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Wyniki wyszukiwania dla: agenty autonomiczne
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Kontekst a relacyjność przestrzeni = Context versus spatial relationality
PublikacjaArchitektoniczna ingerencja zawsze oznacza dla otoczenia zakłócenie, którego konsekwencją jest zmiana środowiska. W artykule rozważane są dwa sposoby podejścia do roli architekta (i jego architektury) w procesie wprowadzania zmiany. Pierwszy zobrazowany został przy pomocy metafory 'dialogu pomiędzy partnerami': Architekt (architektura) stający wobec Otoczenia. Architektoniczna interwencja jest wtedy postrzegana jako autonomiczny...
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Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the antitumor imidazoacridinone C-1311 in human hepatoma cells
PublikacjaThere is increasing evidence that the expression level of drug metabolic enzymes affects the final cellular response following drug treatment. Moreover, anti-tumour agents may modulate enzymatic activity and/or cellular expression of metabolic enzymes in tumour cells. We investigated the influence of CYP3A4 overexpression on the cellular response induced by the anti-tumour agent C-1311 in hepatoma cells. C-1311-mediated CYP3A4...
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Security Information Sharing for the Polish Power System
PublikacjaThe Polish Power System is becoming increasingly more dependent on Information and Communication Technologies which results in its exposure to cyberattacks, including the evolved and highly sophisticated threats such as Advanced Persistent Threats or Distributed Denial of Service attacks. The most exposed components are SCADA systems in substations and Distributed Control Systems in power plants. When addressing this situation...
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Convenient and efficient N-methylation of secondary amines under solvent-free ball milling conditions
PublikacjaIn the present work, we report the development of a rapid, efcient, and solvent-free procedure for the N-methylation of secondary amines under mechanochemical conditions. After optimization of the milling parameters, a vibrational ball mill was used to synthesize 26 tertiary N-methylated amine derivatives in a short time of 20 min (30 Hz frequency) and high yields ranging from 78 to 95%. An exception was compounds having a hydroxyl...
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Atom-economic thiophosphoroselenenylations of C–H acid esters and amides
PublikacjaThree improved thiophosphoroselenenylation procedures of CHacids, including derivatives of malonic and acetyl-, phosphono-, 4-nitrophenyl- and 3-pyridylacetic acids, have been described and compared to previously reported thiophosphoroselenylation of diethyl malonate using bis(disopropoxyphosphinothioyl)diselenide alone or with the aid of methyl iodide. The use of iodine makes it possible to utilize both equivalents of the selenenylating...
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Therapeutic intervention by the simultaneous inhibition of DNA repair and type I or type II DNA topoisomerases: one strategy, many outcomes
PublikacjaMany anticancer drugs reduce the integrity of DNA, forming strand breaks. This can cause mutations and cancer or cell death if the lesions are not repaired. Interestingly, DNA repair-deficient cancer cells (e.g., those with BRCA1/2 mutations) have been shown to exhibit increased sensitivity to chemotherapy. Based on this observation, a new therapeutic approach termed 'synthetic lethality' has been developed, in which radiation...
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Low-volume label-free SARS-CoV-2 detection with the microcavity-based optical fiber sensor
PublikacjaAccurate and fast detection of viruses is crucial for controlling outbreaks of many diseases; therefore, to date, numerous sensing systems for their detection have been studied. On top of the performance of these sensing systems, the availability of biorecognition elements specific to especially the new etiological agents is an additional fundamental challenge. Therefore, besides high sensitivity and selectivity, such advantages...
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Antitumor Activity of Triazine Mimic Antibiotics for DNA-binding Implications (Impressive Activity in Vitro Against a Variety of Tumor Types in the NCI-60 Screen): NSC 710607 To Fight HCT-116 Human Colon Carcinoma Cell Lines in Vivo Using the Hollow Fiber Assay and Xenograft Mouse Models
PublikacjaPurpose Successful clinical applications of DNA-directed selective cytotoxic agents disrupt the vital replication/transcription processes and ultimately lead to cancer cell death. This study aimed to examine the growth screen of two lead triazine compounds in a number of cell lines and xenografts and to develop anticancer agents with noncovalent binding affinity bringing fewer side effects. Methods The NCI initial hollow...
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Pharmaceutical applications of surfactants
PublikacjaIn this study we focused on biological activity of various surfactants. According to our research, they con act both as carriers as well as therapeutic agents. Depending on their concentration, they can create different structures in a solution, which influence their properties. Liposomes have a significant role in drug delivery system. Surfactants in from of bilayer are analogous to natural biological cell membrane.
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Biosurfactants - Biodegradability, toxicity, efficiency in comparison with synthetic surfactants
PublikacjaBiosurfactants are natural surface active agents produced by variety of bacteria yeast and fungi. A review of their biodegradability, toxicity and efficiency is presented in order to compare their properties with synthetic surfactants. Due to their high efficiency in many applications and environmentally friendly character we tried to apply them in oil refining process. The efficiency of biosurfactants in this application was very...
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Umowa rezultatu : Umowa starannego działania
PublikacjaOpracowane w publikacji hsła ''mowa rezultatu'' i ''Umowa starannego działalnia'' poddają analizie umowy, których istotą jest bądź rezultat bądź właśnie staranne działanie. M to szczególne znaczenie w praktyce bowiem od tego typu wyróżnienia uzależnia się stosowanie odpowiednich przepisów i kwalifikację prawną całej umowy - w tym prawa i obowiązki jej stron. W opracowaniu uwzględniono przede wszystkim świadczenie usług medycznych...
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Bilateral Multi-Issue Negotiation Between Active Documents and Execution Devices
PublikacjaMobile document-agents are often in conflict with execution devices when attempting to perform activities of the business process they implement, since preferences of device owners may change depending on their current location and the actual class of the device in use. The paper proposes a bilateral negotiation mechanism based on a simple bargaining game that can effectively resolve such conflicts without any third party support.
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Smart Document-Centric Processing of Human Oriented Information Flows
PublikacjaUsually people prefer to focus on creative rather than repetitive and schematic work patterns. Still, they must spend a lot of time complying with the procedures, selecting the information they receive and repeatedly restoring the previous state of work. This paper proposes the Mobile INteractive Document architecture (MIND) - a document-centric uniform interface to provide both effective communication of content and coordination...
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Toolgraph Design of Optimal and Feasible Control Strategies for Time-Varying Dynamical Systems
PublikacjaArtykuł prezentuje nową metodę projektowania optymalnych i realizowanych strategii sterowania dla wariantnych procesów dynamicznych. Centralnym ośrodkiem i narzędziem tej metody jest struktura grafu przepływowego reprezentująca istotne właściwości autonomicznej dynamiki danego procesu w przestrzeni czasowo-stanowej, składającej się z elementarnych segmentów. Strukturę tę nazywamy grafem narzędziowym przestrzeni czasowo-stanowej....
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Evaluation of Health Hazard Due to Emission of Volatile Organic Compounds from Various Processing Units of Wastewater Treatment Plant
PublikacjaThe paper describes an attempt at health risk assessment and odour concentration determination in the most important units of a wastewater treatment plant. The cancer risk (CR) and hazard index (HI) parameters in selected measurement locations were calculated based on the results of chromatographic analyses (GCxGC-TOF-MS) and the United States Environmental Protection Agency (US EPA) guidelines. No exceedance of the CR and HI acceptable...
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Efficient parallel implementation of crowd simulation using a hybrid CPU+GPU high performance computing system
PublikacjaIn the paper we present a modern efficient parallel OpenMP+CUDA implementation of crowd simulation for hybrid CPU+GPU systems and demonstrate its higher performance over CPU-only and GPU-only implementations for several problem sizes including 10 000, 50 000, 100 000, 500 000 and 1 000 000 agents. We show how performance varies for various tile sizes and what CPU–GPU load balancing settings shall be preferred for various domain...
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Natural carbon-based quantum dots and their applications in drug delivery: A review
PublikacjaNatural carbon based quantum dots (NCDs) are an emerging class of nanomaterials in the carbon family. NCDs have gained immense acclamation among researchers because of their abundance, eco-friendly nature, aqueous solubility, the diverse functionality and biocompatibility when compared to other conventional carbon quantum dots (CDs).The presence of different functional groups on the surface of NCDs such as thiol, carboxyl, hydroxyl,...
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First report on echinocandin resistant Polish Candida isolates
PublikacjaPurpose: Candida spp. are ranked as one of the four major causative agents of fungal infections. The number of infections caused by Candida species resistant to fluconazole, which is applied as the first line drug in candidiasis treatment, increases every year. In such cases the application of echinocandin is necessary. Echinocandin susceptibility testing has become a routine laboratory practice in many countries due to the increasing...
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Synthesis and Cholinesterase Inhibitory Activity of N-Phosphorylated /N-Tiophosphorylated Tacrine
PublikacjaNovel phosphorus and thiophosphorus tacrine derivatives were designed, synthesized and their biological activity and molecular modeling was investigated as a new potential anti-Alzheimer's disease (AD) agents. All new synthesized compound exhibited lower toxicity against neuroblastoma cell line (SH-SY5Y) in comparison with tacrine. Two analogues in the series, 7 and 9, demonstrated lack of cytotoxicity against hepatocellular cells...
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Mobile monitoring system for gaseous air pollution
PublikacjaThe concept of a mobile monitoring system for chemical agents control in the air is presented. The proposed system can be applied to measure industrial and car traffic air pollution. A monitoring station is relatively small and can be placed on cars or public transportation vehicles. Measured concentrations of air pollutants are collected and transferred via the GSM network to a central data base. Exemplary results from a measurement...
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Novel Functionalization of Boron-Doped Diamond by Microwave Pulsed-Plasma Polymerized Allylamine Film
PublikacjaWe report the novel modification of a hydrogen-terminated polycrystalline boron-doped electrode with a microwave pulsed-plasma polymerized allylamine. Boron-doped diamond (BDD) was coated with a very thin layer of adherent cross-linked, pinhole- and additive-free allylamine plasma polymer (PPAAm) resistant to hydrolysis and delamination and characterized by a high density of positively charged amino groups. The pulsed microwave...
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Cognitive motivations and foundations for building intelligent decision-making systems
PublikacjaConcepts based on psychology fit well with current research trends related to robotics and artificial intelligence. Biology-inspired cognitive architectures are extremely useful in building agents and robots, and this is one of the most important challenges of modern science. Therefore, the widely viewed and far-reaching goal of systems research and engineering is virtual agents and autonomous robots that mimic human behavior in...
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‘Acridines’ as New Horizons in Antifungal Treatment
PublikacjaFrequent fungal infections in immunocompromised patients and mortality due to invasive mycosis are important clinical problems. Opportunistic pathogenic Candida species remain one of the leading causes of systemic mycosis worldwide. The repertoire of antifungal chemotherapeutic agents is very limited. Although new antifungal drugs such as lanosterol 14α-demethylase and β-glucan synthase inhibitors have been introduced into clinical...
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FPGA-Based Real-Time Implementation of Detection Algorithm for Automatic Traffic Surveillance Sensor Network
PublikacjaArtykuł opisuje sprzętową implementację w układzie FPGA algorytmu wykrywającego pojazdy, przeznaczonego do zastosowania w autonomicznej sieci sensorowej. Zadaniem algorytmu jest detekcja poruszających się pojazdów w obrazie z kamery pracującej w czasie rzeczywistym. Algorytm ma na celu oszacowanie parametrów ruchu ulicznego, takich jak liczba pojazdów, ich kierunek ruchu i przybliżona prędkość, przy wykorzystaniu sprzętu sieci...
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Big Data i 5V – nowe wyzwania w świecie danych (Big Data and 5V – New Challenges in the World of Data)
PublikacjaRodzaje danych, składające się na zbiory typu Big Data, to m.in. dane generowane przez użytkowników portali internetowych, dane opisujące transakcje dokonywane poprzez Internet, dane naukowe (biologiczne, astronomiczne, pomiary fizyczne itp.), dane generowane przez roboty w wyniku automatycznego przeszukiwania przez nie Internetu (Web mining, Web crawling), dane grafowe obrazujące powiązania pomiędzy stronami WWW itd. Zazwyczaj,...
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Building Polish space sector – from small islands of excellence to a national innovation ecosystem
PublikacjaIn the paper a national potential of Poland to build its space industry after joining the European Space Agency (ESA) in 2012 is assessed, based on the series of survey reports published annually by POLSA since 2016. Their methodology was based on the ESA technology tree, classifying all the space-related technical knowhow and allowed identification of the most promising strengths to exploit and shortages to challenge by policymakers...
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Cartometric: semantic ontology evaluation with cartographic methods
PublikacjaW ostatnich latach, głównie dzięki rozwojowi inicjatywy Sieci Semantycznej (ang. Semantic Web), staliśmy się świadkami powstawania coraz większej liczby gwałtownie ewoluujących ontologii. W takiej sytuacji zarówno użytkownicy Sieci, jak i komputerowe agenty potrzebują metody oceny właściwości ontologii, w szczególności takiej, która uwzględni jej cechy semantyczne, czyli kształt przestrzeni dozwolonych modeli. Niniejsza praca prezentuje...
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CartoMetric: Ocena semantycznych właściwości ontologii za pomocą metody kartograficznej
PublikacjaW ostatnich latach, głównie dzięki rozwojowi inicjatywy Sieci Semantycznej (ang. Semantic Web), staliśmy się świadkami powstawania coraz większej liczby gwałtownie ewoluujących ontologii. W takiej sytuacji zarówno użytkownicy Sieci, jak i komputerowe agenty potrzebują metody oceny właściwości ontologii, w szczególności takiej, która uwzględni jej cechy semantyczne, czyli kształt przestrzeni dozwolonych modeli. Niniejsza praca prezentuje...
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Peptide conjugates of lactoferricin analogues and antimicrobials—Design, chemical synthesis, evaluation of antimicrobial activity and mammalian cytotoxicity
PublikacjaEight new peptide conjugates composed of modified bovine lactoferricin truncated analogues (LFcinB) and oneof the three antimicrobials — ciprofloxacin (CIP), levofloxacin (LVX), and fluconazole (FLC) — were synthesized. Four different linkers were applied to connect a peptide and an antimicrobial agent. The FLC-containing peptidic conjugates were synthesized using the “click chemistry” method. This novel approach is reported here...
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Degradation kinetics and mechanism of pentoxifylline by ultraviolet activated peroxydisulfate
PublikacjaDegradation of pentoxifylline (PTX) by sodium peroxydisulfate (SPDS) assisted by UV irradiation has been investigated in deionized water. The treatment was more favorable over direct photolysis or peroxydisulfate oxidation alone. The effects of various parameters, including different dosage of oxidant agent, PTX concentration, initial solution pH levels, and the presence of inorganic ions like chloride, nitrate and carbonate have...
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The Taste of Waste: The Edge of Eggshell Over Calcium Carbonate in Acrylonitrile Butadiene Rubber
PublikacjaRubber technology experiences a new age by the use of biowaste or natural fillers. In this regard, taking properties of reinforcing agents from biowaste fillers remains as the challenging matter. Chicken eggshell (ES) biowaste has recently been introduced to substitute calcium carbonate (CaCO3) duo to its superior properties and low price. In this work, composites based on acrylonitrile butadiene rubber (NBR) reinforced with ES...
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Wykorzystanie protokołu SNMP do zdalnego monitorowania i sterowania elementami instalacji KNX
PublikacjaW referacie zaproponowano rozwiązanie wykorzystujące do zdalnego monitorowania i sterowania elementów systemu KNX protokół SNMP. Przedstawiono opracowaną strukturę bazy danych informacji zarządzania (MIB) dostosowaną do potrzeb instalacji KNX oraz sposób reprezentacji obiektów komunikacyjnych modułów KNX. Zaprezentowano prototyp opracowanego modułu rozszerzenia do standardowego agenta SNMP systemu Windows umożliwiający zdalne zarządzanie...
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Uczenie poprzez auto-kodowanie w celu redukcji wymiarowości obrazu w zadaniach zaganiania
PublikacjaPraca dotyczy redukcji wymiarowości w problemie zaganiania (spychania) gromady złożonej z dużej liczby dynamicznych obiektów (ludzi, zwierząt, cząstek chemicznych, itp.) przez zespół aktywnych agentów. Proces zaganiania powinien spełniać określone kryteria, a algorytmy działania agentów uzyskiwane są na drodze uczenia. Przy dużej liczbie obiektów w gromadzie powstaje potrzeba redukcji wymiarowości poprzez ekstrakcję cech reprezentujących...
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Analiza pokrycia powierzchni terenu przez działanie robota mobilnego w otoczeniu przeszkód ruchomych
PublikacjaW artykule została opisana metodyka rozwiązania problemu całkowitego pokrycia nieznanej powierzchni przez autonomicznego robota mobilnego podczas jednoczesnego unikania kolizji z przeszkodami ruchomymi. Przedstawiono sformułowanie oraz dokonano szczegółowej analizy obu problemów, ze zwróceniem szczególnej uwagi na występujące ograniczenia. Zaprezentowano behawioralne podejście do sterowania robotem mobilnym wzorowane na reakcjach...
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Proposal of a method for effective tasks distribution in the execution of compolex problems
PublikacjaAn access to a great number of various services allows for decomposition of complex problems into smaller and less complex tasks. Those tasks can be presented in a form of a dependency graph. This paper shows an idea of executing such a problem using cooperating autonomous agents. Main focus of this work is cooperation covering effective tasks distribution among executors. This paper presents an algorithm for dynamic executor selection...
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Harmony Search to Self-Configuration of Fault-Tolerant Grids for Big Data
PublikacjaIn this paper, harmony search algorithms have been proposed to self-configuration of fault-tolerant grids for big data processing. Some tasks related to big data processing have been considered. Moreover, two criteria have been applied to evaluate quality of grids. The first criterion is a probability that all tasks meet their deadlines and the second one is grid reliability. Furthermore, some intelligent agents based on harmony...
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Opioid Growth Factor and its Derivatives as Potential Non-toxic Multifunctional Anticancer and Analgesic Compounds
PublikacjaIn this paper, we review the structure-activity relationship of OGF and its analogues. We highlight also OGF derivatives with analgesic, immunomodulatory activity and the ability to penetrate the blood-brain barrier and may be used as safe agents enhancing chemotherapy efficacy and improving quality of life in cancer patients. The reviewed papers indicate that Met-enkephalin and its analogues are interesting candidates for the...
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Experimental and Theoretical Insights into the Intermolecular Interactions in Saturated Systems of Dapsone in Conventional and Deep Eutectic Solvents
PublikacjaSolubility is not only a crucial physicochemical property for laboratory practice but also provides valuable insight into the mechanism of saturated system organization, as a measure of the interplay between various intermolecular interactions. The importance of these data cannot be overstated, particularly when dealing with active pharmaceutical ingredients (APIs), such as dapsone. It is a commonly used anti-inflammatory and...
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Hybrid approach to ontology specification and development
PublikacjaIn this chapter a first draft of a hybrid ontology development approach is presented. The context of this method encompasses the multi-agent system equipped with knowledge bases and inferring engine. The process of ontology engineering appears as a complex issue, as it addresses different point-views of both, a client and a modeler with a requirements/system analyst. Regarding this, an approach based on the knowledge preprocessing...
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Evaluating Security and Resilience of Critical Networked Infrastructures after Stuxnet
PublikacjaThe chapter presents the current configuration of the simulation environment for the evaluations of the security and resilience of critical networked infrastructures, which enables simulations of Stuxnet-like attacks. The configuration includes new features added to the MAlSim - Mobile Agent Malware Simulator after the advent of Stuxnet in reference to the experiments aiming at the security evaluation of a power plant which we...
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Emotions Embodied in the SVC of an Autonomous Driver System
PublikacjaA concept of embodied intelligence (EI) is considered. None of such implementations can be fully identified with artificial intelligence. Projects that dare to approach AI and EI should be based on both the AI concepts (symbolic and sub-symbolic), in solving real problems of perception and decision-making. Therefore, the EI, in this paper, is understood as a methodology that uses all available resources and algorithms from the...
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Porównanie cystouretrografii mikcyjnej i sonocystografii mikcyjnej z użyciem ultrasonograficznego środka kontrastującego drugiej generacji w badaniu prospektywnym
PublikacjaThe invasiveness and exposure to radiation in voiding cystourethrography led to the introduction of alternative methods of diagnosis of vesicoureteral reflux, including contrast enhanced voiding urosonography. While there is a limited number of studies comparing these methods using new generation ultrasound contrast agents, none of them compared both methods simultaneously. This study is aimed at assessing agreement between contrast...
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Nanomaterials for photothermal and photodynamic cancer therapy
PublikacjaIn recent years, the role of optically sensitive nanomaterials has become powerful moieties in therapeutic techniques and has become particularly emphasized. Currently, by the extraordinary development of nanomaterials in different fields of medicine, they have found new applications. Phototherapy modalities, such as photothermal therapy (PTT) by toxic heat generation and photodynamic therapy (PDT) by reactive oxygen species, are...
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How to meet when you forget: log-space rendezvous in arbitrary graphs
PublikacjaProblem rendezvous został dogłębnie zbadany, zarówno dla agendów anonimowych jak i poetykietowanych. zbadano też problem eksploracji grafu za pomocą agentów mobilnych.
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Nieoczywistość porozumienia w przestrzeni
PublikacjaMonografia realizuje zadanie zbliżone do zadania wystawy, z której bezpośrednio wynika. Prezentowane są wybrane obiekty grupy artystów i architektów, inżynierów, którzy na co dzień są wykładowcami w wyższych uczelniach. Często lepiej znani ze swojego dorobku naukowego tutaj ukazują twórczy aspekt swojej pracy. Zawarta w monografii prezentacja opiera się na tytułowym zderzeniu dwóch dziedzin: Designu i Sztuki. Odbiorca zaproszony...
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Protokół głosowania większościowego w narzędziu wsparcia decyzji handlowych
PublikacjaIstnieje szerokie spektrum narzędzi i metod wspierających decyzje handlowe, lecz brakuj jasnych reguł ich stosowania. Zaproponowano samoorganizujacy się system agentowy do wspierania decyzji handlowych. System bazując na glosowaniu z dynamicznymi wagami, wskazuje efektywne indykatory na podstawie ich poprzednich osiągnięć. Przedstawiono analizę formalną i wyniki weryfikacji, potwierdzającej cechy rozwiązania.
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Chemometrics and Statistics | Multicriteria Decision Making
PublikacjaThis contribution describes the application of Multicriteria Decision Making tools in analytical chemistry. The general scheme of MCDM is presented to show its general steps. The most frequently applied in analytical sciences MCDM techniques – AHP, ELECTRE, PROMETHEE and TOPSIS – are briefly described and their advantages and disadvantages are discussed. The applications in analytical chemistry are selection of an appropriate...
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The possibility of use keratin products in various branches of industry
PublikacjaBird's feather, the main by-product of the poultry industry, are not enough utilized and negatively influencing the environment. They contain large amount of keratin, the protein with high cystine content. The aim of our work was to obtain hydrolysates and isolates of keratin, which can be used in various areas of food, cosmetics, pharmaceutical industry and as animal feed. Keratin can be hydrolyzed and extracted from feather after...
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Assessment and Optimization of Air Monitoring Network for Smart Cities with Multicriteria Decision Analysis
PublikacjaEnvironmental monitoring networks need to be designed in efficient way, to minimize costs and maximize the information granted by their operation. Gathering data from monitoring stations is also the essence of Smart Cities. Agency of Regional Air Quality Monitoring in the Gdańsk Metropolitan Area (pol. ARMAAG) was assessed in terms of its efficiency to obtain variety of information. The results on one-month average concentrations...
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Harmony Search for Data Mining with Big Data
PublikacjaIn this paper, some harmony search algorithms have been proposed for data mining with big data. Three areas of big data processing have been studied to apply new metaheuristics. The first problem is related to MapReduce architecture that can be supported by a team of harmony search agents in grid infrastructure. The second dilemma involves development of harmony search in preprocessing of data series before data mining. Moreover,...