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Search results for: SPECIFIC ANAMMOX ACTIVITY
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Influence of S-Oxidation on Cytotoxic Activity of Oxathiole-Fused Chalcones
PublicationSynthesis, in vitro cytotoxic activity, and interaction with tubulin of oxidized, isomeric 1-(5-alkoxybenzo[d] [1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-ones and 1-(6- alkoxybenzo[d][1,3]oxathiol-5-yl)-3-phenylprop-2-en-1- ones are described. Most of the compounds demonstrated cytotoxic activity at submicromolar concentrations. It was found that oxidation of sulfur atom of the oxathiole-fused chalcones strongly influenced activity...
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Specific cutting resistance while sawing of wood - the size effect
PublicationW artykule przedstawiono wyniki analiz zmian właściwego oporu skrawania, przy zastosowaniu współczesnej mechaniki pękania z uwzględnieniem wiązkości. Analizy wykonano dla procesu przecinania drewna na pilarce ramowej PRW15M drewna jesionu i jesionu modyfikowanego termicznie. Zastosowane podejście pozwala na wyjaśnienie zjawiska wzrostu właściwego powierzchniowego oporu skrawania dla niewielkich grubości warstwy skrawanej jako efektu...
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Evaluation of specific capacity of poultry litter in heavy metal sorption
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Are advanced glycation end-products specific biomarkers for Alzheimer's disease?
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The Role of Specific Side Groups and pH in Magnetization Transfer in Polymers
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Gas turbine as ship prime mover - specific problems and prospects.
PublicationPrzedstawiono ewentualne możliwości zastosowania turbin gazowych w okrętownictwie. Analizowano aspekty ekologiczne, ekonomiczne i techniczne.
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Solid Phase Synthesis and Biological Activity of Tuftsin Conjugates
PublicationNew tuftsin/retro-tuftsin conjugates were designed and synthesized using a classical fluorenylmethoxycarbonyl (Fmoc) solid phase procedure. All the peptide conjugates were divided into three series: 1,4-dihydroxyanthraquinone (type A), 1-nitroacridine (type B), and 4-carboxyacridone (type C) derivatives. In type A conjugates, the N-terminal group of the peptide chain is directly connected to the anthraquinone ring at C1 (Scheme...
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Peptide dendrimers as antifungal agents and carriers for potential antifungal agent—N3‐(4‐methoxyfumaroyl)‐(S)‐2,3‐ diaminopropanoic acid—synthesis and antimicrobial activity
PublicationA series of peptide dendrimers and their conjugates with antimicrobial agent FMDP (N3‐(4‐methoxyfumaroyl)‐(S)‐2,3‐diamino‐propanoic acid) were synthesized. The obtained compounds were tested for the antibacterial and antifungal activity. All novel dendrimers displayed much better activity against the tested strains than FMDP itself. Moreover, their conjugates with FMDP also exhibited antimicrobial activity. The most promising molecules...
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Sprint performance following plyometric conditioning activity in elite sprinters
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Antifungal Activity and Synergism with Azoles of Polish Propolis
PublicationThe aim of our work was to check if one of the products of natural origin, namely honey 19 bee propolis may be an alternative or supplement to currently used antifungal agents. The activity 20 of 50 ethanolic extracts of propolis (EEPs), harvested in Polish apiaries, was tested on a group of 69 21 clinical isolates of C. albicans. Most of the EEPs showed satisfactory activity, with minimum 22 fungicidal concentrations (MFC) mainly...
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Knowledge representation of motor activity of patients with Parkinson’s disease
PublicationAn approach to the knowledge representation extraction from biomedical signals analysis concerning motor activity of Parkinson disease patients is proposed in this paper. This is done utilizing accelerometers attached to their body as well as exploiting video image of their hand movements. Experiments are carried out employing artificial neural networks and support vector machine to the recognition of characteristic motor activity...
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Selected organophosphorus compounds with biological activity. Applications in medicine
PublicationThe purpose of this article is to provide an overview of the latest applications of organophosphorus compounds (OPs) that exhibit biological activity. A large family of OPs have become popular in recent years. The practical application of OPs in modern medicine has been attributed to their unique properties. In this article, the methods used to select these compounds will be emphasized. This paper will first outline the findings...
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Specific Binding of Cholesterol to the Amyloid Precursor Protein: Structure of the Complex and Driving Forces Characterized in Molecular Detail
PublicationC99 is the C-terminal membrane-bound fragment of the amyloid precursor protein that is cleaved by γ-secretase to release Aβ peptides, the hallmark of Alzheimer’s disease (AD). Specific interactions of C99 with cholesterol have been proposed to underlie the recognized role of cholesterol in promoting amyloidogenesis. By using molecular dynamics simulations, we studied cholesterol binding to C99 in a lipid bilayer. We determined...
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Iron–Sulfur Cluster Biogenesis Chaperones: Evidence for Emergence of Mutational Robustness of a Highly Specific Protein–Protein Interaction
PublicationBiogenesis of iron–sulfur clusters (FeS) is a highly conserved process involving Hsp70 and J-protein chaperones. However, Hsp70 specialization differs among species. In most eukaryotes, including Schizosaccharomyces pombe, FeS biogenesis involves interaction between the J-protein Jac1 and the multifunctional Hsp70 Ssc1. But, in Saccharomyces cerevisiae and closely related species, Jac1 interacts with the specialized Hsp70 Ssq1,...
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Antifungal Activity of Homoaconitate and Homoisocitrate Analogs
PublicationThirteen structural analogs of two initial intermediates of the L-alpha-aminoadipate pathway of L-lysine biosynthesis in fungi have been designed and synthesized, including fluoro- and epoxy-derivatives of homoaconitate and homoisocitrate. Some of the obtainedcompounds exhibited at milimolar range moderate enzyme inhibitory properties against homoaconitase and/or homoisocitrate dehydrogenase of Candida albicans. The structural...
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Targeting yeast topoisomerase II by imidazo and triazoloacridinone derivatives resulting in their antifungal activity
PublicationFungal pathogens are considered as serious factors for deadly diseases and are a case of medical concern. Invasive fungal infections also complicate the clinical course of COVID-19, leading to a significant increase in mortality. Furthermore, fungal strains' multidrug resistance has increased the demand for antifungals with a different mechanism of action. The present study aimed to identify antifungal compounds targeting yeast...
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Awareness of patients suffering from selected chronic diseases of the importance of physical activity in treating their disorders
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New conjugates of mycophenolic acid and their antiproliferative activity
PublicationThe new conjugates of mycophenolic acid (MPA) were obtained in the reaction of N6-(ω-aminoalkyl)adenosines with MPA in the presence of EDCI as a coupling reagent. New compounds 4a–h were evaluated on leukemia cell line (Jurkat) and PBMC from healthy donors. Length of the linker influenced observed activity. The compound 4b possessing 1,3-diamine spacer exhibited the most promising results and can be considered to further investigations.
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Synthesis, Antimicrobial and Mutagenic Activity of a New Class of d-Xylopyranosides
PublicationEight N-[2-(2′,3′,4′-tri-O-acetyl-α/β-d-xylopyranosyloxy)ethyl]ammonium bromides, a new class of d-xylopyranosides containing a quaternary ammonium aglycone, were obtained. Their complete structure was confirmed using NMR spectroscopy (1H, 13C, COSY and HSQC) and high-resolution mass spectrometry (HRMS). An antimicrobial activity against fungi (Candida albicans, Candida glabrata) and bacteria (Staphylococcus aureus, Escherichia...
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Folding‐upon‐repair DNA nanoswitches for monitoring DNA repair enzymes activity
PublicationWe demonstrate here a new class of DNA‐based nanoswitches that, upon enzymatic repair, could undergo a conformational change mechanism leading to a change in fluorescent signal. Such folding‐upon‐repair DNA nanoswitches are synthetic DNA sequences containing O6‐methyl‐guanine (O6‐MeG) nucleobases and labelled with a fluorophore/quencher optical pair. The nanoswitches are rationally designed so that only upon enzymatic demethylation...
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The Relation Between Art and Physical Activity in the Public Space of the Contemporary City
PublicationArt has always been and still is a mirror in which human activity is reflected. One of the basic human activities is physical activity, thanks to which humans are able to satisfy their needs, improve health and also function in society. Therefore, there are different relationships between physical activity and art. Both of them are present in the public space of cities and this aspect of connection is addressed in the article. The...
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LSA Is not Dead: Improving Results of Domain-Specific Information Retrieval System Using Stack Overflow Questions Tags
PublicationThe paper presents the approach to using tags from Stack Overflow questions as a data source in the process of building domain-specific unsupervised term embeddings. Using a huge dataset of Stack Overflow posts, our solution employs the LSA algorithm to learn latent representations of information technology terms. The paper also presents the Teamy.ai system, currently developed by Scalac company, which serves as a platform that...
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Diagnosis of Brain Tumors Through Global Specific DNA Methylation Analysis
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Critical Field and Specific Heat in Electron- and Hole-Doped Graphene Superconductors
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Occurrence of specific pollutants in a mixture of sewage and rainwater from an urbanized area
PublicationUrban runoff appears to be a pathway for transferring new emerging pollutants from land-based sources to the aquatic environment. This paper aimed to identify and describe the groups of pollutants present in rainwater surface runoff as well as their mixture with wastewater in the combined sewer system from urbanized catchments and to determine the correlations between these pollutants. Four leading groups of new emerging pollutants...
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Inclusive onboarding process and the specific organizational culture – a theoretical outline of the problem
PublicationPurpose: The aim of this article is to indicate to what extent an organization hiring new employees is able to prepare an individualized, inclusive onboarding process for a diverse workforce; to what extent is it necessary, and to what extent is it possible, so that each new employee efficiently find themselves in the new workplace, but also has the feeling that the organization wants to use their potential and talents. Design/methodology/approach:...
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Application of multistage treatment wetlands as a buffer for effluent from Anammox treatment for reject water from centrifugation
PublicationAccording to the newest knowledge concerning TW technology multistage treatment wetland could be easily applied for ensuring stable and low concentration of biogenic compounds form the effluent of SBR reactor (with nitritation/annamox process) for treatment of digested sludge dewatering in side stream. The working condition and optimising of such MTW will be the issue of carried out investigation.
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The influence of food phytochemicals on cyclic phosphodiesterase 4 (PDE4) activity
PublicationCyclic phosphodiesterase 4 (PDE4) belongs to family of cyclic phosphodiesterases, which are expressed predominantly in inflammatory cells, airway smooth muscles, cardiovascular tissues and brain. Inhibitors of this family of enzymes found medicinal applications as antidepressants, antiinflamatory drugs (mainly in airway diseases) or antiasthmatics (Ibudilast). PDE4 inhibitors are also being tested for preventing the development...
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Comparison of Acoustic and Visual Voice Activity Detection for Noisy Speech Recognition
PublicationThe problem of accurate differentiating between the speaker utterance and the noise parts in a speech signal is considered. The influence of utilizing a voice activity detection in speech signals on the accuracy of the automatic speech recognition (ASR) system is presented. The examined methods of voice activity detection are based on acoustic and visual modalities. The problem of detecting the voice activity in clean and noisy...
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Detection of person presence and its activity in the bathtub
PublicationA practical application of a bioimpedance technique for a detection of a bathing person is presented in the paper. It addresses the possibility of supervising people in the bathtub without voiding of their intimacy. The measurement system installed in a fiber-glass or a plastic bathtub is able to detect a presence of the bathing person, to estimate its activity and thus to detect potentially dangerous events. In the paper a principle...
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Morphology, surface properties and photocatalytic activity of the bismuth oxyhalides semiconductors prepared by ionic liquid assisted solvothermal method
PublicationThis is the first report of the effect of the ILs cation type (imidazolium, pyridinium and pyrrolidinium) on the morphology, surface properties and photoactivity of BiOX semiconductors type obtained by solvothermal method in glycerol. The various ionic liquids (IL) cation type as a halogen source and templating agent for the synthesis of the bismuth oxyhalides nanoparticles has been systematically investigated. The role of ILs...
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Territorial Aspects of Entrepreneurial Activity in Polish Suburban Zones
PublicationGlobalization has led to an increased correlation and integration of various fields in modern civilization, including those connected with allocation of entrepreneurial functions. Connection, on a global scale, has shown an increased significance of worldwide corporations. Territorial allocation of the entrepreneurial function has become the subject of translocation and revaluation. Translocation can be understood as the change...
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Optimal placement of IMU sensor for the detection of children activity
PublicationIn this paper an investigation to determine the optimal placement of IMU sensors for the purpose of children characteristic activity detection is presented. The article compares four different placement of two IMU sensors on human body. Ten healthy volunteers participated within the study. Data were collected firstly from two wireless 9-axial IMU sensors placed at the left and right wrists, then sensors were placed at lower back...
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Catalytic Activity of Nickel and Ruthenium–Nickel Catalysts Supported on SiO2, ZrO2, Al2O3, and MgAl2O4 in a Dry Reforming Process
PublicationDry reforming of methane (DRM) is an eco-friendly method of syngas production due to the utilization of two main greenhouse gases—methane and carbon dioxide. An industrial application of methane dry reforming requires the use of a catalyst with high activity, stability over a long time, and the ability to catalyze a reaction, leading to the needed a hydrogen/carbon monoxide ratio. Thus, the aim of the study was to investigate the...
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Elderly persons professional activity - substantive issues and methodical challenges
PublicationPopulation ageing and mass withdrawal of persons around retirement age from the labour market constitutes a serious threat for European Union economy, especially in the so-called new member states. The coming years are expected to bring a considerable increase in public spending on pensions and health care, as well as changes in the structure and size of consumer demand and an increase in the number of socially excluded individuals....
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Theoretical and Experimental Studies on the Visible Light Activity of TiO2 Modified with Halide-Based Ionic Liquids
PublicationFormation of a surface complex between organic molecules and TiO2 is one of the possible strategies for the development of visible light-induced TiO2 photoactivity. Herein, three ionic liquids (ILs) with the same cation and dierent anions (1-butylpirydynium chloride/bromide/iodide) have been applied for the surface modification of TiO2 and to understand the role of anions in visible light-induced activity of ILs-TiO2 systems. Photocatalytic...
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Antioxidant and antimicrobial activity of fermented beverages obtained from fruit pomace
PublicationFruit pomace should not be considered as a waste product but as a by-product as it contains a lot of valuable components such as dietary fiber, bioactive compounds and a source of nutrients. The reasonable way to utilize these by-products, both fresh or dried, could be the fermentation of its extracts, leading to beverages with functional properties. In our research, we checked the possibility of using chokeberry, apple and...
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Biological Activity of Tea-Chokeberry and Chokeberry Fermented Beverages
PublicationFermented beverages, such as kombucha are gaining more and more popularity due to their beneficial effects on human health. These products are obtained by the fermentation of tea infusion using so called tea fungus. This microbial consortium can also be used to prepare fermented fruit beverages. Therefore, the aim of this study was to determine the changes in the antioxidant profile of tea-chokeberry and chokeberry beverages...
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Method for Clustering of Brain Activity Data Derived from EEG Signals
PublicationA method for assessing separability of EEG signals associated with three classes of brain activity is proposed. The EEG signals are acquired from 23 subjects, gathered from a headset consisting of 14 electrodes. Data are processed by applying Discrete Wavelet Transform (DWT) for the signal analysis and an autoencoder neural network for the brain activity separation. Processing involves 74 wavelets from 3 DWT families: Coiflets,...
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The effect of freeze-drying and storage on lysozyme activity, lactoferrin content, superoxide dismutase activity, total antioxidant capacity and fatty acid profile of freeze-dried human milk
PublicationPooled human milk samples were freeze-dried and stored for 6 weeks at a temperature of 5 C and 25 C. Freeze-drying decreased the water content of milk by 86.5%, and the obtained lyophilizate was readily soluble in water. The freeze-drying process did not affect superoxide dismutase (SOD) activity, fatty acid (FA) profile or lactoferrin (LF) content, but it decreased total antioxidant capacity (TAC) of human milk by 22.1% and induced...
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Comparison of antimicrobial activity of selected, commercially available wound dressing materials
PublicationOBJECTIVE: The aim of our study was to examine the antimicrobial potential of eight selected, commercially available wound dressings containing different antimicrobial agents: silver, chlorhexidine acetate, povidone-iodine, and manuka honey. METHOD: The materials were tested against four reference strains of bacteria: Staphylococcus aureus (PCM 2051), Staphylococcus epidermidis (PCM 2118), Pseudomonas aeruginosa (ATCC 27853),...
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Pr-doped TiO2: The effect of metal content on photocatalytic activity
PublicationThe Pr-TiO2 nanoparticles were prepared by using the sol-gel method. As-prepared samples were characterized by BET measurements, X-ray powder diffraction analysis (XRD) and UV-Vis spectra. Visible and ultraviolet light photocatalytic activity of the sample was studied by photodegradation of phenol while considering the influence of the dopant concentration. TiO2 doped with 0.25 mol% of praseodymium showed the highest photocatalytic...
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Toxoplasma gondii Tetravalent Chimeric Proteins as Novel Antigens for Detection of Specific Immunoglobulin G in Sera of Small Ruminants
PublicationThe detection of Toxoplasma gondii infection in small ruminants has important significance for public health and veterinary medicine. This study, for the first time, describes the reactivity of four tetravalent chimeric proteins (AMA1N-SAG2-GRA1-ROP1, AMA1C-SAG2-GRA1-ROP1, AMA1-SAG2-GRA1-ROP1, and SAG2-GRA1-ROP1-GRA2) containing immunodominant regions from the AMA1 (apical membrane antigen 1), SAG2 (surface antigen 2), GRA1 (dense...
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New Chalcones Derivatives With Potent Antitumor Activity And Their Metabolism In Vitro
PublicationChalcone derivatives exhibit a broad range of biological activities, with antioxidant and cytotoxic properties among the most studied. Despite numerous reports on chalcones as cytotoxic, and potentially anticancer agents, very little is know on their actual mechanism of activity. Generally, chalcones are considered as antimitotic agents, which interfere with tubulin assembly.We have recently developed a new class of chalcones with...
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Accelerometer signal pre-processing influence on human activity recognition
PublicationA study of data pre-processing influence on accelerometer-based human activity recognition algorithms is presented. The frequency band used to filter-out the accelerometer signals and the number of accelerometers involved were considered in terms of their influence on the recognition accuracy.
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A negative effect of carbon phase on specific capacity of electrode material consisted of nanosized bismuth vanadate embedded in carbonaceous matrix
PublicationLithium-ion batteries (LIBs) are widely used all over the world. The LIBs belong to a renewable energy source and energy storage devices. The increase in energy demand causes that new materials of higher energy and higher power densities are still under investigation. Herein, we compare electrochemical properties of bismuth vanadate (BiVO4) embedded and not embedded into carbonaceous matrix as an anode material along with structural...
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Enhanced visible light photocatalytic activity of Pt/I-TiO2 in a slurry system and supported on glass packing
PublicationHighly photoactive I/TiO2, Pt/I-TiO2 nanocomposites were obtained using a hydrothermal and wet impregnation method. The incorporation of iodine and modification with 0.05 mol% of platinum leads to enhanced photocatalytic activity as compared to singly doped TiO2 due to the presence of impurity energy level in the structure of TiO2. X-ray diffraction, TEM microscopy, UV–Vis spectroscopy, X-ray photoelectron spectroscopy and BET...
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Insight into the microbial and genetic response of anammox biomass to broad range concentrations of different antibiotics: Linking performance and mechanism
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Determination of Antioxidant Activity of Vitamin C by Voltammetric Methods
PublicationVoltammetric methods—cyclic (CV) and differential pulse voltammetry (DPV) are considered the most appropriate way to evaluate antioxidant activity of redox active compounds. They provide information about both mechanism and kinetics of electrochemical oxidation of antioxidants as well as their physical and chemical properties such as the redox potential or the number of electrons transferred. These methods are helpful for understanding...
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Comparison of methods for diagnosing marine IC engines based on working medium parameters including exhaust gas specific enthalpy
PublicationArticle points out methods currently used to diagnose marine engines in operation. The development of tools and programs for implementing these methods was pointed out. The problem of unsatisfactory measurement susceptibility of marine engines was highlighted. Three methods of parametric diagnosis are presented: measurement of in-cylinder parameters and in exhaust gas duct, numerical simulation due to computer software and calculations...