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Measurement report: Spatial variations in ionic chemistry and water-stable isotopes in the snowpack on glaciers across Svalbard during the 2015–2016 snow accumulation season
PublicationThe Svalbard archipelago, located at the Arctic sea-ice edge between 74 and 81∘ N, is ∼60 % covered by glaciers. The region experiences rapid variations in atmospheric flow during the snow season (from late September to May) and can be affected by air advected from both lower and higher latitudes, which likely impact the chemical composition of snowfall. While long-term changes in Svalbard snow chemistry have been documented in...
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Raport z badań podczas próbnego obciążenia konstrukcji odciążającej typu mostowego w km 20,151 LK nr 353 w m. Pobiedziska
PublicationW pracy przedstawiono metodykę pomiarów i wyniki badań podczas próbnego konstrukcji odciążającej typu mostowego w km 20,151 LK nr 353 w m. Pobiedziska. Sformułowano wnioski i wydano pinie dotyczącą rzeczywistej pracy konstrukcji i warunków dalszej eksploatacji obiektu.
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Raport z badań podczas próbnego obciążenia wiaduktu kolejowego w km 165,161 LK nr 14 - konstrukcja w torze nr 1
PublicationW pracy przedstawiono metodykę pomiarów i wyniki badań podczas próbnego obciążenia wiaduktu kolejowego w km 165,161 LK nr 14.. Sformułowano wnioski i wydano pinie dotyczącą rzeczywistej pracy konstrukcji i warunków dalszej eksploatacji obiektu.
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Recurrent bowel-blood translocations of Escherichia coli with the unique virulence characteristics over three-year period in the patient with acute myeloid leukaemia – case report
PublicationIn patients with haematological malignancies, the bowel remains the main source of Escherichia coli bloodstream infections. We present the clinical example of recurrent bowel-blood translocations of E. coli with the unique virulence characteristics in a 55-year-old male with the diagnosis of acute myeloid leukaemia. The virulent factors profile of examined strains confirmed that the co-existence of genes papC, sfa, usp and cnf1,...
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Deformation of the Titanium Plate Stabilizing the Lateral Ankle Fracture Due to Its Overloading in Case of the Young, Obese Patient: Case Report Including the Biomechanical Analysis
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Actual problems of dyslipidaemia treatment in Poland — 2nd Declaration of Sopot. Experts’ Group Consensus endorsed by the Polish Cardiac Society Working Group on Cardiovascular Pharmacotherapy
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Ekspertyza w celu ustalenia utraty właściwości powłoki epoksydowej zastosowanej na konstrukcji stalowej - Raport z badań zleconych - Numer umowy: 031008
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Time versus space trade-offs for randezvous in trees
PublicationTwo identical (anonymous) mobile agents start from arbitrary nodes of an unknown tree and have to meet at some node. Agents move in synchronous rounds: in each round an agent can either stay at the current node or move to one of its neighbors. We consider deterministic algorithms for this rendezvous task. The main result of this paper is a tight trade-off between the optimal time of completing rendezvous and the size of memory...
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A facile structural manipulation strategy to prepare ultra-strong, super-tough, and thermally stable polylactide/nucleating agent composites
PublicationPolylactide (PLA) is a biodegradable thermoplastic widely used in diferent felds, but it should be adequately modifed considering high-performance applications. However, the current processes for developing PLA materials achieve high strength at the expense of toughness or ductility of the materials. Therefore, there is need to develop new strategies for generation of PLA materials with high strength, great toughness, good ductility,...
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Formation of chlorinated breakdown products during degradation of sunscreen agent, 2-ethylhexyl-4-methoxycinnamate in the presence of sodium hypochlorite
PublicationIn this study, a new degradation path of sunscreen active ingredient, 2-ethylhexyl-4-methoxycinnamate (EHMC) and 4-methoxycinnamic acid (MCA) in the presence of sodium hypochlorite (NaOCl), was discussed. The reaction products were detected using gas chromatography–mass spectrometry (GC-MS). Since HOCl treatment leads to more polar products than EHMC, application of polar extracting agents, dichloromethane and ethyl acetate/n-hexane...
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Phytotoxic Activity of Metabolites Isolated from Rutstroemia sp.n., the Causal Agent of Bleach Blonde Syndrome on Cheatgrass (Bromus tectorum)
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Pre-clinical evaluation of 1-nitroacridine derived chemotherapeutic agent that has preferential cytotoxic activity towards prostate cancer
PublicationPraca zawiera wyniki badań przedklinicznych pochodnej 1-nitroakrydyny C-1748 wobec komórek ludzkiego raka prostaty CaP in vitro, jak i przeszczepialnego na zwierzęta. W oparciu o fosforylację histonu H2AX jako markera podwójnych cięć DNA wykazano, że C-1748 jest bardziej aktywny w komórkach CaP niż HL60. Zidentyfikowano poza tym receptor androgenny (AR) jako cel molekularny badanego związku. W doświadczeniach na zwierzętach stwierdzono...
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Enhanced Activity and Sustained Release of Protocatechuic Acid, a Natural Antibacterial Agent, from Hybrid Nanoformulations with Zinc Oxide Nanoparticles
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Imidazoacridinone antitumor agent C-1311 as a selective mechanism- based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.
Publication5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311), a promising antitumor agent that is also active against autoimmune diseases, was determined to be a selective inhibitor of the cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1311 might modulate the effectiveness of other drugs used in multidrug therapy. The present work aimed to identify the mechanism of the observed C-1311-mediated inactivation of CYP1A2...
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Thermo-Chemical Decomposition Study of Polyurethane Elastomer Through Glycerolysis Route with Using Crude and Refined Glycerine as a Transesterification Agent
PublicationDue to the increasing amount of polyurethane waste, chemical recycling of these materials is a topic of growing interest for many researchers. The primary pur- pose of polyurethane feedstock recycling is to recover the starting polyol. In this study glycerolysis using glycerine from two sources and two purity grades is proposed as a method of chemical recycling. The main effort of this paper focuses on the employment of commercial...
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The influence of the choice of the cross linking agent on the electrical properties of polyethyleneimine based humidity sensors. Optoelectronic and Electronic Sensors V.
PublicationW pracy przedstawiono wyniki badań impedancyjnych polimerowych czujników wilgotności.Czujniki zostały wykonane z chemicznie modyfikowane polietylenoiminy. Przedstawiono wpływ środków sieciujących na właściwości czujników.
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Consolidating logs in varying formats into a structured repository = konsolidacja logów w zmiennych formatach do strukturalnego repozytorium
PublicationDuring multi-agent systems development, testing and re- search, possibly voluminous logs are created at distributed agent loca-tions. These logs describe individual agents behavior and state changes. To get the complete picture of the multi-agent system working, it is necessary to consolidate these logs and to store them in a format appropriate for diverse analyzes. Specic issues arise during consolidation if the log formats are...
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Integrated geodetic and hydrographic measurements of the yacht port for nautical charts and dynamic spatial presentation
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The use of a simulation model to analyze the impact of heavy transport generated by the port to the city traffic.
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Four-Port Circulator Using Reduced Ground Plane Ferrite Coupled Line Junction
PublicationIn this paper the investigations of four-port circula-tor using longitudinally magnetized ferrite coupled line section are presented. The device is designed by cascading ferrite section with magic-T junction ensuring its even and odd mode excitation. The scattering parameters of ferrite coupled line junction are calculated using own software and verified with the use of commercial software. The even and odd excitation of ferrite...
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Mieszkanie w drzewostanie. Habitat Trzeciej Fali EXPO 2010 Wrocław. Habitat 2002.
Publication''Mieszkanie w drzewostanie'' to próba odpowiedzi na potrzeby miasta Wrocławia w zakresie zaplecza mieszkaniowego dla planowanej w 2010 roku wystawy EXPO.Jest to propozycja stworzenia najbardziej naturalnego i przyjaznego środowiska łączącego w jednym miejscu funkcje: mieszkania, pracy i rekreacje.
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GDP growth in Iran
Open Research DataThe economy of the Islamic Republic of Iran is one of the fastest growing in the Middle East. Iran should not only be associated with crude oil industry but also other areas of the economy. The sanctions that hindered oil exports from Iran meant that the authorities had to take measures to increase exports of other products. There was an increase in...
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Morphology Regulation Mechanism and Enhancement of Photocatalytic Performance of BiOX (X = Cl, Br, I) via Mannitol-Assisted Synthesis
PublicationBiOX (X = Cl, Br, I) photocatalysts with dominant (110) facets were synthesized via a mannitol-assisted solvothermal method. This is the first report on the exposed (110) facets-, size-, and defects-controlled synthesis of BiOX achieved by solvothermal synthesis with mannitol. This polyol alcohol acted simultaneously as a solvent, capping agent, and/or soft template. The mannitol concentration on the new photocatalysts morphology...
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Reputacja i zaufanie w systemach teleinformatycznych z podmiotami anonimowymi podejście dynamiczne
PublicationAbstrakcją współczesnego systemu teleinformatycznego jest system wieloagentowy z autonomicznymi, racjonalnymi i wirtualnie anonimowymi agentami wchodzącymi we wzajemne interakcje dla wymiany usług. W referacie uzasadniono konieczność projektowania dla niego podsystemu budowy reputacji i zaufania oraz odpowiednich analiz w ujęciu dynamicznym. Dokonano przeglądu motywacyjnie zgodnych mechanizmów uczciwego raportowania usług oraz...
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A new phosphonium calix[4]arene for selective anion recognition: synthesis and studies in solution and in ion selective electrodes
PublicationZaprezentowana została synteza i charakteryzacja tetra (trifenylofosfoniowego) p-tert-butylkaliks[4]arenu 2. Oddziaływania z anionami były badane z użyciem (1)H oraz (31)P NMR i spektrofotometrii absorpcyjnej UV. Badania wykazały oddziaływania z anionami: CLO4-, I-, oraz SCN-. Selektywność jonoforu 2 badano również w membranowych elektrodach jonoselektywnych (ISE) PCV/o-NPOE. Elektroda zawierająca związek 2 generuje odpowiedź potencjometryczną...
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Mild X-linked Alport syndrome due to the COL4A5 G624D variant originating in the Middle Ages is predominant in Central/East Europe and causes kidney failure in midlife
PublicationA study of 269 children enrolled into a National Registry for children with persistent glomerular hematuria identified 131 individuals with genetically confirmed X-linked Alport Syndrome. A single variant c.1871G>A p.Gly624Asp (G624D) in COL4A5 was predominant and accounted for 39% of Xlinked Alport Syndrome in unrelated Polish families (44 of 113). To evaluate its origins, the genetic variation in a 2.79 Mb segment encompassing...
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Mild X-linked Alport syndrome due to the COL4A5 G624D variant originating in the Middle Ages is predominant in Central/East Europe and causes kidney failure in midlife
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Future of nature, our future. A preregistered report on future time perspective, social value orientation, and pro-environmental outcomes based on data from Poland and Sweden
PublicationIntroduction: The objective of the study was to examine the role of social value orientation and future time perspective to account for individual differences in pro-environmental behaviors, intentions, and opinions about the link between pro-environmental action and pandemic threat (three separate models) in Polish and Swedish samples expected to differ in rate of pro-environmental behaviors (higher in Sweden). We hypothesized...
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Report for the Short Term Scientific Mission within COST Action FP1101: development of the in-field sensor for estimation of fracture toughness and shear strength by measuring cutting forces
PublicationKnowledge on the fracture properties of materials is essential to assure structural integrity and proper design of mechanical connections in timber constructions. Measurement of this property is, however, a very challenging task. The linear fracture mechanics is usually used for its assessment assisted with experimental data acquired by means of various techniques, usually of destructive nature. The cutting force is an energetic...
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Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems.
PublicationBackground Among the studied antitumor acridinone derivatives developed in our laboratory, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) and 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) exhibited cytotoxic and antitumor properties against several cancer types and were selected to be evaluated in preclinical and early-phase clinical trials. In the present work, we investigated the impact of C-1305...
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Reactive metabolites of acridinone antitumor agents, C-1311 and C-1305, are trapped within the active site of CYP1A2 and CYP3A4, causing irreversible enzymes inactivation
PublicationZwiązki C-1305 i C-1311, zsyntetyzowane w Katedrze Technologii Leków i Biochemii, wykazują najsilniejsze właściwości przeciwnowotworowe wśród pochodnych, odpowiednio, triazolo- i imidazoakrydonu. Obecnie prowadzone są badania mające na celu określenie biochemicznego mechanizmu działania, jak również potencjalnych szlaków biotransformacji C-1305 i C-1311.W bieżącym etapie podjęto próbę określenia mechanizmu obserwowanej inhibicji...
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Acridinone antitumor agents: C-1311, C-1330 and C-1305 are metabolized by flavin-containing monooxygenase isoenzymes: FMO1, FMO3 and FMO5 with different rates
PublicationRekombinantowe ludzkie monooksygenazy flawinowe: FMO1, FMO3, FMO5 indukują przemiany metaboliczne wybranych do badań pochodnych akrydonu. Biotransformacja związków C-1311, C-1330 i C-1305 przez FMO prowadzi do jednego produktu o strukturze N-tlenku. Wyniki badań wskazują, że najbardziej podatna na przemiany wobec FMO jest pochodna triazoloakrydonu C-1305. Wydaje się więc, że głównymi enzymami pierwszej fazy przemian metabolicznych...
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Down-regulation of DNA topoisomerase IIalpha leads to prolonged cell cycle transit in G2 and early M phases and increased survival to microtubule-interacting agents
PublicationInhibitory polimeryzacji mikrotubul wykazują preferencyjną toksyczność wobec komórek mitotycznych. W ramach tego projektu badaliśmy czy oporność komórek ludzkich białaczek na inhibitor mikrotubul, winkrystynę, prowadzi do zmian w regulacji progresji cyklu komórkowego. Nasze wyniki wskazują, że oporności na winkrystynę towarzyszą zmiany w długości fazy G2 i M w nieobecności i obecności inhibitora wrzeciona mitotycznego, nokodazolu....
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Mirosław Wołoszyn dr hab. inż.
PeopleMirosław Wołoszyn born in 1963 in Gdynia. He received the M.Sc. degree in 1987, the Ph.D. degree in 1997, and the D.Sc. (‘habilitation’) degree in 2013, all from the Gdańsk University of Technology. Since 1987 he has been with the above university, where he is currently Associate Professor of Electrical Engineering. His research interests include localization and identification of ferromagnetic objects by means of the magnetometric...
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Wydawnictwo Agencji Bezpieczeństwa Wewnętrznego
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Ts2631 Endolysin from the Extremophilic Thermus scotoductus Bacteriophage vB_Tsc2631 as an Antimicrobial Agent against Gram-Negative Multidrug-Resistant Bacteria
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Capping Agent-Dependent Toxicity and Antimicrobial Activity of Silver Nanoparticles: An In Vitro Study. Concerns about Potential Application in Dental Practice
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Ts2631 Endolysin from the Extremophilic Thermus scotoductus Bacteriophage vB_Tsc2631 as an Antimicrobial Agent against Gram-Negative Multidrug-Resistant Bacteria
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Efficacy and safety of idelalisib in patients with relapsed, rituximab- and alkylating agent-refractory follicular lymphoma: a subgroup analysis of a phase 2 study
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Implementation of spatial information for monitoring and analysis of the area around the port using laser scanning techniques
PublicationNowadays, maritime infrastructure is heavily exploited, which requires monitoring. The article presents the implementation of spatial information which are point clouds for monitoring and analysis of the area around the port (buildings and wharves). For this study, point clouds coming from terrestrial (TLS) and airborne laser scanning (ALS), each of them having different accuracy, were used. An important part of the analysis was...
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Seasonal changes in organotin compounds in water and sediment samples from the semi-closed Port of Gdynia
PublicationThe effect of seasonal changes on the distribution of organotin compounds (OTC) in the sediments and seawaterfrom the docks of the Port of Gdynia was investigated. Sediment and seawater samples were collectedfrom four industrial docks in February (winter) and June (summer) in 2009. The samples were analyzed forbutyltin, phenyltin, octyltin, and tricyclohexyltin (total of 9 OTC derivatives). The fine fraction (b0.063 mm)accumulated...
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Lower-rim-substituted tert-butylcalix[4]arenes. Part IX: one-pot synthesis of calix[4]arene-hydroxamates and calix[4]arene-amides
PublicationZaprezentowano prostą metodę selektywnej acylacji podstawionych i niepodstawionych hydroksyloamin za pomocą di i tetra podstawionych kaliks{4]aren-kwasów. Pokazano pierwszą strukturę krystalograficzną kaliks-hydroksyamidu.
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Raport z badań podczas próbnego obciążenia wiaduktu drogowego WD-6 nad obwodnicą Kościerzyny w ciągu DK 20, w ciągu DG 187088G
PublicationW pracy przedstawiono metodykę pomiarów i wyniki badań statycznych i dynamicznych podczas próbnego obciążenia wiaduktu drogowego WD-6 nad obwodnicą Kościerzyny w ciągu DK 20, w ciągu DG 187088G. Sformułowano wnioski dotyczące rzeczywistej pracy konstrukcji i warunków dalszej eksploatacji obiektu.
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Novel 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives as potent anticancer agents – Synthesis, molecular structure, QSAR studies and metabolic stability
PublicationA series of new 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cancer MCF-7. The obtained results indicated that these compounds display prominent cytotoxic effect. The best anticancer properties have been observed for derivatives...
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Contribution of UDP-glucuronosyltransferases (UGTs) in metabolism of acridinone antitumor agents, C-1311, C-1305, and their less active structural analogues, C-1330 and C-1299
PublicationCelem prowadzonych badań było określenie roli UDP-glukuronylotransferaz, uważanych za najważniejsze enzymy detoksykujące, w metabolizmie pochodnych imidazo- i triazoloakrydonu. Wykazano, że najbardziej aktywne przeciwnowotworowo związki z obu grup, tj. C-1311 i C-1305 są transformowane do O-glukuronidów, w przeciwieństwie do ich metoksylowych analogów, odpowiednio związku C-1330 i C-1299. Analiza składu mieszanin reakcyjnych zawierających...
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Most Uniwersytecki w Bydgoszczy. Teoretyczne podstawy decyzji o wyłączeniu obiektu z ruchu
PublicationW artykule przedstawiono ogólny opis konstrukcji podwieszonego mostu Uniwersyteckiego nad rzeką Brdą w Bydgoszczy. Opisano również prace eksperckie dotyczące oceny nośności konstrukcji. W wyniku badań i analiz obiekt został uznany za niebezpieczny dla użytkowników i wycofany z eksploatacji. W artykule przedstawiono zasadnicze przesłanki, które doprowadziły zarządcę do podjęcia głównych decyzji i postępowania naprawczego.
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ENISA Study: Challenges in Securing Industrial Control Systems
PublicationIn 2011, the European Network and Information Security Agency (ENISA) conducted a study in the domain of Industrial Control Systems (ICS). Its objective was to obtain the current view on the ICS protectionprimarily in Europe but also in the international context. The portrait' included threats, risks, and challenges in the area of ICS protection as well as national, pan European, and international initiatives on ICS security. The...
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IAVI report : newsletter on international AIDS vaccine research.
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USDA Forest Service - General Technical Report PNW
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