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Wyniki wyszukiwania dla: LYME DISEASE, BORRELIA BURGDORFERI SENSU LATO, EPITOPE MAPPING, SERODIAGNOSIS, CHIMERIC PROTEINS
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Role of the disulfide bond in stabilizing and folding of the fimbrial protein DraE from uropathogenic Escherichia coli
PublikacjaDr fimbriae are homopolymeric adhesive organelles of uropathogenic Escherichia coli composed of DraE subunits, responsible for the attachment to host cells. These structures are characterized by enormously high stability resulting from the structural properties of an Ig-like fold of DraE. One feature of DraE and other fimbrial subunits that makes them peculiar among Ig-like domain-containing proteins is a conserved disulfide bond...
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Techniki sprzętowej teselacji do wygładzania i uszczegóławiania modeli trójwymiarowych
PublikacjaDirectX 11 oraz OpenGL 4 wprowadziły do potoku renderującego bardzo oczekiwaną teselację. Wraz z upływem czasu coraz więcej silników graficznych zostaje dostosowywanych do wspierania tej technologii, więc nie można pozostawać wobec niej obojętnym. W artykule przedstawiona zostanie koncepcja teselacji od strony teoretycznej oraz praktycznej. Opisany zostanie nowy potok renderujący, a w szczególności dedykowane teselacji programy...
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A robust design of a numerically demanding compact rat-race coupler
PublikacjaA fast and accurate design procedure of a computationally expensive microwave circuit has been presented step-by-step and experimentally validated on the basis of a compact rat-race coupler (RRC) comprising slow-wave resonant structures (SWRSs). The final compact RRC solution has been obtained by means of a sequential optimization scheme exploiting the implicit space mapping (ISM) algorithm. A well-suited surrogate optimization...
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Recent developmentsinthesynthesisand biological activityofacridine/acridoneanalogues
PublikacjaMany people in the world struggle with cancer or bacterial, parasitic, viral, Alzheimer's and other diseases. Therefore, many scientists seek new, more effective, more selective and less toxic drugs. Acridine/acridone derivatives constitute a class of compounds with a broad spectrum of biological activity and are of great interest to scientists. Todate, many acridine/acridone analogues have been obtained,which, inter alia, exhibit...
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Transcriptomic landscape of blood platelets in healthy donors
PublikacjaBlood platelet RNA-sequencing is increasingly used among the scientific community. Aberrant platelet transcriptome is common in cancer or cardiovascular disease, but reference data on platelet RNA content in healthy individuals are scarce and merit complex investigation. We sought to explore the dynamics of platelet transcriptome. Datasets from 204 healthy donors were used for the analysis of splice variants, particularly with...
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Support for research biobanks among medical students in the Republic of Kazakhstan
PublikacjaBackground: Over the past few years, several biobanks have been organized in the Republic of Kazakhstan (RoK). As research biobanks are becoming an increasingly important tool for precision medicine, they require competent biobankers who will help disseminate the idea of biobanking throughout the society and support donation for research purposes. This study aimed to assess the support for research...
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Development and tuning of irregular divide-and-conquer applications in DAMPVM/DAC
PublikacjaThis work presents implementations and tuning experiences with parallel irregular applications developed using the object oriented framework DAM-PVM/DAC. It is implemented on top of DAMPVM and provides automatic partitioning of irregular divide-and-conquer (DAC) applications at runtime and dynamic mapping to processors taking into account their speeds and even loads by other user processes. New implementations of parallel applications...
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On Radar DoA Estimation and Tilted Rotating Electronically Scanned Arrays
PublikacjaWe consider DoA estimation in a monopulse radar system employing a tilted rotating array. We investigate the case of nonzero steering angles, in which case the mapping between the target’s azimuth and elevation in the global coordinate system and their counterparts in the array local coordinate system becomes increasingly nonlinear and coupled. Since estimating the azimuth using coherently integrated signals might be difficult because...
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Cost-efficient simulation-driven design of compact impedance matching transformers
PublikacjaIn this paper, an algorithmic framework for cost-efficient design optimization of miniaturized impedance matching transformers has been presented. Our approach exploits a bottom-up design that involves translating the overall design specifications for the circuit at hand to its elementary building blocks (here, compact microstrip resonant cells, CMRCs), as well as fast surrogate-assisted optimization of the cells followed by simulation-based...
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Local response surface approximations and variable-fidelity electromagnetic simulations for computationally efficient microwave design optimisation
PublikacjaIn this study, the authors propose a robust and computationally efficient algorithm for simulation-driven design optimisation of microwave structures. Our technique exploits variable-fidelity electromagnetic models of the structure under consideration. The low-fidelity model is optimised using its local response surface approximation surrogates. The high-fidelity model is refined by space mapping with polynomial interpolation of...
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Discovering patterns of Web Page Visits from Associaton Rules Viewpoint
PublikacjaThe popularity of the Internet results from the almost unlimited resources of information stored in it. At the same time, Internet portals have become a widespread source of information and note very large number of visits. The list of web pages opened by users is stored in web servers' log files. Extraction of knowledge on the navigation paths of users has become carefully analyzed problem. Currently, there are a number of algorithms...
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Computer animation system based on rough sets and fuzzy logic
PublikacjaA fuzzy logic inference system was created, based on the analysis of animated motion features. The objective of the system is to facilitate the creation of high quality animation by analyzing personalized styles contained in numerous animations. Sequences portraying a virtual character acting with a differentiating personalized style (natural or exaggerated) and various levels of fluidity were prepared and subjectively evaluated....
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Low-fidelity model considerations for simulation-based optimisation of miniaturised wideband antennas
PublikacjaHere, variable-fidelity electromagnetic (EM)-based design optimisation of miniaturised antennas is discussed. The authors focus on an appropriate selection of discretisation density of the low-fidelity EM model, which results in good performance of the optimisation algorithm in terms of its computational complexity and reliability. Trust-region gradient search with low-fidelity model corrected by means of non-linear frequency scaling...
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On low-fidelity models for variable-fidelity simulation-driven design optimization of compact wideband antennas
PublikacjaThe paper addresses simulation-driven design optimization of compact antennas involving variable-fidelity electromagnetic (EM) simulation models. Comprehensive investigations are carried out concerning selection of the coarse model discretization density. The effects of the low-fidelity model setup on the reliability and computational complexity of the optimization process are determined using a benchmark set of three ultra-wideband...
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Low cost real time UAV stereo photogrammetry modelling technique – accuracy considerations
PublikacjaThe paper presents accuracy considerations regarding three 3D modelling techniques. The tested new consumer type stereo camera (ZED 3D Stereolabs) has been implemented info an aerial mapping system, on board micro air vehicle MAV) and tested object has been mapped using a real-time photogrammetry with original real-time software application. The evaluated results has been compared with model gained with a state of art unmanned...
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Aerodynamic shape optimization by variable-fidelity computational fluid dynamics models: a review of recent progress
PublikacjaA brief review of some recent variable-fidelity aerodynamic shape optimization methods is presented.We discuss three techniques that—by exploiting information embedded in low-fidelity computationalfluid dynamics (CFD) models—are able to yield a satisfactory design at a low computational cost, usu-ally corresponding to a few evaluations of the original, high-fidelity CFD model to be optimized. Thespecific techniques considered here...
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Molecular profiles of thyroid cancer subtypes: Classification based on features of tissue revealed by mass spectrometry imaging
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Insight into the oligomeric structure of PORA from A. thaliana
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Modification of quaternary structure of Candida albicans GlcN-6-P synthase and its desensitization to inhibition by UDP-GlcNAc by site-directed mutagenesis
PublikacjaSite-directed mutagenesis of the CaGFA1 gene encoding glucosamine-6-phosphate synthase from Candida albicans was performed. Desensitization of the enzyme to inhibition by UDPGlcNAc was achieved upon T487I and H492F substitutions at the UDP-GlcNAc binding site, exchange of D524, S525 and S527 for Ala at the dimer:dimer interface and construction of the tail-lock array (L434R and L460A) at the C-tail region. The first two sets if...
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Piekielna pustka: Patologie kształcenia w uniwersytecie neoliberalnym.
PublikacjaUniwersytety na świecie – niezależnie od ich różnych typów i odmian – reformowane są współcześnie zgodnie z neoliberalnymi założeniami modelu rynkowego. Prowadzi to do erozji misji kulturowej uczelni jako „instytucji o potencjale sprzeciwu”, czego przejawem jest korupcja podstawowej funkcji uniwersytetu jaką jest kształcenie. Korupcja w podstawowym sensie zaczerpniętym od Monteskiusza oznacza psucie, zepsucie, demoralizację i skażenie. Autorzy...
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A mechanistically approached review upon assorted cell lines stimulated by athermal electromagnetic irradiation
PublikacjaThe probable influence of electromagnetic irradiation on cancer treatment has been deduced from the interaction of artificial electromagnetic emissions with biological organisms. Nonetheless, the suspected health effects induced by electromagnetic-based technology imply that such a treatment may contaminate the adjacent healthy cells. Thus, gaining mechanistic insights into the problem is required to avoid athermal health hazards....
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Investigation of photothermolysis therapy of human skin diseases using optical phantoms
PublikacjaDermatological diseases, such as neurofibroma (Recklinghausen disease) or hemangiomas can be efficiently treated using photothermolysis from laser irradiation. We have utilized a developed 975 nm fiber diode laser as a low-cost alternative over common Nd:YAG lasers. This paper describes the investigations of interaction of 975 nm diode laser radiation-pulses with optical skin phantoms which were designed and manufactured in our...
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Fault diagnosing system of wheeled tractors
PublikacjaA defect of complex wheeled tractor assembles most frequently negative influence on exploitation efficiency, safety and exhaust gases emission. Structure complexity of wheeled tractors requires more and more advanced diagnostic methods for identification of their serviceable possibilities as well in manufacturing step as in exploitation. In classical diagnosing methods of wheeled tractor defects states mapping by measured diagnostic...
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Application of passive sampling techniques as a usable tool in the field of environmental quality monitoring
PublikacjaAnalysis of literature data published for the past 20 years leads to the conclusion, that passive sampling technique has been developing very quickly and is commonly used in the field of monitoring pollutants in air, water and soil environment. The popularity of application of passive sampling techniques in analytical and environmental chemistry results from its many advantages e.g.: Simplicity in use, low costs of exploitation,...
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Flavones in cocoa defence against Phytophthora megakarya
PublikacjaCross-pollination of suitable genotypes and earlier selection of elite offspring using adequate plants-associated defence markers in plantlets leaves are decisive for development of T. cacao genotypes tolerant to black pods disease (BPD). T. cacao plantlets from manual cross-pollination of ♀SNK64 × ♂UPA143 were analyzed for their susceptibility to BPD using leaf disc test. Subsequently, leaves (healthy, wounded and wound+infected)...
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A new division of bacterial UvrA homologues
PublikacjaThe UvrA protein is a DNA-binding and damage-recognition enzyme which participates in the prokaryotic type nucleotide excision repair (NER) pathway. It has recently been noted that some bacterial genomes comprise additional uvrA genes which encode five distinct types of UvrA homologue. We investigated the sequences of over 2400 bacterial genomes and found 130 examples of bacteria containing uvrA 2 genes. The sequence analyses conducted...
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Low-cost EM-Simulation-based Multi-objective Design Optimization of Miniaturized Microwave Structures
PublikacjaIn this work, a simple yet reliable technique for fast multi-objective design optimization of miniaturized microwave structures is discussed. The proposed methodology is based on point-by-point identification of a Pareto-optimal set of designs representing the best possible trade-offs between conflicting objectives such as electrical performance parameters as well as the size of the structure of interest. For the sake of computational...
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Local properties of organic coatings close to glass transition temperature
PublikacjaAcrylic coating applied on copper substrate has been investigated at different temperatures starting from the ambient one up to the level above the glass transition temperature. Its local topographic and electric properties have been examined with the atomic force microscopy (AFM) based approach including dc current mapping and local impedance spectroscopy. The local findings have been compared with the information from global...
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Wide-field magnetometry using nitrogen-vacancy color centers with randomly oriented micro-diamonds
PublikacjaMagnetometry with nitrogen-vacancy (NV) color centers in diamond has gained significant interest among researchers in recent years. Absolute knowledge of the three-dimensional orientation of the magnetic field is necessary for many applications. Conventional magnetometry measurements are usually performed with NV ensembles in a bulk diamond with a thin NV layer or a scanning probe in the form of a diamond tip, which requires a...
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Inverse surrogate models for fast geometry scaling of miniaturized dual-band couplers
PublikacjaRe-design of microwave structures for various sets of performance specifications is a challenging task, particularly for compact components where considerable electromagnetic (EM) cross-couplings make the relationships between geometry parameters and the structure responses complex. Here, we address geometry scaling of miniaturized dual-band couplers by means of inverse surrogate modeling. Our approach allows for fast estimation...
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System for characterisation and multidimensional imaging of seafloor using multibeam sonar data
PublikacjaMultibeam sonars are widely used in applications like high resolution bathymetry measurements, underwater object detection and imaging, etc. Also, they are the promising tool in seafloor characterisation and classification, having several advantages over conventional single beam echosounders. The proposed approach to seafloor classification relies on the combined use of three different techniques. In each of them, a set of descriptors...
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Condition of Reinforced Concrete Structures and Their Degradation Mechanism at the Former Auschwitz Concentration and Extermination Camp
PublikacjaThis paper presents the results of investigations on reinforced concrete structures present in the former Auschwitz I and Auschwitz II-Birkenau concentration and extermination camp. Field inspection employing the non-destructive method of reinforcement potential measurement according to the ASTM-C 876–15 standard, followed by laboratory investigations performed on genuine historic reinforced concrete samples collected from the...
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Model and laboratory simulation of a induction motor for diagnostic purposes
PublikacjaStatistics say that bearings are this part of induction motors which is most susceptible to damage. The equipment employed for bearing diagnostics usually makes use of vibrations as the criterion for technical condition of the bearings. A faulty bearing results in additional motor vibrations. They are reflected in the harmonic content of stator currents. In certain operating conditions the current signal is the sole source of information...
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Fast surrogate-assisted simulation-driven design of compact microwave hybrid couplers
PublikacjaThis work presents a robust methodology for expedited simulation-driven design optimization of compact microwave hybrid couplers. The technique relies on problem decomposition, and a bot-tom–up design strategy, starting from the level of basic building blocks of the coupler, and finishing with a tuning procedure that exploits a fast surrogate model of the entire structure. The latter is constructed by cascading local response surface...
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Rapid multi-objective design optimisation of compact microwave couplers by means of physics-based surrogates
PublikacjaThe authors introduce a methodology for fast multi-objective design optimisation of miniaturised microwave couplers. The approach exploits the surrogate-based optimisation paradigm with an underlying low-fidelity model constructed from an equivalent circuit of the structure under consideration, corrected through implicit and frequency space mapping. A fast prediction tool obtained this way is subsequently optimised by a multi-objective...
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Analysing the potential for application of the phase shift method in endoscopic examination of marine engines
PublikacjaThe article presents theoretical principles of image processing in digital endoscopy which makes use of a miniaturised spectral scanner “PhaseProbe” designed by General Inspection Technologies LP, the producer of the measuring videoendoscope Everest XLG3. The technology of optoelectronic 3D mapping of the examined surface, which consists in measuring the phase shift between the emitted and reflected light waves, is briefly described....
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Towards Cancer Patients Classification Using Liquid Biopsy
PublikacjaLiquid biopsy is a useful, minimally invasive diagnostic and monitoring tool for cancer disease. Yet, developing accurate methods, given the potentially large number of input features, and usually small datasets size remains very challenging. Recently, a novel feature parameterization based on the RNA-sequenced platelet data which uses the biological knowledge from the Kyoto Encyclopedia of Genes and Genomes, combined with a classifier...
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Computer Aided Telediagnostics System for Stoma Patients
PublikacjaStoma surgery may concern patients with colorectal cancer and inflammatory bowel disease. More than half of patients diagnosed with colon cancer present at an advanced stage, and palliative treatment may involve stoma formation. This type of surgery may change the patient’s life strongly, therefore they should receive special medical care. The paper presents the assumptions, concept, and architecture of the Stoma-Alert diagnosis...
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Characterization of metabolites in different kiwifruit varieties by NMR and fluorescence spectroscopy
PublikacjaIt is known from our previous studies that kiwifruits, which are used in common human diet, have preventive properties of coronary artery disease. This study describes a combination of 1H NMR spectroscopy, multivariate data analyses and fluorescence measurements in differentiating of some kiwifruit varieties, their quenching and antioxidant properties. A total of 41 metabolites were identified by comparing with literature data...
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Electronic Noses in Medical Diagnostics
PublikacjaElectronic nose technology is being developed in order to identify aromas in a way parallel to the biologic olfaction. When applied to the field of medicine, such device should be able to identify and discriminate between different diseases. In recent years this kind of approach finds application in medical diagnostics, and especially in disease screening. Despite the fact that devices utilizing chemical sensor arrays are not routinely...
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Beneficial effects and potential risks of tomato consumption for human health: An overview
PublikacjaTomato and its derived products have a very interesting nutritional value in addition to prominent antioxidant,anti-inflammatory, and anticancer activities. In terms of tomatoes are generally quite safe to eat. However,overall consumption varies from individual to individual. Indeed, either beneficial or harmful effects of plantsor their derived products are closely related to quality, including the presence of biologically active...
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Value of Personalized Dementia-Specific Quality of Life Scales: An Explorative Study in 3 European Countries
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The hydration of the protein stabilizing agents: trimethylamine-N-oxide, glycine and its N-methylderivatives - the volumetric and compressibility studies
PublikacjaThe densities at T = (288.15, 293.15, 298.15, 303.15, and 308.15) K and sound velocities at T = 298.15 K have been measured for aqueous solutions of trimethylamine-N-oxide, glycine, N-methylglycine (sarcosine), N,N-dimethylglycine, N,N,N-trimethylglycine (betaine). From these data the apparent molar volumes, VΦ, the apparent molar isentropic compressions, KS,Φ, and the solvation numbers of solutes have been determined. The concentration...
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The impact of lipophilicity on environmental processes, drug delivery and bioavailability of food components
PublikacjaLipophilic properties of the compound allow to predict its fate in living organisms and to propose the models of chemicals transport and accumulation in the ecosystem. Lipophilicity is also useful as the characteristic of chemicals in respect to their optimal attributes for specific biological and non-biological tasks. The lipophilicity descriptors define the potency of endo- and xenobiotics to metabolic transformations and their...
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Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase
PublikacjaThe antifungal activity of 5‐hydroxy‐4‐oxo‐L‐norvaline (HONV), exhibited under conditions mimicking human serum, may be improved upon incorporation of this amino acid into a dipeptide structure. Several HONV‐containing dipeptides inhibited growth of human pathogenic yeasts of the Candida genus in the RPMI‐1640 medium, with minimal inhibitory concentration values in the 32 to 64 μg mL−1 range. This activity was not affected by multidrug...
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Structure of solvation water around the active and inactive regions of a type III antifreeze protein and its mutants of lowered activity
PublikacjaWater molecules from the solvation shell of the ice-binding surface are considered important for the antifreeze proteins to perform their function properly. Herein, we discuss the problem whether the extent of changes of the mean properties of solvation water can be connected with the antifreeze activity of the protein. To this aim, the structure of solvation water of a type III antifreeze protein from Macrozoarces americanus (eel...
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Characterization of a cryptic plasmid pSFKW33 from Shewanella sp. 33b
PublikacjaA cryptic plasmid pSFKW33 from psychrotrophic bacterium Shewanella sp. 33B, an isolate from the Gulf of Gdansk (the Baltic Sea), was sequenced and characterized. It is an 8021 bpcircular molecule with 38% GC content, which shows a distinctive nucleotide sequence without homology to other known plasmids. The nucleotide sequence analysis predicts eight open reading frames. The deduced amino acid sequence of ORF-1 shared significant...
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Characterization of a single-stranded DNA-binding-like Protein from Nanoarchaeum equitans - a nucleic acid binding protein with broad substrate specificity
PublikacjaBackground SSB (single-stranded DNA-binding) proteins play an essential role in all living cells and viruses, as they are involved in processes connected with ssDNA metabolism. There has recently been an increasing interest in SSBs, since they can be applied in molecular biology techniques and analytical methods. Nanoarchaeum equitans, the only known representative of Archaea phylum Nanoarchaeota, is a hyperthermophilic, nanosized,...
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PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells
PublikacjaTwo cellular proteins encoded by the breast and ovarian cancer type 1 susceptibility (BRCA1 and BRCA2) tumor suppressor genes are essential for DNA integrity and the maintenance of genomic stability.Approximately 5-10% of breast and ovarian cancers result from inherited alterations or mutations in these genes.Remarkably, BRCA1/BRCA2-deficient cells are hypersensitive to selective inhibition of poly(ADPribose) polymerase 1 (PARP-1),...
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Cifrovaâ reprezentaciâ leksem russkogo âzyka
PublikacjaKonfrontowanie zasobów leksyki pokrewnych systemów języka etnicznego w celu określenia stopnia zbieżności przynależnych im homonimik wymaga stosowania wysublimowanych procedur językoznawczych mających na celu oszacowanie wspólnoty akustycznej zawartej w paralelnych parlacjach użytkowników owych języków. Ewidentne zróżnicowanie nawyków aktu artykulacji a zwłaszcza, co szczególnie istotne, nieświadomego procesu intelektualnej percepcji...