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Search results for: hormone-dependent cancer
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Beneficial effects and potential risks of tomato consumption for human health: An overview
PublicationTomato and its derived products have a very interesting nutritional value in addition to prominent antioxidant,anti-inflammatory, and anticancer activities. In terms of tomatoes are generally quite safe to eat. However,overall consumption varies from individual to individual. Indeed, either beneficial or harmful effects of plantsor their derived products are closely related to quality, including the presence of biologically active...
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Biologically active compounds based on the carbazole scaffold - synthetic and mechanistic aspects
PublicationDoctoral dissertation is divided into three main parts: introduction, results and discussion and experimental. The introduction is divided into four main parts which describe: 5-hydroxytryptamine receptors, the most popular antidepressants, new compounds based on the carbazole structure with affinity for serotonin receptors, telomeres and telomerase with their functions, telomerase inhibition strategies, carbazoles approved in...
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Selected problems of experimental investigation of dynamically loaded journal bearings
PublicationIn the paper some problems concerning relations between external bearing loadings and critical lining stresses are described for test stand with rotating load vector. According to the standard ISO 7905/1 this type of test stand, for dynamically loaded slide bearing, is recommended as a basic research unit for material testing in a complete bearing unit. The lining stress calculation results occurred being dependent on applied calculation...
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The homometallic warwickite V 2 OBO 3
PublicationThe synthesis, structure and elementary magnetic characterization of the homometallic warwickite V2OBO3 are reported. The material adopts the orthorhombic warwickite structure type at room temperature, space group Pnma (No. 62) with lattice parameters a = 9.2317(1) Å, b = 3.1172(1) Å, and c = 9.5313(1) Å. Temperature-dependent magnetic susceptibility, electrical resistivity, and specific heat measurements show anomalies near 35 K,...
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Interferometric Sensor of Wavelength Detuning Using a Liquid Crystalline Polymer Waveplate
PublicationOperation of a polarization interferometer for measurement of the wavelength changes of a tunable semiconductor laser was investigated. A lambda/8 waveplate made from liquid crystalline polymer is placed in one of interferometers’ arms in order to generate two output signals in quadrature. Wavelength was measured with resolution of 2 pm in the wavelength range 628–635 nm. Drift of the interferometer, measured in the period of 500...
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TiO2 and Reducing Gas: Intricate Relationships to Direct Reduction of Iron Oxide Pellets
PublicationIn response to the imperative for sustainable iron production with reduced CO2 emissions, this study delves into the intricate role of TiO2 in the direct reduction of iron oxide pellets. The TiO2-dependent reducibility of iron oxide pellets utilizing H2 and CO gas across varied temperatures and gas compositions is thoroughly investigated. Our findings unveil the nuanced nature of the TiO2 effect, underscored by its concentration-dependent...
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Adipokine and cytokine levels in non-functioning adrenal incidentalomas (NFAI)
PublicationDue to the fact that overweight or obesity is accompanied by hormonally active adrenal tumors: Cushing Syndrome-(CS) and Subclinical Cushing Syndrome (SCS), it is of high interest the correlation between different adipokines and cytokines secreted by adipose tissue, with metabolic disorders and hormonal activity in this group. Even in non-functioning adrenal incidentalomas (NFAI) elevated risk for cardiovascular disease and metabolic...
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Rheology of potato starch chemically modified with microwave-assisted reactions
PublicationNative potato starch was sulfated, selenated, borated, silicated and zincatated by means of microwave-assisted reactions with varying doses of relevant reagents. Resulting products were characterized involving rheological behavior of pastes, their weight-average molecular weight (Mw), and radius of gyration (Rg). Most of the pastes showed shear-thinning behavior, with the flow behavior index (n) below unity. The pastes of starch...
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Artificial neural network prophecy of ion exchange process for Cu (II) eradication from acid mine drainage
PublicationThe removal of heavy metal ions from wastewater was found to be significant when the cation exchange procedure was used effectively. The model of the cation exchange process was built using an artificial neural network (ANN). The acid mine drainage waste’s Cu(II) ion was removed using Indion 730 cation exchange resin. Experimental data from 252 cycles were recorded. In a column study, 252 experimental observations validated the...
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Characterization of d-xylose reductase, XyrB, from Aspergillus niger
PublicationD-xylose reductase is a member of the aldo-keto reductase family, and is involved in D-xylose and L-arabinose conversion through the Pentose Catabolic Pathway (PCP) in fungi. In this study, we biochemically characterized a newly identified second D-xylose reductase (XyrB) from Aspergillus niger. This NADPH-dependent reductase is able to efficiently convert D-xylose and L-arabinose, and it has the highest affinity for these sugars...
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Polarization interferometer using a Liquid Crystalline Polymer waveplate for wavelength measurement
PublicationA two-beam polarization interferometer for measuring wavelength changes of a tunable semiconductor laser was designed, built and tested. This interferometer uses a λ/8 waveplate made from Liquid Crystalline Polymer in order to generate two output signals in quadrature. The λ/8 waveplate can be manufactured either on a beamsplitter face or on the mirror surface, reducing the cost and complexity of the optomechnical assembly. Experiment...
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MONITORING OF PERMANENT GPS STATIONS AT THE SUDETY MOUNTAINS
PublicationThe aim of this paper is to show time-dependent baseline variation between GPS stations situated in South-East Poland. This study was based on daily data analysis of selected GPS stations: WROC, GOPE, MOPI, KRAW and KATO. The start date of the analysis is linked at every station with the beginning of its operation and the closing date of the operation is in 2006. The multiresolution signal decomposition method has been used to...
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Właściwości elektryczne szkło-ceramiki zawierającej ferroelektryczną fazę BiV
PublicationKompozyty szklano - ceramiczne zawierające nanokryształy posiadają właściwości fizyczne, które nie są możliwe do uzyskania w innych materiałach. Dzięki możliwości wytworzenia szkło - ceramik posiadających kryształy o różnej wielkości (nano, mikro...) i różnorodnego typu, można w istotny sposób kontrolować właściwości elektryczne takich materiałów. Stała dielektryczna faz ferroelektrycznych jest bardzo wrażliwa na zmiany rozmiarów...
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Wpływ postrzeganego ryzyka oraz czynników wizerunkowych na zamiar zakupu marek własnych sieci handlowych
PublicationCelem przeprowadzonych badań była analiza wpływu wizerunku sklepu, postrzeganego ryzyka oraz wizerunku cenowego marek własnych na zamiar ich zakupu. Dokonano replikacji modelu zaproponowanego przez M.F. Diallo i w jej ramach zastosowano technikę wywiadu realizowanego za pośrednictwem Internetu (CAWI) i przeprowadzono analizy z wykorzystaniem modelu równań strukturalnych (SEM) przy pomocy oprogramowania AMOS. Stwierdzono, że zamiar...
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A procedure for the determination of dichloromethane and tetrachloroethene in water using pervaporation and gas chromatography
PublicationIn the present study, pervaporation was applied to the determination of tetrachloroethene (PCE) and dichloromethane (DCM) in liquid samples. PCE is the most commonly used solvent in dry-cleaning processes. PCE belongs to group 2A of carcinogens (probably carcinogenic to humans) according to the classification of the International Agency for Research on Cancer (IARC). DCM is also widely used as an industrial solvent for the purification...
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X-ray and UV Radiation Damage of dsDNA/Protein Complexes
PublicationRadiation and photodynamic therapies are used for cancer treatment by targeting DNA. However, efficiency is limited due to physico-chemical processes and the insensitivity of native nucleobases to damage. Thus, incorporation of radio- and photosensitizers into these therapies should increase both efficacy and the yield of DNA damage. To date, studies of sensitization processes have been performed on simple model systems, e.g.,...
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A method for a comprehensive lipidomic analysis of flaxseed (Linum usitatissimum) with the use of LC–Q-TOF-MS and dispersive micro-solid-phase (μDSPE) extraction
PublicationFlaxseed (FS) is one of the richest sources of α-linolenic acid oil and lignans, and it is suggested that the consumption of flaxseed may contribute to the prevention of certain chronic diseases such as many types of cancer, diabetes, cardiovascular diseases and cerebrovascular stroke. Here, we demonstrate a new method for comprehensive FS lipidome profiling with the use of LC–Q-TOF-MS and dispersive micro-solid-phase extraction....
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Modelling Coarse Particulate Matter PM10 Concentration in the Tricity Area Using GIS
PublicationEnvironmental pollution is an issue of global concern, with Particulate Matter (PM) poisoning being a prime cause of lung cancer. This has led the European Commission to establish strict daily and annual PM concentration limits. The monitoring of air quality in major cities is the responsibility of European Member States. The Tricity, a 414.81 km 2 area in northern Poland, is monitored by a network of only 9 stations operated by...
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Chiral Pyrazolo[4,3-e][1,2,4]triazine Sulfonamides—Their Biological Activity, Lipophilicity, Protein Affinity, and Metabolic Transformations
PublicationReferring to our previous laboratory results related to the tyrosinase and urease inhibition by pyrazolo[4,3-e][1,2,4]triazine sulfonamides, we examined here in silico the mechanism of action at the molecular level of the investigated pyrazolotriazine sulfonamides by the molecular docking method. The studied compounds being evaluated for their cytotoxic effect against cancer cell lines (MCF-7, K-562) and for recombinant Abl and...
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PERFORMANCE OF ENDOSCOPIC IMAGE ANALYSIS ALGORITHMS IN LARGE BOWEL VIDEOS PROCESSING
PublicationComputer-assisted endoscopy is a rapidly developing eld of study. Many image anal- ysis algorithms exist, achieving very high rates of eciency at processing single endoscopic images. However, most of them were never tested in processing real-life endoscopic videos. In the article such tests of 16 endoscopy image analysis algorithms are presented and dis- cussed. Tests were performed on two real-life endoscopic videos of a human...
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Obtaining a Well-Trained Artificial Intelligence Algorithm from Cross-Validation in Endoscopy
PublicationThe article shortly discusses endoscopic video analysis problems and artificial intelligence algorithms supporting it. The most common method of efficiency testing of these algorithms is to perform intensive cross-validation. This allows for accurately evaluate their performance of generalization. One of the main problems of this procedure is that there is no simple and universal way of obtaining a specific instance of a well-trained...
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Analytical aspects of model compounds toxicity assessment using MTT and Microtox bioanalytica assays
PublicationMore and more increased intensity of anthropopressure processes can be observed, among other things, in the release of great quantities of synthetic substances into the environment, including the Endocrine Disrupting Compounds. The effects of the above-mentioned human impact on the environment not only can be noticed in the homeostasis disturbance in ecosystems, but they are also visible with respect to human. The high incidence...
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Badanie rozkładów parametrów sygnału mowy w zastosowaniach do prognozowania prawdopodobieństwa popełnienia błędów w systemach identyfikacji mówców = Examining distribution of speech signal parameters for the prognosis of error probability in speaker verification systems
PublicationPrzedmiotem pracy jest system identyfikacji mówców w sposób zależny od tekstu ("text dependent''). Dokonano analizy wielu różnych wypowiedzi kilkudziesięciu mówców. Zastosowana metoda parametryzacji to metoda oparta na wynikach analizy cepstralnej sygnału mowy. Zdefiniowane zostały nowe parametry skojarzone z elementarnymi zdarzeniami w procesie weryfikacji mówców. Na tej podstawie dokonano estymacji funkcji gęstości prawdopodobieństwa...
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The Determinants of False Self-Employment: A Survey of Polish Enterprises
PublicationThe main goal of this article is to advance the emergent research on tax evasion in Poland in the form of false self-employment (FSE), in particular to identify its causes. The dependent character of some self-employed workers is a big problem in the Polish economy, which has been completely unexplored because of the lack of available data. In this article, we use data from a survey of Polish companies. Our empirical results show...
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Modified SPWM Technique with Zero-Sequence Voltage Injection for a Five-Phase, Three-Level NPC Inverter
PublicationThis article presents a modified sinusoidal pulse-width modulation (SPWM) scheme for a five-phase, three-level neutral-point-clamped inverter. The modulation scheme deploys a modified min–max function to inject the zero-sequence components into the reference modulating signals; hence enabling the effective utilization of the DC-link voltage. Balanced split-input DC-link voltages were achieved through further incorporation of adjustable...
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Tunable Dielectric Switching of (Quinuclidinium)[MnCl4] Hybrid Compounds
PublicationInorganic−organic hybrid QMnCl (Q = quinuclidinium) crystals were synthesized and characterized. The X-ray and variable-temperature IR/Raman analysis demonstrate that the crystals undergo a reversible structural phase transition, which originates from an order−disorder process and is related to the dynamics of the organic Q cation. Dielectric function measurements disclose a switchability between low (“OFF”) and high (“ON”) dielectric...
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Magnetosonic Excitation of the Entropy Perturbations in a Plasma with Thermal Conduction Depending on Temperature
PublicationNonlinear excitation of the entropy perturbations by magnetosonic waves in a uniform and infinite plasma model is considered. The wave vector of slow or fast mode forms an arbitrary angle (0 B B ) with the equilibrium straight magnetic field, and all perturbations are functions of the time and longitudinal coordinate. Thermal conduction is the only factor which destroys isentropicity of wave perturbations and causes the nonlinear...
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Electrochemical oxidation of sulphamerazine at boron-doped diamond electrodes: Influence of boron concentration
PublicationThe boron-doped diamond (BDD) electrodes with different boron concentrations have been tested as electrode material for sulphamerazine (SRM) oxidation in water solution. An investigation of the electrode morphology and molecular structure was carried out using high resolution scanning electron microscopy (SEM) and Raman spectroscopy. Electrochemical results showed clearly that the kinetics and efficiency of SRM oxidation were dependent...
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Situational Awareness Network for the Electric Power System: the Architecture and Testing Metrics
PublicationThe contemporary electric power system is highly dependent on Information and Communication Technologies which results in its exposure to new types of threats, such as Advanced Persistent Threats (APT) or Distributed-Denial-of-Service (DDoS) attacks. The most exposed components are Industrial Control Systems in substations and Distributed Control Systems in power plants. Therefore, it is necessary to ensure the cyber security of...
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Annihilation rates of low-energy positron scattering from simple diatomic molecules
PublicationWe discuss the calculations of Zeff coefficients for a series of diatomic molecules over the range of energies below the positronium formation. During the development of a general code for polyatomic, nonlinear molecules colliding with positrons, it was discovered that the earlier one, employed only for diatomic molecules, had an error. The error is corrected and the corrected results are presented here. We also discuss a way of...
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TS-based RSM-aided design of cold-formed steel stiffened C-sectional columns susceptible to buckling
PublicationThe paper focuses on joint-performance analysis of a built-up cold-formed thin-walled C-sectional column with a fillister (stiffener) of the same type, interconnected with a series of bolts located along the length of the compressed members in specific spacing. The quantity of bolts and the non-connected starting distance of the fillister are considered random variables of the problem. Optimal distribution of joints on the stiffener...
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Two-photon double ionization of atoms in attosecond x-ray radiation fields
PublicationWe consider two-photon double ionization of helium with 100, 200, and 400 eV excess energy for the two ejected electrons, corresponding to photon energies of 89.5, 139.5, and 239.5 eV, respectively. We focus on the case of ultrashort pulses (two oscillations of the field) and develop an approach to calculate the two-photon transition matrix elements within the lowest order of the time-dependent perturbation theory. One of the...
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The impact of training and neurotrophins on functional recovery after spinal cord transection: cellular and molecular mechanisms contributing to motor improvement
PublicationBeneficial effects of locomotor training on the functional recovery after complete transection of the spinal cord indicate that in chronic spinal animals spontaneous recovery processes are enhanced and shaped by the training. The mechanisms of that use-dependent improvement are still not fully understood. This review tackles three aspects of this issue: (1) neurochemical attributes of functional improvement...
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Evolution of charge density wave order in continuous solid solutions Lu(Ni1-xCox)C2
PublicationPseudo-ternary solid solutions, Lu(Ni1-xCox)C2 (0 ≤ x ≤ 1), were studied by means of powder X-ray diffraction, differential thermal analysis as well as electrical resistivity and heat capacity measurements. The crystal structure of the Lu(Ni1-xCox)C2 series, as investigated by means of X-ray powder diffraction, is of structure type CeNiC2, space group Amm2, Pearson symbol oS8. The structural analysis reveals a non-monotonous evolution,...
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City scan as a tool to assess resilience challenges and vulnerabilities at the community level
PublicationThe majority of the world’s population lives in cities and cities are the key to achieving resilience. Local governments own only part of the land and can only partially decide about measures that should be taken ‘on the ground’. Local governments are therefore highly dependent on individuals, communities, and businesses to adapt and transform and take action in their own backyards or neighbourhoods. Since, for many people, climate...
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Two bacterial small heat shock proteins, IbpA and IbpB, form a functional heterodimer
PublicationSmall heat shock proteins (sHsps) are a conserved class of ATP-independent chaperones which in stress conditions bind to unfolded protein substrates and prevent their irreversible aggregation. Substrates trapped in sHsps-containing aggregates are efficiently refolded into native structures by ATP-dependent Hsp70 and Hsp100 chaperones. Most γ-proteobacteria possess a single sHsp (IbpA), while in a subset of Enterobacterales, as...
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Dissociation of furan-2-carboxylic acid by low energy electrons
PublicationElectron attachment to molecular target can lead to a variety of negative fragment ions. We experi- mentally probe the main dissociative electron attachment channels in furan-2-carboxylic acid (C3H3O2 − COOH) - a molecular target composed of two important structural units: a furan ring and a carboxylic group. In our studies we utilise nearly mono-energetic electrons at electron energies from 0 eV up to 15 eV. Our detection setup...
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Efficient synthesis and antifungal investigation of nucleosides’ quaternary ammonium salt derivatives
PublicationQuaternary ammonium salts are a group of compounds with diverse biological properties, the most important of which are their antiviral, antibacterial, and antifungal activities. The quaternization reactions of 5'-O-tosyl derivatives of uridine and thymidine with triethylamine, trimethylamine, 4-(N ,N -dimethylamino)pyridine, 2-methylpyridine, and pyridine are described in this article. Two of the synthesized compounds are exceptional...
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Methods of determination of C coefficient for period of rolling vessel in calm water for example of pax cargo ship
PublicationThis article presents a different approach to calculate the C coefficient needed to determine the period of own rolling vessel in calm water. The C coefficient is usually adopted as the approximate value from the available literature, usually depending on the type of vessel, and less dependent on the loading condition. In experimental studies of marine properties (seakeeping) often have a problem with the selection of the correct...
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On adaptive selection of estimation bandwidth for analysis of locally stationary multivariate processes
PublicationWhen estimating the correlation/spectral structure of a locally stationary process, one should choose the so-called estimation bandwidth, related to the effective width of the local analysis window. The choice should comply with the degree of signal nonstationarity. Too small bandwidth may result in an excessive estimation bias, while too large bandwidth may cause excessive estimation variance. The paper presents a novel method...
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Discussion of “Development of an Accurate Time integration Technique for the Assessment of Q-Based versus h-Based Formulations of the Diffusion Wave Equation for Flow Routing” by K. Hasanvand, M.R. Hashemi and M.J. Abedini
PublicationThe discusser read the original with great interest. It seems, however, that some aspects of the original paper need additional comments. The authors of the original paper discuss the accuracy of a numerical solution of the diffusion wave equation formulated with respect to different state variables. The analysis focuses on nonlinear equations in the form of a single transport equation with the discharge Q (volumetric flow rate)...
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Fluctuation enhanced gas sensing with WO3-based nanoparticle gas sensors modulated by UV light at selected wavelengths
PublicationThe sensitivity and selectivity of WO3-based gas sensors can be enhanced by UV-irradiation-induced modulation, especially if different wavelengths are employed. We used fluctuation-enhanced gas sensing, based on measurements of resistance fluctuations in the gas sensor, to study the effects of such modulation on the noise intensity for ambient atmospheres of synthetic air without and with additions of small amounts of ethanol,...
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Predicting the viscosity and electrical conductivity of ionic liquids on the basis of theoretically calculated ionic volumes
PublicationSelected physical properties of the ionic liquids might be quantitatively predicted based on the volumes of the ions these systems are composed of. It is demonstrated that the ionic volumes calculated using relatively simple theoretical quantum chemistry methods can be utilised to estimate the viscosities and electrical conductivities of various commonly used ionic liquids. The fitting formulas of the exponential form are offered...
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St. Jude Total Therapy studies from I to XVII for childhood acute lymphoblastic leukemia: a brief review
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DNA methylation analysis of benign and atypical meningiomas: correlation between RUNX3 methylation and WHO grade
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Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma
PublicationPURPOSE: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO2)-Pro-Lys-Thr-OCH3]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocytes, neurons) of neuroectodermal origin, and both are tumors with high heterogeneity and unsatisfactory susceptibility to chemotherapies....
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Synthesis of Combretastatin A-4 Analogs and their Biological Activities
PublicationCombretastatin A-4 (CA-4) is a natural product, which consists of two phenyl rings, linked by an ethylene bridge. CA-4, inhibitor of polymerization of tubulin to microtubules, possesses a strong antitumor and anti-vascular properties both in vitro and in vivo. Previous studies showed that disodium phosphate salt of CA-4, a water-soluble prodrug is well tolerated at therapeutically useful doses. However, it should be noted that...
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Współczynniki strat energetycznych w elementach napędu hydrostatycznego
PublicationW każdym układzie napędowym należy zastąpić obraz przepływu mocy opisany dotychczas powszechnie stosowanym wykresem Sankey’a spadku mocy zgodnego z kierunkiem przepływu mocy proponowanym przez autora wykresem wzrostu mocy w układzie przeciwnego do kierunku przepływu mocy. Należy więc opisywać straty i sprawność energetyczną a także pole pracy każdego silnika i układu napędowego jako zależne od wielkości fizycznych niezależnych...
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Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor
PublicationInositol requiring enzyme 1 alpha (IRE1α) is one of three signaling sensors in the unfolding protein response (UPR) that alleviates endoplasmic reticulum (ER) stress in cells and functions to promote cell survival. During conditions of irrevocable stress, proapoptotic gene expression is induced to promote cell death. One of the three signaling stressors, IRE1α is an serine/threonine-protein kinase/endoribonuclease (RNase) that...
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Explicit solvent repulsive scaling replica exchange molecular dynamics ( RS‐REMD ) in molecular modeling of protein‐glycosaminoglycan complexes
PublicationGlycosaminoglcyans (GAGs), linear anionic periodic polysaccharides, are crucial for many biologically relevant functions in the extracellular matrix. By interacting with proteins GAGs mediate processes such as cancer development, cell proliferation and the onset of neurodegenerative diseases. Despite this eminent importance of GAGs, they still represent a limited focus for the computational community in comparison to other classes...