Search results for: HSP70 ATPASE CYCLE
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Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the antitumor imidazoacridinone C-1311 in human hepatoma cells
PublicationThere is increasing evidence that the expression level of drug metabolic enzymes affects the final cellular response following drug treatment. Moreover, anti-tumour agents may modulate enzymatic activity and/or cellular expression of metabolic enzymes in tumour cells. We investigated the influence of CYP3A4 overexpression on the cellular response induced by the anti-tumour agent C-1311 in hepatoma cells. C-1311-mediated CYP3A4...
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Activation of endogenous regenerative potential in mammals using epigenetic inhibitor zebularine
PublicationIn this work, a nucleoside inhibitor of DNA methyltransferases, zebularine, was investigated as a wound healing and regeneration promoting agent. It was found that a high dose of intraperitoneally delivered zebularine improved punch wound closure in the ear pinna in mice. Both cytidine, a zebularine analogue, and uridine, a zebularine metabolite, did not promote ear pinna hole closure. The effect of zebularine on ear pinna healing...
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Domestic ORC micro-CHP combined with a commercial gas boiler
PublicationThe chapter presents the results of experimental studies conducted during the launch of the first in Poland demonstration prototype of the micro ORC coupled to a domestic gas boiler. The accomplished studies indicated the possibility for the ORC module to work with such boiler (autonomous source of heat) with a prototype single-stage axial micro turbine as the expansion machine. Confirmation of that fact has been delineated in...
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Evolutionary approach to ship's trajectory planning within Traffic Separation Schemes
PublicationThe paper presents the continuation of the author's research on evolutionary approach to ship trajectory planning. While the general problem of the evolutionary trajectory planning has already been solved, no one has yet touched one of its specific aspects: evolutionary trajectory planning within Traffic Separation Schemes. Traffic Separation Scheme (TSS) is a traffic-management route-system complying with rules of the International...
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Analiza obiegów kogeneracyjnych z silnikami tłokowymi i mikroturbi-nami
PublicationPrzeprowadzono analizę dla układów kogeneracyjnych z mikroturbinami wykorzystującymi ciepło odpadowe z silników tłokowych. Rozważono cztery główne źródła ciepła odpadowego z silników tłokowych: spaliny wylotowe, woda chłodząca silnik, olej smarny i ciepło z systemu turbodaładowania. Obliczenia przeprowadzono dla silników General Electric Jerbacher typów: J320 GS-C25 i J416 GS-B05. Uwzględniono różne czynniki robocze siłowni (zarówno...
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Acceptance Testing of Software Products for Cloud-Based On-Line Delivery
PublicationSoftware products intended for on-line delivery by distributors serving an open community of subscribers are developed in a specific life-cycle model, in which roles of the major stakeholders are strongly separated, unlike in any other software development model known in software engineering. Its specificity underlines the fact that a distributor of the final product, responsible for its acceptance for publication and delivery...
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Material Flow Analysis in a cooked mussel processing industry
PublicationGalicia (NW Spain) is an ideal environment for mussel culture owing to its excellent natural conditions. It is the first Spanish and European mussel producer and the second worldwide after China. More than 50% of the mussel collected in Galicia is used in the processing industry, which produces different products, as cooked mussel that is canned, frozen or used in the food industry. In this paper a methodology based on Life Cycle...
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Interdyscyplinarne studia doktoranckie na Politechnice Gdańskiej - przykład dobrych praktyki w zakresie realizacji projektów miękkich współfinansowanych z UE
PublicationNiniejszy artykuł przedstawia teoretyczne podstawy zarządzania projektem współfinansowanym ze środków jednego z funduszy strukturalnych Unii Europejskiej (UE), jakim jest Europejski Fundusz Społeczny (EFS). Jako metodę zarządzania projektem wskazano koncepcję Project Cycle Management - PCM. Za przykład dobrych praktyk został w artykule uznany realizowany przez Politechnikę Gdańską (PG) oraz Instytut Maszyn Przepływowych Polskiej...
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Applicability of an effective conductivity approach in modeling thoracic impedance changes
PublicationThis paper describes numerical simulations of the influence of conductivity changes inside a volume conductor on impedance changes measured on its surface. A simple model based on the finite element method has been developed to estimate an applicability of the effective conductivity theory in human chest modeling. The model consisted of a cylinder with two concentric spheres inside. Simulations were performed for two cases: first...
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Koncepcja, modelowanie i symulacja układu napędowego prototypu samochodu elektrycznego "ELV001"
PublicationAbstract: In this paper a conception, modelling and simulation tool for drive system of the prototype electric vehicle ''ELV001'' have been presented. The design and building of this vehicle have been carried out in frame of the project: ''Building a market of electric vehicle and charging infrastructure - fundamentals of energy safety''. The simulation tools are of great assistance to engineers and researchers to reduce product-development...
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Sensorless IPMSM drive with rotor position estimator based on analysis of phase current derivatives
PublicationThis paper describes a sensorless Interior Permanent Magnet Synchronous Motor (IPMSM) drive designed for traction applications. Wide-speed sensorless operation is provided with the use of three methods of rotor position estimation designed for: a standstill, low- and high-speed range. The paper focuses on the high-speed estimation algorithm. The estimator uses the derivatives of motor phase currentsresulting from PWM modulation...
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Integrated safety and security analysis of hazardous plants and systems of critical infrastructure
PublicationThis article addresses an integrated safety and security analysis approach of hazardous industrial plants and systems of critical infrastructure. Nowadays due to new hazards that emerge there are opinions among experts that these issues require an integrated approach in life cycle, from the design concept, through the design and operation of the plant, to its decommissioning. It is proposed to start from an interesting methodology...
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Composite GFRP U-shaped footbridge
PublicationThe paper presents proposals for the use of glass fiber reinforced polymer composites for the construction of engineering objects, known and commonly used in the shipbuilding industry. An example of a pedestrian footbridge was used in this case, which, despite the considerable thickness of the structural material, was made using infusion technology in one production cycle. The designed and produced footbridge span is durable, dynamically...
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Release and Transport of Toxic, Mobile Organic Compounds (Formaldehyde and Phenols) on an Arctic Glacier
PublicationAs a result of current deglaciation, the chemical cycles of many compounds, including toxic formaldehyde and phenols, are changing. However, the processes by which these chemicals are released have yet to be studied in situ. Here, we quantify fluxes of HCHO and phenols in a glacial catchment within one summer season, obtaining a net release from the glacier of 0.106 · 106 g formaldehyde and 0.255 · 106 g phenols, which can be interpreted...
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Capillary pumped loop as a tool for collecting large heat fluxes from electronic devices on warships
PublicationThe combat potential of future warships will be directly related to the use of modern electronic devices being parts of advanced systems, such as, for instance, radar systems, fire aiming systems, fire detection systems, electric drive systems, and even electronic and radio-electronic weaponry, railguns and lasers, installed on these warships. The capacity and functionality of these devices is continually increasing, at decreasing...
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The hat problem on cycles on at least nine vertices
PublicationThe topic is the hat problem in which each of n players is randomly fitted with a blue or red hat. Then everybody can try to guess simultaneously his own hat color by looking at the hat colors of the other players. The team wins if at least one player guesses his hat color correctly, and no one guesses his hat color wrong; otherwise the team loses. The aim is to maximize the probability of winning. In this version every player...
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Investigations of Aerodynamics of Tesla Bladeless Microturbines
PublicationThe paper presents an analysis of a Tesla bladeless turbine for a co-generating micro-power plant of heat capacity 20 kW, whichoperates in an organic Rankine cycle with a low-boiling medium. Numerical calculations of flow in several Tesla turbine models areperformed for a range of design parameters. Results of investigations exhibit interesting features in the distribution of flowparameters within the turbine interdisk space. The...
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Acoustic Processor of the Mine Countermeasure Sonar
PublicationThis paper presents the concept of an acoustic processor of the mine countermeasure sonar. Developed at the Department of Marine Electronics Systems, Gdansk University of Technology, the acoustic processor is an element of the MG-89, an underwater acoustic station. The focus of the article is on the modules of the processor. They are responsible for sampling analogue signals and implementing the algorithms controlling the measurement...
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TERMODYNAMIC CALCULATIONS OF TURBINE STEAM PARAMETERS
PublicationIn this work a heat balance was made for the nominal conditions of a block working with 18K370 turbine. For the parameters obtained, the thermal-flow calculations of the steam turbine were performed, maintaining the actual geometry of its flow system. Based on the nominal values obtained, iterative thermal and flow calculations were made for both the heat cycle of the power plant block and the steam turbine itself, seeking to obtain...
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A random signal generation method for microcontrollers with DACs
PublicationA new method of noise generation based on software implementation of a 7-bit LFSR based on a common polynomial PRBS7 using microcontrollers equipped with internal ADCs and DACs and a microcontroller noise generator structure are proposed in the paper. Two software applications implementing the method: written in ANSI C and based on the LUT technique and written in AVR Assembler are also proposed. In the method the ADC results are...
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Assessment of image processing methods for the determination of propagation of squat-type defects in rails
PublicationWe demonstrate the idea of squat-type defect measurement in the rail and the concept of tracking of the defect development using the techniques of image acquisition and image processing as well as the methods of metric spaces. We introduce the concepts of a set diameter δ(A) and the metric ρ1, which come from the properties of plane figures, to compare and to observe the development of the defects. We characterize the feasibility...
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DESIGN AND THEORETICAL ANALYSIS OF A PROTOTYPE TILTING-PAD RADIAL BEARING WITH ADJUSTABLE CLEARANCE
PublicationThe article introduces a design and analysis results of a prototype ORC (organic Rankine cycle) turbo generator rotor assembly of 300kW power, supported by tilting-pad bearings of original design. The calculations were performed for a prototype turbo generator rotor. The shaft of this machine is supported with two radial bearings, lubricated with an unusual lubricant – a low-boiling-point agent. The main objective of the presented...
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Zabezpieczenia antykorozyjne stalowych barierek ochronnych na obiektach mostowych w ujęciu kosztów cyklu ich życia
PublicationThe article presents the Life Cycle Costs analysis of steel safety barriers operated in road lane conditions, located on a selected bridge structure. Three corrosion protection systems were proposed, analyzing them in terms of the cost of initial and planned outlays related to maintenance. Based on the LCC analysis for three options, taking into account the 25-year lifetime of the barriers, the optimal solutionwas indicated, i.e....
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Self-Organization in Multi-Agent Systems Based on Examples of Modeling Economic Relationships between Agents
PublicationThe goal of the research was to observe and analyze self-organization patterns in Multi-Agent Systems (MAS) by modeling basic economic relationships between agents forming a closed loop of relations necessary for their survival. The paper describes a worked-out MAS including an example of a production cycle and used economic rules. A special focus is put on behavior rules and decision systems of an individual agent such as: product...
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Shape Memory Materials from Rubbers
PublicationSmart materials are much discussed in the current research scenario. The shape memory effect is one of the most fascinating occurrences in smart materials, both in terms of the phenomenon and its applications. Many metal alloys and polymers exhibit the shape memory effect (SME). Shape memory properties of elastomers, such as rubbers, polyurethanes, and other elastomers, are discussed in depth in this paper. The theory, factors...
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Multi-instrument analysis of L-band amplitude scintillation observed over the Eastern Arabian Peninsula
PublicationThe study of scintillation-causing ionospheric irregularities is important to mitigate their effects on satellite communications. It is also important due to the spatial and temporal variability of these irregularities, given that their characteristics differ from one region to another. This study investigates the spatial and temporal characteristics of L1 amplitude scintillation-causing ionospheric irregularities over the Eastern...
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AN ENERGY APPROACH TO THE FATIGUE LIFE OF SHIP PROPULSION SYSTEMS
PublicationThe conducted research investigations aimed to carry out an identification of the constructional materials fatigue state of the ship propulsions’ rotational mechanical units for diagnostic purposes. The fatigue cracks of the elements transmitting mechanical energy streams from the propulsion engines to the ship propellers or to the generators of the ship’s electric power station stand for a primary reason for the secondary, usually...
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Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma
PublicationPURPOSE: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO2)-Pro-Lys-Thr-OCH3]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocytes, neurons) of neuroectodermal origin, and both are tumors with high heterogeneity and unsatisfactory susceptibility to chemotherapies....
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Weryfikacja Poziomów Nienaruszalności Bezpieczeństwa z uwzględnieniem Zagadnień Ochrony Informacji
PublicationNiniejszy rozdział poświęcono wybranym istotnym zagadnieniom analizy bezpieczeństwa funkcjonalnego, w szczególności weryfikacji poziomów nienaruszalności bezpieczeństwa SIL funkcji bezpieczeństwa implementowanych w rozproszonych systemach sterowania i zabezpieczeń z uwzględnieniem zagadnień ochrony informacji. Zaproponowano metodę opartą na informacji ilościowej i jakościowej do weryfikacji SIL (IEC 61508, 61511) z uwzględnieniem...
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Towards systemic functional safety and security management in hazardous plants
PublicationThe aim of this article is to identify and discuss some issues related to functional safety and security management in hazardous industrial plants. The safety functions are to be realised using the electric / electronic / programmable electronic systems (E/E/PESs) or the safety instrumented systems (SISs) that are designed and operated respectively according to IEC 61508 and IEC 61511 requirements in life cycle. Although the role...
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The effect of elevated temperature on LCF damage growth in 2024AA – Experiment and modeling
PublicationThis paper presents the results of experimental low-cycle fatigue (LCF) tests conducted on EN-AW 2024 alloy in T3511 temper at 100 ◦C, 200 ◦C and 300 ◦C. The material’s basic fatigue characteristics were determined, such as fatigue life curve and cyclic strain curve. Both the hysteresis loop and nature of fracture surfaces obtained in macro- and microscopic observations (scanning electron microscope, SEM) were accounted for. The...
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Comparative study of a combined heat and power plant retrofitted by CO2 capture during the combustion of syngas from sewage sludge gasification versus zero-emission combustion of hydrogen produced using renewables
PublicationWith ecological requirements aimed at limiting the production of CO2, it is necessary to produce all, or most of the energy from RES. During the transformation process, ecological and highly efficient combustion power plants will be needed. The classic cycle of combined heat and power (CCGT) with green improvements will continue to be one of the most suitable technologies for this task. This article presents the modernization of...
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Experimental investigations and damage growth modeling of EN‐AW 2024 aluminum alloy under LCF loading accounting creep pre‐deformation
PublicationThis article presents the results of experimental tests of creep rupture and of low-cycle fatigue (LCF) of EN-AW 2024 aluminum alloy devoid of damage and having preliminary damage. The preliminary damage was dealt in the process of creep at elevated temperature 100C, 200C, and 300C until achievement of two different strain values at each temperature. Samples with preliminary damage were subjected to fatigue tests at room temperature....
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Contaminants in airport runoff water
PublicationDespite the many positives ensuing from the rapid expansion of the air transport sector, airport operations as a whole are a substantial source of environmental pollution.Increases in aviation developments have serious consequences on the surrounding air, soil and water bodies like lakes, rivers and ground water. The present work deals with the determination of polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls...
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Problems in designing and operating the functional safety solutions of higher integriity levels
PublicationThe aim of this article is to identify and discuss some problems that have been encountered in designing and operating the functional safety solutions of higher safety integrity levels (SIL 3 and SIL 4) in the light of analyses outlined in a new version of the international standard IEC 61508:2010. Examples of such solutions are the electric / electronic / programmable electronic systems (E/E/PESs) and the safety instrumented systems...
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Acoustic Processor of the MCM Sonar
PublicationThis paper presents the concept of an acoustic processor of the mine countermeasure sonar. Developed at the Department of Marine Electronics Systems, Gdansk University of Technology, the acoustic processor is an element of the MG-89, a modernised underwater acoustic station. The focus of the article is on the modules of the processor. They are responsible for sampling analogue signals and implementing the algorithms controlling...
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Types of wear and tear of biomaterials used in orthopaedic surgery
PublicationPurpose of this paper is presentation of observations on different kinds of wear and tear of biomaterials used in contemporary orthopaedic surgery. Types of prosthesis damage, encountered in medical practice, and their causes have been described. Results of many clinical studies were analysed to review prosthesis damage from the stage of implanting (such as intrusion of a foreign object between its components) to their natural...
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Comparative testing of numerical models of river ice jams
PublicationIce processes in general, and ice jams in particular, play a dominant role in the hydrologic regime of Canadian rivers, often causing extreme floods and affecting the life cycle of many aquatic, terrestrial, and avian species. Various numerical models have been developed to help simulate the formation and consequences of these very dynamic and often destructive jam events. To test and compare the performance of existing models,...
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Integration of natural and artificial intelligence in production systems
PublicationIntegration processes play an increasingly important role in modern economy, and seriously co-decide about the effectiveness of the company. Integration phase occurs in the system life cycle by preceding the final stages of its implementation and activation. In turn, used in software engineering (SE) iteration-evolutionary models, such as spiral model make that the integration activities can occur in varying degrees in all phases...
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Support Product Development Framework by Means of Set of Experience Knowledge Structure (SOEKS) and Decisional DNA
PublicationIn this paper, we propose a framework to support product development activi-ties by utilizing Set of Experience Knowledge Structure (SOEKS) and Decisional DNA (DDNA). This idea will provide a new direction to researchers working on product development, especially designers and manufacturers. They will be working on the same platform and this will be reducing their communication gap. Once the final idea is perceived about product...
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Safety Integrity Verification Issues of the Control Systems for Industrial Process Plants
PublicationThe aim of this article is to identify and discuss some issues that can be encountered in designing the industrial automation and control systems (IACS) for implementing safety functions. In a functional safety standard IEC 61511 for the process industry such systems are named the basic process control systems (BPCS) and the safety instrumented systems (SIS). In a generic functional safety standard IEC 61508 they are depicted as...
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Application analysis of a hybrid solid oxide fuel cell-gas turbine system for marine power plants
PublicationThe results of theoretical studies of the possibilities of using hybrid solid oxide fuel cell–gas turbine (SOFC-GT) systems for marine power plants are presented. A 500 kW auxiliary marine power plant scheme using stacks of SOFCs in combination with a regenerative gas turbine operating with over-expansion based on our recent patent application is proposed. The results of mathematical modelling showed the opportunity to obtain a...
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Application of the F-statistic of the Fisher-Snedecor distribution to analyze the significance of the effect of changes in the compression ratio of a diesel engine on the value of the specific enthalpy of the exhaust gas flow
PublicationThe paper discusses the impact of changes in the compression ratio on the operating parameters of a diesel engine, e.g. on the temperature of exhaust gases. It presents the construction of the laboratory test stand, on which experimental measurements were realized. It is characterized how the actual changes of the compression ratio were introduced to the existing engine. The program of experimental investigations taking into account...
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Analiza porównawcza kosztów środowiskowych budowy i eksploatacji drogi ekspresowej w technologii asfaltowej i betonowej, CZĘŚĆ 1
PublicationW artykule przedstawiono opis analizy porównawczej kosztów środowiskowych budowy i eksploatacji drogi ekspresowej w technologii asfaltowej i betonowej. Do przeprowadzenia badania wykorzystano analizę LCA (ang. Life Cycle Assessment). Jako założenia przyjęto warianty konstrukcji nawierzchni opracowane dla planowanej drogi ekspresowej S6 na odcinku Lębork (wraz z obwodnicą Lęborka) –obwodnica Trójmiasta, a także trzy scenariusze...
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Effect of operating conditions on N 2 O production in an anammox sequencing batch reactor containing granular sludge
PublicationNitrous oxide (N2O) is one of the gases with the greatest impact in the atmosphere due to its persistence and significant contribution to the greenhouse effect. This study provides an insight into the dynamics of N2O production in wastewater nitrogen removal systems. A 10 L sequencing batch reactor containing enriched anammox biomass was subjected to different operational conditions, i.e., temperature, feed time, NO2 /NH4 þ ratio...
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Review of the Complexity of Managing Big Data of the Internet of Things
PublicationTere is a growing awareness that the complexity of managing Big Data is one of the main challenges in the developing feld of the Internet of Tings (IoT). Complexity arises from several aspects of the Big Data life cycle, such as gathering data, storing them onto cloud servers, cleaning and integrating the data, a process involving the last advances in ontologies, such as Extensible Markup Language (XML) and Resource Description...
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Thermochemical Conversion of Biomass and Municipal Waste into Useful Energy Using Advanced HiTAG/HiTSG Technology
PublicationAn advanced thermal conversion system involving high-temperature gasification of biomass and municipal waste into biofuel, syngas or hydrogen-rich gas is presented in this paper. The decomposition of solid biomass and wastes by gasification is carried out experimentally with a modern and innovative regenerator and updraft continuous gasifier, among others. A ceramic high-cycle regenerator provides extra energy for the thermal conversion...
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Analiza siłowni nadkrytycznych oraz ultranadkrytycznych
PublicationNiniejszy artykuł zawiera przegląd istniejących rozwiązań siłowni nadkrytycznych oraz ultra nadkrytycznych. Przedstawiono historię rozwoju bloków na parametry nadkrytyczne. Obecny stan technologii został zaprezentowany – są to następujące parametry pary świeżej: 650°C oraz 330 bar. W Polsce istnieje 8 bloków pracujących na parametry nadkrytyczne. Ich parametry pracy zostały przedstawione w tekście. Z kolei elektrownią parową posiadającą...
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Od postawy prozdrowotnej w stoczni jachtowej do ograniczania zagrożeń na stanowisku pracy formierza-laminiarza
PublicationTematyka zdrowia i bezpieczeństwa pracowników, coraz częściej popularyzowana w świecie biznesu, nadal stanowi dość mało rozpoznany obszar działalności polskich przedsiębiorstw. Niniejszy artykuł porusza ważką kwestię promocji zdrowia w miejscu pracy jako czynnika zwiększającego efektywność pracy oraz jego wpływ na osiąganie wysokiej jakości produktu. Publikacja omawia znaczenie postawy prozdrowotnej i sposobów jej kształtowania...
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Wojciech Litwin dr hab. inż.
People1992÷1996 - study on Mechanical Department at Gdansk University of Technology1996 – employed in the Faculty of Ocean Engineering and Ship Technology at the Gdansk University of Technology2004 – PhD2014 – habilitation2016 - vice dean for science at Faculty of Ocean Engineering2020 - dean of the Faculty of Ocean Engineering2021 - head of Institute of Naval Architecture He participated in a number of designing and research programs...