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Search results for: WHEY PROTEINS
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In silico assessment and sonochemical synthesis of 2-alkynyl 3-chloropyrazines as prospective ligands for SARS-CoV-2
PublicationThe recent global pandemic caused by COVID-19 has triggered an intense effort worldwide towards the development of an effective cure for this disease. In our effort we have explored the 2-alkynyl substituted 3-chloropyrazine framework as a potential template for the design of molecules for this purpose. Our strategy was supported by the in silico studies of representative compounds to assess their binding affinities via docking...
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Modification of gradient HPLC method for determination of small molecules' affinity to human serum albumin under column safety conditions: Robustness and chemometrics study
PublicationIn the early stages of drug discovery, beyond the biological activity screening, determining the physicochemical properties that affect the distribution of molecules in the human body is an essential step. Plasma protein binding (PPB) is one of the most important investigated endpoints. Nevertheless, the methodology for measuring %PPB is significantly less popular and standardized than other physicochemical properties, like lipophilicity....
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Simultaneous handover scheme for IEEE 802.11 WLANs with IEEE 802.21 tiggers
PublicationHandover performance in wireless networks is important, especially nowadays, when multimedia services are becoming increasingly available over the wireless devices. However, users expect uncompromised mobility when using the service. Thus, the support of multimedia services is not possible if handover is inefficient. At the same time it is clear that a strict separation between IP Layer and the Link Layer results in built-in sources...
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Improving sensitivity of residual current transformers to high frequency earth fault currents
PublicationFor protection against electric shock in low voltage systems residual current devices are commonly used. However, their proper operation can be interfered when high frequency earth fault current occurs. Serious hazard of electrocution exists then. In order to detect such a current, it is necessary to modify parameters of residual current devices, especially the operating point of their current transformer. The authors proposed...
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How Does International Competitiveness Affect Economic Development? A Two-Phase Hypothesis
PublicationThis paper analyses the impact of international competitiveness on economic development, based on the World Economic Forum Global Competitiveness Index (GCI) and GDP/capita of 125 countries during the period 2007-2010. The results reveal two phases of the evolution of competitiveness. When GCI < 4.5 (on 1-7 scale), any improvement of a country’s competitiveness affects current development more than future development. When...
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Calculation methods of interaction of electromagnetic waves with objects of complex geometries
PublicationModeling of the electromagnetic interaction with different homogeneous or inhomo-geneous objects is a fundamental and important problem. It is relatively easy to solve Maxwellequations analytically when the scattering object is spherical or cylindrical, for example. How-ever, when it loses these properties all that is left for us is to useapproximation models, to ac-quire the solution we need. Modeling of complex, non-spherical,...
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Neural network based algorithm for hand gesture detection in a low-cost microprocessor applications
PublicationIn this paper the simple architecture of neural network for hand gesture classification was presented. The network classifies the previously calculated parameters of EMG signals. The main goal of this project was to develop simple solution that is not computationally complex and can be implemented on microprocessors in low-cost 3D printed prosthetic arms. As the part of conducted research the data set EMG signals corresponding...
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The accretion of the new ice layer on the surface of hexagonal ice crystal and the influence of the local electric field on this process
PublicationThe process of creation of a new layer of ice on the basal plane and on the prism plane of a hexagonal ice crystal is analyzed. It is demonstrated that the ordering of water molecules in the already existing crystal affects the freezing. On the basal plane, when the orientations of water molecules in the ice block are random, the arrangement of the new layer in a cubic manner is observed more frequently — approximately 1.7 times...
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Solubility of carbon dioxide in water: Some useful results for hydrate nucleation
PublicationIn this paper, the solubility of carbon dioxide (CO2) in water along the isobar of 400 bar is determined by computer simulations using the well-known TIP4P/Ice force field for water and the TraPPE model for CO2. In particular, the solubility of CO2 in water when in contact with the CO2 liquid phase and the solubility of CO2 in water when in contact with the hydrate have been determined. The solubility of CO2 in a liquid–liquid...
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Context-Aware Indexing and Retrieval for Cognitive Systems Using SOEKS and DDNA
PublicationVisual content searching, browsing and retrieval tools have been a focus area of interest as they are required by systems from many different domains. Context-based, Content-Based, and Semantic-based are different approaches utilized for indexing/retrieving, but have their drawbacks when applied to systems that aim to mimic the human capabilities. Such systems, also known as Cognitive Systems, are still limited in terms of processing...
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Low-frequency noise in Au-decorated graphene–Si Schottky barrier diode at selected ambient gases
PublicationWe report results of the current–voltage characteristics and low-frequency noise in Au nanoparticle (AuNP)-decorated graphene–Si Schottky barrier diodes. Measurements were conducted in ambient air with addition of either of two organic vapors, tetrahydrofuran [(CH2)4O; THF] and chloroform (CHCl3), as also during yellow light illumination (592nm), close to the measured particle plasmon polariton frequency of the Au nanoparticle...
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Validating the Rules of Government Automation
PublicationThere is growing evidence on the benefits and risks of government automation, and how should government organizations proceed with automation when the benefits outweigh the risks. This evidence was recently consolidated into the "rules of government automation", part of the project funded by the Inter-American Development Bank. The project uncovered that the combined nature of government work and its transformation into digital...
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Binding modes of a new epoxysuccinyl–peptide inhibitor of cysteine proteases. Where and how do cysteine proteases express their selectivity?
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Glucosamine-6-phosphate synthase - the multi-facets enzyme
PublicationAmidotransferaza L-glutamina: D-frukozo-6-fosforan, nazywana zwyczajowo syntazą glukozamino-6-fosforanu, jako jedyny enzym należący do grupy amidotransferaz, nie wykazuje aktywności amoniakozależnej. Enzym ten, katalizujący pierwszy wyjątkowy etap w szlaku metabolicznym prowadzącym do ostatecznego wytworzenia 5´difosfourydyno-N-acetylo-D-glukozaminy (UDG-GlcNAc) stanowi ważny punkt kontroli metabolicznej biosyntezy makromolekuł...
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Thermodynamic modeling of combustion process of the internal combustion engines – an overview
PublicationThe mathematical description of combustion process in the internal combustion engines is a very difficult task, due to the variety of phenomena that occurring in the engine from the moment when the fuel-air mixture ignites up to the moment when intake and exhaust valves beginning open. Modeling of the combustion process plays an important role in the engine simulation, which allows to predict incylinder pressure during the combustion,...
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Method of sum of power losses as a way for determining the ki coefficients of energy losses in hydraulic motor
PublicationThis paper shows application of the method of sum of power losses to determining energy losses which occur in hydraulic rotary motor in situation when not all laboratory data are at one’s disposal or when no use is made of data contained in catalogue charts. The method makes it possible to determine the coefficients ,ki , of energy losses occurring in the motor. The method of sum of power losses is based on the approach proposed...
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High-Precision FIR-Model-Based Dynamic Weighing System
PublicationConveyor belt-type checkweighers are increasingly popular components of modern production lines. They are used to assess the weight of the produced items in motion, i.e., without stopping them on the weighing platform. The main challenge one faces when designing a dynamic weighing system is providing high measurement accuracy, especially at high conveyor belt speeds. The approach proposed in this paper can be characterized as a...
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Entrepreneurial education and attitudes among young generations in a gender perspective: the case of Polish educational system
PublicationThis paper is an attempt to analyze the impact of entrepreneurship education on entrepreneurial attitudes and intentions of young people: male and female students of Polish high schools and universities. The author makes an effort to verify the impact of the exposure to the business education and entrepreneurs on the decision to start-up. Special emphasis will be placed on the gender differences when discussing a respective factors’...
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Entrepreneurial Education and Attitude among Young Generations in a Gender perspective: the Case of Polish Education System
PublicationThis article is an attempt to analyze the impact of entrepreneurship education on entrepreneurial attitudes and intentions of young people: male and female students of Polish high schools and universities. The author makes an effort to verify the impact of the exposure to the business education and entrepreneurs on the decision to start-up. Special emphasis will be placed on the gender differences when discussing a respective factors’...
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Enzymes of the lysine biosynthetic pathway as targets for antifungals ?
PublicationSystemic infections caused by human pathogenic fungi in immunocompromized patients continue to be one of the important clinical problems. Limited availability of safe and efficacious antifungal chemotherapeutics and emerging resistance to existing drugs stimulates search for novel molecular targets for antifungals. The α-aminoadipate pathway (AAP) of L-lysine biosynthesis is unique in fungi and thus has been so far considered...
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Transcriptomic Effects of Estrogen Starvation and Induction in the MCF7 Cells. The Meta-analysis of Microarray Results
PublicationEstrogen is one of the most important signaling molecules which targets a number of genes. Estrogen levels regulate cell proliferation and a plethora of metabolic processes, which may interfere with a range of medical conditions and drug metabolism. The MCF7 breast cancer cell line, expressing the estrogen receptor α, is a well-studied model of cellular answer to estrogen. The aim of this study was to characterize transcriptomic...
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Cell Density-Dependent Cytological Stage Profile and Its Application for a Screen of Cytostatic Agents Active Toward Leukemic Stem Cells
PublicationProliferation and expansion of leukemia is driven by leukemic stem cells (LSCs). Multidrug resistance (MDR) of LSCs is one of the main reasons of failure and relapses in acute myeloid leukemia (AML) treatment. In this study, we show that maintaining HL-60 at low cell culture density or applying a 240-day treatment with anthrapyridazone (BS-121) increased the percentage of primitive cells, which include LSCs determining the overall...
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Processing and structure–property relationships of natural rubber/wheat bran biocomposites
PublicationIn this work, wheat bran was used as cellulosic filler in biocomposites based on natural rubber. The impact of wheat bran content [ranging from 10 to 50 parts per hundred rubber (phr)] on processing, structure, dynamic mechanical properties, thermal properties, physico-mechanical properties and morphology of resulting biocomposites was investigated. For better characterization of interfacial interactions between natural rubber...
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Processing, mechanical and thermal behavior assessments of polycaprolactone/agricultural wastes biocomposites
PublicationIn this paper, brewer’s spent grain (BSG) was applied as potential lignocellulose biofiller in biocompos-ites based on polycaprolactone (PCL). The PCL/BSG biocomposites filled with varying content of biofillerswere prepared via low-temperature melt-compounding. These conditions allow limiting thermal degra-dation of used biofillers during processing. The influence of biofiller content (ranging from 25 to 200parts by weight on 100...
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Membrane separation processes for the extraction and purification of steviol glycosides: an overview
PublicationSteviol glycosides (SGs), as natural sweeteners from Stevia rebaudiana, are currently employed for replacing sugar and its derivatives in several food products and formulations. Such compounds play an essential role in human health. Their usage provides a positive effect on preventing diseases related to sugar consumption, including diabetes mellitus, cancer, and lipid metabolism disorders. The traditional extraction of SGs is...
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Hydrogen Production Mechanism in Low-Temperature Methanol Decomposition Catalyzed by Ni3Sn4 Intermetallic Compound: A Combined Operando and Density Functional Theory Investigation
PublicationHydrogen production from methanol decomposition to syngas (H2 + CO) is a promising alternative route for clean energy transition. One major challenge is related to the quest for stable, cost-effective, and selective catalysts operating below 400 °C. We illustrate an investigation of the surface reactivity of a Ni3Sn4 catalyst working at 250 °C, by combining density functional theory, operando X-ray absorption spectroscopy, and high-resolution...
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Escherichia coli Strains with Virulent Factors Typical for Uropathogens were Isolated from Sinuses from Patients with Chronic Rhinosinusitis—Case Report
PublicationEscherichia coli were isolated from three patients with chronic rhinosinusitis (CRS) by intraoperative sinus tissue biopsy. Taking into account the unusual replicative niche and previous treatment failures, it was decided to focus on the virulence and drug resistance of these bacteria. The strains turned out to be multi-sensitive, but the rich virulence factors profile of bacteria typical for phylogenetic group B2 deserved attention....
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Modulation of carcinogen metabolizing cytochromes p450 in rat liver and kidney by cabbage and sauerkraut juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate
PublicationThis study investigated the effect of raw cabbage and sauerkraut juices on the activity and expression of CYP1A1, 1A2, 1B1 and 2B in Wistar rat liver and kidney. The results were compared with those of two commercially available products of glucosinolates degradation: indole-3-carbinol (I3C) and phenethyl isothiocyanate (PEITC). Significant differences in the effect of the cabbage juices as well as I3C and PEITC between the liver...
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Future opportunities for products derived from black soldier fly (BSF) treatment as animal feed and fertilizer - A systematic review
PublicationThe pursuit of novel food products with good nutritional value for both direct and indirect human consumption is crucial. Given the nutritional benefits of insects and the sustainability of this sort of farming, using them as food for farmed animals is a promising alternative. In this regard, the black soldier fly (Hermetia illucens) is most capable of efficiently converting a wide variety of organic materials, from food waste...
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Robust Object Detection with Multi-input Multi-output Faster R-CNN
PublicationRecent years have seen impressive progress in visual recognition on many benchmarks, however, generalization to the out-of-distribution setting remains a significant challenge. A state-of-the-art method for robust visual recognition is model ensembling. However, recently it was shown that similarly competitive results could be achieved with a much smaller cost, by using multi-input multi-output architecture (MIMO). In this work,...
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If Gravity is Geometry, is Dark Energy just Arithmetic?
PublicationArithmetic operations (addition, subtraction, multiplication, division), as well as the calculus they imply, are non-unique. The examples of four-dimensional spaces, R^4 and (−L/2,L/2)^4, are considered where different types of arithmetic and calculus coexist simultaneously. In all the examples there exists a non-Diophantine arithmetic that makes the space globally Minkowskian, and thus the laws of physics are formulated in terms...
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Efficient algorithm for blinking LED detection dedicated to embedded systems equipped with high performance cameras
PublicationThis paper presents the concept and implementation of an efficient algorithm for detection of blinking LED or similar signal sources. Algorithm is designed for embedded devices equipped with high performance cameras being a part of an indoor positioning embedded system. An algorithm to be implemented in such a system should be efficient in terms of computational power what is hard to be achieved when large amount of data from camera...
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Robust Object Detection with Multi-input Multi-output Faster R-CNN
PublicationRecent years have seen impressive progress in visual recognition on many benchmarks, however, generalization to the out-of-distribution setting remains a significant challenge. A state-of-the-art method for robust visual recognition is model ensembling. However, recently it was shown that similarly competitive results could be achieved with a much smaller cost, by using multi-input multi-output architecture (MIMO). In this work,...
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Framing the Temporal Dimensions of a Brand
PublicationDrawing on existing research dealing with time in brand and brand management, this paper aims at providing a comprehensive and coherent framework of some time-related concepts, with a special emphasis on what happens when a brand reaches the senescence stage. In addition, it strives to consider what happens when a brand becomes long-lived enough, looking at the brand’s customer base. While undoubtedly time affects customers’ age...
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On optimal tracking of rapidly varying telecommunication channels
PublicationWhen parameters of mobile telecommunication channels change rapidly, classical adaptive filters, such as exponentially weighted least squares algorithms or gradient algorithms, fail to estimate them with sufficient accuracy. In cases like this, one can use identification methods based on explicit models of parameter changes such as the method of basis functions (BF). When prior knowledge about parameter changes is available the...
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Fracture prediction in flat PMMA notched specimens under tension - effectiveness of the equivalent material concept and fictitious material concept
PublicationThe fracture of notched elements under mode I loading (tension) remains an inexhaustible research topic, especially when it comes to the fracture of thermoplastic materials such as polymethylmethacrylate (PMMA), which experience considerable plastic strains under tension. The paper points out that traditional brittle fracture criteria such as mean stress (MS) or maximum tangential stress (MTS) criteria used to predict this phenomenon do...
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Forced vibrations in a dynamic system that is damped by a mechanism that trans-pass through its singular position
PublicationIn the paper, vibrations of a hybrid multibody-continuous system are investigated. For all the mechanical devices, effective damping methods are crucial in the design process. To obtain it, installation of viscous dampers or elasto-viscous elements is dominant. In the paper, an alternative method is investigated. It is based on modal disparity. To describe the method briefly, when structural damping is present in continuous systems,...
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The influence of SVC on the progress of voltage collapse
PublicationThe article presents the simulation concerning the cooperation of SVC circuit with a generative set in time, when of power system reaches low values which may lead to the fall-out of generator from the synchronous operation.
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Laboratory bioreactor with pH control system for investigations of hydrogen production in the dark fermentation process
PublicationThe work presents the construction of a low-cost research bioreactor equipped with a pH control sys-tem. The developed bioreactor was applied for hydrogen production in the dark fermentation process using Enterobacter aerogenes ATCC 13048. Presented paper compares the results obtained during the process without and with pH regulation for different feed materials: glucose, energetic poplar hydro-lysates, acid whey and glycerol....
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DMI measurements impact on a position estimation with lack of GNSS signals during Mobile Mapping
PublicationNowadays, Mobile Laser Scanning is common in use in addition to geodesy measurements. The data which are provided by the system characterizes with high precision and flexibility. To precise mapping, the accuracy of the data should be maintained. In Poland, according to the minister’s dispositions, the accuracy of the data should not exceeded 10 cm. With fully operated system it is easy to uphold, but there is a situation when a...
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Sudden death of effective entanglement
PublicationSudden death of entanglement is a well-known effect resulting from the finite volume of separable states. We study the case when the observer has a limited measurement capability and analyze the effective entanglement (i.e., entanglement minimized over the output data). We show that in the well-defined system of two quantum dots monitored by single-electron transistors, one may observe a sudden death of effective entanglement when...
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Finite-window RLS algorithms
PublicationTwo recursive least-squares (RLS) adaptive filtering algorithms are most often used in practice, the exponential and sliding (rectangular) window RLS algorithms. This popularity is mainly due to existence of low-complexity versions of these algorithms. However, these two windows are not always the best choice for identification of fast time-varying systems, when the identification performance is most important. In this paper, we...
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Karhunen-Loeve-based approach to tracking of rapidly fading wireless communication channels
PublicationWhen parameters of wireless communication channels vary at a fast rate, simple estimation algorithms, such as weighted least squares (WLS) or least mean squares (LMS) algorithms, cannot estimate them with the accuracy needed to secure the reliable operation of the underlying communication systems. In cases like this, the local basis function (LBF) estimation technique can be used instead, significantly increasing the achievable...
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A Wearable System Developed to Monitor People Suffering from Vasovagal Syncope
PublicationA wearable system for monitoring non-invasively signals invaluable when examining person suffering from vasovagal syncope is presented in the paper. Following signals are continuously recorded: electrocardiogram, photopletysmogram, impedance cardiogram and electrodermal resistance.
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AN OVERVIEW OF HEAT TRANSFER ENHANCEMENT BASED UPON NANOPARTICLES INFLUENCED BY INDUCED MAGNETIC FIELD WITH SLIP CONDITION VIA FINITE ELEMENT STRATEGY
PublicationThe mathematical model of heat generation and dissipation during thermal energy transmission employing nanoparticles in a Newtonian medium is investigated. Dimensionless boundary layer equations with correlations for titanium dioxide, copper oxide, and aluminium oxide are solved by the finite element method. Parameters are varied to analyze their impact on the flow fields. Various numerical experiments are performed consecutively...
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Conjectured strong complementary-correlations tradeoff
PublicationWe conjecture uncertainty relations that restrict correlations between the results of measurements performed by two separate parties on a shared quantum state. The first uncertainty relation bounds the sum of two mutual informations when one party measures a single observable and the other party measures one of two observables. The uncertainty relation does not follow from the Maassen-Uffink uncertainty relation and is much stronger...
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Stochastic resonance in measurements
PublicationNoise is usually associated with the negative phenomenon, hampering the measurements data and their analysis. This view has been broken in the '80s when the phenomenon of stochastic resonance (Stochastic Resonance - SR) was discovered. It is a phenomenon that occurs in nonlinear dynamic measurement systems when the selected input noise can optimize system performance. SR became a way to improve efficiency of weak signals detection....
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New Aspects of Virtual Sound Source Localization Research—Impact of Visual Angle and 3-D Video Content on Sound Perception
PublicationThe influence of image on virtual sound source localization, called the “image proximity effect” or the “ventriloquism effect”, is a well known phenomenon. This paper focuses on other aspects related to this effect, namely the impact of the visual angle of the presented object and 3D video content on sound perception. The research conducted confirmed that the visual angle of the presented object determines the image proximity effect...
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Credibility of Threats to Jam Anonymous Traffic Remapping Attacks in Ad Hoc WLANs
PublicationIn ad hoc networks, selfish stations can pursue a better quality of service (QoS) by performing traffic remapping attacks (TRAs), i.e., by falsely assigning their traffic to a higher priority class, which can hurt honest stations’ QoS. To discourage the attackers, honest stations can announce their dissatisfaction with the perceived QoS. If such a threat fails, a costly data frame jamming defense can be launched. We analyze the...
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Rotating rod and ball
PublicationWe consider a mechanical system consisting of an infinite rod (a straight line) and a ball (a massless point) on the plane. The rod rotates uniformly around one of its points. The ball is reflected elastically when colliding with the rod and moves freely between consecutive hits. A sliding motion along the rod is also allowed. We prove the existence and uniqueness of the motion with a given position and velocity at a certain time...