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Profiling and Qualitative Assessment of Enzymatically and Thermally Oxidized Egg Yolk Phospholipids using a Two‐Step High‐Performance Liquid Chromatography Protocol
PublikacjaA two‐step high‐performance liquid chromatography (HPLC) method for the profiling and qualitative assessment of oxidized phospholipids (oxPL) present in foods was developed. The applicability of the investigated two‐step HPLC protocol was verified for separation of enzymatically and thermally oxidized hen egg yolk phospholipids (PL) as a relevant food model. In the first step, seven individual PL classes were separated using hydrophilic...
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EVALUATING THE INFLUENCE OF BENDING STRESS ON A 1H18N9 STEEL SHAFT WEAR PROCESS IN A WATER LUBRICATED SLIDING BEARING WITH A RUBBER BUSHING
PublikacjaThe issue of excessive wear of shaft journals co-working with a rubber bearing has been unexplained so far. Premature and sometimes very intensive wear of ship sliding bearings in water conditions is the reason for carry out very expensive and more frequent than expected repairs. The authors (E. Piątkowska, W. Litwin) made an attempt to find a case that influences the value of this wear described in the paper “Attempt at Evaluating...
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Estimation of the amplitude of the signal for the active optical gesture sensor with sparse detectors
PublikacjaIn this paper we deal with the problem of precise gesture recognition for the active optical proximity sensor with sparse 8 photodiodes. We particularly focus on developing the method of estimating the real, usually not observable, maximum signal value representing maximum intensity of light reflected from an obstacle present in the front of the sensor. Different configurations of the fingers were used as an obstacle. The Monte Carlo...
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TEST FOR ASSESSING THE ENERGY EFFICIENCY OF VEHICLES WITH INTERNAL COMBUSTION ENGINES
PublikacjaThe most popular method for assessing the energy efficiency of vehicles is to compare the fuel consumption achieved in the conditions of selected approval test. Operating conditions are defined using the speed profiles, usually for only two categories: urban and extra-urban driving. Assessing the energy efficiency of vehicles should be performed using a more detailed classification of conditions. Presented results of comparison...
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The influence of roasting and additional processing on the content of bioactive components in special purpose coffees
PublikacjaCoffee being the beverage consumed worldwide is also a very competitive commodity. Consequently, producers seek ways of attracting consumers by proposing e.g. novel ingredient combinations usually without evaluating their health quality. In this study, variations in health-promoting determinants for five special purpose coffee brews were characterized. The major bioactive components - chlorogenic acids (CAs) - detected by HPLC-DAD-MS...
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The Impact of urban Localizations on the Growth Possibilities for Small Firms
PublikacjaThe purpose of this study was to identify the differences in the profiles of firms and their owners in urban and non-urban locations and also to asses the impact of those differences on the possibilities of growth for firms from both types of locations. Findings: urban entrepreneurs are better educated, more experienced and more positively motivated. Their firms are more innovative, with more qualified employeesadn better access...
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On topology optimization of large deformation contact-aided shape morphing compliant mechanisms
PublikacjaA topology optimization approach for designing large deformation contact-aided shape morphing compliant mechanisms is presented. Such mechanisms can be used in varying operating conditions. Design domains are described by regular hexagonal elements. Negative circular masks are employed to perform dual task, i.e., to decide material states of each element and also, to generate rigid contact surfaces. Each mask is characterized by...
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Assessment of the Steering Precision of a Hydrographic Unmanned Surface Vessel (USV) along Sounding Profiles Using a Low-Cost Multi-Global Navigation Satellite System (GNSS) Receiver Supported Autopilot
Publikacjahe performance of bathymetric measurements by traditional methods (using manned vessels) in ultra-shallow waters, i.e., lakes, rivers, and sea beaches with a depth of less than 1 m, is often difficult or, in many cases, impossible due to problems related to safe vessel maneuvering. For this reason, the use of shallow draft hydrographic Unmanned Surface Vessels (USV) appears to provide a promising alternative method for performing...
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Experimental Investigations of Fracture Process Using DIC in Plain and Reinforced Concrete Beams under Bending
PublikacjaThe fracture behaviour of concrete and reinforced concrete beams under quasi-static three-point bending was comprehensively investigated with experiments at laboratory scale. The eight various concrete mixes were tested. The influence of the shape, volume and size of aggregate particles and reinforcement on concrete fracture under bending was studied. Displacements on the surface of concrete beams were measured by means of the...
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Modern GFRP Composite Footbridges
PublikacjaApplication of GFRP composites in civil engineering is still not large but already noticeable. Advantages of this material, such as: low volume weight, relatively high stiffness and strength, well fatigue resistance, easiness in shaping, high material damping and high environmental resistance, make it attractive for bridge and in particular foot-bridge designers. It is estimated that nowadays in the world there are realized hundreds...
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Is the Solid Electrolyte Interphase an Extra-Charge Reservoir in Li-Ion Batteries?
PublikacjaAdvanced metal oxide electrodes in Li-ion batteries usually show reversible capacities exceeding the theoretically expected ones. Despite many studies and tentative interpretations, the origin of this extra-capacity is not assessed yet. Lithium storage can be increased through different chemical processes developing in the electrodes during charging cycles. The solid electrolyte interface (SEI), formed already during the first...
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Evaluation of the Impact of Storage Conditions on the Biogenic Amines Profile in Opened Wine Bottles
PublikacjaA survey of biogenic amine (BA) profiles in opened wine bottles has been established to monitor the level of biogenic amines (BAs) in opened bottles against time and other conditions. Bottles of red and white wine were submitted to different temperatures, stopper type (screw cap, cork), and use of vacuum devices. A total of six wines made from a variety of grapes were obtained from vineyards from regions across Poland. Dispersive...
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Structural and electrical properties of Cr-doped SrTiO 3 porous materials
PublikacjaSeries of single-phase materials with assumed formula SrTi1−xCrxO3 (where x = 0, 1, 4, 6 mol.%) were obtained by sol-gel method. The structure and microstructure of materials were characterised by X-ray diffraction and scanning electron microscopy methods. Moreover, the study of electrical properties and evaluation of chemical stability in CO2/H2O atmosphere was performed by electrochemical impedance spectroscopy and thermogravimery...
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Pressure drop related to flow maldistribution in a model minichannel plate heat exchanger
PublikacjaThe paper describes the issues related to the pressure drop that accompanies the phenomenon of maldistribution of working fluid between the channels of a model minichannel plate heat exchanger. The research concerns a single exchanger's plate containing 51 (in every geometry) parallel rectangular minichannels of hydraulic diameters 461 µm, 571 µm, 750 µm and 823 µm. In addition, the more complex geometry has been investigated,...
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Molecular dynamics simulations reveal the balance of forces governing the formation of a guanine tetrad—a common structural unit of G-quadruplex DNA
PublikacjaG-quadruplexes (G4) are nucleic acid conformations of guanine-rich sequences, in which guanines are arranged in the square-planar G-tetrads, stacked on one another. G4 motifs form in vivo and are implicated in regulation of such processes as gene expression and chromosome maintenance. The structure and stability of various G4 topologies were determined experimentally; however, the driving forces for their formation are not fully...
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Religious social action and its organizational profiles
PublikacjaPurpose Social action implemented by the Church via its affiliated entities, foundations and associations may be viewed as a uniform activity. In reality, however, several organizational profiles exist that depend on the origin of these organizations (lay or religious), the scope of their activities (local or general) and their dependence on resources (whether from public administration or civil society). The paper aims to discuss...
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Discriminatory expressions, the young and social networks: The effect of gender
PublikacjaIn the framework of the «Project I: CUD» (Internet: Creatively Unveiling Discrimination), carried out in the United Kingdom, Italy, Belgium, Romania and Spain, we conducted a study into the expressions of discrimination used by young people on social network sites. To do so we designed a methodological strategy for detecting discriminatory content in 493 Facebook profiles and used this strategy to collect 363 examples for further...
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Numerical Analysis of Recharge Rates and Contaminant Travel Time in Layered Unsaturated Soils
PublikacjaThis study focused on the estimation of groundwater recharge rates and travel time of conservative contaminants between ground surface and aquifer. Numerical simulations of transient water flow and solute transport were performed using the SWAP computer program for 10 layered soil profiles, composed of materials ranging from gravel to clay. In particular, sensitivity of the results to the thickness and position of weakly permeable...
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Generation and Propagation of Nonlinear Waves in a Towing Tank
PublikacjaThe paper presents the results of the research focused on linear and nonlinear wave generation and propagation in a deepwater towing tank equipped with a single flap-type wavemaker of variable draft. The problem of wave generation and propagation has been theoretically formulated and solved by applying an analytical method; linear and nonlinear solutions were obtained. The linear solution has been verified experimentally. The...
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Estimation of Conservative Contaminant Travel Time through Vadose Zone Based on Transient and Steady Flow Approaches
PublikacjaEstimation of contaminant travel time through the vadose zone is needed for assessing groundwater vulnerability to pollution, planning monitoring and remediation activities or predicting the effect of land use change or climate change on groundwater quality. The travel time can be obtained from numerical simulations of transient flow and transport in the unsaturated soil profile, which typically require a large amount of data and...
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Study of pH and temperature effect on lipophilicity of catechol-containing antioxidants by reversed phase liquid chromatography
PublikacjaLipophilicity of selected antioxidant phytochemicals, including flavonoids, phenolic acids and xanthonoids, was determined by reversed phase high performance liquid chromatography with UV detection (RP-HPLC-UV). The analyses run at different temperature and pH conditions in isocratic mode suggested that lipophilicity as distribution coefficient (logD) between aqueous and organic phase decreases with increasing temperature. For...
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Decision-making under stress: A psychological and neurobiological integrative model
PublikacjaUnderstanding the impact of stress on cognitive processes, particularly decision-making, is crucial as it underpins behaviors essential for survival. However, research in this domain has yielded disparate results, with inconsistencies evident across stress-induction paradigms and drug administration protocols designed to investigate specific stress pathways or neuromodulators. Building upon empirical studies, this research identifies...
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Comparison of various flow maldistribution quantification methods in mini heat exchangers
PublikacjaThe aim of study is to compare various flow maldistribution quantification methods, using velocity, mass flow rate, pressure, and temperature. An experimentally validated numerical study has been prepared and a heat exchanger with 34 semi-circular channels with a diameter of 3.1 mm has been tested. The minichannels were heated from the bottom with a heat flux of 50, 60, 70, and 80 kW/m2. The cases for various inlet velocities of...
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Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition
PublikacjaHeterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based...
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The correlation between nutritional and health potential and antioxidant properties of raw edible oils from cultivated and wild plants
PublikacjaThe nutritional properties and health potential of oils from 15 various cultivated and wild plants were investigated on the basis of the fatty acids profiles, total carotenoids and tocopherols content, antioxidant properties and health potential indexes such as atherogenicity index (AI). The oil contents of the plants varied between 0.9 g/100 g for lychee seeds and 29.7 g/100 g for borage seeds. The tocopherol content in oils ranged...
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How do sterols determine the antufungal activitiy of amphotericin B? Free energy of binding between the drug and its membrane targets.
PublikacjaAmphotericin B (AmB) is a well-known polyene antibiotic used to treat systemic fungal infections. It is commonly accepted that the presence of sterols in the membrane is essential for the AmB biological activity, that is, for the formation of transmembrane ion channels. The selective toxicity of AmB for fungal cells is attributed to the fact that it is more potent against fungal cell membranes containing ergosterol than against...
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Identification and antimicrobial resistance of Enterococcus spp. isolated from surface water
PublikacjaIn the study species distributions and antimicrobial resistance profiles were determined among riverine Enterococcus spp. Susceptibility of the isolates was tested against: ampicillin, imipenem, teicoplanin, vancomycin, erythromycin, linezolid, fosfomycin, ciprofloxacin,levofloxacin, moxifloxacin, tetracycline, high levels of gentamicin and streptomycin. The enterococci were detected in all of the analyzed water samples, periodically...
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Interaction of cisplatin and two potential antitumoral platinum(ii) complexes with a model lipid membrane: a combined NMR and MD study
PublikacjaIn this study, the interaction of cisplatin (1) and two potential antitumoral Pt(II) complexes (2 and 3) with a model DMPC bilayer was investigated by multinuclear NMR spectroscopy and MD simulations in order to understand its implication for the different antitumoral properties shown by the three complexes. In particular, 31P, 13C and 2H solid state NMR experiments were performed to obtain information on the phase structure, phase...
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Prediction of Bioactive Peptides From Chicken Feather and Pig Hair Keratins Using In Silico Analysis Based on Fragmentomic Approach
PublikacjaBackground: Keratin is among the most abundant structural proteins of animal origin, however it remains broadly underutilized. Objective: Bioinformatic investigation was performed to evaluate selected keratins originating from mass-produced waste products, i.e., chicken feathers and pig hair, as potential sources of bioactive peptides. Methods: Pepsin, trypsin, chymotrypsin, papain, and subtilisin were used for in silico keratinolysis...
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A five-year retrospective study shows increasing rates of antimicrobial drug resistance in Cabo Verde for both Staphylococcus aureus and Escherichia coli
PublikacjaObjectives Data on baseline drug resistance is important in informing future antimicrobial stewardship programs. So far, no data on the antimicrobial drug resistance of clinical isolates was available for the African archipelago of Cabo Verde. Methods We have performed a retrospective analysis over five-years (2013-17) of the antimicrombial drug susceptibility profiles of clinical isolates in the two main hospitals of Cabo Verde....
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Load capacity of steel-aluminium brackets under static and cyclic laboratory tests
PublikacjaThe aim of the research is the laboratory investigation of steel-aluminium brackets employed to fasten lightweight curtain walls to building facilities. Static pressure, suction forces, and cyclic loads parallel to end plates (horizontal – to simulate wind influence) were applied in the study. The steel-aluminium brackets were tested on a reinforced concrete substrate made of C30/37 concrete class to simulate the real working conditions....
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Real-time monitoring of the emission of volatile organic compounds from polylactide 3D printing filaments
PublikacjaEstablishing the emission profile of volatile organic compounds generated during fused deposition modeling 3D printing using polymer filaments is important in terms of both understanding the processes taking place during thermal degradation of thermoplastics, and assessing the user's exposure to potentially harmful volatiles. However, obtaining detailed, real-time qualitative and quantitative results poses a challenge. In this...
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Self-Organising map neural network in the analysis of electromyography data of muscles acting at temporomandibular joint.
PublikacjaThe temporomandibular joint (TMJ) is the joint that via muscle action and jaw motion allows for necessary physiological performances such as mastication. Whereas mandible translates and rotates [1]. Estimation of activity of muscles acting at the TMJ provides a knowledge of activation pattern solely of a specific patient that an electromyography (EMG) examination was carried out [2]. In this work, a Self-Organising Maps (SOMs)...
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Comprehensive Comparison of a Few Variants of Cluster Analysis as Data Mining Tool in Supporting Environmental Management
PublikacjaA few variants of hierarchical cluster analysis (CA) as tool of assessment of multidimensional similarity in environmental dataset are compared. The dataset consisted of analytical results of determination of metals (Na, K, Ca, Sc, Fe, Co, Zn, As, Br, Rb, Mo, Sb, Cs, Ba, La, Ce, Sm, Hf and Th) in ambient air dried and kept alive, by the means of hydroponics, moss baskets collected in 12 locations on the area of Tricity (Poland)....
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Updating the Coupling Algorithm between HYDRUS and MODFLOW in the HYDRUS Package for MODFLOW
PublikacjaThe HYDRUS-based flow package for MODFLOW (the HPM or the HYDRUS package) is an existing unsaturated zone flow package for MODFLOW. In MODFLOW with the HPM, the groundwater modeling domain is discretized into regular grids that can be combined into multiple zones based on similarities in soil hydrology, topographical characteristics, and the depth to the groundwater. Each of these zones is assigned one unsaturated soil profile...
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Principles and applications of Ligation Mediated PCR methods for DNA-based typing of microbial organisms
PublikacjaA significant number of DNA-based techniques has been introduced into the field of microorganisms’ characterization and taxonomy. These genomic fingerprinting methods were developed to detect DNA sequence polymorphisms by using general principles, such as restriction endonuclease analysis, molecular hybridization, and PCR amplification. In recent years, some alternative techniques based on ligation of oligonucleotide adapters before...
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pH-Responsive Drug Delivery Nanoplatforms as Smart Carriers of Unsymmetrical Bisacridines for Targeted Cancer Therapy
PublikacjaSelective therapy and controlled drug release at an intracellular level remain key challenges for effective cancer treatment. Here, we employed folic acid (FA) as a self-navigating molecule in nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) for the delivery of antitumor unsymmetrical bisacridine compound (C-2028) to lung and prostate cancers as well as normal cells. The bisacridine derivative can form the...
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May Staphylococcus lugdunensis Be an Etiological Factor of Chronic Maxillary Sinuses Infection?
PublikacjaStaphylococcus lugdunensis is an opportunistic pathogen found in the healthy human skin microbiome bacterial community that is able to cause infections of diverse localization, manifestation, and course, including laryngological infections, such as necrotizing sinusitis. Chronic maxillary sinusitis is a disease present in up to one third of European and American populations, and its etiology is not fully described. Within this...
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Combining Computational Fluid Dynamics with a Biokinetic Model for Predicting Ammonia and Phosphate Behavior in Aeration Tanks
PublikacjaThe aim of this study was to use computational fluid dynamics for predicting the behavior of reactive pollutants (ammonia and phosphate) in the aerobic zone of the bioreactor located at the Wschod wastewater treatment plant in Gdansk, Poland. The one-dimensional advection-dispersion equation was combined with simple biokinetic models incorporating the Monod-type expressions as source terms for the two pollutants. The problem was...
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Bacterial Community Structures in Freshwater Polar Environments of Svalbard
PublikacjaTwo thirds of Svalbard archipelago islands in the High Arctic are permanently covered with glacial ice and snow. Polar bacterial communities in the southern part of Svalbard were characterized using an amplicon sequencing approach. A total of 52,928 pyrosequencing reads were analyzed in order to reveal bacterial community structures in stream and lake surface water samples from the Fuglebekken and Revvatnet...
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Design and investigations of a micro-turbine flow part
Publikacja-generative micro-power plant with the HFE7100 as a working medium was designed and built for experimental investigations. The heat output of the plant was assumed equal to 20 kW, while the electric output amounted to about 3kW.In the paper a multi-stage micro-turbine with partial admission of all the stages is described in detail and the results of the particular experimental investigations and numerical calculations are shown,...
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Epigenetic Basis of Regeneration: Analysis of Genomic DNA Methylation Profiles in the MRL/MpJ Mouse
PublikacjaEpigenetic regulation plays essential role in cell differentiation and dedifferentiation, which are the intrinsic processes involved in regeneration. To investigate the epigenetic basis of regeneration capacity, we choose DNA methylation as one of the most important epigenetic mechanisms and the MRL/MpJ mouse as a model of mammalian regeneration known to exhibit enhanced regeneration response in different organs. We report the...
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Design and computational fluid dynamics analysis of the last stage of innovative gas-steam turbine
PublikacjaResearch regarding blade design and analysis of flow has been attracting interest for over a century. Meanwhile new concepts and design approaches were created and improved. Advancements in information technologies allowed to introduce computational fluid dynamics and computational flow mechanics. Currently a combination of mentioned methods is used for the design of turbine blades. These methods enabled us to improve flow efficiency...
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Diagnostic Accuracy of Liquid Biopsy in Endometrial Cancer
PublikacjaBackground: Liquid biopsy is a minimally invasive collection of a patient body fluid sample. In oncology, they offer several advantages compared to traditional tissue biopsies. However, the potential of this method in endometrial cancer (EC) remains poorly explored. We studied the utility of tumor educated platelets (TEPs) and circulating tumor DNA (ctDNA) for preoperative EC diagnosis, including histology determination. Methods:...
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Permeability of the small intestinal mucus for physiologically relevant studies: Impact of mucus location and ex vivo treatment
PublikacjaThe small intestinal mucus is a complex colloidal system that coats the intestinal mucosa. It allows passage on nutrients/pharmaceuticals from the gut lumen towards the epithelium, whilst preventing it from direct contact with luminal microorganisms. Mucus collected from intestinal tissue is often used in studies looking at inter-mucosal transport of food particulates, drug carriers, etc. However, detaching the highly hydrated...
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Evaluation of flavour profiles in e-cigarette refill solutions using gas chromatography–tandem mass spectrometry
PublikacjaMany flavour compounds that are present in e-liquids for e-cigarettes are responsible for specific tastes and smoking sensations for users. Data concerning content and specific types of flavours is often limited and unknown to users. The aim of the research was to define and compare flavour profiles of e-liquids with the same group taste from different manufacturers. Gas chromatography coupled with tandem mass spectrometry (GC–MS/MS)...
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Decision support system for design of long distance heat transportation system
PublikacjaDistrict Heating (DH) systems are commonly supplied using local heat sources. Nowadays, modern insulation materials allow for effective and economically viable heat transportation over long distances (over 20 km). The paper proposes a Decision Support System (DSS) for optimized selection of design and operating parameters of a long distance Heat Transportation System (HTS). The method allows for evaluation of feasibility and effectiveness...
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Hospital as a landscape mark
PublikacjaHalf of the nineteenth century brought significant changes in the organization and operation of hospitals. The on-coming takeover by the state and its agencies tasks related to medical care resulted in a significant jump in quantitative and almost massive construction of new hospitals. Several hospitals and nursing homes functioned on a relatively small area of a city or town, with different specializations and profiles of care....
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Thermodynamics aspects of interactions between acridine derivatives and DNA
PublikacjaDNA is a molecular target for many anticancer and antiviral drugs. Therefore, a clear understanding of the interaction of small molecules with DNA is important in the rational design of ligands that can bind to DNA with high affinity and selectivity. There are several methods to investigate interactions between drug and DNA. Some of them measure changing into DNA structures, such as lengthening and untwisting of helix of DNA. Other...
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Climbing university rankings under resources constraints: a combined approach integrating DEA and directed Louvain community detection
PublikacjaOver recent years, scholarly interest in universities’ allocation and effective utilisation of financial resources has been growing. When used efficiently, financial resources may improve universities’ quality of research and teaching, and therefore their positions inworld university rankings. However, despite the relevance of financial efficiency to university placement in academic rankings, universities’ total available financial...