LS) is associated with poor prognosis. The predisposing factors of LS are unknown, apart from KMT2A rearrangements that have been reported to be associated with LS. Herein, we present two cases and review all 104 published cases to identify risk factors for LS. Most of the patients (75.5%) experienced a switch from the lymphoid phenotype to the myeloid phenotype. Eighteen patients (17.0%)...
-
Sol–gel glasses with enhanced luminescence of laser dye Rhodamine B due to plasmonic coupling by copper nanoparticles
Publikacja -
Characterisation of adenovirus strains represented species B and E isolated from broiler chicken flocks in eastern Poland
Publikacja -
Investigation of changes in the type B PLC effect of Al-Mg-Cu type alloy for various strain rates
PublikacjaEfekt Portevina-LeChateliera ujawnia się w postaci skokowych zmian naprężenia w trakcie procesu odkształcenia próbek pewnych stopów. Zjawisko PLC występuje w kilku odmianach charakteryzujących się istotnymi różnicami zarówno w przestrzennym rozkładzie pasm odkształcenia jak też przebiegu krzywej naprężeniowej. Przebiegi odpowiadające różnym odmianom serration charakteryzują się odmiennymi właściwościami rozkładu energetycznego...
-
Investigation of changes in the type B PLC effect of Al–Mg–Cu type alloy for various strain rates
Publikacja -
Molecular organization of antifungal antibiotic amphotericin B in lipid monolayers studied by means of Fluorescence Lifetime Imaging Microscopy
Publikacja -
Mechanical and Thermal Properties of W-Ta-B Coatings Deposited by High-Power Impulse Magnetron Sputtering (HiPIMS)
Publikacja -
Epoxydibenzo[b,f][1,5]diazocines: From a Hidden Structural Motif to an Efficient Solvent-Free Synthetic Protocol
Publikacja -
The existence and stability of the anions matching the formula (M=Li, Na, K, Be, Mg, Ca, B, Al, Ga)
Publikacja -
Experimental ORC micro-power plant for CHP application Part B: Radial and Multi-stage axial turbines
PublikacjaThe co-generative micro-power plant with the HFE7100 applied as a working medium was designed and built for experimental investigations. Special attention is paid to a micro-turbine which was built and tested in two variants: a radial turbine and an axial turbine. A concept of a radial turbine with 2 centripetal and 2 centrifugal stages is shown. This prototype was equipped with an aerostatic gas bearing and, alternatively, with...
-
Phase IIa study of the CD19 antibody MOR208 in patients with relapsed or refractory B-cell non-Hodgkin’s lymphoma
Publikacja -
Amperometryczne czujniki ditlenku siarki oraz polimerowe czujniki wilgotności. właściwości prototypów własnej konstrukcji / B. Chachulski.
PublikacjaW pracy przedstawiono aktualny stan wiedzy obejmujący podstawy teoretyczne mechanizmu działania amperometrycznych czujników gazowych zanieczyszczeń atmosfery z ciekłym elektrolitem. Opisano większość opublikowanych dotąd rozwiązań konstrukcyjnych takich czujników wraz z ich właściwościami metrologicznymi. Zamieszczono dane dotyczące materiałów elektrodowych stosowanych w czujnikach z elektrodami metalowymi oraz z elektrodami gazodyfuzyjnymi,...
-
On the Possibility of the Amphotericin B-Sterol Complex Formation in Cholesterol- and Ergosterol-Containing Lipid Bilayers: A Molecular Dynamics Study
PublikacjaAmphotericin B (AmB) is a well-known membrane-active antibiotic that has been used to treat systemicfungal infections for more than 45 years. Therapeutic application of AmB is based on the fact that it is moreactive against ergosterol-containing membranes of fungal cells than against mammalian membranes withcholesterol. In this paper, we examine the hypothesis according to which the selectivity of the AmB's membraneaction originates...
-
Rozstaw rys według PN-EN 1992-1-1:2008 oraz PN-B 03264:2002
PublikacjaW pracy opisano mechanizm powstawania rys dla osiowo rozciąganego pręta żelbetowego. Na tej podstawie określono maksymalny i minimalny rozstaw rys, konfrontując otrzymane wyniki z procedurami podanymi w normie europejskiej PN-EN 1992-1-1:2008 oraz w normie polskiej PN-B 03264:2002. Przedstawiono praktyczne wnioski do projektowania, wynikajace z przeprowadzonej analizy.
-
Application of Micro-cloud point extraction for spectrophotometric determination of Malachite green, Crystal violet and Rhodamine B in aqueous samples
Publikacja -
Changes in subcellular localization of visfatin in human colorectal HCT-116 carcinoma cell line after cytochalasin B treatment
Publikacja