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Search results for: AGENTY EDUKACYJNE
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9,10-Dioxoanthracenyldithiocarbamates effectively inhibit the proliferation of non-small cell lung cancer by targeting multiple protein tyrosine kinases
PublicationAnthraquinones have attracted considerable interest in the realm of cancer treatment owing to their potent anticancer properties. This study evaluates the potential of a series of new anthraquinone derivatives as anticancer agents for non-small-cell lung cancer (NSCLC). The compounds were subjected to a range of tests to assess their cytotoxic and apoptotic properties, ability to inhibit colony formation, pro-DNA damage functions,...
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A document-centric processing paradigm for collaborative computing
PublicationKlasyczne modele przetwarzania rozproszonego zakładają, że dokumenty są biernymi obiektami, które rozsyła się w formie komunikatów lub pobiera z serwerów do przetwarzania jako pliki.W artykule przedstawiono koncepcję dokumentu jako aktywnego obiektu, zdolnego do samodzielnej migracji miedzy węzłami sieci i interakcji z użytkownikami w ich lokalnym środowisku. Takie podejście jest szczególnie przydatne do realizacji procesów biznesowych...
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Security Information Sharing for the Polish Power System
PublicationThe Polish Power System is becoming increasingly more dependent on Information and Communication Technologies which results in its exposure to cyberattacks, including the evolved and highly sophisticated threats such as Advanced Persistent Threats or Distributed Denial of Service attacks. The most exposed components are SCADA systems in substations and Distributed Control Systems in power plants. When addressing this situation...
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Atom-economic thiophosphoroselenenylations of C–H acid esters and amides
PublicationThree improved thiophosphoroselenenylation procedures of CHacids, including derivatives of malonic and acetyl-, phosphono-, 4-nitrophenyl- and 3-pyridylacetic acids, have been described and compared to previously reported thiophosphoroselenylation of diethyl malonate using bis(disopropoxyphosphinothioyl)diselenide alone or with the aid of methyl iodide. The use of iodine makes it possible to utilize both equivalents of the selenenylating...
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Convenient and efficient N-methylation of secondary amines under solvent-free ball milling conditions
PublicationIn the present work, we report the development of a rapid, efcient, and solvent-free procedure for the N-methylation of secondary amines under mechanochemical conditions. After optimization of the milling parameters, a vibrational ball mill was used to synthesize 26 tertiary N-methylated amine derivatives in a short time of 20 min (30 Hz frequency) and high yields ranging from 78 to 95%. An exception was compounds having a hydroxyl...
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Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the antitumor imidazoacridinone C-1311 in human hepatoma cells
PublicationThere is increasing evidence that the expression level of drug metabolic enzymes affects the final cellular response following drug treatment. Moreover, anti-tumour agents may modulate enzymatic activity and/or cellular expression of metabolic enzymes in tumour cells. We investigated the influence of CYP3A4 overexpression on the cellular response induced by the anti-tumour agent C-1311 in hepatoma cells. C-1311-mediated CYP3A4...
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Dagmara Nikulin dr
PeopleBio: Dagmara Nikulin Dagmara Nikulin has been employed at the Faculty of Management and Economics as a research and teaching assistant professor since 2014. Initially, she worked at the Department of Economic Sciences, and now at the Department of Statistics and Econometrics. She is a graduate of the Faculty of Economics at the Poznań University of Economics (2009) and the Faculty of Social Sciences of the Adam Mickiewicz University...
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Umowa rezultatu : Umowa starannego działania
PublicationOpracowane w publikacji hsła ''mowa rezultatu'' i ''Umowa starannego działalnia'' poddają analizie umowy, których istotą jest bądź rezultat bądź właśnie staranne działanie. M to szczególne znaczenie w praktyce bowiem od tego typu wyróżnienia uzależnia się stosowanie odpowiednich przepisów i kwalifikację prawną całej umowy - w tym prawa i obowiązki jej stron. W opracowaniu uwzględniono przede wszystkim świadczenie usług medycznych...
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Therapeutic intervention by the simultaneous inhibition of DNA repair and type I or type II DNA topoisomerases: one strategy, many outcomes
PublicationMany anticancer drugs reduce the integrity of DNA, forming strand breaks. This can cause mutations and cancer or cell death if the lesions are not repaired. Interestingly, DNA repair-deficient cancer cells (e.g., those with BRCA1/2 mutations) have been shown to exhibit increased sensitivity to chemotherapy. Based on this observation, a new therapeutic approach termed 'synthetic lethality' has been developed, in which radiation...
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Low-volume label-free SARS-CoV-2 detection with the microcavity-based optical fiber sensor
PublicationAccurate and fast detection of viruses is crucial for controlling outbreaks of many diseases; therefore, to date, numerous sensing systems for their detection have been studied. On top of the performance of these sensing systems, the availability of biorecognition elements specific to especially the new etiological agents is an additional fundamental challenge. Therefore, besides high sensitivity and selectivity, such advantages...
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International Workshop on Human Aspects in Ambient Intelligence: Agent Technology, Human-Oriented Knowledge and Applications
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Antitumor Activity of Triazine Mimic Antibiotics for DNA-binding Implications (Impressive Activity in Vitro Against a Variety of Tumor Types in the NCI-60 Screen): NSC 710607 To Fight HCT-116 Human Colon Carcinoma Cell Lines in Vivo Using the Hollow Fiber Assay and Xenograft Mouse Models
PublicationPurpose Successful clinical applications of DNA-directed selective cytotoxic agents disrupt the vital replication/transcription processes and ultimately lead to cancer cell death. This study aimed to examine the growth screen of two lead triazine compounds in a number of cell lines and xenografts and to develop anticancer agents with noncovalent binding affinity bringing fewer side effects. Methods The NCI initial hollow...
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Pharmaceutical applications of surfactants
PublicationIn this study we focused on biological activity of various surfactants. According to our research, they con act both as carriers as well as therapeutic agents. Depending on their concentration, they can create different structures in a solution, which influence their properties. Liposomes have a significant role in drug delivery system. Surfactants in from of bilayer are analogous to natural biological cell membrane.
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Biosurfactants - Biodegradability, toxicity, efficiency in comparison with synthetic surfactants
PublicationBiosurfactants are natural surface active agents produced by variety of bacteria yeast and fungi. A review of their biodegradability, toxicity and efficiency is presented in order to compare their properties with synthetic surfactants. Due to their high efficiency in many applications and environmentally friendly character we tried to apply them in oil refining process. The efficiency of biosurfactants in this application was very...
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Piotr Marczak dr inż. arch.
PeoplePiotr Marczak is an Assistant Professor at the Faculty of Architecture, Gdańsk University of Technology and since 2016 a Vice-Dean for Education and Promotion. He is also is also a member of the Pomeranian District Chamber of Architects (POIA RP). His research and publications focus on the theory of architecture, revitalization and transformation within the ports areas and the Baltic coast. These studies are associated with the...
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Beyond the standard entropic inequalities: stronger scalar separability criteria and their applications
PublicationNiedawno pokazano, że jeżeli dwupodukładowy stan kwantowy spełnia strukturalne kryterium separowalności oparte na pewnym liniowym odwzorowaniu dodatnim (tzw. odwzorowanie redukcyjne) to musi także spełniać skalarne kryterium separowalności oparte na nierównościach entropijnych. Ponieważ nierówności te są obiecującymi z eksperymentalnego punktu widzenia detektorami splątania w układach kwantowych, interesującym wydaje się pytanie...
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MOST Wiedzy jako narzędzie promocji otwartych zasobów nauki
PublicationRośnie znaczenie wiedzy zgromadzonej w różnego rodzaju systemach, w tym w kursach on-line. Połączenie systemów je przetwarzających z Internetem w znaczącym stopniu usprawniło rozprzestrzenianie informacji i zwiększyło jej dostępność. Coraz szersze uznanie zyskują ruchy Otwartego Dostępu (ang. Open Access). Politechnika Gdańska w ramach projektu Multidyscyplinarny Otwarty System Transferu Wiedzy – MOST Wiedzy buduje platformę o...
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Elżbieta Marczak dr inż. arch.
PeopleElżbieta Marczak (Architect, Phd) – Assistant Professor at the Faculty of Architecture, Gdańsk University of Technology, Department of Urban Architecture and Waterscapes (since 1997). Studies at the Faculty of Architecture GUT graduated in 1995. Degree of Doctor obtained in 2006 presenting dissertation The ship’s architecture against the background of the maritime transport development. Her research and publications focus on...
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Bilateral Multi-Issue Negotiation Between Active Documents and Execution Devices
PublicationMobile document-agents are often in conflict with execution devices when attempting to perform activities of the business process they implement, since preferences of device owners may change depending on their current location and the actual class of the device in use. The paper proposes a bilateral negotiation mechanism based on a simple bargaining game that can effectively resolve such conflicts without any third party support.
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Smart Document-Centric Processing of Human Oriented Information Flows
PublicationUsually people prefer to focus on creative rather than repetitive and schematic work patterns. Still, they must spend a lot of time complying with the procedures, selecting the information they receive and repeatedly restoring the previous state of work. This paper proposes the Mobile INteractive Document architecture (MIND) - a document-centric uniform interface to provide both effective communication of content and coordination...
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Phong B. Dao D.Sc., Ph.D.
PeoplePhong B. Dao received the Engineer degree in Cybernetics in 2001, the M.Sc. degree in Instrumentation and Control in 2004, both from Hanoi University of Science and Technology in Vietnam, and the Ph.D. degree in Control Engineering in 2011 from the University of Twente, the Netherlands. In May 2020, Dr. Dao received the degree of D.Sc. (Habilitation) in Mechanical Engineering from the AGH University of Science and Technology, Poland....
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Herbaria i florilegia od XV do XVIII wieku ze zbiorów PAN Biblioteki Gdańskiej
PublicationPublikacja przedstawia wstępną analizę ilości i zawartości zespołu botanicznych druków tekstowych i graficznych, znajdujących się w historycznych zbiorach PAN Biblioteki Gdańskiej. W tekście uwzględniono także informacje o rozproszonej spuściźnie gdańskiej rodziny Breyne, znajdującej się obecnie w Forschungsbibliothek Gotha (Niemcy) oraz w Brenthurst Library w Johannesburgu (RPA), w tym o kolekcji 189 ilustracji botanicznych sióstr...
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First report on echinocandin resistant Polish Candida isolates
PublicationPurpose: Candida spp. are ranked as one of the four major causative agents of fungal infections. The number of infections caused by Candida species resistant to fluconazole, which is applied as the first line drug in candidiasis treatment, increases every year. In such cases the application of echinocandin is necessary. Echinocandin susceptibility testing has become a routine laboratory practice in many countries due to the increasing...
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Natural carbon-based quantum dots and their applications in drug delivery: A review
PublicationNatural carbon based quantum dots (NCDs) are an emerging class of nanomaterials in the carbon family. NCDs have gained immense acclamation among researchers because of their abundance, eco-friendly nature, aqueous solubility, the diverse functionality and biocompatibility when compared to other conventional carbon quantum dots (CDs).The presence of different functional groups on the surface of NCDs such as thiol, carboxyl, hydroxyl,...
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Efficient parallel implementation of crowd simulation using a hybrid CPU+GPU high performance computing system
PublicationIn the paper we present a modern efficient parallel OpenMP+CUDA implementation of crowd simulation for hybrid CPU+GPU systems and demonstrate its higher performance over CPU-only and GPU-only implementations for several problem sizes including 10 000, 50 000, 100 000, 500 000 and 1 000 000 agents. We show how performance varies for various tile sizes and what CPU–GPU load balancing settings shall be preferred for various domain...
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Evaluation of Health Hazard Due to Emission of Volatile Organic Compounds from Various Processing Units of Wastewater Treatment Plant
PublicationThe paper describes an attempt at health risk assessment and odour concentration determination in the most important units of a wastewater treatment plant. The cancer risk (CR) and hazard index (HI) parameters in selected measurement locations were calculated based on the results of chromatographic analyses (GCxGC-TOF-MS) and the United States Environmental Protection Agency (US EPA) guidelines. No exceedance of the CR and HI acceptable...
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Synthesis and Cholinesterase Inhibitory Activity of N-Phosphorylated /N-Tiophosphorylated Tacrine
PublicationNovel phosphorus and thiophosphorus tacrine derivatives were designed, synthesized and their biological activity and molecular modeling was investigated as a new potential anti-Alzheimer's disease (AD) agents. All new synthesized compound exhibited lower toxicity against neuroblastoma cell line (SH-SY5Y) in comparison with tacrine. Two analogues in the series, 7 and 9, demonstrated lack of cytotoxicity against hepatocellular cells...
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Student - klient : czy uczelnia ma zawsze spelniać oczekiwania studentów?
PublicationJednym z podstawowych dylematów związanych z wprowadzaniem orientacji marketingowej do uczelni, a zarazem najistotniejszą barierą, jest problem traktowania studentów jako klientów. Na pierwszy rzut oka oznacza to, że zgodnie z regułami marketingowymi uczelnia powinna zaspokajać wszelkie wymagania i oczekiwania swoich klientów.Postępowanie zgodne z hasłem "Klient nasz Pan" niepokoi jednak władze zarządzające szkołami wyższymi. Autorka...
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Fotogrametria internetowa w edukacji i gospodarce.Internet photogrammetry in education and business.
PublicationReferat traktuje o możliwościach wykorzystania nowej technologii fotogrametrycznej - fotogrametrii internetowej - tak w realizacji procesu dydaktycznego, jak i w przedsięwzięciach komercyjnych na rzecz gospodarki. Zaprezentowany zostaje wynik odejścia od stanowiskowych realizacji fotogrametrycznych (stacje robocze) na rzecz wykorzystania koncepcji rozproszonych klientów serwera fotogrametrycznego. Analizie poddano możliwości wykorzystania...
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Inteligentny system decyzyjny jako maszynowa realizacja procesów poznawczych i motywacyjnych
PublicationW niniejszej książce przedstawiono własny, kompletny i spójny oraz realizowalny model Inteligentnego Systemu Decyzji (ISD), oparty na wiedzy zaczerpniętej z psychologii z elementami motywacyjnymi, w skład którego wchodzi podsystem xEmotion. Wykorzystuje on funkcję i strukturę ludzkich procesów decyzyjnych oraz pewne szczegółowe mechanizmy dedykowane dla obliczeniowych systemów emocji. Model ISD jest w szczególności przeznaczony...
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Mobile monitoring system for gaseous air pollution
PublicationThe concept of a mobile monitoring system for chemical agents control in the air is presented. The proposed system can be applied to measure industrial and car traffic air pollution. A monitoring station is relatively small and can be placed on cars or public transportation vehicles. Measured concentrations of air pollutants are collected and transferred via the GSM network to a central data base. Exemplary results from a measurement...
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Izabela Mironowicz dr hab. inż. arch.
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DK16 Mrągowo-Ełk 2017- video data
Open Research DataDK16 Mrągowo-Ełk 2017- video data
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Rola pomiaru efektywności szkoły wyższej w kształtowaniu jej pozycji konkurencyjnej
PublicationPubliczne uczelnie wyższe, szczególnie techniczne, aby utrzymać się na konkurencyjnym rynku usług edukacyjnych, muszą dbać o efektywność swojego funkcjonowania. Uzyskanie przewagi na konkurencyjnym rynku edukacyjnym wymaga od uczelni działań przedsiębiorczych. Sukces wielu tego typu działań uzależniony jest od ilościowej oceny różnych parametrów. Jedną z metod pozwalających na ilościową ocenę efektywności jest Data Envelopment...
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‘Acridines’ as New Horizons in Antifungal Treatment
PublicationFrequent fungal infections in immunocompromised patients and mortality due to invasive mycosis are important clinical problems. Opportunistic pathogenic Candida species remain one of the leading causes of systemic mycosis worldwide. The repertoire of antifungal chemotherapeutic agents is very limited. Although new antifungal drugs such as lanosterol 14α-demethylase and β-glucan synthase inhibitors have been introduced into clinical...
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Novel Functionalization of Boron-Doped Diamond by Microwave Pulsed-Plasma Polymerized Allylamine Film
PublicationWe report the novel modification of a hydrogen-terminated polycrystalline boron-doped electrode with a microwave pulsed-plasma polymerized allylamine. Boron-doped diamond (BDD) was coated with a very thin layer of adherent cross-linked, pinhole- and additive-free allylamine plasma polymer (PPAAm) resistant to hydrolysis and delamination and characterized by a high density of positively charged amino groups. The pulsed microwave...
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Cognitive motivations and foundations for building intelligent decision-making systems
PublicationConcepts based on psychology fit well with current research trends related to robotics and artificial intelligence. Biology-inspired cognitive architectures are extremely useful in building agents and robots, and this is one of the most important challenges of modern science. Therefore, the widely viewed and far-reaching goal of systems research and engineering is virtual agents and autonomous robots that mimic human behavior in...
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Hemocompatibility of nanocrystalline diamond layers
Open Research DataThe biocompatibility of the diamond films were investigated with whole human blood samples. Blood used in this study was drawn from 10 healthy human patients of different age, sex, and blood group. A 2 ml samples were collected into standard tubes with EDTA anticoagulation agent. Blood was used within 6 hours from the collection time. A reference blood...
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Satish Raina prof. dr
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Edukacja+ Dostępna Szkoła - innowacyjne rozwiązania w kreowaniu przyjaznej przestrzeni edukacyjnej z uwzględnieniem potrzeb uczniów oraz otoczenia
ProjectsProject realized in Department of Technical Fundamentals of Architecture Design according to POWR.04.01.00-00-DS10/19 agreement from 2019-12-30
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Building Polish space sector – from small islands of excellence to a national innovation ecosystem
PublicationIn the paper a national potential of Poland to build its space industry after joining the European Space Agency (ESA) in 2012 is assessed, based on the series of survey reports published annually by POLSA since 2016. Their methodology was based on the ESA technology tree, classifying all the space-related technical knowhow and allowed identification of the most promising strengths to exploit and shortages to challenge by policymakers...
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Monika Bizewska dr
Peopledr Monika Bizewska, doktor nauk humanistycznych Uniwersytetu Gdańskiego. Doktorat pt. „Państwo Środka w kulturze materialnej i w piśmiennictwie polskiego oświecenia” obroniła pod nazwiskiem Kwietniewska w 2009 roku. Od stycznia 2019 roku zatrudniona w Biurze Politechniki Otwartej na stanowisku kierownika jednostki realizującej zadania związane z popularyzacją nauki oraz organizacją wydarzeń edukacyjno-kulturalnych. Na pełnym etacie,...
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Cartometric: semantic ontology evaluation with cartographic methods
PublicationW ostatnich latach, głównie dzięki rozwojowi inicjatywy Sieci Semantycznej (ang. Semantic Web), staliśmy się świadkami powstawania coraz większej liczby gwałtownie ewoluujących ontologii. W takiej sytuacji zarówno użytkownicy Sieci, jak i komputerowe agenty potrzebują metody oceny właściwości ontologii, w szczególności takiej, która uwzględni jej cechy semantyczne, czyli kształt przestrzeni dozwolonych modeli. Niniejsza praca prezentuje...
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CartoMetric: Ocena semantycznych właściwości ontologii za pomocą metody kartograficznej
PublicationW ostatnich latach, głównie dzięki rozwojowi inicjatywy Sieci Semantycznej (ang. Semantic Web), staliśmy się świadkami powstawania coraz większej liczby gwałtownie ewoluujących ontologii. W takiej sytuacji zarówno użytkownicy Sieci, jak i komputerowe agenty potrzebują metody oceny właściwości ontologii, w szczególności takiej, która uwzględni jej cechy semantyczne, czyli kształt przestrzeni dozwolonych modeli. Niniejsza praca prezentuje...
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Degradation kinetics and mechanism of pentoxifylline by ultraviolet activated peroxydisulfate
PublicationDegradation of pentoxifylline (PTX) by sodium peroxydisulfate (SPDS) assisted by UV irradiation has been investigated in deionized water. The treatment was more favorable over direct photolysis or peroxydisulfate oxidation alone. The effects of various parameters, including different dosage of oxidant agent, PTX concentration, initial solution pH levels, and the presence of inorganic ions like chloride, nitrate and carbonate have...
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Peptide conjugates of lactoferricin analogues and antimicrobials—Design, chemical synthesis, evaluation of antimicrobial activity and mammalian cytotoxicity
PublicationEight new peptide conjugates composed of modified bovine lactoferricin truncated analogues (LFcinB) and oneof the three antimicrobials — ciprofloxacin (CIP), levofloxacin (LVX), and fluconazole (FLC) — were synthesized. Four different linkers were applied to connect a peptide and an antimicrobial agent. The FLC-containing peptidic conjugates were synthesized using the “click chemistry” method. This novel approach is reported here...
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Anna Sobieraj-Żłobińska dr inż.
PeopleAnna Sobieraj-Żłobińska (born in 1977 in Przasnysz) graduated from the National Education Commission High School in Przasnysz. From 1996 she continued her studies at the Faculty of Geodesy and Spatial Management at the University of Agriculture and Technology Michał Oczapowski in Olsztyn. In 2001, she obtained a master's degree in engineering at the University of Warmia and Mazury in Olsztyn (thesis topic "Determining a multiple...
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The Taste of Waste: The Edge of Eggshell Over Calcium Carbonate in Acrylonitrile Butadiene Rubber
PublicationRubber technology experiences a new age by the use of biowaste or natural fillers. In this regard, taking properties of reinforcing agents from biowaste fillers remains as the challenging matter. Chicken eggshell (ES) biowaste has recently been introduced to substitute calcium carbonate (CaCO3) duo to its superior properties and low price. In this work, composites based on acrylonitrile butadiene rubber (NBR) reinforced with ES...
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Wykorzystanie protokołu SNMP do zdalnego monitorowania i sterowania elementami instalacji KNX
PublicationW referacie zaproponowano rozwiązanie wykorzystujące do zdalnego monitorowania i sterowania elementów systemu KNX protokół SNMP. Przedstawiono opracowaną strukturę bazy danych informacji zarządzania (MIB) dostosowaną do potrzeb instalacji KNX oraz sposób reprezentacji obiektów komunikacyjnych modułów KNX. Zaprezentowano prototyp opracowanego modułu rozszerzenia do standardowego agenta SNMP systemu Windows umożliwiający zdalne zarządzanie...
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UBIS Urban Baltic Industrial Symbiosis
ProjectsProject realized in Department of Process Engineering and Chemical Technology according to STHB.02.02.00-SE-0056/16-00 agreement from 2017-01-17