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Search results for: VIRAL INFECTION
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Thermodynamics and kinetics of amphotericin B self-association in aqueous solution characterized in molecular detail
PublicationAmphotericin B (AmB) is a potent but toxic drug commonly used to treat systemic mycoses. Its efficiency as a therapeutic agent depends on its ability to discriminate between mammalian and fungal cell membranes. The association of AmB monomers in an aqueous environment plays an important role in drug selectivity, as oligomers formed prior to membrane insertion – presumably dimers – are believed to act differently on fungal (ergosterol-rich)...
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Determinants of the primary stability of cementless acetabular cup implants: A 3D finite element study
PublicationPrimary stability of cementless implants is crucial for the surgical success and long–term stability. However, primary stability is difficult to quantify in vivo and the biomechanical phenomena occurring during the press–fit insertion of an acetabular cup (AC) implant are still poorly understood. The aim of this study is to investigate the influence of the cortical and trabecular bone Young's moduli Ec and Et, the interference...
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Rapid Assays for Specific Detection of Fungi of Scopulariopsis and Microascus Genera and Scopulariopsis brevicaulis Species
PublicationPurpose Fungi of Scopulariopsis and Microascus genera cause a wide range of infections, with S. brevicaulis being the most prevalent aetiological agent of mould onychomycosis. Proper identification of these pathogens requires sporulating culture, which considerably delays the diagnosis. So far, sequencing of rDNA regions of clinical isolates has produced ambiguous results due to the lack of reference sequences in publicly available...
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USE OF LANGMUIR PROBE IN DIESEL ENGINE DIAGNOSTIC RESEARCH Part I MEASUREMENT TECHNOLOGY. - Part 1 : MEASUREMENT TECHNOLOGY
PublicationIn the paper, the basic assumptions of diesel engine cylinder system's diagnosing method, based on observation of emerging and moving electric charges of ionized gas in the combustion workspaces, using Langmuir's probe. In the first part of the paper, only the technology of the measurement and results of the preliminary diagnostic tests of laboratory engine Farymann Diesel D10 were presented. The primary purpose of the research...
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Theory and implementation of a virtualisation level Future Internet defence in depth architecture
PublicationAn EU Future Internet Engineering project currently underway in Poland defines three parallel internets (PIs). The emerging IIP system (IIPS, abbreviating the project’s Polish name), has a four-level architecture, with level 2 responsible for creation of virtual resources of the PIs. This paper proposes a three-tier security architecture to address level 2 threats of unauthorised traffic injection and IIPS traffic manipulation...
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PCR-RFLP assays for species-specific identification of fungi belonging to Scopulariopsis and related genera
PublicationFungi of the Scopulariopsis genus, commonly found in the environment, are opportunistic pathogens that can cause various types of human infections. So far, no efficient molecular method has been developed for species differentiation among Scopulariopsis and related genera. In order to advance this field, we have evaluated performance of polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assays, based...
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Experimental research on a hydrodynamic thrust bearing with hydrostatic lift pockets: Influence of lubrication modes on bearing performance
PublicationThe aim of the study is to investigate the performance of a thrust bearing equipped with hydrostatic lift pockets under different lubrication modes. Three types of flat land bearing lubrication modes are studied experimentally: hydrostatic lubrication (HS; forced oil injection to the pockets), hybrid lubrication (HS + HD; hydrostatic lubrication combined with the external forced bearing oil supply) and hydrodynamic lubrication...
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Electrophoretically Deposited Chitosan/Eudragit E 100/AgNPs Composite Coatings on Titanium Substrate as a Silver Release System
PublicationDue to the possibility of bacterial infections occurring around peri-implant tissues, it is necessary to provide implant coatings that release antibacterial substances. The scientific goal of this paper was to produce by electrophoretic deposition (EPD) a smart, chitosan/Eudragit E 100/silver nanoparticles (chit/EE100/AgNPs) composite coating on the surface of titanium grade 2 using different deposition parameters, such as the...
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Genotyping Techniques for Determining the Diversity of Microorganisms
PublicationTyping of microbial pathogens, or identifying bacteria at the strain level, is particularly important for diagnosis, treatment, and epidemiological surveillance of bacterial infections. This is especially the case for bacteria exhibiting high levels of antibiotic resistance or virulence, and those involved in nosocomial or pandemic infections. Strain typing also has applications in studying bacterial population dynamics. The part...
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Consequences of lysine auxotrophy for Candida albicans adherence and biofilm formation
PublicationA number of factors are known to be involved in Candida albicans virulence, although biofilm development on the surfaces of indwelling medical devices is considered to promote superficial or systemic disease. Based on previously reported up-regulation of saccharopine and acetyllysine in biofilm cells and activation of the lysine biosynthesis/degradation pathway, we investigated...
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Photonic sensor to detect rapid changes in CRP levels
PublicationOne of the most important biomarkers used to determine inflammation is C-reactive protein (CRP). Its level, when it is within the range that does not define inflammation, informs about the risk of cardiovascular events. If the norm is exceeded and inflammation is detected in the body, CRP level can increase 1000 times within a few hours. The type of infection can also be determined based on the level of elevated CRP. All this makes...
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Antibacterial evaluation of bioactive modifiers of bone cements: antibiotics, nanometals and chitosan
PublicationModern biomaterials in addition to their basic tasks, can serve as carriers of active substance. The release of a bioactive particles allows to locally fight infection or its prevent it. Bone cements additionally to their basic applications in orthopedic surgery can also serve to deliver locally active substances. Currently, only antibiotics are routinely used as modifiers for bone cements. Bioactive bone cements constitute...
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Slow-wave fractal-shaped compact microstrip resonant cell
PublicationA novel fractal-shaped compact microstrip resonant cell (CMRC) featuring a strong slow-wave effect has been presented. Its vital usefulness in the process of microstrip line miniaturisation has been proved and experimentally validated on the basis of a compact 3-dB branch-line coupler illustrating the possibilities of the approach. A prototype example structure has been designed to mirror the characteristics of a conventional device,...
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Acoustic journal bearing - A search for adequate configuration
PublicationClassical non-contact bearings are already used in a number of specialist applications but there are somespecialist areas where they cannot be used for variety of reasons and acoustic sliding bearings could be an alternative. The paper presents the quest for a configuration of an acoustic journal bearing and shows that the overall shape of the bearing and its geometry are of a vital importance for the load capacity oft he bearing....
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Virtual Engineering Object / Virtual Engineering Process: A specialized form of Cyber Physical System for Industrie 4.0
PublicationThis paper reviews the theories, parallels and variances between Virtual Engineering Object (VEO) / Virtual Engineering Process (VEP) and Cyber Physical System (CPS). VEO and VEP is an experience based knowledge representation of engineering objects and processes respectively. Cyber–physical systems (CPSs) are the next generation of engineered systems in which computing, communication, and control technologies are tightly integrated....
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Slow-wave resonant structures in branch-line coupler miniaturization: a case study
PublicationA case study of novel slow-wave resonant structures dedicated to efficient microstrip branch-line coupler size reduction has been presented. A compact 3-dB branch-line coupler has been designed to mimic the performance of its conventional counterpart, simultaneously demonstrating a substantial 88% surface area reduction. The vital usefulness of the approach in the process of microstrip line abbreviation has been experimentally...
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Big Data in Regenerative Urban Design
PublicationWhy the use of Big Data in regenerative planning matters? The aim of this chapter is to study under what conditions Big Data can be integrated into regenerative design and sustainable planning? Authors seek to answer how – when related to the ecosystem and to human activities – Big Data can be used to: • both shape policies that support the development of regenerative human settlements, • support restorative design for practitioners...
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The UK's banking system as financial hub for Islamic banking
PublicationThis paper examines the phenomenon of London as "the Islamic banking hub". It contends that London has become not only an international centre for Islamic finance, but also that there is big interest and demand for Islamic banking products. The authors are also positive that Islamic banking may be a certain solution for the problems that Europe has been suffering since 2007 when the global debt crisis started. Our intention is...
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Electrochemical Activity of Electrode Material Consisting of Porous Copper and Silica Aerogel
PublicationElectrochemically obtained copper was combined with silica aerogel (SiO2ag). Obtained composite (SiO2@Cu/CuxOy) was tested as an electrode in contact with LiPF6 in EC/DMC electrolyte. The electrochemical measurements showed the presence of complex redox couple activities of SiO2@Cu/CuxOy. This experiment was employed to help in understanding the carbon role used as an electric contact for silica in Li-Ion batteries and clarify...
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A predictive estimation based control strategy for a quasi-resonant dc-link inverter
PublicationIn this paper the predictive estimation based control strategy for a quasi-resonant dc link inverter (PQRDCLI) is developed. Instead of direct measurement of dc link input inverter current – its estimation with one step prediction is applied. The PQRDCLI fed induction motor, controlled with a predictive current estimation stabilized inverter output voltage slopes independently of load. Moreover, reduction of overvoltage spikes...
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Law regulation in Poland related to biofuels
PublicationThe situation in the area of using biofuels in transport mostly the law aspects was presented and discussed. In Poland there are various legal issues with biofuel production, examination and use. These include among the others: quality inspection, production costs and market prices of biofuels, forms of public and legal service for biofuel producers or programs of biofuels promotion. In order to popularise biofuels it is significant...
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Motor bearing diagnostics performed by means of laser vibrometer
PublicationDamage of bearings is the most common cause of failures in squirrel-cage induction motors. That is why the issues connected with diagnostics of bearings are so important. The equipment employed for bearing diagnostics usually makes use of vibrations as the criterion for technical condition of the bearings. This paper presents exemplary results of the research conducted on bearings with artificially introduced damage. A scanning...
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Human capital quality indicators for measuring regional knowledge economy advances
PublicationBuilding Knowledge Economies (KE) is a long-term process. However, civilizational and technological changes together with EU's Lisbon Strategy help in creating solutions that may speed up economical growth of countries and their regions. This seems to be a very important issue, as during last two centuries history shown, that wisdom and human invention and innovation are the most important factor driving economical growth. In this...
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EMC disturbances in connection of driving system
PublicationIt is known the steep voltage changes caused by IGBT frequency inverters may cause some electromagnetic problems in driving system. Special dU/dt type as well as sinusoidal filters are used in order to limit the level of the disturbances. The paper presents investigation results of EMC disturbances in inverter supplied induction motor. Experiments have proved that disturbances in current connection differ essentially. Important...
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Power Hardware-in-the-Loop Approach In Power System Development
PublicationThe main objective of the research is the verification of the Power Hardware-In-The-Loop (PHIL) approach in power system analysis and design. The premise of the article is that using PHIL approach the performance of the power system in steady and transient state conditions can be analysed in real power system conditions. Models of induction machine were developed and real time simulations were performed. Simulation variables were...
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Subharmonic solutions for a class of Lagrangian systems
PublicationWe prove that second order Hamiltonian systems with a potential of class C1, periodic in time and superquadratic at infinity with respect to the space variable have subharmonic solutions. Our intention is to generalise a result on subharmonics for Hamiltonian systems with a potential satisfying the global Ambrosetti-Rabinowitz condition from [P. H. Rabinowitz, Proc. Roy. Soc. Edinburgh Sect. A, 114 (1990), 33-38]. Indeed, we weaken...
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Analytical Expression for the Time-Domain Discrete Green's Function of a Plane Wave Propagating in the 2-D FDTD Grid
PublicationIn this letter, a new closed-form expression for the time-domain discrete Green's function (DGF) of a plane wave propagating in the 2-D finite-difference time-domain (FDTD) grid is derived. For the sake of its verification, the time-domain implementation of the analytic field propagator (AFP) technique was developed for the plane wave injection in 2-D total-field/scattered-field (TFSF) FDTD simulations. Such an implementation of...
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A conceptual design and numerical analysis of the mixerless urea-SCR system
PublicationIn the present study, an innovative design of the urea-selective catalytic reduction (SCR) system without conventional mixing elements was developed. The aim was to obtain a high degree of urea decomposition, and uniform ammonia distribution at the inlet to the catalyst, while minimising the liquid film deposition and keeping the compact design. The concept of the design was based on creating high turbulences and elongating...
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Cuticular lipids of insects as potential biofungicides
PublicationThe term ''lipids'' refers to fatty acids, their derivatives and substances related with them biochemically or by the functions in the body. Lipids include compounds with different chemical structure. There are lipids with structures based on long-chain carboxylic acids and their direct derivatives, namely: fatty acids, alkanes, some alkenes, aldehydes and long chain alcohols and their derivatives (esters). The variety of lipid...
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Distillation cleanup preceded gc determination of short-chain monocarboxylic acids in aqueous and solid samples of wastewater origin = Oznaczanie krótkołańcuchowych kwasów monokarboksylowych w próbkach wodnych i stałych pochodzących z oczyszczalni ścieków z wykorzystaniem chromatografii gazowej poprzedzonej destylacją
PublicationShort-chain monocarboxylic acids (SCMAs) (C2-C5) formed in the process of aerobic biodegradation of larger organic molecules should often be monitored to optimize wastewater biological treatment and study the processes of converting organic waste matter into methane, etc. Gas chromatography (GC) seems a method of choice for such a task. Majority of samples require clean up before they can be injected into GC system. In this work...
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OPTIMALIZATION OF SORBENT FEEDING IN THE DRY METHOD OF FLUE GAS DESULFURIZATION
PublicationThe swiftly developing sea transport contributes to a considerable increase of fuel usage in the international shipping, which results in the escalation of toxic compounds emitted into the atmosphere. It is followed by the constantly heightened requirements limiting those emissions. In the case of sulfur oxide emission, inside of SECA (Sulfur Emission Control Area), the maximum content of sulfur in the shipping fuels used on the...
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Analysis of the macrostructure of the fuel spray atomized with marine engine injector
PublicationOne of the main problem influencing the combustion process in the cylinder of the marine engine is an fuel spray phenomena. The parameters describing the shape of the fuel spray are named macro parameters. This article presents the research results of the macrostructure parameters of the fuel spray atomized with the marine engine injector. The research were carried out by optical visualization measurement method of Mie scattering....
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Review on Current Status of Echinocandins Use
PublicationFungal infections are rising all over the world every year. There are only five medical compound classes for treatment: triazoles, echinocandins, polyenes, flucytosine and allylamine. Currently, echinocandins are the most important compounds, because of their wide activity spectrum and much lower sides effects that may occur during therapy with other drugs. Echinocandins are secondary metabolites of fungi, which can inhibit the...
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Distinction of clenbuterol intake from drug or contaminated food of animal origin in a controlled administration trial – the potential of enantiomeric separation for doping control analysis
PublicationThe differentiation of clenbuterol abuse and unintentional ingestion by contaminated meat is crucial with respect to the valuation of an adverse analytical finding in human sports doping control. The proportion of the two enantiomers of clenbuterol may serve as potential discriminating parameter. For the determination of the individual enantiomers, specific methods were developed and validated for the different matrices under investigation...
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The effect of social media communication on consumer perceptions of brands
PublicationResearchers and brand managers have limited understanding of the effects social media communication has on how consumers perceive brands. We investigated 504 Facebook users in order to observe the impact of firm-created and user-generated (UG) social media communication on brand equity (BE), brand attitude (BA) and purchase intention (PI) by using a standardized online survey throughout Poland. To test the conceptual model, we...
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Genotoxic properties of glucosinolates and isothiocyanates present in Brassica vegetables
PublicationThe bioactive phytochemicals found in Brassica vegetables, in this number glucosinolates (GLS), as well as products of their degradation such as isothiocyanates (ITC) and indoles, are regarded as the most promising chemopreventive compounds. These secondary metabolites display stron antibiological activity and constitute defence system preventing the development of agrophages attacking Brassica plants. Such properties suggest...
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Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2
PublicationWe combine molecular dynamics, statistical mechanics, and hybrid quantum mechanics/molecular mechanics simulations to describe mechanistically the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp). Our study analyzes the binding mode of both natural triphosphate substrates as well as remdesivir triphosphate (the active form of drug), which is bound preferentially over ATP by RdRp while...
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Other placental disorders - Female, 33 - Tissue image [5310730015849971]
Open Research DataThis is the histopathological image of PLACENTA tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Other placental disorders - Female, 33 - Tissue image [5310730015842621]
Open Research DataThis is the histopathological image of PLACENTA tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Other placental disorders - Female, 33 - Tissue image [5310730015844041]
Open Research DataThis is the histopathological image of PLACENTA tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Assessment of Road Restraint Systems in Polish Conditions
PublicationKey to understanding the needs and tools of road infrastructure management is identifying the hazards and their sources involved in having no or faulty road restraint systems. Clarity is also needed on why the systems are wrongly designed, constructed, built and operated. To ensure that the problem is adequately understood, research and site observations were conducted and...
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SELECTION OF DIAGNOSTIC FUNCTIONS IN A WHEELED TRACTOR
PublicationIn a classical approach to damage diagnosis, the technical condition of an analyzed machine is identified based on the measured symptoms, such as performance, thermal state or vibration parameters. In wheeled tractor the fundamental importance has monitoring and diagnostics during exploitation concerning technical inspection and fault element localizations. The main functions of a diagnostic system are: monitoring tractor components...
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Syntheses and structures of the first terminal phosphanylphosphido complexes of molybdenum(IV)
PublicationThe reactions of R2P-P(SiMe3)Li (R = tBu, iPr2N) with [Cp2MoCl2] yield terminal phosphanylphosphido complexes formally via the insertion of the phosphinidene P-atom into the C - H bond of a cyclopentadienyl ring and the migration of the hydrogen atom or SiMe3 moiety to the molybdenum centre. Solid state structures of [Cp(C5H4P-PtBu2)MoH], [Cp(C5H4P-PtBu2)Mo(SiMe3)] and [Cp{C5H4P-P(NiPr2)2}Mo(SiMe3)] were established by single crystal...
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The Relationship between Gene Activity and Nitrous Oxide Production during Nitrification in Activated Sludge Systems
PublicationNitrite is an important factor which inhibits the first stage of the nitrification, the effect is stronger with the decrease of the DO concentrations. NO2- presence at concentration above 15 mg N – NO2 in the aeration tanks stimulates N2O production regardless of the DO concentration. The significant nirS gene induction, observed especially during the experiments with the nitrite addition indicates that N2O production is basically...
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Parametrical 3D model of an asynchronous motor - AutoCAD application.
PublicationA computer program for automatic drawing of 3D models of squirrel-cage induction motors is presented in this paper. The created model of a machine is of parametrical nature, which means that the user defines geometry of particular elements (shaft, stator core, bearing, windings etc.) on the basis dimensions and some other parameters e.g. type of bearing, kind of winding, number of slots. This program is useful for 3D modelling...
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Non-Destructive Assessment of Masonry Pillars using Ultrasonic Tomography
PublicationIn this paper, a condition assessment of masonry pillars is presented. Non-destructive tests were performed on an intact pillar as well as three pillars with internal inclusions in the form of a hole, a steel bar grouted by gypsum mortar, and a steel bar grouted by cement mortar. The inspection utilized ultrasonic stress waves and the reconstruction of the velocity distribution was performed by means of computed tomography. The...
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Possibility of Fault Detection in Sensorless Electric Drives
PublicationThe work presents a fault detection method for an induction motor drive system with inverter output filter. This approach make use of a load torque state observer, which complete structure is presented along with the used control structure. Moreover, the demonstrated drive system operates without rotor speed measurement in conjunction with the multiscalar control. The verification of the demonstrated idea was performed on an experimental...
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A Review of Reduction Methods of Impact of Common-Mode Voltage on Electric Drives.
PublicationIn this survey paper, typical solutions that focus on the reduction in negative effects resulting from the common-mode voltage influence in AC motor drive applications are re-examined. The critical effectiveness evaluation of the considered methods is based on experimental results of tests performed in a laboratory setup with an induction machine fed by an inverter. The capacity of a common-mode voltage level reduction and voltage...
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Use of Escherichia coli Nissle 1917 producing recombinant colicins for treatment of IBD patients
PublicationPatients with Crohn’s Disease and ulcerative colitis infected with Adherent-Invasive Escherichia coli strains constitute the largest group among Inflammatory Bowel Disease subjects, when taking into account all known etiological agents of the disease. A possible link between these pathogenic bacteria and inflammation process has gained the confidence in recently published papers. Observed enteric neuroglial cells apoptosis and...
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Corrosion degradation of spacers – examination of changes in bone cement coating.
PublicationSpacer is a special implant used at the time of infection after endoprosthetic surgery. It consists of a metal core and bone cement coating with an antibiotic. In the human body spacers are exposed to degradation processes. This paper looks at the effect of corrosion on spacers. Electrochemical corrosion tests were performer on titanium pins with bone cement coating in two solutions: Ringer’s solution and artificial...