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Search results for: landscape ecology
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Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities
PublicationRecent studies have shown that modified human lactoferrin 20−31 fragment, named HLopt2, possesses antibacterial and antifungal activity. Thus, we decided to synthesize and evaluate the biological activity of a series of conjugates based on this peptide and one of the antimicrobials with proven antibacterial (ciprofloxacin, CIP, and levofloxacin, LVX) or antifungal (fluconazole, FLC) activity. The drugs were covalently connected...
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Two-step mechanism of J-domain action in driving Hsp70 function
PublicationJ-domain proteins (JDPs), obligatory Hsp70 cochaperones, play critical roles in protein homeostasis. They promote key allosteric transitions that stabilize Hsp70 interaction with substrate polypeptides upon hydrolysis of its bound ATP. Although a recent crystal structure revealed the physical mode of interaction between a J-domain and an Hsp70, the structural and dynamic consequences of J-domain action once bound and how Hsp70s...
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Molecularly targeted nanoparticles: an emerging tool for evaluation of expression of the receptor for advanced glycation end products in a murine model of peripheral artery disease
PublicationAbstract Background: Molecular imaging with molecularly targeted probes is a powerful tool for studying the spatio-temporal interactions between complex biological processes. The pivotal role of the receptor for advanced glycation end products (RAGE) in numerous pathological processes, aroused the demand for RAGE targeted imaging in various diseases. In the study, we evaluated the use of a diagnostic imaging agent for RAGE quantification...
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Molecular mechanism of proton-coupled ligand translocation by the bacterial efflux pump EmrE
PublicationThe current surge in bacterial multi-drug resistance (MDR) is one of the largest challenges to public health, threatening to render ineffective many therapies we rely on for treatment of serious infections. Understanding different factors that contribute to MDR is hence crucial from the global “one health” perspective. In this contribution, we focus on the prototypical broad-selectivity proton-coupled antiporter EmrE, one of the...
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Two bacterial small heat shock proteins, IbpA and IbpB, form a functional heterodimer
PublicationSmall heat shock proteins (sHsps) are a conserved class of ATP-independent chaperones which in stress conditions bind to unfolded protein substrates and prevent their irreversible aggregation. Substrates trapped in sHsps-containing aggregates are efficiently refolded into native structures by ATP-dependent Hsp70 and Hsp100 chaperones. Most γ-proteobacteria possess a single sHsp (IbpA), while in a subset of Enterobacterales, as...
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Determinants of the primary stability of cementless acetabular cup implants: A 3D finite element study
PublicationPrimary stability of cementless implants is crucial for the surgical success and long–term stability. However, primary stability is difficult to quantify in vivo and the biomechanical phenomena occurring during the press–fit insertion of an acetabular cup (AC) implant are still poorly understood. The aim of this study is to investigate the influence of the cortical and trabecular bone Young's moduli Ec and Et, the interference...
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Why do G-quadruplexes dimerize through the 5’-ends? Driving forces for G4 DNA dimerization examined in atomic detail
PublicationG-quadruplexes (G4) are secondary structures formed by guanine-rich nucleic acid sequences and shown to exist in living cells where they participate in regulation of gene expression and chromosome maintenance. G-quadruplexes with solvent-exposed guanine tetrads show the tendency to associate together through cofacial stacking, which may be important for packaging of G4-forming sequences and allows for the design of higher-order...
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Can architecture be 11-dimensional? The nature of space in the architecture of the digital world era
PublicationThis research aims to explore the development of architectural theories about ‘architectural dimensions’ and look at architecture as a multidimensional space. It is important to understand that with today's development of virtual reality technology and through the combination of theories of physics and architecture, a new possibility of creating space has emerged. The arguments are made through inductive reasoning and grounded...
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Ensembling noisy segmentation masks of blurred sperm images
PublicationBackground: Sperm tail morphology and motility have been demonstrated to be important factors in determining sperm quality for in vitro fertilization. However, many existing computer-aided sperm analysis systems leave the sperm tail out of the analysis, as detecting a few tail pixels is challenging. Moreover, some publicly available datasets for classifying morphological defects contain images limited only to the sperm head. This...
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Integrating Art into Places in Transition - Rose Kennedy Greenway in Boston as a Case Study
PublicationAmong the many projects realized in public spaces, some are truly unique – and these are the ones that build the identity of a place. The aim of this paper is to examine how integrating art and cultural strategies into public space can enhance and reinforce the sense of a place. Particular attention is devoted to urban spaces that we call “places in transition”, where public art improves the city’s imaginative capacity, enlivens...
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Reactions on the surface of the implant under the influence of biofilm
PublicationThe contact of a biomaterial with the biological environment in in vitro and in vivo tests leads to the production of a particular ecosystem in which the active roles perform both, the material surface and the extracellular matrix protein forming a biofilm. Proteins affect cell and bacteria adhesion processes, biological activity of cells and activation of inflammatory response.The knowledge of the reaction mechanisms active on...
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PUBLIC SOURCES OF FINANCE FOR CULTURE AS AN ELEMENT OF CULTURAL SECURITY IN POLAND
PublicationCulture is an important element of the country, playing an important role both for its security and the economy. It cannot be only seen as a cost-creating sector, but may be a significant factor in economic development. For this to happen, it is necessary to create a system of financing this economic sector. This article’s aim is to analyze the use of funds from public sources in Poland to finance culture-related activities. The...
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Historical, technical and economic aspects of biogas development: Case Polanda and Ukraine
PublicationThe paper describes 3700 years of biogas manufacture with more details of last 120 years. Due to V. Omelianskij׳s researches 120 years ago, Ukrainians achieved a share in biogas manufacture in the overall biogas development. Poland started to take part in biogas development 96 years ago by finishing biogas plant in Posen 1928. History and current status of biogas plants achievements are collected and analyzed. Faults and achievements...
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Safety Assessment of the Regional Warmia and Mazury Road Network Using Time-Series Analysis
PublicationWarmia and Mazury still belongs to the areas with the smallest transport accessibility in Europe. Unsatisfactory state of road infrastructure is a major barrier to the development of the regional economy, impacting negatively on the life conditions of the population. Also in terms of road safety Warmia and Mazury is one of the most endangered regions in Poland. The Police statistics show that beside a high pedestrian risk observed...
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Family business experience and the probability of starting a venture: gender differences in Poland
PublicationThe aim of this study is to analyse whether the experience of working in a family member’s business is related differently to the assessed probabilities of men and women starting their own new venture in the future. The research is conducted on a sample of 334 Polish undergraduate students. Poland is an efficiency-driven European economy with a substantial gender gap in entrepreneurship. The results obtained indicate that the relationship...
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Georg Simmel’s The Philosophy of Money and the Modernization Paradigm
PublicationThis article examines Georg Simmel’s contribution to the understanding of how money functions in modern society, mainly scrutinizing his most important work on that topic, The Philosophy of Money, in the context of modernization theories. Modernization theories, as developed (most notably) by Marx, Weber, Durkheim, and Elias, attempted to explain the transition from feudalism and a closed agrarian economy to capitalism and industrial...
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The Life Cycle Assessment and Life Cycle Cost in public works contracts
PublicationAn important goal, implemented by EU countries under the Europe 2020 strategy, is sustainable development, which includes supporting economy that effectively uses natural and environmentally friendly resources. Solutions in this area are also promoted in tender proceedings in the area of public procurement. The LCA (Life Cycle Assessment) and LCC (Life Cycle Cost) analysis are indicated as the basis for decision-making by awarding...
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Implementation of International Standards of Fiscal and Monetary Transparency - Case of Poland
PublicationResearch background: Financial managers, investors, lenders, counterparties and citizens should have useful, reliable, timely, complete, comparable, readable information on fiscal and monetary policy. The actions taken and instruments used by fiscal and monetary authorities have an important impact on economic conditions. Purpose of the article: The aim of the article is to assess Poland's compliance with international standards...
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Nowe kierunki usuwania azotu w oczyszczalniach ścieków
PublicationW 2015 roku Komisja Europejska przyjęła nową strategię gospodarki o obiegu zamkniętym (ang. Circular Economy), której celem jest efektywne wykorzystanie zasobów, a także zwiększenie roli gospodarki odpadami. Działania prowadzone w ostatnich latach w sektorze oczyszczania ścieków były ukierunkowane na rozwój efektywnej, niskoemisyjnej gospodarki zasobami, sprzyjającej wzrostowi bezpieczeństwa energetycznego i poprawie stanu jakości...
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Inter-governmental Collaborative Networks for Digital Government Innovation Transfer -Structure, Membership, Operation
PublicationDigital government refers to the transformation of government organizations and their relationships with citizens, business and each other through digital technology. It entails digital innovation in processes, services, organizations, policies, etc. which are increasingly developed and tested in one country and transferred, after adaptation, to other countries. The process of innovation transfer and the underlying information...
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Kształtowanie wartości wskaźników wspomagania finan-sowego przez ponadprzeciętnie rentowne MSP w okresie dobrej i złej koniunktury gospodarczej
PublicationW artykule porównano kształtowanie wartości wskaźników z obszaru wspomagania finansowego przez ponadprzeciętnie rentowne MSP w okresie dobrej i złej koniunktury gospodarczej. Celem przeprowadzonych badań było ponadto zaproponowanie przedziałów wartości rekomendowanych dla wskaźników z obszaru wspomagania finansowego, z osobna dla okresu dobrej jak i złej koniunktury gospodarczej. W trakcie przepro-wadzonych badań uwzględniono...
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Kształtowanie wartości wskaźników płynności finansowej przez ponadprzeciętnie rentowne MSP w okresie dobrej i złej koniunktury gospodarczej
Publication: W artykule porównano kształtowanie wartości wskaźników z obszaru płynności finansowej przez ponadprzeciętnie rentowne MSP w okresie dobrej i złej koniunktury gospodarczej. Celem przeprowadzonych badań było ponadto zaproponowanie przedziałów wartości rekomendowanych dla wskaźników z obszaru płynności finansowej z osobna dla okresu dobrej, jak i złej koniunktury gospodarczej. W trakcie przeprowadzonych badań uwzględniono 67 317...
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Characterization of single-stranded DNA-binding proteins from the psychrophilic bacteria Desulfotalea psychrophila, Flavobacterium psychrophilum, Psychrobacter arcticus, Psychrobacter cryohalolentis, Psychromonas ingrahamii, Psychroflexus torquis, and Photobacterium profundum
PublicationBackground: Single-stranded DNA-binding proteins (SSBs) play essential roles in DNA replication, recombination and repair in Bacteria, Archaea and Eukarya. In recent years, there has been an increasing interest in SSBs, since they find numerous applications in diverse molecular biology and analytical methods. Results: We report the characterization of single-stranded DNA-binding proteins from the psychrophilic bacteria Desulfotalea...
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Synagogi dawnej Polski - ich teraźniejszość i przyszłość
PublicationTekst stanowi próbę ujęcia w szerszej perspektywie złożonego zjawiska zmiany formy użytkowania ocalałych obiektów kultu religijnego. Postępująca sekularyzacja współczesnych społeczeństw stanowi wyzwanie dla religijnych społeczności różnych wyznań, przynosząc również pytania dotyczące zmiany przeznaczenia pustoszejących świątyń. Biorąc pod uwagę społeczny kontekst zarysowany powyżej, ocalałe budynki synagog można uznać za odrębny,...
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Training Services in Small and Medium-sized Enterprises: Evidence from Poland
PublicationIn the knowledge-based economy knowledge and skills are becoming more and more significant for the success of companies. This applies also to firms from small and medium-sized enterprises (SMEs) sector. As large companies in many cases posses special divisions devoted to trainings, they normally have no problems with updating the knowledge and skills of their employees. The situation is different with regard to SMEs, which often...
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New oryginal generic technologies: A Polish R&D strategic implementation programme
PublicationPolands's pharmaceutical industry is of great significance to the whole economy. According to Forbs (2 October 2012), the cost of launching a new drug varies from USD 1 to 11 bilion. There is little Chance of a Polish pharmaceutical company developing an original drug due to financial reason.Many research teams in Poland take up research projects aimed at new biologically active compounds. But such an objective has no broader perspective,...
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Shaping the New Vistula Spit Channel: Political, Economic, and Environmental Aspects
PublicationIn September 2022, the new shipping channel in Poland was opened for service. It connects the Port of Elbląg and the Gdańsk Bay in Poland, cutting through the Vistula Spit and the Vistula Lagoon. It was intended to enable direct access to the Baltic Sea from the Port of Elbląg without crossing Russian territory. Originally conceptualized decades ago, it has taken its final shape only recently. Its construction was associated with...
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EXPERIMENTAL EVALUATION OF DLC/STEEL SLIDING CONTACTS’ OPERATIONAL ENVELOPE
PublicationIn an industrial project concerning sliding bearings, a sliding pair was selected of high alloy steel vs. industrial grade DLC coated high alloy steel as a basis for an innovative design of high performance sliding bearings lubricated with a synthetic oil for use in geared transmission units. The development process required credible data on the ultimate resistance of the sliding pair to very high contact stress. An experimental...
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Tacit knowledge awareness and sharing as a focal part of knowledge production, Polish-US view on IT, healthcare, and construction industry
PublicationIn the knowledge economy era, knowledge production and dissemination are of key interest to individuals, organizations, and economies. Tacit knowledge results from experience, leading to innovation. The learning culture can facilitate the transformation of errors into experiences. This study explores whether mistake acceptance facilitates tacit knowledge awareness and sharing in the information technology, healthcare, and construction...
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Estimation of Housing Demand with Adaptive Neuro-Fuzzy Inference Systems (ANFIS)
PublicationIt has always been important to anticipate the demand for a product. To determine the demand for any product, the parameters such as the economic situation and the demands of the rival products are used generally. Especially in the housing sector, which is the locomotive sector for emerging countries, it is critical to anticipate housing demand and its relationship with economic variables. Because of that, economists, real estate...
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Katalizatory wykorzystywane w syntezie biodiesla
PublicationRising prices of electricity, conventional fuels and heating require decisive steps in the further development of technologies based on renewable energy sources. These include geothermal-; hydrothermal-; aerothermal-; and solar energy. Due to the fact that the petrochemical industry is one of the fastest growing branches of the economy, we would like to expand on the topic related to biofuels. Biodiesel is an alternative fuel similar...
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Labour resources in Kazakhstan and Uzbekistan - a comparative study
PublicationThe aim of the paper is to show the transformation and comparison of labour resources in Kazakhstan and Uzbekistan using the following methods: deductive data analysis, observation of changes in the structure of resources based on publicly available macroeconomic data. During the two decades of the 21st century, both countries experienced population growth which translated into an increased number of persons of working age. In...
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Interline power flow controller - properties and control strategy in dynamic states
PublicationHigh-power electronic converter topologies, in such forms as Unified Power Flow Controllers (UPFC), Static Compensators (STATCOM) and Interline Power Flow Controllers (IPFC), have been used to enhance and optimize the use of transmission facilities, under the concept of a flexible ac transmission system (FACTS). In Europe, the anticipated proliferation of distributed-generation (DG) in the near future, driven by governmental initiatives...
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Innovations in Wastewater Treatment: Harnessing Mathematical Modeling and Computer Simulations with Cutting-Edge Technologies and Advanced Control Systems
PublicationThe wastewater treatment landscape in Central Europe, particularly in Poland, has undergone a profound transformation due to European Union (EU) integration. Fueled by EU funding and rapid technological advancements, wastewater treatment plants (WWTPs) have adopted cutting-edge control methods to adhere to EU Water Framework Directive mandates. WWTPs contend with complexities such as variable flow rates, temperature fluctuations,...
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On Accelerated Metaheuristic-Based Electromagnetic-Driven Design Optimization of Antenna Structures Using Response Features
PublicationDevelopment of present-day antenna systems is an intricate and multi-step process requiring, among others, meticulous tuning of designable (mainly geometry) parameters. Concerning the latter, the most reliable approach is rigorous numerical optimization, which tends to be re-source-intensive in terms of computing due to involving full-wave electromagnetic (EM) simu-lations. The cost-related issues are particularly pronounced whenever...
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Use of Daylight and Aesthetic Image of Glass Facades in Contemporary Buildings
PublicationThe paper deals with the architecture of contemporary buildings in respect to their aesthetic image created by the use of natural light. Sustainability is regarded as a principle of contemporary architecture, where daylighting is an important factor as it affects energy consumption and environmental quality of the space inside a building. Environmental awareness of architecture, however, involves a much wider and more holistic...
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Long-Term Impact of Wind Erosion on the Particle Size Distribution of Soils in the Eastern Part of the European Union
PublicationWind erosion is the leading cause of soil degradation and air pollution in many regionsof the world. As wind erosion is controlled by climatic factors, research on this phenomenon isurgently needed in soil and land management in order to better adapt to climate change. In thispaper, the impact of wind erosion on the soil surface in relation to particle size distribution wasinvestigated. Changes in percentage of sand, silt and...
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Zarządzanie opóźnieniami w ruchu kolejowym
PublicationZarządzanie opóźnieniami w ruchu kolejowym zostało przedstawione jako wielokryterialny problem optymalizacyjny, do rozwiązania którego został użyty model ogólny (job-shop) szeregowania zadań. W artykule przedstawiono sposób zastosowania trzech algorytmów metaheurystycznych: algorytmu genetycznego (Genetic Algorithm), algorytmu roju (Particle Swarm Optimization) i algorytmu mrówkowego (Ant Colony Optimization) do znalezienia optymalnego...
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Rewitalizacja dróg wodnych delty Wisły jako podstawa nowej perspektywy osiedleńczej
PublicationW artykule opisano badania dotyczące rewitalizacji dróg wodnych Delty Wisły. Problematyka badawcza dotyczy rozwoju obszaru na styku lądu i wody. Wpływ lokalizacji nadmorskiej, i związana z nią problematyka wynikająca z położenia poniżej poziomu morza są dostrzegalne nawet do stu kilometrów od wybrzeża. Dodatkowym aspektem, który ujemnie wpływa na rozwój obszaru delty po II wojnie światowej jest utrata tożsamości regionalnej. Dlatego...
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Szara strefa na krajowym rynku pracy
PublicationW artykule przedstawiono zjawisko szarej strefy w Polsce, wskazując m.in. przyczyny jej tworzenia się oraz szacowane jej rozmiary. Zwrócono też uwagę na to, że mimo jej generalnie negatywnej oceny, niesie ona ze sobą także pewne pozytywne skutki dla gospodarki.
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OCENA MOŻLIWOŚCI WYKORZYSTANIA CHARAKTERYSTYK ENERGETYCZNYCH PROCESU DO PRZEWIDYWANIA WSKAŹNIKÓW ENERGETYCZNYCH NA BIEŻĄCO
PublicationW artykule autorka zaprezentowała możliwości wykorzystania charakterystyk energetycznych procesu do bieżącej kontroli wskaźników energetycznych. Metoda bieżącej kontroli wskaźników wykorzystuje jako wartości porównawcze wskaźniki wyznaczane na podstawie charakterystyk energetycznych procesów. Metoda ma przede wszystkim mieć zastosowanie do wczesnego wykrywania i eliminowania nadmiernego, nieracjonalnego zużycia nośników energii...
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A Systematic Review for Establishing Relevant Environmental Parameters for Urban Lighting: Translating Research into Practice
PublicationThe application of lighting technologies developed in the 20th century has increased the brightness and changed the spectral composition of nocturnal night-time habitats and night skies across urban, peri-urban, rural, and pristine landscapes, and subsequently, researchers have observed the disturbance of biological rhythms of flora and fauna. To reduce these impacts, it is essential to translate relevant knowledge about the potential...
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Optimised five-hour multiplex PCR test for the detection of Tinea ungium: performance in a routine PCR laboratory
PublicationWe recently published the development of a 5-hour multiplex PCR test for the detection of dermatophyte nail infection. We have optimized this test by inclusion of an inhibition control and evaluated the test in a routine laboratory when compared to the conventional microscopy and culture. A total of 109 clinical samples received at the mycology reference lab at Statens Serum Institute were included. The samples were divided equally...
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A novel approach to enhance high optically active L-lactate production from food waste by landfill leachate
PublicationThe recycling of food waste (FW) through anaerobic fermentation into lactic acid (LA), with two isomers L-LA and D-LA, aligns with the principles of a bio-based circular economy. However, FW fermentation is often limited by competing pathways, acidification inhibition, and trace metals deficiency. This study investigates the introduction of landfill leachate, containing buffering agents (ammonia) and trace metals, into FW fermentation....
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Metody zwiększania dostępności i efektywności informatycznej infrastruktury w inteligentnym mieście
PublicationW pracy omówiono metody zwiększania dostępności i efektywności informatycznej infrastruktury w inteligentnym mieście. Sformułowano dwa kryteria do oceny rozmieszczenia kluczowych zasobów w systemie smart city. Zobrazowano proces wyznaczania rozwiązań kompromisowych spośród rozwiązań Pareto-optymalnych. Omówiono metaheurystyki inteligencji zbiorowej, w tym roju cząstek, kolonii mrówek, roju pszczół oraz ewolucji różnicowej, za pomocą...
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Barriers to inter-company cooperation in clusters
PublicationClusters have proved to be an important source of competitiveness for the economic development of regions within the European Union. One of the main goals of cluster development is to stimulate cooperation between companies in one or a few related sectors. The stakeholders of a cluster, as well as the local economy, can derive many benefits from such cooperation. However, there are numerous barriers, which make it difficult for...
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Analysis of the applicability of laser scanning to making an inventory of swimming pool facilities
Publication3D scanning can be used in many branches of economy, e.g. reverse and prototype engineering, industrial design, quality control, pros-thetics, orthodontics, archiving of historic objects and archeological findings, examination of a scene of crime, making films and comput-er games. The technology of terrestrial laser scanning has a bright fu-ture as we are living in the time of blooming measurement tech-niques, which can provide...
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New bulk liquid membrane oscillator composed of two coupled oscillators with diffusion-mediated physical coupling
PublicationA new type of bulk liquid membrane system, which represents the first example of a bulk liquid membrane oscillator characterised by the presence of two coupled oscillators, is described. When the benzyldimethyltetradecylammonium chloride surfactant undergoes an oscillatory mass transfer through a nitromethane liquid membrane, a new liquid layer (phase X) appears between the membrane and the acceptor phase. Kinetic analysis provides...
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Integration of natural and artificial intelligence in production systems
PublicationIntegration processes play an increasingly important role in modern economy, and seriously co-decide about the effectiveness of the company. Integration phase occurs in the system life cycle by preceding the final stages of its implementation and activation. In turn, used in software engineering (SE) iteration-evolutionary models, such as spiral model make that the integration activities can occur in varying degrees in all phases...
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ISO/IEC 27001-Based Estimation of Cybersecurity Costs with Caspea
PublicationIn the contemporary, knowledge-based economy, enterprises are forced to bear the costs related to cybersecurity. While breaches negatively affect companies' budgets, accurate decisions on security investments result in visible savings. At the same time, cybersecurity cost assessment methods that support these decisions are lacking. Caspea addresses the gap by enabling the estimation of costs related to personnel activities involved...