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Search results for: post-burn therapy
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VUV photofragmentation of the six-membered heterocyclic molecules containing oxygen
PublicationCancer is a significant public health concern worldwide, which results in millions of deaths each year. The standard cure routine for cancer is surgery, and nowadays, radiotherapy or a hadrontherapy. Depending on the type of cancer, patients may undergo additional treatment, including targeted therapy. A combination of radio- or hadron-therapy with proper drug treatment can inhibit the proliferation of cancer cells and thus can...
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Environmentally friendly polymer-rubber composites obtained from waste tyres: A review
PublicationThe paper is transdisciplinary. The complex overview on changes in policy and approach to waste tyres that leads to both solving environmental problem of post consumer tyres and creating environmentally friendlier novel materials are presented. It is shown that in the world, the amount of polymer wastes increases every year. Most of them are in the form of post-consumer tyres. Recycling and recovery of such tyres is a serious environmental...
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Zastosowanie spowalniania wypowiedzi w celu poprawy rozumienia mowy przez dzieci w szkole
PublicationThis paper presents a time-scale modification algorithms that could be used for hearing impairment therapy supported by real-time speech stretching. In this paper the OLA based algorithms and Phase Vocoder were described. In the experimental part usability of those algorithms for real-time speech stretching was discussed
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In vitro studies of antimicrobial activity of Gly-His-Lys conjugates as potential and promising candidates for therapeutics in skin and tissue infections
PublicationWe presented in vitro studies of antimicrobial activity of Gly-His-Lys conjugates that are important point in preliminary biological evaluation of their potential application in skin and tissue therapy. The novel compounds include the conjugation of fatty acids with a modification of the amino acid sequence in the primary structure of Gly-His-Lys.
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Mechanisms of Damage to DNA Labeled with Electrophilic Nucleobases Induced by Ionizing or UV Radiation
PublicationHypoxia—a hallmark of solid tumors—makes hypoxic cells radioresistant. On the other hand, DNA, the main target of anticancer therapy, is not sensitive to the near UV photons and hydrated electrons, one of the major products of water radiolysis under hypoxic conditions. A possible way to overcome these obstacles to the efficient radio- and photodynamic therapy of cancer is to sensitize the cellular DNA to electrons and/or ultraviolet...
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Exposure of a small Arctic seabird, the little auk (Alle alle) breeding in Svalbard, to selected elements throughout the course of a year
PublicationThe Arctic marine ecosystem can be altered by processes of natural and anthropogenic origin. Spatio-temporal variation in species exposure to contamination is still poorly understood. Here, we studied elemental concentrations in the non-lethally collected samples from the most numerous seabird in European Arctic, the little auk (Alle alle) nesting in one breeding colony in Svalbard. This seabird spent the breeding season in the...
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Intra-operative biopsy in chronic sinusitis detects pathogenic Escherichia coli that carry fimG/H, fyuA and agn43 genes coding biofilm formation
PublicationThe aim of this study was to investigate whether or not surgical biopsy of sinus tissue in chronic sinusitis, not responsive to treatment, would detect E. coli. We intended to evaluate E. coli virulence genes, therefore dispute the causal role of such an unusual microorganism in chronic sinusitis, as well as consider effective pathogen-targeted therapy. Patients with E. coli isolated by intra-operative puncture biopsy were included...
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Recovery and Management of Postindustrial Spaces in the City on Selected Examples od European Implementations
PublicationUndeveloped, neglected and then abandoned post-industrial areas often located in a short distance from city centers have become, on one hand a major problem for city stewards due to the formation of dead urban tissue disturbing the continuity and cohesion of urbanized areas, on the other hand are spaces with high potential for a good location. The article aims to formulate, from the architectural and urban perspective, an answer...
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Effect Of Resveratrol And Quercetin On Telomerase Regulation In Cancer Cells And Their Anti-Cancer Potential
PublicationTelomeres and telomerase are nowadays one on targets for anticancer therapy. Telomerase is expressed in ~90% of human cancer cell lines and tumor specimens, whereas its enzymatic activity is not detectable in most human somatic cells. Was found that some dietary compounds can modulate telomerase activity in cancer cells. This review summarizes the current knowledge about the effects of resveratrol and quercetin on telomerase regulation...
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Procedura powiadamiania o śmierci pacjenta —“In Person, In Time…”
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Discovering the mechanisms of strain-dependent response of Staphylococcus aureus to photoinactivation: Oxidative stress toleration, endogenous porphyrin level and strain's virulence
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Nanosecond pulsed electric fields (nsPEFs) impact and enhanced Photofrin II® delivery in photodynamic reaction in cancer and normal cells
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Do bacteria isolated from ICU patients ‘ESKAPE’ antibiotic treatment? In vitro susceptibility of the Enterobacteriaceae family to tigecycline
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CARDINAL REGENERATIVE FEATURES OF THE MRL MOUSE — AN UPDATE
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Susceptibility to tigecycline of Acinetobacter baumannii strains isolated from intensive care unit patients
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The Combination of Beta-Blockers and ACE Inhibitors Across the Spectrum of Cardiovascular Diseases
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Comparison of propofol-ketamine versuspropofol-remifentanil in children anaesthetized for gastroscopy
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Triage during the COVID-19 pandemic
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Prenatally Evolving Ectopia Cordis with Successful Surgical Treatment
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Concomitant use of veno-arterial extracorporeal membrane oxygenation and Impella in the intensive care unit: a case report of fulminant myocarditis with multi-organ failure
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Implementation of veno-venous extracorporeal membrane oxygenation in a COVID-19 convalescent
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Utilisation and outcomes of a mobile (ambulance and air transport) venovenous extracorporeal membrane oxygenation (VV-ECMO) program in Poland during the COVID-19 pandemic – a retrospective, two-centres, case-series study
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Vitamin D serum levels in multiorgan failure critically ill patients undergoing continuous renal replacement therapies
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Infraclavicular access to the axillary vein — new possibilities for the catheterization of the central veins in the intensive care unit
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Nutritional management in critically ill patients with COVID-19: a retrospective multicentre study
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Pre-clinical evaluation of 1-nitroacridine derived chemotherapeutic agent that has preferential cytotoxic activity towards prostate cancer
PublicationPraca zawiera wyniki badań przedklinicznych pochodnej 1-nitroakrydyny C-1748 wobec komórek ludzkiego raka prostaty CaP in vitro, jak i przeszczepialnego na zwierzęta. W oparciu o fosforylację histonu H2AX jako markera podwójnych cięć DNA wykazano, że C-1748 jest bardziej aktywny w komórkach CaP niż HL60. Zidentyfikowano poza tym receptor androgenny (AR) jako cel molekularny badanego związku. W doświadczeniach na zwierzętach stwierdzono...
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Cardinal regenerative features of the MRL mouse
PublicationIn this review, we discuss recent studies relating to major features of adult MRL mouse biology that contribute to the regenerative responses seen. These include an increased inflammatory cell profile, a unique glycolytic metabolic state typically found during embryogenesis, and a cell cycle phenotype of DNA damage and G2/M arrest. These traits have been found in other mammalian and non-mammalian regenerative systems. How these...
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Anticancer imidazoacridinone C-1311 inhibits hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and angiogenesis
PublicationAntitumor imidazoacridinone C-1311 is a DNA-reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor. Here, we demonstrate the mechanism of C-1311 inhibitory action on novel targets: hypoxia-inducible factor-1α (HIF-1α), vascular-endothelial growth factor (VEGF), and angiogenesis. In a cell-free system, C-1311 prevented HIF-1α binding to an oligonucleotide encompassing a canonical hypoxia-responsive element (HRE),...
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Muramyl dipeptide-based analogs as potential anticancer compounds: Strategies to improve selectivity, biocompatibility, and efficiency
PublicationAccording to the WHO, cancer is the second leading cause of death in the world. This is an important global problem and a major challenge for researchers who have been trying to find an effective anticancer therapy. A large number of newly discovered compounds do not exert selective cytotoxic activity against tumorigenic cells and have too many side effects. Therefore, research on muramyl dipeptide (MDP) analogs has attracted interest...
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Screening of predicted synergistic multi-target therapies in glioblastoma identifies new treatment strategies
PublicationAbstract Background IDH-wildtype glioblastoma (GBM) is a highly malignant primary brain tumor with a median survival of 15 months after standard of care, which highlights the need for improved therapy. Personalized combination therapy has shown to be successful in many other tumor types and could be beneficial for GBM patients. Methods We performed the largest drug combination screen to date in GBM, using a high-throughput effort...
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Normy akademickie wyznacznikami tworzenia strategii uniwersytetu?
PublicationW opracowaniu postawiono tezę, że zmianom w uczelniach powinna towarzyszyć szersza refleksja na miejscem i rolą norm akademickich. Porównując normy akademickie zaproponowane przez Mertona i post-akademickie autorstwa Zimana wskazano, na przykładzie polskich publicznych uczelni technicznych, że w podstawowych dokumentach uczelni dominują odniesienia do norm post-akademickich. W podsumowaniu stwierdzono, że celowa byłaby szersza...
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Inhibition of T-type calcium channel disrupts Akt signaling and promotes apoptosis in glioblastoma cells.
PublicationGlioblastoma multiforme (GBM) are brain tumors that are exceptionally resitant to both radio- and chemotherapy regimens and novel approaches to treatment are needed. T-type calcium channels are one type of low voltage-gated channel (LVCC) involved in embryonic cell proliferation and differentiation; however they are often over-expressed in tumors, including GBM. In this study, we found that inhibition of T-type Ca channels in GBM...
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Future of medicine: personalized oncology
PublicationUnderstanding genetic and epigenetic mechanisms of tumorigenesis allows identifying many vital mutations affected the formation of various malignancies. This led to the discovery of a new therapeutic approach, based on molecular mechanisms in the world of medicine, which is called personalized medicine (PM). This review aims to outline the state of the art of the personalized medicine in treatment, taking into account anti-cancer...
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Verwandlungen der polnischen Städte- vor der postsozialistischen Stadt zur Stadt der Globalisierungszeit
PublicationW artykule przedstawiono - na tel współczesnych tendencji urbanizacyjnych - ewolucję miasta polskiego - od struktury post-socjalistycznej do miasta doby globalizacji.
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Metropolitan dimension of Tri-City: Development of the new harbor structures
PublicationThis article deals with the phenomenon of urban waterfront transformation. The special focus is on the Tri-City area in Poland. Both the transformation of port structures and redevelopment of the post-harbor areas are presented.
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Electromagnetic plane wave scattering from a cylindrical object with an arbitrary cross section using a hybrid technique
PublicationA hybrid technique combining finite-element and mode-matching methods for the analysis of scattering problems in open and closed areas is presented. The main idea of the analysis is based on the utilization of the finite-element method to calculate the post impedance matrix and combine it with external excitation. The discrete analysis, which is the most time- and memory-consuming, is limited here only to the close proximity of...
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Patterns of Business Internationalisation in Poland: Empirical Results from the V4 Survey
PublicationThe chapter focuses on the specifics of internationalisation process among Polish businesses at post-slowdown period of the turn of 2013-2014. The main research method was the survey conducted among 216 firms.
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Poland: Quality Monitoring of Therapeutic Processes in a Small Treatment Center for Children
PublicationThis article presents the case of the first ISO 9001:2000-certified small healthcare organization (the Center for Therapy and Rehabilitation) providing therapeutic and rehabilitation services for disabled children in Northern Poland. Elements of the process-oriented healthcare quality system implementation, initial benefits, and the organization's quality system structure and process descriptions are described. Particular attention...
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Marine polymers in tissue bioprinting: Current achievements and challenges
PublicationBioprinting has a critical role in tissue engineering, allowing the creation of sophisticated cellular scaffolds with high resolution, shape fidelity, and cell viability. Achieving these parameters remains a challenge, necessitating bioinks that are biocompatible, printable, and biodegradable. This review highlights the potential of marine-derived polymers and crosslinking techniques including mammalian collagen and gelatin along...
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O obliczaniu kablobetonowych ciągłych dźwigarów mostowych
PublicationPrzedstawiono analityczną metodę obliczania kablobetonowych ciągłych dźwigarów z wykorzystaniem metody sił. Podano przykład analizy zrealizowanego kablobetonowego wiaduktu o schemacie dwuprzęsłowej belki ciągłej. Porównano wyniki obliczeń analitycznych i numerycznych (model belkowy, program Sofistik).
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Rehabilitation device supporting active and passive upper limb exercises
PublicationThis article presents a mechatronic solution for rehabilitation devices supporting active and passive exercises in persons with motor dysfunctions of the upper limbs in the area of the elbow and shoulder joints. A planar positioner integrated with original software and a control system, served as the basis for creating the present solution. Bellman’s programming method was applied to optimize the motion trajectory of the planar...
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Współczesne trendy zmian w strukturze i funkcjonowaniu miast
PublicationPraca dotyczy podstwowych zagadnień związanych ze współczesnymi przeobrażeniami miast. Na bazie omówienia sytuacji w innych krajach opisuje trendy i sytuacje występujące w mieście post-socjalistycznym
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Mechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by antitumor triazoloacridinone C-1305.
Publication5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone, C-1305, is a promising antitumor therapeutic agent with high activity against several experimental tumors. It was determined to be a potent and selective inhibitor of liver microsomal and human recombinant cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1305 might modulate the effectiveness of other drugs used in multidrug therapy. The objective of this study was...
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Biomarkers of alcohol consumption in body fluids - possibilities and limitations of application in toxicological analysis
PublicationEthyl alcohol is the most popular legal drug, but its excessive consumption causes social problems. Despite many public campaigns against alcohol use, car accidents, instances of aggressive behaviour, sexual assaults and deterioration in labor productivity caused by inebriated people is still commonplace. Fast and easy diagnosis of alcohol consumption is required in order to introduce proper and effective therapy, and is crucial...
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Polyurethane-wood composites (PU-WC) as a method of wood waste management
PublicationIn recent years, due to the progressive environmental degradation and increase of environmental awareness, the sustainability of production systems in wood processing, the wood industry, and wood waste management is a crucial issue for European industry and society. Consequently, the problem of generating wood-like waste and the associated risks has become an increasingly noticeable challenge for science. Although various methods...
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Body surface area formulae: an alarming ambiguity
PublicationBody surface area (BSA) plays a key role in several medical fields, including cancer chemotherapy, transplantology, burn treatment and toxicology. BSA is often a major factor in the determination of the course of treatment and drug dosage. A series of formulae to simplify the process have been developed. Because easy-to-identify, yet general, body coefficient results of those formulae vary considerably, the question arises as to...
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Dilemmas associated with the implementation of quality management systems in Polish smaller health care units
PublicationThe article presents the considerations and recommendations for the implementation of the process-oriented quality management systems (QMS) in small health care units. As an example, the unit providing services for children with disabilities (therapy and rehabilitation) localized in northern part of Poland have been selected. The essential elements of the implementation of the quality system, taking into account the objectives...
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Remote Sensing Methods In the Study of the Impact of Long-Term Process of Sulphur Mining on Environmental Changes of the Carpathian Foreland
PublicationThe paper presents research on the extent of impact of sulphur mining process and post-mining activities upon properties of selected elements of the environment, as well as the assessment of the influence of indirect effects resulting from many years' process of exploitation of sulphur deposits in the areas of the Carpathian Foreland (south-east Poland). Within the scope of research conducted, the assessment of the extent of...
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Double layer adhesive silicone dressing as a potential dermal drug delivery film in scar treatment
PublicationThe present studies focused on the evaluation of design of an adhesive silicone film intended for scar treatment. Developed silicone double layer film was examined in terms of its future relevance to therapy and applicability on the human skin considering properties which included in vitro permeability of water vapor and oxygen. In order to adapt the patches for medical use in the future there were tested such properties as...
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Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers
PublicationMultidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR cells display a marked increase in lysosome number. We further demonstrate that imidazoacridinones (IAs), which are cytotoxic fluorochromes,...