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Search results for: clarithromycin resistance mutation
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An Influence of Factors of Flow Condition, Particle and Material Properties on Slurry Erosion Resistance
PublicationThe degradation of materials due to slurry erosion is the serious problem which occurs in the power industries. The paper presents actual knowledge about an influence of individual factors connected with flow conditions, particles and material properties on the slurry erosion resistance. Among the factors connected with operating conditions, an influence of impact angle, and velocity of impact, particle concertation and liquid...
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A new method of fault loop resistance measurement in low voltage systems with residual current devices
PublicationThis paper presents a new method of fault loop resistance measurement in low voltage systems with residual current devices. The method enables measuring fault loop resistance without nuisance tripping of residual current devices, by application an unconventional waveform of measurement current. It is important for proper verification of the effectiveness of protection against electric shock.
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Effect of annealing temperature on slurry erosion resistance of ferritic X10CrAlSi18 steel
PublicationIn the present work, the slurry erosion tests were carried out to investigate the influence of heat treatment on slurry erosion process of ferritic X10CrAlSi18 stainless steel using a slurry pot test rig. X10CrAlSi18 stainless steel was tested in as-received condition and after annealing at three different temperatures: 600°C, 800°C and 1000°C. Degradation of materials due to slurry erosion depends on many factors connected with...
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Effect of Processing Parameters on Strength and Corrosion Resistance of Friction Stir-Welded AA6082
PublicationThe friction stir welding method is increasingly attracting interest in the railway sector due to its environmental friendliness, low cost, and ease of producing high-quality joints. Using aluminum alloys reduces the weight of structures, increasing their payload and reducing fuel consumption and running costs. The following paper presents studies on the microstructure, strength, and corrosion resistance of AA6082 aluminum alloy...
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Buckling resistance of a metal column in a corrugated sheet silo - experiments and non-linear stability calculations
PublicationThe results of experimental and numerical tests of a single corrugated sheet silo column’s buckling resistance are presented in this study. The experiments were performed in a real silo with and without bulk solid (wheat). A very positive impact of the bulk solid on the column buckling resistance occurred. The experimental results were first compared to the buckling resistance calculated by Eurocode 3 formulae. The comparison revealed that...
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Case report: Successful treatment with biologics in a pediatric patient with a severe inflammatory skin disease and novel CARD14 mutation
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Suppressors of lapC mutation identify new regulators of LpxC, which mediates the first committed step in lipopolysaccharide biosynthesis
PublicationGram-negative bacteria, such as Escherichia coli, are characterized by an asymmetric outer membrane (OM) with lipopolysaccharide (LPS) located in the outer leaflet and phospholipids facing the inner leaflet. E. coli recruits LPS assembly proteins LapB, LapC and LapD in concert with FtsH protease to ensure a balanced biosynthesis of LPS and phospholipids. We recently reported that bacteria either lacking the periplasmic domain of...
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The influence of applying supplementary web plates on structural joint moment resistance and rotational stiffness
PublicationContinual trend to simplify structural elements and find less time-consuming solutions on construction site as well as inevitable increase in labour costs determine for instance elimination of those technological steps that are difficult to automation. Welding additional reinforcements and web stiffeners is a great example of such a step. The method presented in EN 1993-1-8 [8] is a result of long-term studies focused on calculating...
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SAMPLE-AND-HOLDING METHOD FOR GAS SENSING APPLIED FOR RESISTANCE GAS SENSORS
PublicationThe DC resistance of a Taguchi gas sensor is influenced by the ambient gas. To improve the selectivity and sensitivity of a sensor the fluctuation enhanced sensing (FES) was used. The paper proposes a novel methodology of utilizing FES technique that sample composition of an ambient atmosphere and hold it for further processing (sample-and-holding technique). The method uses the heated gas sensor to sample an ambient atmosphere...
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Effect of Thermal Treatment and Erosion Aggressiveness on Resistance of S235JR Steel to Cavitation and Slurry
PublicationS235JR steel is used in many applications, but its resistance to the erosion processes has been poorly studied. To investigate this resistance, cavitation, and slurry erosion tests were conducted. These tests were carried out at different erosion intensities, i.e., different flow rates in the cavitation tunnel with a system of barricades and different rotational speeds in the slurry pot. The steel was tested as-received and after...
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Support for Employees with ASD in the Workplace Using a Bluetooth Skin Resistance Sensor–A Preliminary Study
PublicationThe application of a Bluetooth skin resistance sensor in assisting people with Autism Spectrum Disorders (ASD), in their day-to-day work, is presented in this paper. The design and construction of the device are discussed. The authors have considered the best placement of the sensor, on the body, to gain the most accurate readings of user stress levels, under various conditions. Trial tests were performed on a group of sixteen...
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Corrosion resistance examinations of Ti6Al4V alloy with the use of potentiodynamic method in Ringer`s and artificial saliva solutions
PublicationThe research results of corrosion resistance of the Ti6Al4V alloy in the simulated body fluids (SBF) are presented. The polished specimens have shown better corrosion resistance than grinded surfaces in both liquids. The artificial saliva has revealed more aggressive test solution than Ringer`s solution. The pitting tendency has been observed in Ringer`s solution for grinded specimens.
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Enhanced aging resistance of poly(ε-caprolactone)/brewers’ spent grain composites
PublicationThe presented paper investigated the influence of brewers’ spent grain (BSG) extrusion pa-rameters on the photo-oxidative resistance of poly(ε-caprolactone)-based wood polymer composites. Filler samples characterized by the higher melanoidin content were more efficient in hindering of poly-mer degradation, inhibiting the decomposition of the polymer amorphous phase. As aresult, deteriora-tion of mechanical performance was limited,...
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Enterococci isolated from plant-derived food - Analysis of antibiotic resistance and the occurrence of resistance genes
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Moment resistance of I-section end-plate roof girder splices; a case study
PublicationThis article deals with the problem of determining the resistance of end-plate connections. A nonlinear FEM model of the joint was constructed in order to predict its carrying capacity. A standard code procedure was done as well. The analyses have been done to assess atypical end-plate joints designed and constructed as a part of roof structures.
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Calculations of the resistance values of 20 thermistors at 100°C
Open Research DataThe presented data set is part of the research aimed at determining the actual characteristics of each thermistor in a package of twenty NTC10k type sensors.
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ANALYSIS OF ROLLING RESISTANCE OF TIRES WITH RUN FLAT INSERT APPLYING DRUM METHOD AND RADIAL CHARACTERISTIC
PublicationThis paper presents analysis of rolling resistance of tires with RUN FLAT insert applying drum method and radial characteristic. The conducted studies indicated changes in operational properties of wheel, occurring as a result of inflation pressure drop in the wheel. As regards radial elasticity, such changes result in significant drop of radial rigidity and increase of static deflection and increase of tire rolling resistance....
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Removal of selected sulfonamides and sulfonamide resistance genes from wastewater in full-scale constructed wetlands
PublicationSulfonamides are high-consumption antibiotics that reach the aquatic environment. The threat related to their presence in wastewater and the environment is not only associated with their antibacterial properties, but also with risk of the spread of drug resistance in bacteria. Therefore, the aim of this work was to evaluate the occurrence of eight commonly used sulfonamides, sulfonamide resistance genes (sul1–3) and integrase genes...
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Tetracycline and ampicillin resistance of Escherichia coli strains of surface water origin: the potential for horizontal transfer of resistance genes = Oporność na tetracyklinę i ampicylinę szczepów Escherichia Coli wyizolowanych z wody powierzchniowej : możliwość horyzontalnego przenoszenia genów oporności
PublicationThe aim of this preliminary study was to assess the occurrence and molecular diversity of tetracycline and ampicillin resistance genes carried by Escherichia coli present in surface water. Bacterial strains were isolated from two watercourses (the Reda River and the Oliwski Stream) that influence the quality of coastal waters in the Gdańsk Bay (Northern Poland) by direct discharge. The bacterial drug susceptibility, tested against...
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Elevated level of 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine in leukocytes of BRCA1 mutation carriers compared to healthy controls
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Calculations of the resistance values of 20 thermistors at 0°C
Open Research DataThe presented data set is part of the research aimed at determining the actual characteristics of each thermistor in a package of twenty NTC10k type sensors.
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Impact analysis of surface roughness of the plate-plate measuring system on resistance torque in interaction with MR fluid
PublicationMagnetorheological (MR) fluids are complex suspensions of magnetic particles in a non-magnetic carrier fluid. They exhibit ‘smart’ properties that enable them to change their rheological parameters in response to a change in the external magnetic field applied. This behavior is used in some engineering solutions, e.g. MR clutches or brakes. For such systems to work correctly, the resistance torque achieved by contact with the...
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Crack Resistance of Asphalt Concrete Subjected to Environmental Factors
PublicationThe paper presents an analysis of the influence of environmental factors on the cracking susceptibility of asphalt concrete resulting in a change in the durability of asphalt pavement. In order to assess the phenomenon, laboratory tests were carried out taking into account the destructive effects of moisture, freeze-thaw cycle and long-term ageing. The influence of both factors occurring simultaneously was also verified. Due to...
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Noise and Rolling Resistance Properties of Various Types of Winter Tyres Compared to Normal Car Tyres
PublicationTo cope with winter weather conditions, potentially including snow and ice, it is common to use winter tyres, or ”all-seasons” tyres assumed to be safe both in summer and winter. In some northern countries, winter tyres are mandatory. Traditionally, it has been assumed that winter tyres are noisier than normal tyres (here called summer tyres) and winter tyres equipped with studs are assumed to be very noisy.This paper presents...
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TIME-DOMAIN NUMERICAL EVALUATION OF SHIP RESISTANCE AND MOTION IN REGULAR WAVES BY USING THE CFD URANS METHOD
PublicationTaking into account the International Maritime Organisation’s (IMO) strategy to radically reduce the GHG emitted by the shipping industry towards zero emission operation, today's assessment of ship behaviour in waves, its seakeeping characteristics and resistance and their interrelation with fuel consumption and emissions are one of the most attended research subject. There are three methods to conduct this analysis, which are...
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Wear Resistance Enhancement of Al6061 Alloy Surface Layer by Laser Dispersed Carbide Powders
PublicationIn this paper, results of the experimental study on improving wear resistance in sliding friction of Al-based alloy are presented. The technique used involves the formation of a metal matrix composite (MMC) in the alloy surface layer by laser dispersion of carbide powders such as WC, TiC and SiC. For WC and TiC MMC surface coatings fabricated under conditions typical for most of the technologically relevant solid-state lasers (wavelength...
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A five-year retrospective study shows increasing rates of antimicrobial drug resistance in Cabo Verde for both Staphylococcus aureus and Escherichia coli
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Experimental Study of the Resistance to Influence of Aggressive Liquids on Lightweight Concrete
PublicationIn light of the scientific research, the corrosion of concrete structures is one of the main problems that may reduce their durability due to the negative impact of the natural environment. The paper analyzes the influence of the type of component on the selected properties of lightweight concrete subjected to the influence of aggressive liquids. Four concrete mixes were prepared with a granular aggregate made of foamed glass (GEGA)...
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Study of the Resistance to Influence of Aggressive Liquids on Concrete with Lightweight Aggregate
PublicationThe corrosion of the structure of concrete caused by the aggressive external environment is one of the main problems that can reduce the durability of buildings. The paper analyzes the influence of the type of component on selected properties of lightweight concrete (LWC) exposed to aggressive liquids. When lightweight concrete containing porous aggregates is used, the influence of an aggressive environment may be of particular...
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Does the chemical modification of Nystatin A1 affect the drug's ability to overcome the multidrug resistance of fungi?
PublicationAlthough the contemporary medicine keeps moving forward, disseminated infections caused by fungal pathogens are an emerging challenge. The dramatic rise of fungal diseases, especially the most life-threatening systemic mycoses is associated with a permanently growing number of immunodeficient patients. Undoubted difficulties in the treatment of fungal infections are caused by lack of highly effective and selective antifungal drugs,...
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International Journal for Parasitology-Drugs and Drug Resistance
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Estimation of cavitation erosion resistance of materials
PublicationW pracy przedstawiono ocenę odporności kawitacyjnej 17 materiałów. Do opisu odporności kawitacyjnej zaproponowano nowy wskaźnik liczbowy uwzględniający długość okresu inkubacji, maksymalną prędkość niszczenia oraz czas po którym wystąpi maksymalna prędkość niszczenia materiału. Zaproponowany wskaźnik porównano ze wskaźnikiem δcav, który reprezentuje całą krzywą erozji kawitacyjnej materiału.
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Rolling resistance measurements of studded tires
PublicationW pracy przedstawiono wyniki pomiaru oporu toczenia opon kolcowanych i po usunięciu kolców na nawierzchni poroelastycznej. Badania przeprowadzono na stanowisku bębnowym Katedry Pojazdów i Maszyn Roboczych Politechniki Gdańskiej. Opony kolcowane mają o około 5% wyższy współczynnik oporu toczenia w porównaniu z oponami nie kolcowanymi.
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Voriconazole and multidrug resistance in Candida albicans
PublicationPorównano aktywność grzybostatyczną in vitro worikonazolu, flukonazolu, ketokonazolu i klotrimazolu wobec opornych na flukonazol szczepów klinicznych Candida albicans oraz rekombinowanych szczepów Saccharomyces cerevisiae eksprymujących jeden z genów kodujących białka oporności wielolekowej (MDR) C. albicans: Cdr1p. Cdr2p lub CaMdr1p. Stwierdzono, że nadekspresja genów MDR czyni komórki drożdżaków mniej wrażliwymi na działanie...
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Difficulties with evaluating resistance of materials to cavitation.
PublicationW pracy dokonano analizy wyników Międzynarodowego Testu Erozji Kawitacyjnej (ICET), któremu koordynował Instytut Maszyn Przepływowych Polskiej Akademii Nauk (IMP PAN) w Gdańsku. Kluczowe parametry wpływające na zmianę przebiegu krzywych erozji uzyskanych na stanowiskach badawczych zostały wskazane. Wykazano konieczność przeprowadzenia badań w zakresie oceny wpływu efektu skali. Zaprezentowano wyniki uzyskane na stanowiskach magnetostrykcyjnych...
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Type of surface and tire rolling resistance
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Full-scale CFD simulations for the determination of ship resistance as a rational, alternative method to towing tank experiments
PublicationResults of ship resistance predictions obtained from towing tank experiments are affected by the method used to extrapolate from a model scale to a ship scale. Selection of method to determine a form factor is subjective and the extrapolation method is accurate for typical hull forms. For innovative hull forms the proper method for calculating the form factor is questionable. Moreover, the influence of the extrapolation method...
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Optimization of biocorrosion resistance and mechanical properties of PM Ti–XAl–2Fe–3Cu alloys by response surface methodology
PublicationIn the current study, the biocorrosion resistance and mechanical properties of the Ti–XAl–2Fe–3Cu (wt%) (X = 6, 4, 2 wt%) alloy produced by powder compact extrusion of blended elemental powders were optimized by using the response surface methodology in order to gain the best combination of processing parameters. To run the optimization process, central composite design with three equal levels of oxygen, hydrogen and aluminum was...
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Dynamic mechanical properties and flexing fatigue resistance of tire sidewall rubber as function of waste tire rubber reclaiming degree
PublicationA stepwise downsizing method of gel particles in reclaimed rubber to a micro-nano scale and its excellent dynamic performance in tire sidewall were introduced by this work. The results showed that the size of gel particles decreased from several micrometers to micro-nanometers with the increase of reclaiming degree, accompanied by reduced molecular weight and widened molecular weight distribution of sol fraction. The addition of...
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Effect of microstructure on mechanical properties and corrosion resistance of 2205 duplex stainless steel
PublicationThis paper presents results of the research on impact of microstructure of austenitic-ferritic steel of duplex type on its mechanical properties and susceptibility to stress corrosion cracking. As showed, improper processing technologies more and more often used in shipbuilding industry for plates and other half-finished products made of duplex steel may cause significant lowering their properties, which frequently makes their...
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KRAS mutation testing in borderline ovarian tumors and low-grade ovarian carcinomas with a rapid, fully integrated molecular diagnostic system
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Mutation Research - Genetic Toxicology and Environmental Mutagenesis
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Experimental verification of a new method of loop resistance testing in low voltage systems with residual current devices
PublicationA periodical verification of the effectiveness of protection against electric shock shall be performed in low voltage systems. The scope of this verification includes loop impedance/resistance testing. If a residual current device is installed in a tested circuit, this testing is problematic. A residual current device trips out during the test, because of the high value of measurement current. This precludes the execution of the...
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The abrasive wear resistance of coatings manufactured on high-strength low-alloy (HSLA) offshore steel in wet welding conditions
PublicationSome marine and offshore structure elements exploited in the water cannot be brought to the surface of the water as this will generate high costs, and for this reason, they require in-situ repairs. One of the repair techniques used in underwater pad welding conditions is a wet welding method. This paper presents an investigation of the abrasive wear resistance of coatings made in wet welding conditions with the use of two grades...
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Two small RNAs conserved in Enterobacteriaceae provide intrinsic resistance to antibiotics targeting the cell wall biosynthesis enzyme glucosamine-6-phosphate synthase
PublicationFormation of glucosamine-6-phosphate GlcN6P) by enzyme GlcN6P synthase (GlmS) represents the first step in bacterial cell envelope synthesis. In Escherichia coli, expression of glmS is controlled by small RNAs (sRNAs) GlmY and GlmZ. GlmZ activates the glmS mRNA by base-pairing. When not required, GlmZ is bound by adapter protein RapZ and recruited to cleavage by RNase E inactivating the sRNA. The homologous sRNA GlmY activates...
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Calculations of the resistance values of 20 thermistors at 50°C
Open Research DataThe presented data set is part of the research aimed at determining the actual characteristics of each thermistor in a package of twenty NTC10k type sensors.
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Corrosion Resistance and Surface Bioactivity of Ti6Al4V Alloy after Finish Turning under Ecological Cutting Conditions
PublicationThe influence of cooling conditions and surface topography after finish turning of Ti6Al4V titanium alloy on corrosion resistance and surface bioactivity was analyzed. The samples were machined under dry and minimum quantity lubrication (MQL) conditions to obtain different surface roughness. The surface topographies of the processed samples were assessed and measured using an optical profilometer. The produced samples were subjected...
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Bortezomib induces methylation changes in neuroblastoma cells that appear to play a significant role in resistance development to this compound
PublicationThe anticancer activity of bortezomib (BTZ) has been increasingly studied in a number of indications and promising results for the use of this treatment have been shown in neuroblastoma. As BTZ treatment is usually administered in cycles, the development of resistance and side effects in patients undergoing therapy with BTZ remains a major challenge for the clinical usage of this compound. Common resistance development also means...
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Relieving the Measuring System of the Trailer for Tyre/Road Rolling Resistance Measurements from the Inertia Force
PublicationIn the article the principle of measuring of tyre/road rolling resistance tyres in road conditions applied in a special measuring trailer is presented. This trailer was built in Faculty of Mechanical Engineering at Gdansk University of Technology. The construction of two special devices used in this trailer was discussed. These devices eliminate the influence of some chosen confounding measurements factors such as: the inertia...
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Evaluation of the resistance of steel–concrete adhesive connection in reinforced concrete beams using guided wave propagation
PublicationThe development of the nondestructive diagnostic methods is of significant importance in the last decades. A special attention is paid to diagnostics of reinforced concrete structures, which are very popular in the civil engineering field. A possible use of the guided waves in the estimation of the resistance of steel–concrete adhesive connection is studied in the following paper. The relationships relating adhesive connection...