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Search results for: human topoisomerase II
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A novel chemiluminescent immunoassay based on original acridinium ester labels as better solution for diagnosis of human toxoplasmosis than conventional ELISA test
PublicationToxoplasma gondii infection is one of the most common human zoonosis. Laboratory diagnosis of this disease is mainly based on the results of serological methods detecting specific antibodies in the patient’s sera. In this study we aimed to evaluate the performance of a chemiluminescence immunoassay (CLIA) based on the use of a novel immunochemical reagent in the form of the conjugate of original acridinium label (AL) attached to...
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Spotkanie z doktorantami II roku
EventsDn. 16.03.2023 r. (czwartek) o godz. 13.00 odbędzie się spotkanie informacyjne dla doktorantów II roku w Szkole Doktorskiej na Politechnice Gdańskiej, poświęcone ocenie śródokresowej. Spotkanie będzie prowadzone w języku
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Chemia II ćwiczenia grupa II
e-Learning CoursesChemia II, ćwiczenia dla kierunku Nanotechnologia st. I sem II grupa II semestr letni 2020/2021
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Three-dimensional modeling and automatic analysis of the human nasal cavity and paranasal sinuses using the computational fluid dynamics method
PublicationPurpose The goal of this study was to develop a complete workflow allowing for conducting computational fluid dynam- ics (CFD) simulation of airflow through the upper airways based on computed tomography (CT) and cone-beam computed tomography (CBCT) studies of individual adult patients. Methods This study is based on CT images of 16 patients. Image processing and model generation of the human nasal cavity and paranasal sinuses...
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Łambinowicki Rocznik Muzealny. Jeńcy wojenni w latach II wojny światowej
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Wojna i Pamięć. Czasopismo Muzeum II Wojny Światowej w Gdańsku
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Occurrence and levels of polybrominated diphenyl ethers (PBDEs) in house dust and hair samples from Northern Poland; an assessment of human exposure
PublicationPolybrominated diphenyl ethers (PBDEs) are among most ubiquitous compounds to be found in indoor environment and ingestion of household dust is considered an important route of exposure to PBDEs, especially in toddlers and young children. The present work reported concentration levels of PBDE congeners (PBDE-28, -47, -99, -100, -153, -154, -183 and -209) in hair and dust samples from selected households from Northern Poland. The...
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The Application of 2,6-Bis(4-Methoxybenzoyl)-Diaminopyridine in Solvent Extraction and Polymer Membrane Separation for the Recovery of Au(III), Ag(I), Pd(II) and Pt(II) Ions from Aqueous Solutions
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Adam Dąbrowski dr inż.
PeopleAdam Dabrowski has obtained a PhD in mechanical engineering from Gdańsk University of Technology and MSc. degree in mechatronics from Technische Universität Hamburg. He has an industry experience in Institute of Aviation Engineering Design Center (Warsaw, Poland) and SICK AG (Hamburg, Germany). Additionally, as an assistant at Gdansk University of Technology he teaught courses on mechanics, space mechanisms and dynamics of space...
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Matematyczny model hydraulicznych skutków awarii obwałowania kanału derywacyjnego Elektrowni Wodnej Bielkowo oraz zapór zbiornika Kolbudy II wraz z wyznaczeniem zasięgu obszarów zalewu dla różnych scenariuszy awarii.
PublicationCelem opracowania było wykonanie matematycznego modelu hydraulicznych skutków awarii obwałowania kanału derywacyjnego Elektrowni Wodnej Bielkowo oraz zapór zbiornika Kolbudy II wraz z wykonaniem obliczeń propagacji fali spiętrzenia i wyznaczeniem zasięgu stref zalewów dla różnych scenariuszy awarii budowli hydrotechnicznych.
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A new human IgG avidity test, using mixtures of recombinant antigens (rROP1, rSAG2, rGRA6), for the diagnosis of difficult-to-identify phases of toxoplasmosis
PublicationThe preliminary diagnostic utility of two mixtures of Toxoplasma gondii recombinant antigens (rROP1+rSAG2 and rROP1+rGRA6) in IgG ELISA and IgG avidity test has been evaluated. A total of 173 serum samples from patients with toxoplasmosis and seronegative people were examined. The sensitivity of IgG ELISA for rROP1+rSAG2 and rROP1+rGRA6 was 91.1% and 76.7%, respectively, while the reactivity for sera from patients where acute toxoplasmosis...
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No Evidence for Sex-specificity in Vitamin C, E and Fatty Acid Content of Human Milk from Healthy Polish Mothers
PublicationHuman milk (HM) is a complex fluid that meets the nutritional needs of infants. Its composition idrfs associated with environmental, maternal, and foetal variables. It provides nutrients and bioactive substances, including cytokines, immunoglobulins, and constituents with antioxidative properties. Boys are reportedly more susceptible to oxidative stress. This study aimed to determine the relationship between infant sex and the...
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Imidazoacridinone antitumor agent C-1311 as a selective mechanism- based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.
Publication5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311), a promising antitumor agent that is also active against autoimmune diseases, was determined to be a selective inhibitor of the cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1311 might modulate the effectiveness of other drugs used in multidrug therapy. The present work aimed to identify the mechanism of the observed C-1311-mediated inactivation of CYP1A2...
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Rapid Characterization of the Human Breast Milk Lipidome Using a Solid-Phase Microextraction and Liquid Chromatography-Mass Spectrometry-Based Approach.
PublicationHuman breast milk (HBM) is a biofluid consisting of various biomolecules such as proteins, lipids, carbohydrates, minerals and bioactive substances. Due to its unique and complex composition, HBM provides not only nutritional components required for the growth of the infant, but also additional protection against infections. Global insight into the composition of HBM is crucial to understanding the health benefits infants receive...
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Humanistic Scientific Fascicles Human Rights
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II Ogólnopolski Turniej Tańca Sportowego
Events14.05.2022 r. w hali Centrum Sportu Akademickiego PG odbędzie się Grand Prix Polski Ekstraklasa oraz II Ogólnopolski Turniej Tańca Sportowego, pod patronatem prof. Krzysztofa Wildego.
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Metabolic activity of tree saps of different origin towards cultured human cells in the light of grade correspondence analysis and multiple regression modeling
PublicationTree saps are nourishing biological media commonly used for beverage and syrup production. Although the nutritional aspect of tree saps is widely acknowledged, the exact relationship between the sap composition, origin, and effect on the metabolic rate of human cells is still elusive. Thus, we collected saps from seven different tree species and conducted composition-activity analysis. Saps from trees of Betulaceae, but not from...
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Carbon (II) oxide (CO) calibration set of FTIR spectra
Open Research DataThe calibration spectra for CO concentration calibration were supplied with this dataset
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Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression
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The Influence of the Mixed DPC:SDS Micelle on the Structure and Oligomerization Process of the Human Cystatin C
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Theoretical Study on Interactions of Bicyclic Vasopressin Analogues with Human Neurohypophyseal Hormone Receptors
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Studies of human and veterinary drugs' fate in environmental solid samples- analytical problems.
PublicationW różnych ośrodkach naukowych na całym świecie trwają prace nad poznaniem losu środowiskowego zanieczyszczeń z grupy farmaceutyków. Obecność pozostałości farmaceutycznych w poszczególnych elementach środowiska stanowi nowe wyzwanie zarówno z punktu widzenia technologii oczyszczania wód i ścieków jak i analityków, których zadaniem jest opracowanie nowych metodyk analitycznych. W publikacji przedstawiono problemy z jakimi stykają...
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Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1
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A Peptidomimetic Fluorescent Probe to Detect the Trypsin β2 Subunit of the Human 20S Proteasome
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Inhibition of Human and Yeast 20S Proteasome by Analogues of Trypsin Inhibitor SFTI-1
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A new proteinase 3 substrate with improved selectivity over human neutrophil elastase
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A Redundant Role of Human Thyroid Peroxidase Propeptide for Cellular, Enzymatic, and Immunological Activity
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The propeptide of human thyroid peroxidase is not required for its cellular, enzymatic or immunological activity
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The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L
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Erratum to: Activities of genes controlling sphingolipid metabolism in human fibroblasts treated with flavonoids
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The formal safety assessment and influence of human factor in application to chosen ship's type
PublicationTragedia jednego ze statków typu ro-ro pokazała podatność tego typu statków na utratę stateczności, przewrócenie się, a w ostateczności zatonięcie. Wszystkie ro-rowce charakteryzują się małym zanurzeniem, a wynurzona część kadłuba podatna jest na działanie wiatru. Jeżeli dodatkowo w takich warunkach dochodzi element nieprawidłowego rozmieszczenia pojazdów i ich słabego zamocowania to groźba przesunięcia ładunku staje się realna....
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Apoptosis of human leukemia cells induced by imidazoacridinone derivative C-1311 (Symadex)
PublicationPraca dotyczy różnej wrażliwości komórek białaczek ludzkich do ulegania apoptozie pod wpływem pochodnej imidazoakrydonu C-1311, co jest zgodne z aktywnością cytotoksyczną tego związku (EC90) wobec badanych komórek.
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Comparisson between impulsive and periodic non-newtonian lubrication of human hip joint
PublicationOpis smarowania powierzchni sferycznych stawu biodrowego człowieka przedstawiono w aspektach hydromechaniki, przy pomocy równań zachowania pędu i ciągłości strugi dla osiowo niesymetrycznego przepływu cieczy lepkosprężystej z wykorzystaniem związków konstytutywnych Rivlina Ericksena we współrzędnych sferycznych.
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Vitamin D derivatives enhance cytotoxic effects of H2O2 or cisplatin on human keratinocytes
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Human Female Hair Follicles Are a Direct, Nonclassical Target for Thyroid-Stimulating Hormone
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Investigating Human Visual Behavior by Hidden Markov Models in the Design of Marketing Information
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The effects of graphical interface design characteristics on human–computer interaction task efficiency
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The effect of electromagnetic field on reactive oxygen species production in human neutrophilsin vitro
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Human Granulosa Cells—Stemness Properties, Molecular Cross-Talk and Follicular Angiogenesis
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Cytotoxic effect on human melanoma cell lines and tyrosinase inhibition of Hottonia palustris
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Human amniotic-fluid-derived stem cells: a unique source for regenerative medicine
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THE IMPACT OF EMOTIONS ON CHANGES IN THE CORRELATION COEFFICIENT BETWEEN DIGITAL IMAGES OF THE HUMAN FACE
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A Comparison of ABTS and DPPH methods for assessing the total antioxidant capacity of human milk
PublicationCałkowitą zdolność przeciwutleniająca (TAC) mleka ludzkiego odzwierciedla zawartość i aktywność w mleku składników, które zapobiegają degradacji tłuszczów i białek na drodze utlenienia. Celem badania było porównuje testu ABTS i DPPH w odniesieniu do odzysku, precyzji i czułości (granica wykrywalności i oznaczalności) obu metod służących do oznaczania wartości TAC mleka ludzkiego. Wartości TAC zostały określone dla dwudziestu pięciu...
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Rough Set Based Modeling and Visualization of the Acoustic Field Around the Human Head
PublicationThe presented research aims at modeling acoustical wave propagation phenomena by applying rough set theory in a novel manner. In a typical listening environment sound intensity is determined by numerous factors: a distance from a sound source, signal levels and frequencies, obstacles’ locations and sizes. Contrarily, a free-field is characterized by direct, unimpeded propagation of the acoustical waves. The proposed approach is...
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Intracranial electrophysiological recordings from the human brain during memory tasks with pupillometry
PublicationData comprise intracranial EEG (iEEG) brain activity represented by stereo EEG (sEEG) signals, recorded from over 100 electrode channels implanted in any one patient across various brain regions. The iEEG signals were recorded in epilepsy patients (N=10) undergoing invasive monitoring and localization of seizures when they were performing a battery of four memory tasks lasting approx. 1 hour in total. Gaze tracking on the task...
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Voriconazole-Based Salts Are Active against Multidrug-Resistant Human Pathogenic Yeasts
PublicationVoriconazole (VOR) hydrochloride is unequivocally converted into VOR lactates and valinates upon reaction with silver salts of organic acids. This study found that the anticandidal in vitro activity of these compounds was comparable or slightly better than that of VOR. The Candida albicans clinical isolate overexpressing CaCDR1/CaCDR2 genes, highly resistant to VOR, was apparently more susceptible to VOR salts. On the other hand,...
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Combined anticancer therapy with imidazoacridinone analogue C‐1305 and paclitaxel in human lung and colon cancer xenografts—Modulation of tumour angiogenesis
PublicationThe acridanone derivative 5-dimethylaminopropylamino- 8- hydroxytriazoloacridinone (C-1305) has been described as a potent inhibitor of cancer cell growth. Its mechanism of action in in vitro conditions was attributed, among others, to its ability to bind and stabilize the microtubule network and subsequently exhibit its tumour- suppressive effects in synergy with paclitaxel (PTX). Therefore, the objective of the present study...
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Antitumor DNA-Damaging C-1748 is a New Inhibitor of Autophagy that Triggers Apoptosis in Human Pancreatic Cancer Cell Lines
PublicationDespite the enormous progress that has been made over the past decades in diagnosis, treatment and prevention of many types of tumors, survival rates in pancreatic cancer still remain poor. Pancreatic cancer is one of the most malignant and chemoresistant tumors and the profound mechanism supporting these phenomena is the constitutively activated prosurvival autophagy. The antitumor 1-nitroacridine derivative C-1748 belongs to...
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Starogard Gdański 2019, Tadeusza Kościuszki – aleja Jana Pawła II street - video data - pedestrian, bicycles, vehicles
Open Research DataThe data contain video traffic data (pedestrian, cyclists, vehicles) registered at Kościuszki street. Date 13.06.2019, 6:00-18:00. The video camera was installed around intersections at Kościuszki and Jana Pawła II street. Camera was mounted on 7-meter-high mast.
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Sound Field Intensity Measurements and Visualization around the Human Head Model . Rozkłąd natężenia pola akustycznego w komorze bezechowej obecności sztucznej głowy i w przypadku braku jej obecności
PublicationThe main goal of this research study was to measure and visualize sound field intensity distribution in and without presence of the human head model. Measurements were performed in the anechoic chamber with the 5 cm grid. Experimental setup consisted of a multitone generator, two loudspeakers, human head model, intensimetric probe, the Cartesian robot applied for precise positioning of the acoustic sensor, and an analyzer. Based...