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Long range molecular dynamics study of interactions of the eukaryotic glucosamine-6-phosphate synthase with fructose-6-phosphate and UDP-GlcNAc
PublikacjaGlucosamine-6-phosphate synthase (EC 2.6.1.16) is responsible for catalysis of the first and practically irreversible step in hexosamine metabolism. The final product of this pathway, uridine 5 diphospho Nacetyl- d-glucosamine (UDP-GlcNAc), is an essential substrate for assembly of bacterial and fungal cell walls. Moreover, the enzyme is involved in phenomenon of hexosamine induced insulin resistance in type II diabetes, which...
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Modelling Long‐Term Transition from Coal‐Reliant to Low‐Emission Power Grid and District Heating Systems in Poland
PublikacjaEnergy systems require technological changes towards climate neutrality. In Poland, where the power system is dominated by outdated coal-fired power plants, efforts to minimize the environmental impact are associated with high costs. Therefore, optimal paths for the development of the energy sector should be sought in order to achieve ambitious long-term strategic goals, while minimizing the negative impact on the consumers’ home...
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Functionalized Peptide Fibrils as a Scaffold for Active Substances in Wound Healing
PublikacjaTechnological developments in the field of biologically active peptide applications in medicine have increased the need for new methods for peptide delivery. The disadvantage of peptides as drugs is their low biological stability. Recently, great attention has been paid to self-assembling peptides that can form fibrils. Such a formulation makes bioactive peptides more resistant to enzymatic degradation and druggable. Peptide fibrils...
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Surrogate-Assisted Design of Checkerboard Metasurface for Broadband Radar Cross-Section Reduction
PublikacjaMetasurfaces have been extensively exploited in stealth applications to reduce radar cross section (RCS). They rely on the manipulation of backward scattering of electromagnetic (EM) waves into various oblique angles. However, arbitrary control of the scattering properties poses a significant challenge as a design task. Yet it is a principal requirement for making RCS reduction possible. This article introduces a surrogate-based...
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Quantitative Risk Assessment in Construction Disputes Based on Machine Learning Tools
PublikacjaA high monetary value of the construction projects is one of the reasons of frequent disputes between a general contractor (GC) and a client. A construction site is a unique, one-time, and single-product factory with many parties involved and dependent on each other. The organizational dependencies and their complexity make any fault or mistake propagate and influence the final result (delays, cost overruns). The constant will...
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Study of the Performance of DSSS UAC System Depending on the System Bandwidth and the Spreading Sequence
PublikacjaA signal transmitted in an Underwater Acoustic Communication (UAC) system operating in a shallow-water channel suffers from strong time dispersion due to multipath propagation. This causes the Inter-Symbol Interference (ISI) observed in the received signal, which significantly limits the communication system’s reliability and transmission rate. In such propagation conditions, the Direct-Sequence Spread Spectrum (DSSS) method is...
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Simultaneous opto-electrochemical monitoring of carbamazepine and its electro-oxidation by-products in wastewater
PublikacjaThe growing human impact on aquatic environments, due to the extensive use of pharmaceuticals and the release of persistent pollutants, makes it necessary to implement new widespread methods for the characterisation and quantification of such contaminants and relative degradation products. Carbamazepine, 5H-dibenzo[b,f]azepine-5-carboxamide, (CBZ) is a widely used anti-epileptic drug, characterised by its limited removal by conventional...
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Normalized Partial Scattering Cross Section for Performance Evaluation of Low-Observability Scattering Structures
PublikacjaThe development of diffusion metasurfaces created new opportunities to elevate the stealthiness of combat aircraft. Despite the potential significance of metasurfaces, their rigorous design methodologies are still lacking, especially in the context of meticulous control over the scattering of electromagnetic (EM) waves through geometry parameter tuning. Another practical issue is insufficiency of the existing performance metrics,...
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Impact evaluation of a cycling promotion campaign using daily bicycle counters data: The case of Cycling May in Poland
PublikacjaThe promotion of active and sustainable transport modes as an alternative to motorised individual transport has become a key policy priority in Europe, to reduce air pollution, road congestion, noise, traffic injuries, and the adverse health outcomes of sedentary lifestyles. Policymakers are implementing a wide range of measures to encourage this shift in attitudes and behaviours. These interventions are most valuable when targeting...
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A Highly Sensitive Planar Microwave Sensor for Detecting Direction and Angle of Rotation
PublikacjaThis article presents a technique based on a modified complementary split-ring resonator (CSRR) to detect angular displacement and direction of rotation with high resolution and sensitivity over a wide dynamic range. The proposed microwave planar sensor takes advantage of the asymmetry of the sensor geometry and measures the angle of rotation in terms of the change in the relative phase of the reflection coefficients. The sensor...
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Degradation of ferritic X10CrAlSi18 stainless steel caused by slurry
PublikacjaThe slurry erosion tests of ferritic X10CrAlSi18 steel were carried out using a slurry pot device. In order to investigate the erosion process, two series of tests were performed: first one with a constant impact velocity of 5 m/s, 7 m/s and 9 m/s and the second one, during which the impact velocity was changed after every exposure. During each test, an influence of test conditions on volume loss, surface hardness and roughness...
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Flooding Extent Mapping for Synthetic Aperture Radar Time Series Using River Gauge Observations
PublikacjaThe flooding extent area in a river valley is related to river gauge observations such as discharge and water elevations. The higher the water elevations, or discharge, the larger the flooding area. Flooding extent maps are often derived from synthetic aperture radar (SAR) images using thresholding methods. The thresholding methods vary in complexity and number of required parameters. We proposed a simple thresholding method that...
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Structure and the space vector modulation for a medium-voltage power-electronic-transformer based on two seven-level cascade H-bridge inverters
PublikacjaThis study presents the structure and the space vector pulse-width modulation (SVPWM) for power electronic transformer (PET) based on two seven-level cascade H-bridge (CHB) inverters. The DC links of CHB inverters are coupled with nine dual-active bridge (DAB) converters with medium-frequency transformers. The DC-link voltages are equalised with two methods – through the control of DAB voltages...
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Application of shifted Chebyshev polynomial-based Rayleigh–Ritz method and Navier’s technique for vibration analysis of a functionally graded porous beam embedded in Kerr foundation
PublikacjaPresent study is dealt with the applicability of shifted Chebyshev polynomial based Rayleigh-Ritz method and Navier’s technique on free vibration of Functionally Graded (FG) beam with uniformly distributed porosity along the thickness of the beam. The material properties such as Young’s modulus, mass density, and Poisson’s ratio are also considered to vary along the thickness of the FG beam as per the power-law exponent model....
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Fast Multi-Objective Aerodynamic Optimization Using Sequential Domain Patching and Multifidelity Models
PublikacjaExploration of design tradeoffs for aerodynamic surfaces requires solving of multi-objective optimization (MOO) problems. The major bottleneck here is the time-consuming evaluations of the computational fluid dynamics (CFD) model used to capture the nonlinear physics involved in designing aerodynamic surfaces. This, in conjunction with a large number of simulations necessary to yield a set of designs representing the best possible...
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DETERMINATION OF SEAKEEPING PERFORMANCE FOR A CASE STUDY VESSEL BY THE STRIP THEORY METHOD
PublikacjaThe increase of seakeeping performance is of particular importance for car and passenger ferries, service ships in the gas and oil extraction industry and offshore wind power farm industry, as well as for special purpose ships (including military applications). In the water areas of the Baltic Sea, North Sea, and Mediterranean Sea, which are characterised by a short and steep wave, the hull shape has a substantial impact on the...
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Probabilistic analysis of settlements under a pile foundation of a road bridge pylon
PublikacjaThe paper addresses the reliability change of a road bridge pile foundation due to the unpredictable increase of settlements in time. The analysis is based on the Rędziński Bridge in Wrocław, Poland, its design assumptions, and monitoring results. The bridge foundation rests on a multi-layered subsoil assumed random. The Finite Element model of the subgrade is generated in ZSoil® software. To simplify the probabilistic approach,...
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Monte Carlo simulations of the fracture resistance degradation of asphalt concrete subjected to environmental factors
PublikacjaThe paper presents the results of laboratory tests of SCB (semi-circular beam) samples of asphalt concrete, subjected to the destructive effect of water and frost as well as the aging processes. The determined values of material parameters show significant dispersions, which makes the design of mixtures difficult. Statistical analysis of the test results supplemented by computer simulations made with the use of the proprietary...
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Experimental Study of the Influence of Noise Level on the Uncertainty Value in a Measurement System Containing an Analog-to-Digital Converter
Dane BadawczeFor newly developed measuring systems it is easy to estimate type B uncertainties based on the technical data of the measuring modules applied. However, it is difficult to estimate A type un-certainties due to the unknown type and level of interferences infiltrating into the measuring sys-tem. This is a particularly important problem for measurements...
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Long-term hindcast simulation of water temperature and salinity in the Baltic Sea
Dane BadawczeThe dataset contains the results of numerical modelling of water temperature and salinity over a period of 50 years (1958-2007) in the Baltic Sea. A long-term hindcast simulation was performed using a three-dimensional hydrodynamic model PM3D (Kowalewski and Kowalewska-Kalkowska, 2017), a new version of the M3D model (Kowalewski, 1997). The hydrodynamic...
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Long-term hindcast simulation of currents in the Baltic Sea
Dane BadawczeThe dataset contains the results of numerical modelling of currents over a period of 50 years (1958-2007) in the Baltic Sea . A long-term hindcast simulation was performed using a three-dimensional hydrodynamic model PM3D (Kowalewski and Kowalewska-Kalkowska, 2017), a new version of the M3D model (Kowalewski, 1997). The hydrodynamic model was coupled...
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Finite element models used in diagnostics of transverse cracks in bridge approach pavement
Dane BadawczeTransverse cracks in the asphalt pavement were observed on bridge structures next to single-module expansion joints with a 5 meter approach slab set at the depth of 1 m. The finite element (FE) models of the approach pavement were created to investigate the reasons of premature cracking and crack initiation mechanism over the back edge of the abutment...
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Otwarte innowacje w inicjatywach klastrowych
PublikacjaSpecyfika funkcjonowania inicjatyw klastrowych czyni z nich idealne podłoże do wcielania w życie idei open innovation – ułatwiają bowiem nawiązywanie kontaktów z innymi podmiotami, stawiają na otwartość swoich członków i budowę relacji opartych na zaufaniu, stanowią platformę wymiany zasobów (w tym przede wszystkim informacji i wiedzy) oraz wspólnego kreowania rozwiązań innowacyjnych. W artykule podjęto rozważania teoretyczne dotyczące...
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System monitoringu odbieraków prądu pojazdów kolejowych w aspekcie bezpieczeństwa i ciągłości ruchu.
PublikacjaOmówiono metodę monitorowania stanu technicznego odbieraków prądu w oparciu o pomiar uniesienia przewodów jezdnych sieci trakcyjnej w czasie przejazdu pociągu. Opisano konstrukcję i zasadę działania wdrożonego na linii kolejowej pilotażowego stanowiska monitoringu. Przedstawiono metodę analizy i sposób wizualizacji wyników pomiarów. Zastosowany algorytm szacowania siły statycznej odbieraka uwzględnia prędkości pociągu i działanie...
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Sterowanie predykcyjne i fuzja danych w systemie dynamicznego pozycjonowania statku
PublikacjaRozprawa doktorska poświęcona jest badaniu zastosowania fuzji danych oraz sterowania predykcyjnego w systemie dynamicznego pozycjonowania statku. W pierwszej części pracy przedstawiono historię rozwoju systemów dynamicznego pozycjonowania, różne metody estymacji położenia statku, metody sterowania oraz cel i tezę pracy. Następnie zaprezentowano model matematyczny statku, kinematykę oraz dynamikę. W kolejnej części przedstawiono...
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Zasady efektuacji w działaniach początkujących przedsiębiorców
PublikacjaArtykuł dotyczy efektuacyjnego, dynamicznego modelu przedsiębiorczości stanowiącego odpowiedź na wymagania zmiennego, niepewnego otoczenia biznesowego, w którym funkcjonują współcześni przedsiębiorcy. We wcześniejszych badaniach, obejmujących stosowanie pięciu zasad efektuacji w prowadzeniu firm, różni autorzy odnosili się głównie do dojrzałych przedsiębiorców, charakteryzujących się doświadczeniem w zakładaniu i prowadzeniu własnego...
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Bacterial Community Structures in Freshwater Polar Environments of Svalbard
PublikacjaTwo thirds of Svalbard archipelago islands in the High Arctic are permanently covered with glacial ice and snow. Polar bacterial communities in the southern part of Svalbard were characterized using an amplicon sequencing approach. A total of 52,928 pyrosequencing reads were analyzed in order to reveal bacterial community structures in stream and lake surface water samples from the Fuglebekken and Revvatnet...
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Ice Phenomena in River Mouths
PublikacjaRiver outlets located in tideless areas are analyzed in this paper. First, ice processes in the St Clair River mouth are presented. The river mouth, called St. Clair Flats is a typical river delta located on the shore of Lake St. Clair. Based on this example ice jam formation in river delta has been analyzed followed by a presentation of the main mechanism of ice jam formation. The Vistula River mouth is a man-made, artificial...
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Architectural Project Sem. II 2021/2022
Kursy OnlineProwadzący: dr hab. inż. arch. Jacek Krenz, prof. PG mgr inż. arch. Marta Golińska Architecture influenced by Art The aim of the course is to teach the method of creating an architectural form in a style that reflects a given topic drawn in the form of an ideogram. Creating architecture in this way makes it possible to endow the architectural form with meanings so that it becomes an important element of the existential space....
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Architectural Project II 2022/2023
Kursy OnlineProwadzący: dr hab. inż. arch. Jacek Krenz, prof. PG mgr inż. arch. Marta Golińska Architecture influenced by Art The aim of the course is to teach the method of creating an architectural form in a style that reflects a given topic drawn in the form of an ideogram. Creating architecture in this way makes it possible to endow the architectural form with meanings so that it becomes an important element of the existential space....
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Modernisation of existing hospitals
PublikacjaProgress in medicine and development of medical technologies directly affect the evolution of methods for treating patients in hospitals. The main task of 19th-century hospitals was patient care and nursing, while the aim of hospitals today is to diagnose and treat patients effectively in the shortest time possible. The changes which are taking place in methods of treatment affect the functional-spatial layout of hospitals. This...
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Mechanisms of Damage to DNA Labeled with Electrophilic Nucleobases Induced by Ionizing or UV Radiation
PublikacjaHypoxia—a hallmark of solid tumors—makes hypoxic cells radioresistant. On the other hand, DNA, the main target of anticancer therapy, is not sensitive to the near UV photons and hydrated electrons, one of the major products of water radiolysis under hypoxic conditions. A possible way to overcome these obstacles to the efficient radio- and photodynamic therapy of cancer is to sensitize the cellular DNA to electrons and/or ultraviolet...
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Microporous Polyurethane Thin Layer as a Promising Scaffold for Tissue Engineering
PublikacjaThe literature describes that the most efficient cell penetration takes place at 200–500 µm depth of the scaffold. Many different scaffold fabrication techniques were described to reach these guidelines. One such technique is solvent casting particulate leaching (SC/PL). The main advantage of this technique is its simplicity and cost efficiency, while its main disadvantage is the scaffold thickness, which is usually not less than...
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Center for Scientific and Technical Information - Library Services for Business and Science at Wroclaw University of Technology
PublikacjaWroclaw University of Technology is situated in Lower Silesia – the dynamically developing region of Poland. Focusing on adopting its own offer to the market needs had been selected as a strategy. Due to that, a synergy effect has been achieved with the development of segments strategic for the region. The University is strongly oriented to cooperation with the economy and industry. One of the key initiatives was establishment...
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Design Methodology for Small Passenger Ships On the Example of the Ferryboat Motława 2 Driven by Hybrid Propulsion System
PublikacjaDynamic development in practically all elds of science and engineering has not passed over shipbuilding . In last years , engineers got to their use computer soware which makes it possible to perform strength and hydrodynamic calculations as well as to visualize design projects in 3 D space [1-4]. At their disposal they have full spectrum of modern solutions associated with the use of advanced materials and technologies [5-7]....
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Role of the disulfide bond in stabilizing and folding of the fimbrial protein DraE from uropathogenic Escherichia coli
PublikacjaDr fimbriae are homopolymeric adhesive organelles of uropathogenic Escherichia coli composed of DraE subunits, responsible for the attachment to host cells. These structures are characterized by enormously high stability resulting from the structural properties of an Ig-like fold of DraE. One feature of DraE and other fimbrial subunits that makes them peculiar among Ig-like domain-containing proteins is a conserved disulfide bond...
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FPGA implementation of the multiplication operation in multiple-precision arithmetic
PublikacjaAlthough standard 32/64-bit arithmetic is sufficient to solve most of the scientific-computing problems, there are still problems that require higher numerical precision. Multiple-precision arithmetic (MPA) libraries are software tools for emulation of computations in a user-defined precision. However, availability of a reconfigurable cards based on field-programmable gate arrays (FPGAs) in computing systems allows one to implement...
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Strategic aspects in spatial planning - theory and practice in largest cities of Poland
PublikacjaThe rate of changes and the growing uncertainty rise to the need for a strategic approach to development planning, which is active and flexible in relation to the changing reality. Strategic planning, occurring in companies, was adapted by the social-economic development planning of self-government units. However, there are difficulties in applying the strategic planning in the spatial planning and integration of the two forms...
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Synthesis, structural characterization and reactivity of new trisubstituted N1-acylamidrazones: solid state and solution studies
PublikacjaA series of new linear trisubstituted N1-acylamidrazones have been investigated using a variety of analytical techniques and theoretical calculations to check the influence of the type of N1-acyl substituent on the resonance forms and conformational behavior in the solid state and in solution. The 1D- and 2D-NMR experiments, supported by computational studies, revealed that in solution all amidrazones exhibit conformational syn/anti...
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Safety assessment of a concrete viaduct damaged by vehicle impact and an evaluation of the repair
PublikacjaDamage to lower parts of viaducts caused by impact from under-passing high vehicles is relatively frequent. One such incident, in which a viaduct was damaged by the impact from a truck with an improperly assembled hydraulic crane, is considered in this work. The analysis is based on a detailed object damage evaluation, 3D laser scanning, and numerical simulations. The aim of the study is to accurately model the vehicle impact into...
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IMPACT OF THE ORGANISATION OF MEGA SPORTING EVENTS ON SELECTED ELEMENTS OF THE TOURISM SECTOR
PublikacjaIntroduction. In the world-wide literature, there is no unanimity in the assessment of the impact of mega sporting events on the tourism sector. Therefore, the main purpose of this study was to quantify the impact of mega sporting events on changes in tourist inflow and the amount of expenditure incurred by visitors. Material and methods. In this study, an ex-post analysis of many different categories of mega sporting events was...
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Stabilities of bisphenol A diglycidyl ether, bisphenol F diglycidyl ether, and their derivatives under controlled conditions analyzed using liquid chromatography coupled with tandem mass spectrometry
PublikacjaBisphenol A diglycidyl ether (BADGE), bisphenol F diglycydyl ether (BFDGE), and their related compounds are widely used as precursors in production of epoxy resins. The high reactivity of these compounds makes the development of analytical methodologies that ensure appropriate metrological accuracy crucial. Consequently, we aimed to determine whether and to what extent the composition of the solution and storage conditions affect...
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Chemical variability of Rhododendron tomentosum (Ledum palustre) essential oils and their pro-apoptotic effect on lymphocytes and rheumatoid arthritis synoviocytes
PublikacjaRhododendron tomentosum (Ledum palustre) is an aromatic plant traditionally used for alleviating rheumatic complaints which makes it a potential candidate for a natural drug in rheumatoid arthritis (RA) treatment. However, the effects of plants’ volatiles on apoptosis of synovial fibroblasts and infiltrating leucocytes of RA synovia, have not been reported. Volatile fraction of R. tomentosum is chemically variable and chemotypes...
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How to teach architecture? – Remarks on the edge of Polish transformation processes after 1989
PublikacjaThe political changes in Poland after 1989 have resulted in a whole range of dynamic processes including the transformation of space. Until that time the established institutional framework for spatial, urban and architectural planning policy was based on uniform provisions of the so-called planned economy. The same applied to the training of architects, which was based on a unified profile of education provided at the state’s...
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Advanced nanomaterials and metal-organic frameworks for catalytic bio-diesel production from microalgal lipids – A review
PublikacjaIncreasing energy demands require exploring renewable, eco-friendly (green), and cost-effective energy resources. Among various sources of biodiesel, microalgal lipids are an excellent resource, owing to their high abundance in microalgal biomass. Transesterification catalyzed by advanced materials, especially nanomaterials and metal-organic frameworks (MOFs), is a revolutionary process for overcoming the energy crisis. This review...
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Design and Evaluation of the Compact and Autonomous Energy Subsystem of a Wave Energy Converter
PublikacjaThis paper presents the results of the design process focused on the development of the energy subsystem (ES) of a wave energy converter (WEC). The ES is an important electrical part that significantly affects the energy reliability and energy efficiency of the entire WEC device. The designed ES was intended for compact WECs powering IoT network devices working in the distributed grid. The developed ES is an electronic circuit...
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Seismic response and performance prediction of steel buckling-restrained braced frames using machine-learning methods
PublikacjaNowadays, Buckling-Restrained Brace Frames (BRBFs) have been used as lateral force-resisting systems for low-, to mid-rise buildings. Residual Interstory Drift (RID) of BRBFs plays a key role in deciding to retrofit buildings after seismic excitation; however, existing formulas have limitations and cannot effectively help civil engineers, e.g., FEMA P-58, which is a conservative estimation method. Therefore, there is a need to...
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How to make membrane distillation greener? A review on environmentally friendly and sustainable aspects
PublikacjaThere is an urgent need for the development of new water resources in order to solve the problem of the world’s growing demand for clean water. Membrane distillation (MD) is a promising alternative to conventional seawater desalination. Although MD itself is often defined as sustainable desalination technology, there are many aspects within the membrane manufacture and process operation that make it far from being green. For instance,...
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Quality control of cheese samples for the presence of natamycin preservative – A natural deep eutectic solvent (NADES) based extraction coupled with HPLC
PublikacjaA new protocol for the determination of natamycin – an antifungal agent used as a food preservative - in cheese samples – is described. This new method is based on a natural deep eutectic solvent (NADES) green extraction procedure. High-performance liquid chromatography (HPLC) was used for detection and quantification. NADESs with different molar ratios were evaluated for efficient and selective extraction. NADES made of thymol...
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Steady magnetohydrodynamic flow in a diverging channel with suction or blowing
PublikacjaAn analysis is made of steady two-dimensional divergent flow of an electrically conducting incompressible viscous fluid in a channel formed by two non-parallel walls, the flow being caused by a source of fluid volume at the intersection of the walls. The fluid is permeated by a magnetic field produced by an electric current along the line of intersection of the channel walls. The walls are porous and subjected to either suction...