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TOTAL CROSS SECTION MEASUREMENTS FOR ELECTRON SCATTERING ON METHYL FORMATE (HCOOCH3) MOLECULE: METHYLATION EFFECT
PublicationWe present the absolute total cross section (TCS) for electron scattering from the methyl formate (HCOOCH3) molecule measured in the 10-300 eV energy range, with electrostatic electron spectrometer working in the linear transmission mode. Comparison of TCS for the HCOOCH3 molecule with that measured earlier for the formic acid (HCOOH) compound manifests the methylation effect i.e. the response of the electron scattering dynamics...
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Novel Diazocrowns with Pyrrole Residue as Lead(II) Colorimetric Probes
PublicationNovel 18- and 23-membered diazomacrocycles were obtained with satisfactory yields by diazocoupling of aromatic diamines with pyrrole in reactions carried under high dilution conditions. X-ray structure of macrocycle bearing five carbon atoms linkage was determined and described. Compounds were characterized as chromogenic heavy metal ions receptors. Selective color and spectral response for lead(II) was found in acetonitrile and...
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Methodology of Selecting the Optimal Receptor to Create an Electrochemical Immunosensor for Equine Arteritis Virus Protein Detection
PublicationThe study reports a methodology of selecting the optimal receptor to create an electrochemical immunosensor for equine arteritis virus (EAV) protein detection. The detection was based on antigen recognition by antibodies immobilized on gold electrodes. Modification steps were controlled by electrochemical impedance spectroscopy and cyclic voltammetry measurements. In order to obtain the impedance immunosensor with the best parameters,...
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Chemometrics approaches to green analytical chemistry procedure development
PublicationChemometric tools are widely used in analytical chemistry for the reduction of data dimensionality, grouping of variables and processing of analytical signals. They have also the potential to be applied in analytical procedure development with the aim of minimizing the procedure’s environmental impact. The design of experiment gives the possibility to obtain much better information on the system response than in case of “changing...
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Evaluation of Foundation Input Motions Based on Kinematic Interaction Models
PublicationThe present study was designed to demonstrate the importance of baseslab averaging and embedment effects on the foundation-level input motions due to earthquake excitations. Evaluation of foundation-level input motions based on the most commonly adopted kinematic interaction models are presented. In order to conduct this investigation, original records of horizontal accelerations for two casestudy buildings were utilized. Computed...
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Dielectric Spectroscopy Studies and Modelling of Piezoelectric Properties of Multiferroic Ceramics
PublicationCompounds and solid solutions of bismuth ferrite (BiFeO3)—barium titanate (BaTiO3) system are of great scientific and engineering interest as multiferroic and potential high-temperature lead-free piezoelectric materials. In the present paper, the results of research on the synthesis and characterisation of 0.67Bi1.02FeO3–0.33BaTiO3 (67BFBT) ceramics in terms of crystal structure and dielectric and piezoelectric properties are reported....
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Experimental study on earthquake-induced pounding between steel structures
PublicationPounding between adjacent structures has been repeatedly observed during major earthquakes. The phenomenon may cause some local damage at the points of interactions, it may also lead to substantial destruction, permanent deformations or total collapse of colliding structures. The effects of earthquake-induced structural pounding have been studied for more than three decades now. However, most of the studies concerned masonry as...
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The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748
PublicationDrug resistance is one of the major cause of pancreatic cancer treatment failure. Thus, it is still imperative to develop new active compounds and novel approach to improve drug efficacy. Here we present 9-amino-1-nitroacridine antitumor agent, C-1748, developed in our laboratory, as a candidate for pancreatic cancer treatment. We examined (i) the cellular response of pancreatic cancer cell lines: Panc-1, MiaPaCa-2, BxPC-3 and...
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Expedited constrained multi-objective aerodynamic shape optimization by means of physics-based surrogates
PublicationIn the paper, computationally efficient constrained multi-objective design optimization of transonic airfoil profiles is considered. Our methodology focuses on fixed-lift design aimed at finding the best possible trade-offs between the two objectives: minimization of the drag coefficient and maximization of the pitching moment. The algorithm presented here exploits the surrogate-based optimization principle, variable-fidelity computational...
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Muramyl dipeptide-based analogs as potential anticancer compounds: Strategies to improve selectivity, biocompatibility, and efficiency
PublicationAccording to the WHO, cancer is the second leading cause of death in the world. This is an important global problem and a major challenge for researchers who have been trying to find an effective anticancer therapy. A large number of newly discovered compounds do not exert selective cytotoxic activity against tumorigenic cells and have too many side effects. Therefore, research on muramyl dipeptide (MDP) analogs has attracted interest...
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Spurious Modes in Model Order Reduction in Variational Problems in Electromagnetics
PublicationIn this work, we address an everlasting issue in 2 model order reduction (MOR) in electromagnetics that has 3 remained unnoticed until now. Contrary to what has been 4 previously done, we identify for the very first time spurious 5 modes in MOR for time-harmonic Maxwell’s equations and 6 propose a methodology to remove their negative influence on the 7 reduced order model (ROM) response. These spurious modes 8 have nonzero resonance...
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Activation of endogenous regenerative potential in mammals using epigenetic inhibitor zebularine
PublicationIn this work, a nucleoside inhibitor of DNA methyltransferases, zebularine, was investigated as a wound healing and regeneration promoting agent. It was found that a high dose of intraperitoneally delivered zebularine improved punch wound closure in the ear pinna in mice. Both cytidine, a zebularine analogue, and uridine, a zebularine metabolite, did not promote ear pinna hole closure. The effect of zebularine on ear pinna healing...
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On a flexomagnetic behavior of composite structures
PublicationThe popularity of the studies is getting further on the flexomagnetic (FM) response of nano-electro-magneto machines. In spite of this, there are a few incompatibilities with the available FM model. This study indicates that the accessible FM model is inappropriate when considering the converse magnetization effect that demonstrates the necessity and importance of deriving a new FM relation. Additionally, the literature has neglected...
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Bridge Non-Destructive Measurements Using a Laser Scanning during Acceptance Testing: Case Study
PublicationOwing to the recent proliferation of inventory works on roads and railways, bridge acceptance tests have increased exponentially. These tests’ results are often misinterpreted owing to the use of various measuring equipment types, rendering integrated interpretation problematic. It is also problematic that adjusting the measurement method is difficult when the structure’s response to load is uncertain. Therefore, it is important...
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A framework for accelerated optimization of antennas using design database and initial parameter set estimation
PublicationThe purpose of this paper is to exploit a database of pre-existing designs to accelerate parametric optimization of antenna structures is investigated. Design/methodology/approach The usefulness of pre-existing designs for rapid design of antennas is investigated. The proposed approach exploits the database existing antenna base designs to determine a good starting point for structure optimization and its response sensitivities....
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Vibro-Electrical Behavior of a Viscoelastic Piezo-Nanowire in an Elastic Substrate Considering Stress Nonlocality and Microstructural Size-Dependent Effects
PublicationThis research deals with dynamics response of a Pol/BaTiO3 nanowire including viscosity influences. The wire is also impressed by a longitudinal electric field. Hamilton's principle and Lagrangian strains are employed in conjunction with a refined higher-order beam theory in order to derive equations of motion. By combining nonlocality and small size...
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Viscoplastic damage analysis of structures subjected to impact loading. Plate and shell structures. - Ł. Pyrzowski.
PublicationThe work presents the investigation in the response of plate-shell structures subjected to impact loading (gas mixture explosions). This phenomenon is studied in the context of its mechanical aspects, mainly the ductile fracture prediction. The work starts with the literature review and the description of theories, which are nowadays the most popular in the damage and failure modelling. After selecting the theoretical models and...
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Methodology of Selecting the Optimal Receptor to Create an Electrochemical Immunosensor for Equine Arteritis Virus Protein Detection
PublicationThe study reports a methodology of selecting the optimal receptor to create an electrochemical immunosensor for equine arteritis virus (EAV) protein detection. The detection was based on antigen recognition by antibodies immobilized on gold electrodes. Modification steps were controlled by electrochemical impedance spectroscopy and cyclic voltammetry measurements. In order to obtain the impedance immunosensor with the best parameters,...
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Removal of organic matter and nitrogen in an horizontalsubsurface flow (HSSF) constructed wetland undertransient loads
PublicationA monitoring campaign in a horizontal subsurface flow constructed wetland under the influence of transient loads of flow-rate, organic matter, nitrogen and suspended solids showed an irregular removal of COD and TSS and lower both removal efficiencies and mass removal rates than the ones observed in other studies for similar operating conditions. This circumstance is associated to the presence of large amount of particulate organic...
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Transmission parameters of underwater communication channels
PublicationThe underwater environment is tough and demanding as a communication channel for ultrasonic signals. The channel transmission characteristics in marine and inland waters depend much on local bathymetry and changing weather conditions. The architecture and performance of a reliable underwater acoustic communication (UAC) system should allow real-time adaptation of its transmission parameters to a large variety of possible channel...
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A Time Delay Controller Included Terminal Sliding Mode and Fuzzy Gain Tuning for Underwater Vehicle-Manipulator Systems
PublicationAn improved Time Delay Control (TDC) method for an Underwater Vehicle-Manipulator System (UVMS) is proposed. The proposed controller consists of three terms: a time-delay-estimation term that cancels nonlinearities of the UVMS dynamics, a Terminal Sliding Mode (TSM) term that provides a fast response and a PID term that reduces the tracking error. In addition the proposed controller uses fuzzy rules to adaptively tune the gains...
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NUMERICAL ANALYSIS OF RUBBER BUMPERS INFLUENCE ON THE COLLIDING STEEL STRUCTURES
PublicationProblem of collisions of neighbouring structures is one of the important issues related to the safety of civil engineering structures. The safety and reliability of steel structures under impact loading is among a number of different aims during the design state. The aim of this paper is to present the results of numerical investigation of dynamic behavior of closely-separated steel structures under seismic excitation. Modal and transient...
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Targeting shelterin proteins for cancer therapy.
PublicationAs a global health challenge, cancer prompts continuous exploration for innovative therapies that are also based on new targets. One promising avenue is targeting the shelterin protein complex, a safeguard for telomeres crucial in preventing DNA damage. The role of shelterin in modulating ataxia- telangiectasia mutated (ATM) and ataxia-telangiectasia and Rad3-related (ATR) kinases, key players in the DNA damage response (DDR),...
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Approximate Cramér–Rao bound on Doppler error in correlation-processing relatively narrowband noise radar
PublicationThe paper studies limitations on accuracy of Doppler estimation in continuous-wave noise radar with correlation processing. Second order properties of output of the correlation receiver are evaluated and an approximate Cram´er-Rao bound on errors of Doppler measurement is derived. The accuracy of Doppler measurements is found to be affected by the following factors: power spectral density of noise signal, frequency response of the...
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Three-objective antenna optimization by means of kriging surrogates and domain segmentation
PublicationIn this paper, an optimization framework for multi-objective design of antenna structures is discussed which exploits data-driven surrogates, a multi-objective evolutionary algorithm, response correction techniques for design refinement, as well as generalized domain segmentation. The last mechanism is introduced to constrain the design space region subjected to sampling, which permits reduction of the number of training data samples...
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Pareto Ranking Bisection Algorithm for Expedited Multi-Objective Optimization of Antenna Structures
PublicationThe purpose of this letter is introduction of a novel methodology for expedited multi-objective design of antenna structures. The key component of the presented approach is fast identification of the initial representation of the Pareto front (i.e., a set of design representing the best possible trade-offs between conflicting objectives) using a Pareto-ranking bisection algorithm. The algorithm finds a discrete set of Pareto-optimal...
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Cost-efficient simulation-driven design of compact impedance matching transformers
PublicationIn this paper, an algorithmic framework for cost-efficient design optimization of miniaturized impedance matching transformers has been presented. Our approach exploits a bottom-up design that involves translating the overall design specifications for the circuit at hand to its elementary building blocks (here, compact microstrip resonant cells, CMRCs), as well as fast surrogate-assisted optimization of the cells followed by simulation-based...
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Probabilistic sensitivity of limit states of structures. The Monte Carlo simulation
PublicationDesign sensitivity deals with the variation of structural response, implicitly dependent on the design variables of the problem. An attempt is made to implement probabilistic notation in engineering sensitivity analysis. The procedure to implement the sensitivity of a structural limit state to a given basic variable is described in the paper - its main idea, depicted by a flowchart and numerical examples of engineering analysis....
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Selection of excitation signals for high-impedance spectroscopy
PublicationA method of fast impedance spectroscopy of technical objects with high impedance (|Zx| > 1 GOhm) is evaluated in this paper. An object is excited with a signal generated by a digital-to-analog converter (DAC) located on the U2531A DAQ module. Response signals proportional to current flowing through and voltage across the measured object are sampled by analog-to-digital converters (ADC) in the DAQ module. The object impedance spectrum...
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A nine-input 1.25 mW, 34 ns CMOS analog median filter for image processing in real time
PublicationIn this paper an analog voltage-mode median filter, which operates on a 3 × 3 kernel is presented. The filter is implemented in a 0.35 μm CMOS technology. The proposed solution is based on voltage comparators and a bubble sort configuration. As a result, a fast (34 ns) time response with low power consumption (1.25 mW for 3.3 V) is achieved. The key advantage of the configuration is relatively high accuracy of signal processing,...
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Knowledge-based functional safety and security management in hazardous industrial plants with emphasis on human factors
PublicationExisting and emerging new hazards have significant potential to impact destructively operation of technical systems, hazardous plants, and systems / networks of critical infrastructure. The programmable control and protection systems play nowadays an important role in reducing and controlling risk in the process of hazardous plant operation. It is outlined how to deal with security related hazards concerning such systems to be...
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3D Sound Intensity Measurement Around Organ Pipes Using Acoustic Vector Sensors
PublicationThe aim of the presented paper was to obtain and visualize sound intensity distribution of radiated acoustic energy around the organ pipes. The experimental setup consisted of the multichannel acoustic vector sensor and the specialized Cartesian robot. Measurements were performed in free field with spatial resolution of 0.1 [m]. Two organ pipes, i.e. wooden and metal were measured during the ex-periment. The organ pipes were activated...
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Earthquake-induced pounding between superstructure segments of isolated bridge
PublicationThe use of seismic isolation in bridges is considered as one of the most promising advanced technologies to enhance the structural safety during earthquakes. However, the method results in larger displacements of superstructure segments increasing the probability of pounding between them. Reports after severe ground motions show that the earthquake-induced structural pounding may lead to significant damage in isolated bridges....
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Electronic Noses in Medical Diagnostics
PublicationElectronic nose technology is being developed in order to identify aromas in a way parallel to the biologic olfaction. When applied to the field of medicine, such device should be able to identify and discriminate between different diseases. In recent years this kind of approach finds application in medical diagnostics, and especially in disease screening. Despite the fact that devices utilizing chemical sensor arrays are not routinely...
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Dynamic characteristics of the proton exchange membrane fuel cell module
PublicationThe paper describes a fuel cell based system and its performance. The system is based on two fuel cell units, DC/DC converter, DC/AC inverter, microprocessor control unit, load unit, bottled hydrogen supply system and a set of measurement instruments. In the study presented in the paper a dynamic response of the proton exchange membrane (PEM) fuel cell system to unit step change load as well as to periodical load changing cycles...
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Dynamic analysis of temporary steel grandstand equipped with different types of bracing system
PublicationIn the paper, behaviour of a temporary steel grandstand equipped with two different types of bracing system has been analysed through the numerical study. A typical solution concerning application of a diagonal tubular members has been compared with elements proposed by authors and called polymer dampers. A polymer element consists of two L-shape steel members bonded with polymer mass. The aim of the paper is to verify the effectiveness...
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Dynamics of the small-span railway bridge under moving loads
PublicationThe paper presents the results of dynamic analysis of the small-span railway bridge, subjected to an action of moving trains. Numerical simulations were performed using three different load models: series of moving forces, series of moving single-mass and double-mass oscillators. The parameters of the vehicle were taken from the existing EN57 train. The parameters of the bridge were taken from the existing steel span of 10,24 m...
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Evaluation of foundation input motions based on kinematic interaction models
PublicationThe present study was designed to demonstrate the importance of base-slab averaging and embedment effects on the foundation-level input motions due to earthquake excitations. Evaluation of foundation-level input motions based on the most commonly adopted kinematic interaction models are presented. In order to conduct this investigation, original records of horizontal accelerations for two case-study buildings were utilized. Computed...
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Timber Frame Houses with Different Insulation Materials - Seismic Analysis
PublicationThe aim of this article is to present results of a dynamic numerical analysis focused on the response of two timber frame building structures exposed to seismic excitations. The first structure was insulated with mineral wool, while the second one with polyurethane foam. Specifications and technology involved in the models' construction are based on the previously conducted experimental study, upon which numerical structural models...
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Wideband Channel Measurements for Polarised Indoor Off-Body Communications
PublicationThis paper presents the initial results of wideband channel measurements for polarised off-body communication at 5.8 GHz, in an indoor environment. Channel Impulse Response measurements were performed simultaneously for two orthogonal polarisations of the wearable antenna, and repeated for vertical and horizontal orientations of the off-body one. Four types of measurement scenarios were considered in order to investigate the influence...
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Reduced-cost constrained miniaturization of wideband antennas using improved trust-region gradient search with repair step
PublicationIn the letter, an improved algorithm for electromagnetic (EM)-driven size reduction of wideband antennas is proposed. Our methodology utilizes variable-fidelity EM simulation models, auxiliary polynomial regression surrogates, as well as multi-point response correction. The constraint handling is implicit, using penalty functions. The core optimization algorithm is a trust-region gradient search with a repair step added in order...
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Synthesis and properties of porous Sr 0.96 Y 0.04 Ti 1−x Nb x O 3
PublicationA series of porous, single phase Sr0.96Y0.04Ti1-xNbxO3 samples was obtained using a wet synthesis method (modified citrate sol-gel) method. Temperature-programmed reduction (TPR) and temperature-programmed oxidation (TPO) measurements have shown high stability of the obtained material in variable (oxidizing/reducing) atmospheres. All samples exhibit high conductivity in hydrogen atmosphere with the highest value (around 1S/cm)...
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Long way to awareness. Architecture and Aesthetic at the crossroads
PublicationThe architectural criticism is not invited to the common analysis of the architecture together with the aesthetics. The aesthetics judges entireties whereas criticism describes the architecture from the aesthetic point of view without using common scientific language. Research areas are not located in the joint research space! The result is the ambiguity of critical judgments, the ambiguous estimation of an architectural work....
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Identification and non-integer order modelling of synchronous machines operating as generator
PublicationThis paper presents an original mathematical model of a synchronous generator using derivatives of fractional order. In contrast to classical models composed of a large number of R-L ladders, it comprises half-order impedances, which enable the accurate description of the electromagnetic induction phenomena in a wide frequency range, while minimizing the order and number of model parameters. The proposed model takes into account...
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Efficient analysis of structures with rotatable elements using model order reduction
PublicationThis paper presents a novel full-wave technique which allows for a fast 3D finite element analysis of waveguide structures containing rotatable tuning elements of arbitrary shapes. Rotation of these elements changes the resonant frequencies of the structure, which can be used in the tuning process to obtain the S-characteristics desired for the device. For fast commutations of the response as the tuning elements are rotated, the...
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The methylome and transcriptome of fetal skin: implications for scarless healing
PublicationAim: Fetal skin is known to heal without scarring. In mice, the phenomenon is observed until the 16–17 day of gestation – the day of transition from scarless to normal healing. The study aims to identify key methylome and transcriptome changes following the transition. Materials & methods: Methylome and transcriptome profiles were analyzed in murine dorsal skin using microarray approach. Results & conclusion: The genes associated...
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Performance Analysis of Interaction between Smart Glasses and Smart Objects Using Image-Based Object Identification
PublicationWe propose the use of smart glasses to collaborate with smart objects in the Internet of Things environment. Particularly we are focusing on new interaction methods and the analysis of acceptable reaction times in the process of object recognition using smart glasses. We evaluated the proposed method using user studies and experiments with three different smart glasses: Google Glass, Epson Moverio, and the developed eGlasses platform....
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Alternative Approach to Convolution Term of Viscoelasticity in Equations of Unsteady Pipe Flow
PublicationIn the paper the selected aspects concerning description of viscoelastic behavior of pipe walls during unsteady flow are analyzed. The alternative convolution expression of the viscoelastic term is presented and compared with the corresponding term referring to unsteady friction. Both approaches indicate similarities in the forms of impulse response functions and the parameter properties. The flow memory was introduced into convolution...
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Aerodynamic shape optimization by variable-fidelity computational fluid dynamics models: a review of recent progress
PublicationA brief review of some recent variable-fidelity aerodynamic shape optimization methods is presented.We discuss three techniques that—by exploiting information embedded in low-fidelity computationalfluid dynamics (CFD) models—are able to yield a satisfactory design at a low computational cost, usu-ally corresponding to a few evaluations of the original, high-fidelity CFD model to be optimized. Thespecific techniques considered here...
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Efficient FPGA Implementation of an RFIR Filter Using the APC–OMS Technique with WTM for High-Throughput Signal Processing
PublicationNowadays, Finite Impulse Response (FIR) filters are used to change the attributes of a signal in the time or frequency domain. Among FIR filters, a reconfigurable filter has the advantage of changing the coefficient in real-time, while performing the operation. In this paper, the Anti-Symmetric Product Coding (APC) and Odd Multiple Storage (OMS) modules are utilized to implement the reconfigurable FIR filter (RFIR–APC–OMS). Herein,...